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Wikipedia

PEX5

August 24, 2023

Peroxisomal targeting signal 1 receptor (PTS1R) is a protein that in humans is encoded by the PEX5 gene.[5]

PEX5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPEX5, peroxisomal biogenesis factor 5, RCDP5, PTS1R, PBD2B, PTS1-BP, PXR1, PBD2A
External IDsOMIM: 600414 MGI: 1098808 HomoloGene: 270 GeneCards: PEX5
Orthologs
SpeciesHumanMouse
Entrez

5830

19305

Ensembl

ENSG00000139197
ENSG00000288217

ENSMUSG00000005069

UniProt

P50542

O09012

RefSeq (mRNA)

NM_001277330
NM_001277805
NM_008995
NM_175933
NM_001360570

RefSeq (protein)

NP_001264259
NP_001264734
NP_033021
NP_787947
NP_001347499

Location (UCSC)Chr 12: 7.19 – 7.22 MbChr 6: 124.37 – 124.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PTS1R is a peroxisomal targeting sequence involved in the specific transport of molecules for oxidation inside the peroxisome. SKL binds to PTS1R in the cytosol followed by binding to the Pex14p receptor allowing importation of the peroxisomal protein through the pexsubunit transporter.

Diseases associated with dysfunctional PTS1R receptors include X-linked adrenoleukodystrophy and Zellweger syndrome.

Interactions Edit

PEX5 has been shown to interact with PEX12,[6][7] PEX13[8][9] and PEX14.[7][9][10]

References Edit

  1. ^ a b c ENSG00000288217 GRCh38: Ensembl release 89: ENSG00000139197, ENSG00000288217 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005069 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PEX5 Peroxisomal biogenesis factor 5".
  6. ^ Chang CC, Warren DS, Sacksteder KA, Gould SJ (Nov 1999). "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import". The Journal of Cell Biology. 147 (4): 761–74. doi:10.1083/jcb.147.4.761. PMC 2156163. PMID 10562279.
  7. ^ a b Okumoto K, Abe I, Fujiki Y (Aug 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". The Journal of Biological Chemistry. 275 (33): 25700–10. doi:10.1074/jbc.M003303200. PMID 10837480.
  8. ^ Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (Oct 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC 2121023. PMID 8858165.
  9. ^ a b Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (Mar 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.
  10. ^ Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (Apr 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". The Journal of Biological Chemistry. 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238.

