^ abOtera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC135613. PMID 11865044.
^Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC2121023. PMID 8858165.
^Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC2174547. PMID 10704444.
^Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC87101. PMID 11390669.
Further readingedit
Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC2121023. PMID 8858165.
Albertini M, Rehling P, Erdmann R, Girzalsky W, Kiel JA, Veenhuis M, Kunau WH (April 1997). "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways" (PDF). Cell. 89 (1): 83–92. doi:10.1016/S0092-8674(00)80185-3. PMID 9094717. S2CID 18878596.
Fransen M, Terlecky SR, Subramani S (July 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8087–92. Bibcode:1998PNAS...95.8087F. doi:10.1073/pnas.95.14.8087. PMC20933. PMID 9653144.
Girzalsky W, Rehling P, Stein K, Kipper J, Blank L, Kunau WH, Erdmann R (March 1999). "Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes". The Journal of Cell Biology. 144 (6): 1151–62. doi:10.1083/jcb.144.6.1151. PMC2150583. PMID 10087260.
Shimozawa N, Suzuki Y, Zhang Z, Imamura A, Toyama R, Mukai S, et al. (June 1999). "Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders". Human Molecular Genetics. 8 (6): 1077–83. doi:10.1093/hmg/8.6.1077. PMID 10332040.
Toyama R, Mukai S, Itagaki A, Tamura S, Shimozawa N, Suzuki Y, et al. (September 1999). "Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants". Human Molecular Genetics. 8 (9): 1673–81. doi:10.1093/hmg/8.9.1673. PMID 10441330.
Liu Y, Björkman J, Urquhart A, Wanders RJ, Crane DI, Gould SJ (September 1999). "PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders". American Journal of Human Genetics. 65 (3): 621–34. doi:10.1086/302534. PMC1377968. PMID 10441568.
Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC2174547. PMID 10704444.
Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC87101. PMID 11390669.
Jones JM, Morrell JC, Gould SJ (June 2001). "Multiple distinct targeting signals in integral peroxisomal membrane proteins". The Journal of Cell Biology. 153 (6): 1141–50. doi:10.1083/jcb.153.6.1141. PMC2192020. PMID 11402059.
Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC135613. PMID 11865044.
Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP (March 2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Molecular & Cellular Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (March 2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes". The Journal of Biological Chemistry. 279 (13): 12615–24. doi:10.1074/jbc.M304941200. PMID 14715663.
Hashimoto K, Kato Z, Nagase T, Shimozawa N, Kuwata K, Omoya K, et al. (August 2005). "Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder". Pediatric Research. 58 (2): 263–9. doi:10.1203/01.PDR.0000169984.89199.69. PMID 16006427.
Nguyen T, Bjorkman J, Paton BC, Crane DI (February 2006). "Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance". Journal of Cell Science. 119 (Pt 4): 636–45. doi:10.1242/jcs.02776. hdl:2440/23242. PMID 16449325.
External linksedit
GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
pex13, peroxisomal, membrane, protein, protein, that, humans, encoded, gene, located, chromosome, next, kiaa1841available, structurespdbortholog, search, pdbe, rcsblist, codes1wxuidentifiersaliases, nald, pbd11a, pbd11b, peroxisomal, biogenesis, factor, 13exte. Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene 4 5 It located on chromosome 2 next to KIAA1841PEX13Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1WXUIdentifiersAliasesPEX13 NALD PBD11A PBD11B ZWS peroxisomal biogenesis factor 13External IDsOMIM 601789 MGI 1919379 HomoloGene 1967 GeneCards PEX13Gene location Human Chr Chromosome 2 human 1 Band2p15Start61 017 225 bp 1 End61 051 990 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytespermgerminal epitheliumvisceral pleuraAchilles tendonparietal pleurapalpebral conjunctivaganglionic eminenceamniotic fluidjejunal mucosan aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein bindingCellular componentperoxisome peroxisomal membrane membrane integral component of peroxisomal membrane intracellular membrane bounded organelle integral component of membrane peroxisomal importomer complexBiological processcerebral cortex cell migration protein transport suckling behavior fatty acid alpha oxidation microtubule based peroxisome localization locomotory behavior protein import into peroxisome matrix docking neuron migration transport protein targeting to peroxisome protein ubiquitinationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez519472129EnsemblENSG00000162928ENSMUSG00000020283UniProtQ92968Q9D0K1RefSeq mRNA NM 002618NM 023651RefSeq protein NP 002609NP 076140Location UCSC Chr 2 61 02 61 05 Mbn aPubMed search 2 3 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editPEX13 has been shown to interact with PEX14 6 PEX5 6 7 and PEX19 8 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000162928 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Bjorkman J Stetten G Moore CS Gould SJ Crane DI December 1998 Genomic structure of PEX13 a candidate peroxisome biogenesis disorder gene Genomics 54 3 521 8 doi 10 1006 geno 1998 5520 