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Robert H. Grubbs

January 25, 2023

Robert Howard Grubbs ForMemRS (February 27, 1942 – December 19, 2021) was an American chemist and the Victor and Elizabeth Atkins Professor of Chemistry at the California Institute of Technology in Pasadena, California.[7] He was a co-recipient of the 2005 Nobel Prize in Chemistry for his work on olefin metathesis.[8]

Robert H. Grubbs
Grubbs at the Royal Society admissions day in London in 2018
Born
Robert Howard Grubbs

(1942-02-27)February 27, 1942
Marshall County, Kentucky, U.S.
DiedDecember 19, 2021(2021-12-19) (aged 79)
Duarte, California, U.S.
EducationUniversity of Florida (BS)
University of Florida (MS)
Columbia University (PhD)
Known forCatalysts for olefin metathesis in organic synthesis
SpouseHelen O'Kane
Awards
Scientific career
FieldsOrganic chemistry
InstitutionsStanford University
Michigan State University
California Institute of Technology
ThesisI. Cyclobutadiene Derivatives II. Studies of Cyclooctatetraene Iron Tricarbonyl Complexes (1968)
Doctoral advisorRonald Breslow[2]
Doctoral students
Websitegrubbsgroup.caltech.edu

Grubbs was elected a member of the National Academy of Engineering in 2015 for developments in catalysts that have enabled commercial products.

He was a co-founder of Materia, a university spin-off startup to produce catalysts.[9]

Early life and education

Grubbs was born on February 27, 1942, on a farm in Marshall County, Kentucky, midway between Possum Trot and Calvert City.[10][11] His parents were Howard and Faye (Atwood) Grubbs.[10][12] Faye was a schoolteacher. After serving in World War II, the family moved to Paducah, Kentucky, where Howard trained as a diesel mechanic, and Robert attended Paducah Tilghman High School.[10][11]

At the University of Florida, Grubbs initially intended to study agriculture chemistry.[13] However, he was convinced by professor Merle A. Battiste to switch to organic chemistry.[14] Working with Battiste, he became interested in how chemical reactions occur.[11] He received his B.S. in 1963 and M.S. in 1965 from the University of Florida.[14][15]

Next, Grubbs attended Columbia University, where he worked with Ronald Breslow on organometallic compounds which contain carbon-metal bonds. Grubbs received his PhD in 1968.[2][11]

Career

Grubbs worked with James Collman at Stanford University as a National Institutes of Health fellow during 1968–1969. With Collman, he began to systematically investigate catalytic processes in organometallic chemistry, a then relatively new area of research.[11]

In 1969, Grubbs was appointed to the faculty of Michigan State University, where he began his work on olefin metathesis. Harold Hart, Gerasimos J. Karabatsos, Gene LeGoff, Don Farnum, Bill Reusch and Pete Wagner served as his early mentors at MSU.[11] Grubbs was an assistant professor from 1969 to 1973, and an associate professor from 1973 to 1978.[16] He received a Sloan Fellowship for 1974–1976.[17] In 1975, he went to the Max Planck Institute for Coal Research in Mülheim, Germany on a fellowship from the Alexander von Humboldt Foundation.[18]

In 1978, Grubbs moved to California Institute of Technology as a professor of chemistry. As of 1990 he became the Victor and Elizabeth Atkins Professor of Chemistry.[19][20]

As of 2021, Grubbs has an h-index of 160 according to Google Scholar[21] and of 137 according to Scopus.[22]

Commercial activities

Both first and second generation Grubbs catalysts were commercially available from Materia, a startup company that Grubbs co-founded with Mike Giardello in Pasadena, California, in 1998.[23][24][25] Materia has been able to obtain exclusive rights to manufacture many of the known olefin catalysts.[26] Under Giardello, Materia was able to sell their catalysts through Sigma-Aldrich's chemicals catalogue. Sigma-Aldrich became their exclusive worldwide provider.[24][27] In 2008, Materia partnered with Cargill to form Elevance Renewable Sciences to produce specialty chemicals from renewable oils,[28] including biofuels.[29] In 2017, Materia sold its catalyst business to Umicore.[30] In 2021, Materia was acquired by ExxonMobil.[31]

Grubbs was a member of the Reliance Innovation Council formed by Reliance Industries Limited, India.[32]

Grubbs was a member of the USA Science and Engineering Festival's Advisory Board.[33]

Research

Grubbs's main research interests were in organometallic chemistry and synthetic chemistry, particularly the development of novel catalysts for olefin metathesis. In olefin metathesis, a catalyst is used to break the bonds of carbon molecules, which can then re-form to create chemical bonds in new ways, producing new compounds with unique properties.[14][34] The basic technique can be used for creation of polymers, pharmaceuticals and petrochemicals[35] and has broad applications in areas including pharmaceuticals, biotechnology, agriculture, and plastics.[14]