Further reading Edit

  • Fransen M, Brees C, Baumgart E, Vanhooren JC, Baes M, Mannaerts GP, Van Veldhoven PP (Mar 1995). "Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor". The Journal of Biological Chemistry. 270 (13): 7731–6. doi:10.1074/jbc.270.13.7731. PMID 7706321.
  • Dodt G, Braverman N, Wong C, Moser A, Moser HW, Watkins P, Valle D, Gould SJ (Feb 1995). "Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders". Nature Genetics. 9 (2): 115–25. doi:10.1038/ng0295-115. PMID 7719337. S2CID 8469214.
  • Wiemer EA, Nuttley WM, Bertolaet BL, Li X, Francke U, Wheelock MJ, Anné UK, Johnson KR, Subramani S (Jul 1995). "Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders". The Journal of Cell Biology. 130 (1): 51–65. doi:10.1083/jcb.130.1.51. PMC 2120514. PMID 7790377.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Marynen P, Fransen M, Raeymaekers P, Mannaerts GP, Van Veldhoven PP (Nov 1995). "The gene for the peroxisomal targeting signal import receptor (PXR1) is located on human chromosome 12p13, flanked by TPI1 and D12S1089". Genomics. 30 (2): 366–8. doi:10.1006/geno.1995.0032. PMID 8586442.
  • Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (Oct 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC 2121023. PMID 8858165.
  • Dodt G, Gould SJ (Dec 1996). "Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor". The Journal of Cell Biology. 135 (6 Pt 2): 1763–74. doi:10.1083/jcb.135.6.1763. PMC 2133940. PMID 8991089.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Reuber BE, Germain-Lee E, Collins CS, Morrell JC, Ameritunga R, Moser HW, Valle D, Gould SJ (Dec 1997). "Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders". Nature Genetics. 17 (4): 445–8. doi:10.1038/ng1297-445. PMID 9398847. S2CID 34034756.
  • Otera H, Okumoto K, Tateishi K, Ikoma Y, Matsuda E, Nishimura M, Tsukamoto T, Osumi T, Ohashi K, Higuchi O, Fujiki Y (Jan 1998). "Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants". Molecular and Cellular Biology. 18 (1): 388–99. doi:10.1128/mcb.18.1.388. PMC 121509. PMID 9418886.
  • Fransen M, Terlecky SR, Subramani S (Jul 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8087–92. Bibcode:1998PNAS...95.8087F. doi:10.1073/pnas.95.14.8087. PMC 20933. PMID 9653144.
  • Amery L, Brees C, Baes M, Setoyama C, Miura R, Mannaerts GP, Van Veldhoven PP (Dec 1998). "C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal". The Biochemical Journal. 336 (Pt 2): 367–71. doi:10.1042/bj3360367. PMC 1219880. PMID 9820813.
  • Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (Apr 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". The Journal of Biological Chemistry. 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238.
  • Shimozawa N, Zhang Z, Suzuki Y, Imamura A, Tsukamoto T, Osumi T, Fujiki Y, Orii T, Barth PG, Wanders RJ, Kondo N (Aug 1999). "Functional heterogeneity of C-terminal peroxisome targeting signal 1 in PEX5-defective patients". Biochemical and Biophysical Research Communications. 262 (2): 504–8. doi:10.1006/bbrc.1999.1232. PMID 10462504.
  • Chang CC, Warren DS, Sacksteder KA, Gould SJ (Nov 1999). "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import". The Journal of Cell Biology. 147 (4): 761–74. doi:10.1083/jcb.147.4.761. PMC 2156163. PMID 10562279.
  • Watters D, Kedar P, Spring K, Bjorkman J, Chen P, Gatei M, Birrell G, Garrone B, Srinivasa P, Crane DI, Lavin MF (Nov 1999). "Localization of a portion of extranuclear ATM to peroxisomes" (PDF). The Journal of Biological Chemistry. 274 (48): 34277–82. doi:10.1074/jbc.274.48.34277. PMID 10567403. S2CID 14334129.
  • Okumoto K, Abe I, Fujiki Y (Aug 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". The Journal of Biological Chemistry. 275 (33): 25700–10. doi:10.1074/jbc.M003303200. PMID 10837480.
  • Gatto GJ, Geisbrecht BV, Gould SJ, Berg JM (Dec 2000). "Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5". Nature Structural Biology. 7 (12): 1091–5. doi:10.1038/81930. PMID 11101887. S2CID 35168630.
  • Harano T, Nose S, Uezu R, Shimizu N, Fujiki Y (Jul 2001). "Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1". The Biochemical Journal. 357 (Pt 1): 157–65. doi:10.1042/0264-6021:3570157. PMC 1221938. PMID 11415446.
  • Saidowsky J, Dodt G, Kirchberg K, Wegner A, Nastainczyk W, Kunau WH, Schliebs W (Sep 2001). "The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14". The Journal of Biological Chemistry. 276 (37): 34524–9. doi:10.1074/jbc.M104647200. PMID 11438541.
  • Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M (Dec 2006). "Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p". Molecular Cell. 24 (5): 653–63. doi:10.1016/j.molcel.2006.10.024. PMC 5030714. PMID 17157249.