PMID 9878256 Entrez Gene PEX13 peroxisome biogenesis factor 13 a b Otera H Setoguchi K Hamasaki M Kumashiro T Shimizu N Fujiki Y March 2002 Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner conserved Pex5p WXXXF Y motifs are critical for matrix protein import Molecular and Cellular Biology 22 6 1639 55 doi 10 1128 MCB 22 6 1639 1655 2002 PMC 135613 PMID 11865044 Gould SJ Kalish JE Morrell JC Bjorkman J Urquhart AJ Crane DI October 1996 Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor The Journal of Cell Biology 135 1 85 95 doi 10 1083 jcb 135 1 85 PMC 2121023 PMID 8858165 Sacksteder KA Jones JM South ST Li X Liu Y Gould SJ March 2000 PEX19 binds multiple peroxisomal membrane proteins is predominantly cytoplasmic and is required for peroxisome membrane synthesis The Journal of Cell Biology 148 5 931 44 doi 10 1083 jcb 148 5 931 PMC 2174547 PMID 10704444 Fransen M Wylin T Brees C Mannaerts GP Van Veldhoven PP July 2001 Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences Molecular and Cellular Biology 21 13 4413 24 doi 10 1128 MCB 21 13 4413 4424 2001 PMC 87101 PMID 11390669 Further reading editGould SJ Kalish JE Morrell JC Bjorkman J Urquhart AJ Crane DI October 1996 Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor The Journal of Cell Biology 135 1 85 95 doi 10 1083 jcb 135 1 85 PMC 2121023 PMID 8858165 Albertini M Rehling P Erdmann R Girzalsky W Kiel JA Veenhuis M Kunau WH April 1997 Pex14p a peroxisomal membrane protein binding both receptors of the two PTS dependent import pathways PDF Cell 89 1 83 92 doi 10 1016 S0092 8674 00 80185 3 PMID 9094717 S2CID 18878596 Fransen M Terlecky SR Subramani S July 1998 Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import Proceedings of the National Academy of Sciences of the United States of America 95 14 8087 92 Bibcode 1998PNAS 95 8087F doi 10 1073 pnas 95 14 8087 PMC 20933 PMID 9653144 Girzalsky W Rehling P Stein K Kipper J Blank L Kunau WH Erdmann R March 1999 Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2 dependent protein import into peroxisomes The Journal of Cell Biology 144 6 1151 62 doi 10 1083 jcb 144 6 1151 PMC 2150583 PMID 10087260 Shimozawa N Suzuki Y Zhang Z Imamura A Toyama R Mukai S et al June 1999 Nonsense and temperature sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders Human Molecular Genetics 8 6 1077 83 doi 10 1093 hmg 8 6 1077 PMID 10332040 Toyama R Mukai S Itagaki A Tamura S Shimozawa N Suzuki Y et al September 1999 Isolation characterization and mutation analysis of PEX13 defective Chinese hamster ovary cell mutants Human Molecular Genetics 8 9 1673 81 doi 10 1093 hmg 8 9 1673 PMID 10441330 Liu Y Bjorkman J Urquhart A Wanders RJ Crane DI Gould SJ September 1999 PEX13 is mutated in complementation group 13 of the peroxisome biogenesis disorders American Journal of Human Genetics 65 3 621 34 doi 10 1086 302534 PMC 1377968 PMID 10441568 Sacksteder KA Jones JM South ST Li X Liu Y Gould SJ March 2000 PEX19 binds multiple peroxisomal membrane proteins is predominantly cytoplasmic and is required for peroxisome membrane synthesis The Journal of Cell Biology 148 5 931 44 doi 10 1083 jcb 148 5 931 PMC 2174547 PMID 10704444 Fransen M Wylin T Brees C Mannaerts GP Van Veldhoven PP July 2001 Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences Molecular and Cellular Biology 21 13 4413 24 doi 10 1128 MCB 21 13 4413 4424 2001 PMC 87101 PMID 11390669 Jones JM Morrell JC Gould SJ June 2001 Multiple distinct targeting signals in integral peroxisomal membrane proteins The Journal of Cell Biology 153 6 1141 50 doi 10 1083 jcb 153 6 1141 PMC 2192020 PMID 11402059 Otera H Setoguchi K Hamasaki M Kumashiro T Shimizu N Fujiki Y March 2002 Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner conserved Pex5p WXXXF Y motifs are critical for matrix protein import Molecular and Cellular Biology 22 6 1639 55 doi 10 1128 MCB 22 6 1639 1655 2002 PMC 135613 PMID 11865044 Fransen M Brees C Ghys K Amery L Mannaerts GP Ladant D Van Veldhoven PP March 2002 Analysis of mammalian peroxin interactions using a non transcription based bacterial two hybrid assay Molecular amp Cellular Proteomics 1 3 243 52 doi 10 1074 mcp M100025 MCP200 PMID 12096124 Fransen M Vastiau I Brees C Brys V Mannaerts GP Van Veldhoven PP March 2004 Potential role for Pex19p in assembly of PTS receptor docking complexes The Journal of Biological Chemistry 279 13 12615 24 doi 10 1074 jbc M304941200 PMID 14715663 Hashimoto K Kato Z Nagase T Shimozawa N Kuwata K Omoya K et al August 2005 Molecular mechanism of a temperature sensitive phenotype in peroxisomal biogenesis disorder Pediatric Research 58 2 263 9 doi 10 1203 01 PDR 0000169984 89199 69 PMID 16006427 Nguyen T Bjorkman J Paton BC Crane DI February 2006 Failure of microtubule mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance Journal of Cell Science 119 Pt 4 636 45 doi 10 1242 jcs 02776 hdl 2440 23242 PMID 16449325 External links editGeneReviews NCBI NIH UW entry on Peroxisome Biogenesis Disorders Zellweger Syndrome Spectrum OMIM entries on Peroxisome Biogenesis Disorders Zellweger Syndrome Spectrum nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia 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