Grubbs was instrumental in developing a family of ruthenium catalysts, including Grubbs catalyst for olefin metathesis.[36] He studied olefin transformations for ring-closing metathesis (RCM),[37] cross-metathesis reaction (CMR),[38] and ring-opening metathesis polymerization (ROMP) with cyclic olefins such as norbornene.[39] He also contributed to the development of "living polymerization", in which the termination ability of a polymerization reaction is removed. The polymer will continue to replicate until a quenching agent is presented.[40]

The Grubbs group successfully polymerized the 7-oxo norbornene derivative using ruthenium trichloride, osmium trichloride as well as tungsten alkylidenes.[41] They identified a Ru(II) carbene as an effective metal center and in 1992 published the first well-defined, ruthenium-based olefin metathesis catalyst, (PPh3)2Cl2Ru=CHCH=CPh2.[39]

 

The corresponding tricyclohexylphosphine complex (PCy3)2Cl2Ru=CHCH=CPh2 was also shown to be active.[42] This work culminated in the now commercially available first-generation Grubbs catalyst in 1995.[23][43][44] Second generation catalysts were developed as well.[45][46]

Ruthenium is stable in air and has higher selectivity and lower reactivity than molybdenum, the most promising of the previously discovered catalysts. In addition, Grubbs took a green chemistry approach to catalysis that reduced the potential to create hazardous waste. The Grubbs catalyst has become a standard for general metathesis applications in ordinary laboratories.[7][36][45]

By controlling the catalyst used, it became possible to synthesize polymers with specialized structures and functional capabilities, including cyclic olefins, alternating copolymers, and multiblock copolymers.[34] Using catalysts allows chemists to speed up chemical transformations and to lower the cost of what were previously complicated multi-step industrial processes.[24]

Personal life

While at Columbia University, Grubbs also met his future wife, Helen O'Kane, a special-education teacher, with whom he had three children: Barney (born 1972), Brendan H. (born 1974) and Kathleen (Katy) (born 1977).[11][47][48]

Grubbs died from a heart attack at the City of Hope Comprehensive Cancer Center in Duarte, California, on December 19, 2021, at age 79.[49][48] At the time of his death, he was being treated for lymphoma.[48]

Awards and honors

Grubbs received the 2005 Nobel Prize in Chemistry, along with Richard R. Schrock and Yves Chauvin, for his work in the field of olefin metathesis.[8][50] He has received a number of other awards and honors, including the following:

 
AIC Gold Medal recipient, 2010

Publications

  • Grubbs, Robert (2003). Handbook of Metathesis. Weinheim, Germany; Chichester, England: Wiley-VCH John Wiley distributor. ISBN 978-3-527-30616-9. OCLC 52485738.