External links Edit

  • GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
  • OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum

August 24, 2023
pex5, peroxisomal, targeting, signal, receptor, pts1r, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1fch, 2c0l, 2c0m, 2j9q, 2w84, 3r9a, 4bxu, 4kxk, 4kyoidentifiersaliases, peroxisomal, biogenesis, factor,. Peroxisomal targeting signal 1 receptor PTS1R is a protein that in humans is encoded by the PEX5 gene 5 PEX5Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYOIdentifiersAliasesPEX5 peroxisomal biogenesis factor 5 RCDP5 PTS1R PBD2B PTS1 BP PXR1 PBD2AExternal IDsOMIM 600414 MGI 1098808 HomoloGene 270 GeneCards PEX5Gene location Human Chr Chromosome 12 human 1 Band12p13 31Start7 188 685 bp 1 End7 218 574 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 F2 6 59 15 cMStart124 373 775 bp 2 End124 392 026 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius muscleskeletal muscle tissuesubstantia nigraprefrontal cortexputamenhippocampus properhypothalamusamygdalapituitary glanddorsolateral prefrontal cortexTop expressed inleft lobe of liverproximal tubulelipspermatocytebrown adipose tissueyolk sacmedullary collecting ductsuperior frontal gyruskidneyneural tubeMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein C terminus binding small GTPase binding protein N terminus binding peroxisome targeting sequence binding enzyme binding protein binding peroxisome matrix targeting signal 1 bindingCellular componentcytoplasm peroxisome membrane peroxisomal matrix intracellular anatomical structure Golgi apparatus cytosol peroxisomal membrane protein containing complexBiological processnegative regulation of protein homotetramerization protein import into peroxisome membrane protein import into peroxisome matrix docking protein tetramerization protein transport protein targeting to peroxisome protein import into peroxisome matrix translocation protein import into peroxisome matrix protein ubiquitination transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez583019305EnsemblENSG00000139197ENSG00000288217ENSMUSG00000005069UniProtP50542O09012RefSeq mRNA NM 000319NM 001131023NM 001131024NM 001131025NM 001131026NM 001300789NM 001351124NM 001351126NM 001351127NM 001351128NM 001351130NM 001351131NM 001351132NM 001351133NM 001351134NM 001351135NM 001351136NM 001351137NM 001351138NM 001351139NM 001351140NM 001374645NM 001374646NM 001374647NM 001374648NM 001374649NM 001277330NM 001277805NM 008995NM 175933NM 001360570RefSeq protein NP 000310NP 001124495NP 001124496NP 001124497NP 001124498NP 001287718NP 001338053NP 001338055NP 001338056NP 001338057NP 001338059NP 001338060NP 001338061NP 001338062NP 001338063NP 001338064NP 001338065NP 001338066NP 001338067NP 001338068NP 001338069NP 001264259NP 001264734NP 033021NP 787947NP 001347499Location UCSC Chr 12 7 19 7 22 MbChr 6 124 37 124 39 MbPubMed search 3 4 WikidataView Edit HumanView Edit MousePTS1R is a peroxisomal targeting sequence involved in the specific transport of molecules for oxidation inside the peroxisome SKL binds to PTS1R in the cytosol followed by binding to the Pex14p receptor allowing importation of the peroxisomal protein through the pexsubunit transporter Diseases associated with dysfunctional PTS1R receptors include X linked adrenoleukodystrophy and Zellweger syndrome Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions EditPEX5 has been shown to interact with PEX12 6 7 PEX13 8 9 and PEX14 7 9 10 References Edit a b c ENSG00000288217 GRCh38 Ensembl release 89 ENSG00000139197 ENSG00000288217 