References

  1. ^ a b Anon (2017). "Professor Robert Grubbs ForMemRS". royalsociety.org. London: Royal Society.
  2. ^ a b Grubbs, Robert Howard (1968). I. Cyclebutadiene Derivatives II. Studies of Cyclooctatetraene Iron Tricarbonyl Complexes (PhD thesis). Columbia University. ProQuest 302317287. (subscription required)
  3. ^ Swager, Timothy Manning (1988). Precursor Routes to Conducting Polymers from the Ring-Opening Metathesis Polymerization of Cyclic Olefins (phd). California Institute of Technology. doi:10.7907/KF6P-FC76. Retrieved December 20, 2021. Research Advisor(s): Grubbs, Robert H.
  4. ^ Sanford, Melanie Sarah (2001). Synthetic and mechanistic investigations of ruthenium olefin metathesis catalysts (phd). California Institute of Technology. doi:10.7907/Q96P-VK05. Retrieved December 20, 2021. Research Advisor(s): Grubbs, Robert H.
  5. ^ "People – The Sanford Group". WordPress Websites – Offered by LSA Technology Services. October 29, 2021. Retrieved December 20, 2021.
  6. ^ Nguyen, SonBinh TheBao (1995). The designs, syntheses, and applications of well-defined, single component group VIII olefin metathesis catalysts (phd). California Institute of Technology. doi:10.7907/1BVB-S189. Retrieved December 20, 2021. Research Advisor(s): Grubbs, Robert H.
  7. ^ a b c "American Institute of Chemists Gold Medal". Science History Institute. March 22, 2018.
  8. ^ a b c "Press Release, 5 October 2005". The Nobel Prize in Chemistry 2005. NobelPrize.org. Retrieved April 12, 2016.
  9. ^ "Lanxess rubber employs Materia catalysts". Chemical & Engineering News. 84 (34): 23. August 21, 2006. Retrieved January 9, 2018.
  10. ^ a b c "Jackson Purchase Nobel Laureate". Jackson Purchase Historical Society. Retrieved April 12, 2016.
  11. ^ a b c d e f g "Robert H. Grubbs – Biographical". The Nobel Prize in Chemistry 2005. NobelPrize.org. Retrieved April 12, 2016. In some places, my birthplace is listed as Calvert City and in others Possum Trot. I was actually born between the two, so either one really is correct.
  12. ^ History and Families, McCracken County, Kentucky, 1824-1989. Turner Publishing Company. December 22, 1989. ISBN 9780938021360. Retrieved December 22, 2021 – via Google Books.
  13. ^ "Nobel laureate Robert Grubbs dies at 79". cen.acs.org. Retrieved December 22, 2021.{{cite web}}: CS1 maint: url-status (link)
  14. ^ a b c d Janine Young, Sikes (October 6, 2005). . The Gainesville Sun. Archived from the original on April 21, 2016. Retrieved April 14, 2016.
  15. ^ Doerfler, Andrew (December 20, 2021). "UF Mourns the Passing of Robert H. Grubbs, Nobel-Winning Alumnus". News – College of Liberal Arts & Sciences. Retrieved December 22, 2021.
  16. ^ "Robert H. Grubbs PhD " Leadership Board". Department of Chemistry, University of Florida. Retrieved April 14, 2016.
  17. ^ "Nobel Laureates". Alfred P. Sloan Foundation. Retrieved April 15, 2016.
  18. ^ . The Alexander von Humboldt Foundation. October 5, 2005. Archived from the original on November 14, 2018.
  19. ^ "Robert H. Grubbs American chemist". Encyclopædia Britannica.
  20. ^ a b "2002 Robert H. Grubbs, Caltech". Southern California Section of the American Chemical Society. July 20, 2012. Retrieved April 12, 2016.
  21. ^ Robert H. Grubbs publications indexed by Google Scholar  
  22. ^ Robert H. Grubbs publications indexed by the Scopus bibliographic database. (subscription required)
  23. ^ a b Notman, Nina (January 28, 2015). "Grubbs catalyst". Chemistry World. Retrieved April 15, 2016.
  24. ^ a b c . Caltech News. Archived from the original on September 10, 2015. Retrieved April 17, 2014.
  25. ^ "Leading Innovation in Catalysis". Materia. Retrieved April 15, 2016.
  26. ^ "The History of Materia". Materia. Retrieved April 15, 2016.
  27. ^ "Materia and Sigma-Aldrich Announce Exclusive Distribution Deal for Grubbs' Metathesis Catalysts". Business Wire. August 18, 2003. Retrieved April 15, 2016.
  28. ^ Tullo, Alexander H. (March 31, 2008). "Cargill, Materia Launch New Firm Elevance will make specialty chemicals from vegetable oils". Chemical & Engineering News. 86 (13): 6. doi:10.1021/cen-v086n013.p006.
  29. ^ Kotrba, Ron (March 23, 2010). "Newton plant to become biorefinery showcase". Biodiesel Magazine. Retrieved April 15, 2016.
  30. ^ "Materia, Inc. Sells Catalyst Business to Umicore". Materia. December 20, 2017. Retrieved June 10, 2021.
  31. ^ "ExxonMobil acquires Materia, Inc., a high-performance structural polymers company". ExxonMobil. Retrieved December 18, 2021.
  32. ^ . Reliance Industries Limited. Archived from the original on December 16, 2021. Retrieved December 20, 2021.
  33. ^ . USA Science & Engineering Festival. Archived from the original on April 21, 2010. Retrieved April 12, 2016.
  34. ^ a b Miree-Luke, Lisa (October 8, 2015). "Axalta's Distinguished Lecture Series at the University of Pennsylvania Features Presentation on Methathesis Polymerization". Business Wire. Retrieved April 14, 2016.
  35. ^ a b Pearson, Rodney (April 3, 2001). . EurekaAlert. Archived from the original on April 15, 2016. Retrieved April 14, 2016.
  36. ^ a b Singh, Okram Mukherjee (2006). "Metathesis catalysts: Historical perspective, recent developments and practical applications" (PDF). Journal of Scientific & Industrial Research. 65 (December): 957–965. Retrieved April 12, 2016.
  37. ^ Grubbs, Robert H. (2006). "Olefin-Metathesis Catalysts for the Preparation of Molecules and Materials (Nobel Lecture)". Angewandte Chemie International Edition. 45 (23): 3760–3765. doi:10.1002/anie.200600680. PMID 16724297.
  38. ^ Chatterjee, Arnab K.; Choi, Tae-Lim; Sanders, Daniel P.; Grubbs, Robert H. (September 2003). "A General Model for Selectivity in Olefin Cross Metathesis" (PDF). Journal of the American Chemical Society. 125 (37): 11360–11370. doi:10.1021/ja0214882. PMID 16220959. Retrieved April 14, 2016.
  39. ^ a b Nguyen, SonBinh T.; Johnson, Lynda K.; Grubbs, Robert H.; Ziller, Joseph W. (May 1992). "Ring-opening metathesis polymerization (ROMP) of norbornene by a Group VIII carbene complex in protic media" (PDF). Journal of the American Chemical Society. 114 (10): 3974–3975. doi:10.1021/ja00036a053.
  40. ^ Schrock, R. R.; Feldman, J.; Cannizzo, L. F.; Grubbs, R. H. (September 1987). "Ring-opening polymerization of norbornene by a living tungsten alkylidene complex". Macromolecules. 20 (5): 1169–1172. Bibcode:1987MaMol..20.1169S. doi:10.1021/ma00171a053.
  41. ^ Novak, Bruce M.; Grubbs, Robert H. (1988). "The ring opening metathesis polymerization of 7-oxabicyclo[2.2.1]hept-5-ene derivatives: a new acyclic polymeric ionophore". Journal of the American Chemical Society. 110 (3): 960–961. doi:10.1021/ja00211a043.
  42. ^ Nguyen, Sonbinh T.; Grubbs, Robert H.; Ziller, Joseph W. (1993). "Syntheses and activities of new single-component, ruthenium-based olefin metathesis catalysts". Journal of the American Chemical Society. 115 (21): 9858–9859. doi:10.1021/ja00074a086.
  43. ^ Schwab, Peter; France, Marcia B.; Ziller, Joseph W.; Grubbs, Robert H. (1995). "A Series of Well-Defined Metathesis Catalysts–Synthesis of [RuCl2(CHR')(PR3)2] and Its Reactions". Angew. Chem. Int. Ed. Engl. 34 (18): 2039–2041. doi:10.1002/anie.199520391.
  44. ^ Schwab, Peter; Grubbs, Robert H.; Ziller, Joseph W. (1996). "Synthesis and Applications of RuCl2(=CHR')(PR3)2: The Influence of the Alkylidene Moiety on Metathesis Activity". Journal of the American Chemical Society. 118: 100–110. doi:10.1021/ja952676d.
  45. ^ a b Astruc, Didier (2005). (PDF). New Journal of Chemistry. 29 (1): 42. doi:10.1039/b412198h. Archived from the original (PDF) on June 16, 2016. Retrieved April 12, 2016.
  46. ^ Wilson, Gerald O.; Porter, Keith A.; Weissman, Haim; White, Scott R.; Sottos, Nancy R.; Moore, Jeffrey S. (August 14, 2009). "Stability of Second Generation Grubbs' Alkylidenes to Primary Amines: Formation of Novel Ruthenium-Amine Complexes". Advanced Synthesis & Catalysis. 351 (11–12): 1817–1825. doi:10.1002/adsc.200900134.
  47. ^ . www.columbia.edu. Archived from the original on March 1, 2017. Retrieved July 21, 2016.
  48. ^ a b c McClain, Dylan Loeb (December 24, 2021). "Robert H. Grubbs, 79, Dies; Chemistry Breakthrough Led to a Nobel". The New York Times. Retrieved December 24, 2021.
  49. ^ "Caltech Mourns the Loss of Nobel Laureate Robert H. Grubbs". Caltech. December 19, 2021. Retrieved December 19, 2021.
  50. ^ "Robert H. Grubbs – Facts". The Nobel Prize in Chemistry 2005. NobelPrize.org. Retrieved April 15, 2016.
  51. ^ "National Academy of Sciences Members". Caltech. Retrieved April 15, 2016.
  52. ^ "Robert H. Grubbs". American Academy of Arts & Sciences. November 18, 2021. Retrieved December 20, 2021.
  53. ^ "Robert H. Grubbs". The Franklin Institute. January 10, 2014. Retrieved April 14, 2016.
  54. ^ . Division of Polymer Chemistry, Inc. of the American Chemical Society. Archived from the original on March 15, 2016. Retrieved April 14, 2016.
  55. ^ "Pasadena chemist wins national award for cata". EurekAlert!. Retrieved December 20, 2021.
  56. ^ "Arthur C. Cope Award". ACS Chemistry for Life. American Chemical Society. Retrieved April 12, 2016.
  57. ^ "Tetrahedron Prize for Creativity". Elsevier B.V. Retrieved April 12, 2016.
  58. ^ "Members Grubbs". rsc.org. Royal Society of Chemistry. Retrieved April 15, 2016.
  59. ^ . University of Zurich. Archived from the original on April 23, 2016. Retrieved April 12, 2016.
  60. ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  61. ^ . American Chemical Society. Archived from the original on February 24, 2019. Retrieved April 15, 2016.
  62. ^ "2015 Inductees: Robert Howard Grubbs". Florida Inventors Hall of Fame. September 28, 2015. Retrieved April 14, 2016.
  63. ^ "Current NAI Fellows". National Academy of Inventors. Retrieved April 15, 2016.
  64. ^ "Professor Robert Howard Grubbs". National Academy of Engineering. Retrieved April 12, 2016.
  65. ^ "New Academicians and Foreign Members of the Chinese Academy of Sciences". Angewandte Chemie International Edition. 55 (8): 2633–2634. February 2016. doi:10.1002/anie.201511637.
  66. ^ "12 Famous Scientists Elected 2015 CAS Foreign Members". CASAD. Retrieved April 12, 2016.
  67. ^ Wang, Linda (February 13, 2017). "Robert Grubbs wins Remsen Award". Chemical & Engineering News. American Chemical Society. 59 (7). Retrieved December 20, 2021.