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000005069 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene PEX5 Peroxisomal biogenesis factor 5 Chang CC Warren DS Sacksteder KA Gould SJ Nov 1999 PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import The Journal of Cell Biology 147 4 761 74 doi 10 1083 jcb 147 4 761 PMC 2156163 PMID 10562279 a b Okumoto K Abe I Fujiki Y Aug 2000 Molecular anatomy of the peroxin Pex12p ring finger domain is essential for Pex12p function and interacts with the peroxisome targeting signal type 1 receptor Pex5p and a ring peroxin Pex10p The Journal of Biological Chemistry 275 33 25700 10 doi 10 1074 jbc M003303200 PMID 10837480 Gould SJ Kalish JE Morrell JC Bjorkman J Urquhart AJ Crane DI Oct 1996 Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor The Journal of Cell Biology 135 1 85 95 doi 10 1083 jcb 135 1 85 PMC 2121023 PMID 8858165 a b Otera H Setoguchi K Hamasaki M Kumashiro T Shimizu N Fujiki Y Mar 2002 Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner conserved Pex5p WXXXF Y motifs are critical for matrix protein import Molecular and Cellular Biology 22 6 1639 55 doi 10 1128 MCB 22 6 1639 1655 2002 PMC 135613 PMID 11865044 Shimizu N Itoh R Hirono Y Otera H Ghaedi K Tateishi K Tamura S Okumoto K Harano T Mukai S Fujiki Y Apr 1999 The peroxin Pex14p cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant characterization and functional analysis The Journal of Biological Chemistry 274 18 12593 604 doi 10 1074 jbc 274 18 12593 PMID 10212238 Further reading EditFransen M Brees C Baumgart E Vanhooren JC Baes M Mannaerts GP Van Veldhoven PP Mar 1995 Identification and characterization of the putative human peroxisomal C terminal targeting signal import receptor The Journal of Biological Chemistry 270 13 7731 6 doi 10 1074 jbc 270 13 7731 PMID 7706321 Dodt G Braverman N Wong C Moser A Moser HW Watkins P Valle D Gould SJ Feb 1995 Mutations in the PTS1 receptor gene PXR1 define complementation group 2 of the peroxisome biogenesis disorders Nature Genetics 9 2 115 25 doi 10 1038 ng0295 115 PMID 7719337 S2CID 8469214 Wiemer EA Nuttley WM Bertolaet BL Li X Francke U Wheelock MJ Anne UK Johnson KR Subramani S Jul 1995 Human peroxisomal targeting signal 1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders The Journal of Cell Biology 130 1 51 65 doi 10 1083 jcb 130 1 51 PMC 2120514 PMID 7790377 Maruyama K Sugano S Jan 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Marynen P Fransen M Raeymaekers P Mannaerts GP Van Veldhoven PP Nov 1995 The gene for the peroxisomal targeting signal import receptor PXR1 is located on human chromosome 12p13 flanked by TPI1 and D12S1089 Genomics 30 2 366 8 doi 10 1006 geno 1995 0032 PMID 8586442 Gould SJ Kalish JE Morrell JC Bjorkman J Urquhart AJ Crane DI Oct 1996 Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor The Journal of Cell Biology 135 1 85 95 doi 10 1083 jcb 135 1 85 PMC 2121023 PMID 8858165 Dodt G Gould SJ Dec 1996 Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p the PTS1 receptor evidence that PTS1 protein import is mediated by a cycling receptor The Journal of Cell Biology 135 6 Pt 2 1763 74 doi 10 1083 jcb 135 6 1763 PMC 2133940 PMID 8991089 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S Oct 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Reuber BE Germain Lee E Collins CS Morrell JC Ameritunga R Moser HW Valle D Gould SJ Dec 1997 Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders Nature Genetics 17 4 445 8 doi 10 1038 ng1297 445 PMID 9398847 S2CID 34034756 Otera H Okumoto K Tateishi K Ikoma Y Matsuda E