External links

  • "Press Release, 5 October 2005". The Nobel Prize in Chemistry 2005. NobelPrize.org.
  • Robert H. Grubbs on Nobelprize.org  
  • Robert H. Grubbs publications indexed by Google Scholar  

January 25, 2023
robert, grubbs, robert, howard, grubbs, formemrs, february, 1942, december, 2021, american, chemist, victor, elizabeth, atkins, professor, chemistry, california, institute, technology, pasadena, california, recipient, 2005, nobel, prize, chemistry, work, olefi. Robert Howard Grubbs ForMemRS February 27 1942 December 19 2021 was an American chemist and the Victor and Elizabeth Atkins Professor of Chemistry at the California Institute of Technology in Pasadena California 7 He was a co recipient of the 2005 Nobel Prize in Chemistry for his work on olefin metathesis 8 Robert H GrubbsGrubbs at the Royal Society admissions day in London in 2018BornRobert Howard Grubbs 1942 02 27 February 27 1942Marshall County Kentucky U S DiedDecember 19 2021 2021 12 19 aged 79 Duarte California U S EducationUniversity of Florida BS University of Florida MS Columbia University PhD Known forCatalysts for olefin metathesis in organic synthesisSpouseHelen O KaneAwardsTolman Award 2002 Linus Pauling Award 2003 Nobel Prize in Chemistry 2005 AIC Gold Medal 2010 ForMemRS 2017 1 Scientific careerFieldsOrganic chemistryInstitutionsStanford UniversityMichigan State UniversityCalifornia Institute of TechnologyThesisI Cyclobutadiene Derivatives II Studies of Cyclooctatetraene Iron Tricarbonyl Complexes 1968 Doctoral advisorRonald Breslow 2 Doctoral studentsTimothy M Swager 3 Melanie Sanford 4 5 SonBinh Nguyen 6 Websitegrubbsgroup wbr caltech wbr eduGrubbs was elected a member of the National Academy of Engineering in 2015 for developments in catalysts that have enabled commercial products He was a co founder of Materia a university spin off startup to produce catalysts 9 Contents 1 Early life and education 2 Career 2 1 Commercial activities 3 Research 4 Personal life 5 Awards and honors 6 Publications 7 References 8 External linksEarly life and education EditGrubbs was born on February 27 1942 on a farm in Marshall County Kentucky midway between Possum Trot and Calvert City 10 11 His parents were Howard and Faye Atwood Grubbs 10 12 Faye was a schoolteacher After serving in World War II the family moved to Paducah Kentucky where Howard trained as a diesel mechanic and Robert attended Paducah Tilghman High School 10 11 At the University of Florida Grubbs initially intended to study agriculture chemistry 13 However he was convinced by professor Merle A Battiste to switch to organic chemistry 14 Working with Battiste he became interested in how chemical reactions occur 11 He received his B S in 1963 and M S in 1965 from the University of Florida 14 15 Next Grubbs attended Columbia University where he worked with Ronald Breslow on organometallic compounds which contain carbon metal bonds Grubbs received his PhD in 1968 2 11 Career EditGrubbs worked with James Collman at Stanford University as a National Institutes of Health fellow during 1968 1969 With Collman he began to systematically investigate catalytic processes in organometallic chemistry a then relatively new area of research 11 In 1969 Grubbs was appointed to the faculty of Michigan State University where he began his work on olefin metathesis Harold Hart Gerasimos J Karabatsos Gene LeGoff Don Farnum Bill Reusch and Pete Wagner served as his early mentors at MSU 11 Grubbs was an assistant professor from 1969 to 1973 and an associate professor from 1973 to 1978 16 He received a Sloan Fellowship for 1974 1976 17 In 1975 he went to the Max Planck Institute for Coal Research in Mulheim Germany on a fellowship from the Alexander von Humboldt Foundation 18 In 1978 Grubbs moved to California Institute of Technology as a professor of chemistry As of 1990 he became the Victor and Elizabeth Atkins Professor of Chemistry 19 20 As of 2021 update Grubbs has an h index of 160 according to Google Scholar 21 and of 137 according to Scopus 22 Commercial activities Edit Both first and second generation Grubbs catalysts were commercially available from Materia a startup company that Grubbs co founded with Mike Giardello in Pasadena California in 1998 23 24 25 Materia has been able to obtain exclusive rights to manufacture many of the known olefin catalysts 26 Under Giardello Materia was able to sell their catalysts through Sigma Aldrich s chemicals catalogue Sigma Aldrich became their exclusive worldwide provider 24 27 In 2008 Materia partnered with Cargill to form Elevance Renewable Sciences to produce specialty chemicals from renewable oils 28 including biofuels 29 In 2017 Materia sold its catalyst business to Umicore 30 In 2021 Materia was acquired by ExxonMobil 31 Grubbs was a member of the Reliance Innovation Council formed by Reliance Industries Limited India 32 Grubbs was a member of the USA Science and Engineering Festival s Advisory Board 33 Research EditGrubbs s main research interests were in organometallic chemistry and synthetic chemistry particularly the development of novel catalysts for olefin metathesis In olefin metathesis a catalyst is used to break the bonds of carbon molecules which can then re form to create chemical bonds in new ways producing new compounds with unique properties 14 34 The basic technique can be used for creation of polymers pharmaceuticals and petrochemicals 35 and has broad applications in areas including pharmaceuticals biotechnology agriculture and plastics 14 Grubbs was instrumental in developing a family of ruthenium catalysts including Grubbs catalyst for olefin metathesis 36 He studied olefin transformations for ring closing metathesis RCM 37 cross metathesis reaction CMR 38 and ring opening metathesis polymerization ROMP with cyclic olefins such as norbornene 39 He also contributed to the development of living polymerization in which the termination ability of a polymerization reaction is removed The polymer will continue to replicate until a quenching agent is presented 40 The Grubbs group successfully polymerized the 7 oxo norbornene derivative using ruthenium trichloride osmium trichloride as well as tungsten alkylidenes 41 They identified a Ru II carbene as an effective metal center and in 1992 published the first well defined ruthenium based olefin metathesis catalyst PPh3 2Cl2Ru CHCH CPh2 39 The corresponding tricyclohexylphosphine complex PCy3 2Cl2Ru CHCH CPh2 was also shown to be active 42 This work culminated in the now commercially available first generation Grubbs catalyst in 1995 23 43 44 Second generation catalysts were developed as well 45 46 Ruthenium is stable in air and has higher selectivity and lower reactivity than molybdenum the most promising of the previously discovered catalysts In addition Grubbs took a green chemistry approach to catalysis that reduced the potential to create hazardous waste The Grubbs catalyst has become a standard for general metathesis applications in ordinary laboratories 7 36 45 By controlling the catalyst used it became possible to synthesize polymers with specialized structures and functional capabilities including cyclic olefins alternating copolymers and multiblock copolymers 34 Using catalysts allows chemists to speed up chemical transformations and to lower the cost of what were previously complicated multi step industrial processes 24 Personal life EditWhile at Columbia University Grubbs also met his future wife Helen O Kane a special education teacher with whom he had three children Barney born 1972 Brendan H born 1974 and Kathleen Katy born 1977 11 47 48 Grubbs died from a heart attack at the City of Hope Comprehensive Cancer Center in Duarte California on December 19 2021 at age 79 49 48 At the time of his death he was being treated for lymphoma 48 Awards and honors EditGrubbs received the 2005 Nobel Prize in Chemistry along with Richard R Schrock and Yves Chauvin for his work in the field of olefin metathesis 8 50 He has received a number of other awards and honors including the following AIC Gold Medal recipient 2010 1989 National Academy of Sciences 51 1994 American Academy of Arts and Sciences 52 2000 Benjamin Franklin Medal in Chemistry from the Franklin Institute 53 2000 ACS Herman F Mark Polymer Chemistry Award 54 2001 ACS Herbert C Brown Award for Creative Research in Synthetic Methods 35 2002 Tolman Medal 20 2002 Arthur C Cope Award 55 56 2003 Tetrahedron Prize for Creativity in Organic Chemistry amp BioMedicinal Chemistry with Dieter Seebach 57 2005 Nobel Prize in Chemistry with Richard R Schrock and Yves Chauvin 8 2005 Honorary Fellow of the Royal Society of Chemistry 58 2005 Paul Karrer Gold Medal 59 2006 Golden Plate Award of the American Academy of Achievement 60 2009 Fellow of the American Chemical Society 61 2010 American Institute of Chemists Gold Medal 7 2015 Inducted into the Florida Inventors Hall of Fame 62 2013 National Academy of Inventors 63 2015 National Academy of Engineering 64 2015 Chinese Academy of Sciences foreign academician 65 66 2017 Ira Remsen Award 67 2017 Elected a Foreign Member of the Royal Society 1 Publications EditGrubbs Robert 2003 Handbook of Metathesis Weinheim Germany Chichester England Wiley VCH John Wiley distributor ISBN 978 3 527 30616 9 OCLC 52485738 References Edit a b Anon 2017 Professor Robert Grubbs ForMemRS royalsociety org London Royal Society a b Grubbs Robert Howard 1968 I Cyclebutadiene Derivatives II Studies of Cyclooctatetraene Iron Tricarbonyl Complexes PhD thesis Columbia University ProQuest 302317287 subscription required Swager Timothy Manning 1988 Precursor Routes to Conducting Polymers from the Ring Opening Metathesis Polymerization of Cyclic Olefins phd