Nishimura M Tsukamoto T Osumi T Ohashi K Higuchi O Fujiki Y Jan 1998 Peroxisome targeting signal type 1 PTS1 receptor is involved in import of both PTS1 and PTS2 studies with PEX5 defective CHO cell mutants Molecular and Cellular Biology 18 1 388 99 doi 10 1128 mcb 18 1 388 PMC 121509 PMID 9418886 Fransen M Terlecky SR Subramani S Jul 1998 Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import Proceedings of the National Academy of Sciences of the United States of America 95 14 8087 92 Bibcode 1998PNAS 95 8087F doi 10 1073 pnas 95 14 8087 PMC 20933 PMID 9653144 Amery L Brees C Baes M Setoyama C Miura R Mannaerts GP Van Veldhoven PP Dec 1998 C terminal tripeptide Ser Asn Leu SNL of human D aspartate oxidase is a functional peroxisome targeting signal The Biochemical Journal 336 Pt 2 367 71 doi 10 1042 bj3360367 PMC 1219880 PMID 9820813 Shimizu N Itoh R Hirono Y Otera H Ghaedi K Tateishi K Tamura S Okumoto K Harano T Mukai S Fujiki Y Apr 1999 The peroxin Pex14p cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant characterization and functional analysis The Journal of Biological Chemistry 274 18 12593 604 doi 10 1074 jbc 274 18 12593 PMID 10212238 Shimozawa N Zhang Z Suzuki Y Imamura A Tsukamoto T Osumi T Fujiki Y Orii T Barth PG Wanders RJ Kondo N Aug 1999 Functional heterogeneity of C terminal peroxisome targeting signal 1 in PEX5 defective patients Biochemical and Biophysical Research Communications 262 2 504 8 doi 10 1006 bbrc 1999 1232 PMID 10462504 Chang CC Warren DS Sacksteder KA Gould SJ Nov 1999 PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import The Journal of Cell Biology 147 4 761 74 doi 10 1083 jcb 147 4 761 PMC 2156163 PMID 10562279 Watters D Kedar P Spring K Bjorkman J Chen P Gatei M Birrell G Garrone B Srinivasa P Crane DI Lavin MF Nov 1999 Localization of a portion of extranuclear ATM to peroxisomes PDF The Journal of Biological Chemistry 274 48 34277 82 doi 10 1074 jbc 274 48 34277 PMID 10567403 S2CID 14334129 Okumoto K Abe I Fujiki Y Aug 2000 Molecular anatomy of the peroxin Pex12p ring finger domain is essential for Pex12p function and interacts with the peroxisome targeting signal type 1 receptor Pex5p and a ring peroxin Pex10p The Journal of Biological Chemistry 275 33 25700 10 doi 10 1074 jbc M003303200 PMID 10837480 Gatto GJ Geisbrecht BV Gould SJ Berg JM Dec 2000 Peroxisomal targeting signal 1 recognition by the TPR domains of human PEX5 Nature Structural Biology 7 12 1091 5 doi 10 1038 81930 PMID 11101887 S2CID 35168630 Harano T Nose S Uezu R Shimizu N Fujiki Y Jul 2001 Hsp70 regulates the interaction between the peroxisome targeting signal type 1 PTS1 receptor Pex5p and PTS1 The Biochemical Journal 357 Pt 1 157 65 doi 10 1042 0264 6021 3570157 PMC 1221938 PMID 11415446 Saidowsky J Dodt G Kirchberg K Wegner A Nastainczyk W Kunau WH Schliebs W Sep 2001 The di aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14 The Journal of Biological Chemistry 276 37 34524 9 doi 10 1074 jbc M104647200 PMID 11438541 Stanley WA Filipp FV Kursula P Schuller N Erdmann R Schliebs W Sattler M Wilmanns M Dec 2006 Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p Molecular Cell 24 5 653 63 doi 10 1016 j molcel 2006 10 024 PMC 5030714 PMID 17157249 External links EditGeneReviews NCBI NIH UW entry on Peroxisome Biogenesis Disorders Zellweger Syndrome Spectrum OMIM entries on Peroxisome Biogenesis Disorders Zellweger Syndrome Spectrum Retrieved from https en wikipedia org w index php title PEX5 amp oldid 1116740437, wikipedia, wiki, book, books, library,

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