California Institute of Technology doi 10 7907 KF6P FC76 Retrieved December 20 2021 Research Advisor s Grubbs Robert H Sanford Melanie Sarah 2001 Synthetic and mechanistic investigations of ruthenium olefin metathesis catalysts phd California Institute of Technology doi 10 7907 Q96P VK05 Retrieved December 20 2021 Research Advisor s Grubbs Robert H People The Sanford Group WordPress Websites Offered by LSA Technology Services October 29 2021 Retrieved December 20 2021 Nguyen SonBinh TheBao 1995 The designs syntheses and applications of well defined single component group VIII olefin metathesis catalysts phd California Institute of Technology doi 10 7907 1BVB S189 Retrieved December 20 2021 Research Advisor s Grubbs Robert H a b c American Institute of Chemists Gold Medal Science History Institute March 22 2018 a b c Press Release 5 October 2005 The Nobel Prize in Chemistry 2005 NobelPrize org Retrieved April 12 2016 Lanxess rubber employs Materia catalysts Chemical amp Engineering News 84 34 23 August 21 2006 Retrieved January 9 2018 a b c Jackson Purchase Nobel Laureate Jackson Purchase Historical Society Retrieved April 12 2016 a b c d e f g Robert H Grubbs Biographical The Nobel Prize in Chemistry 2005 NobelPrize org Retrieved April 12 2016 In some places my birthplace is listed as Calvert City and in others Possum Trot I was actually born between the two so either one really is correct History and Families McCracken County Kentucky 1824 1989 Turner Publishing Company December 22 1989 ISBN 9780938021360 Retrieved December 22 2021 via Google Books Nobel laureate Robert Grubbs dies at 79 cen acs org Retrieved December 22 2021 a href Template Cite web html title Template Cite web cite web a CS1 maint url status link a b c d Janine Young Sikes October 6 2005 A Gator wins Nobel in chemistry The Gainesville Sun Archived from the original on April 21 2016 Retrieved April 14 2016 Doerfler Andrew December 20 2021 UF Mourns the Passing of Robert H Grubbs Nobel Winning Alumnus News College of Liberal Arts amp Sciences Retrieved December 22 2021 Robert H Grubbs PhD Leadership Board Department of Chemistry University of Florida Retrieved April 14 2016 Nobel Laureates Alfred P Sloan Foundation Retrieved April 15 2016 Chemistry Nobel Prize for two Humboldtians The Alexander von Humboldt Foundation October 5 2005 Archived from the original on November 14 2018 Robert H Grubbs American chemist Encyclopaedia Britannica a b 2002 Robert H Grubbs Caltech Southern California Section of the American Chemical Society July 20 2012 Retrieved April 12 2016 Robert H Grubbs publications indexed by Google Scholar Robert H Grubbs publications indexed by the Scopus bibliographic database subscription required a b Notman Nina January 28 2015 Grubbs catalyst Chemistry World Retrieved April 15 2016 a b c Industry s Secret Ingredient Caltech News Archived from the original on September 10 2015 Retrieved April 17 2014 Leading Innovation in Catalysis Materia Retrieved April 15 2016 The History of Materia Materia Retrieved April 15 2016 Materia and Sigma Aldrich Announce Exclusive Distribution Deal for Grubbs Metathesis Catalysts Business Wire August 18 2003 Retrieved April 15 2016 Tullo Alexander H March 31 2008 Cargill Materia Launch New Firm Elevance will make specialty chemicals from vegetable oils Chemical amp Engineering News 86 13 6 doi 10 1021 cen v086n013 p006 Kotrba Ron March 23 2010 Newton plant to become biorefinery showcase Biodiesel Magazine Retrieved April 15 2016 Materia Inc Sells Catalyst Business to Umicore Materia December 20 2017 Retrieved June 10 2021 ExxonMobil acquires Materia Inc a high performance structural polymers company ExxonMobil Retrieved December 18 2021 Reliance Innovation Council 2007 2017 Raghunath Mashelkar Mukesh Ambani Jean Marie Lehn Robert Grubbs George Whitesides Gary Hamel William Haseltine Reliance Industries Limited Archived from the original on December 16 2021 Retrieved December 20 2021 Nobel Laureates USA Science amp Engineering Festival Archived from the original on April 21 2010 Retrieved April 12 2016 a b Miree Luke Lisa October 8 2015 Axalta s Distinguished Lecture Series at the University of Pennsylvania Features Presentation on Methathesis Polymerization Business Wire Retrieved April 14 2016 a b Pearson Rodney April 3 2001 South Pasadena chemist wins national award for designing new catalysts EurekaAlert Archived from the original on April 15 2016 Retrieved April 14 2016 a b Singh Okram Mukherjee 2006 Metathesis catalysts Historical perspective recent developments and practical applications PDF Journal of Scientific amp Industrial Research 65 December 957 965 Retrieved April 12 2016 Grubbs Robert H 2006 Olefin Metathesis Catalysts for the Preparation of Molecules and Materials Nobel Lecture Angewandte Chemie International Edition 45 23 3760 3765 doi 10 1002 anie 200600680 PMID 16724297 Chatterjee Arnab K Choi Tae Lim Sanders Daniel P Grubbs Robert H September 2003 A General Model for Selectivity in Olefin Cross Metathesis PDF Journal of the American Chemical Society 125 37 11360 11370 doi 10 1021 ja0214882 PMID 16220959 Retrieved April 14 2016 a b Nguyen SonBinh T Johnson Lynda K Grubbs Robert H Ziller Joseph W May 1992 Ring opening metathesis polymerization ROMP of norbornene by a Group VIII carbene complex in protic media PDF Journal of the American Chemical Society 114 10 3974 3975 doi 10 1021 ja00036a053 Schrock R R Feldman J Cannizzo L F Grubbs R H September 1987 Ring opening polymerization of norbornene by a living tungsten alkylidene complex Macromolecules 20 5 1169 1172 Bibcode 1987MaMol 20 1169S doi 10 1021 ma00171a053 Novak Bruce M Grubbs Robert H 1988 The ring opening metathesis polymerization of 7 oxabicyclo 2 2 1 hept 5 ene derivatives a new acyclic polymeric ionophore Journal of the American Chemical Society 110 3 960 961 doi 10 1021 ja00211a043 Nguyen Sonbinh T Grubbs Robert H Ziller Joseph W 1993 Syntheses and activities of new single component ruthenium based olefin metathesis catalysts Journal of the American Chemical Society 115 21 9858 9859 doi 10 1021 ja00074a086 Schwab Peter France Marcia B Ziller Joseph W Grubbs Robert H 1995 A Series of Well Defined Metathesis Catalysts Synthesis of RuCl2 CHR PR3 2 and Its Reactions Angew Chem Int Ed Engl 34 18 2039 2041 doi 10 1002 anie 199520391 Schwab Peter Grubbs Robert H Ziller Joseph W 1996 Synthesis and Applications of RuCl2 CHR PR3 2 The Influence of the Alkylidene Moiety on Metathesis Activity Journal of the American Chemical Society 118 100 110 doi 10 1021 ja952676d a b Astruc Didier 2005 The metathesis reactions from a historical perspective to recent developments PDF New Journal of Chemistry 29 1 42 doi 10 1039 b412198h Archived from the original PDF on June 16 2016 Retrieved April 12 2016 Wilson Gerald O Porter Keith A Weissman Haim White Scott R Sottos Nancy R Moore Jeffrey S August 14 2009 Stability of Second Generation Grubbs Alkylidenes to Primary Amines Formation of Novel Ruthenium Amine Complexes Advanced Synthesis amp Catalysis 351 11 12 1817 1825 doi 10 1002 adsc 200900134 Columbia News Alumnus Robert Grubbs Wins Nobel Prize in Chemistry www columbia edu Archived from the original on March 1 2017 Retrieved July 21 2016 a b c McClain Dylan Loeb December 24 2021 Robert H Grubbs 79 Dies Chemistry Breakthrough Led to a Nobel The New York Times Retrieved December 24 2021 Caltech Mourns the Loss of Nobel Laureate Robert H Grubbs Caltech December 19 2021 Retrieved December 19 2021 Robert H Grubbs Facts The Nobel Prize in Chemistry 2005 NobelPrize org Retrieved April 15 2016 National Academy of Sciences Members Caltech Retrieved April 15 2016 Robert H Grubbs American Academy of Arts amp Sciences November 18 2021 Retrieved December 20 2021 Robert H Grubbs The Franklin Institute January 10 2014 Retrieved April 14 2016 Herman F Mark Award 2000 Division of Polymer Chemistry Inc of the American Chemical Society Archived from the original on March 15 2016 Retrieved April 14 2016 Pasadena chemist wins national award for cata EurekAlert Retrieved December 20 2021 Arthur C Cope Award ACS Chemistry for Life American Chemical Society Retrieved April 12 2016 Tetrahedron Prize for Creativity Elsevier B V Retrieved April 12 2016 Members Grubbs rsc org Royal Society of Chemistry Retrieved April 15 2016 Robert H Grubbs 31st Paul Karrer Lecture 2005 University of Zurich Archived from the original on April 23 2016 Retrieved April 12 2016 Golden Plate Awardees of the American Academy of Achievement www achievement org American Academy of Achievement 2009 ACS Fellows American Chemical Society Archived from the original on February 24 2019 Retrieved April 15 2016 2015 Inductees Robert Howard Grubbs Florida Inventors Hall of Fame September 28 2015 Retrieved April 14 2016 Current NAI Fellows National Academy of Inventors Retrieved April 15 2016 Professor Robert Howard Grubbs National Academy of Engineering Retrieved April 12 2016 New Academicians and Foreign Members of the Chinese Academy of Sciences Angewandte Chemie International Edition 55 8 2633 2634 February 2016 doi 10 1002 anie 201511637 12 Famous Scientists Elected 2015 CAS Foreign Members CASAD Retrieved April 12 2016 Wang Linda February 13 2017 Robert Grubbs wins Remsen Award Chemical amp Engineering News American Chemical Society 59 7 Retrieved December 20 2021 External links Edit Press Release 5 October 2005 The Nobel Prize in Chemistry 2005 NobelPrize org Robert H Grubbs on Nobelprize org Robert H Grubbs publications indexed by Google Scholar Retrieved from https en wikipedia org w index php title Robert H Grubbs amp oldid 1131482462, wikipedia, wiki, book, books, library,

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