The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains.[1] They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells.[2] The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13.4.
A subset of LILR recognise MHC class I (also known as HLA class I in humans). The LILR family is a cluster of paired receptors with both activating and inhibitory functions.[3] Of these, the inhibitory receptors LILRB1 and LILRB2 show a broad specificity for classical and non-classical MHC alleles with preferential binding to b2m-associated complexes. In contrast, the activating receptors LILRA1 and LILRA3 prefer b2m-independent free heavy chains of MHC class I, and in particular HLA-C alleles.[4]
^David E. Sloane; Nicodemus Tedla; Muyiwa Awoniyi; Donald W. MacGlashan Jr.; Luis Borges; K. Frank Austen; Jonathan P. Arm (November 2004). "Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition" (PDF). Blood. 104 (9): 2832–2839. doi:10.1182/blood-2004-01-0268. PMID 15242876.
^Burshtyn, Deborah N.; Morcos, Chris (2016-02-01). "The Expanding Spectrum of Ligands for Leukocyte Ig-like Receptors". The Journal of Immunology. 196 (3): 947–955. doi:10.4049/jimmunol.1501937. PMID 26802060.
^Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL (Mar 2011). "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding". J Immunol. 186 (5): 2990–7. doi:10.4049/jimmunol.1003078. PMID 21270408.
This biochemistry article is a stub. You can help Wikipedia by expanding it.
leukocyte, immunoglobulin, like, receptors, leukocyte, immunoglobulin, like, receptors, lilr, family, receptors, possessing, extracellular, immunoglobulin, domains, they, also, known, cd85, ilts, exert, immunomodulatory, effects, wide, range, immune, cells, hu. The leukocyte immunoglobulin like receptors LILR are a family of receptors possessing extracellular immunoglobulin domains 1 They are also known as CD85 ILTs and LIR and can exert immunomodulatory effects on a wide range of immune cells 2 The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13 4 Leukocyte immunoglobulin like receptorsIdentifiersSymbolLILRMembranome17They include LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 LILRA6 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 LILRB6 or LILRA6 LILRB7 or LILRA5A subset of LILR recognise MHC class I also known as HLA class I in humans The LILR family is a cluster of paired receptors with both activating and inhibitory functions 3 Of these the inhibitory receptors LILRB1 and LILRB2 show a broad specificity for classical and non classical MHC alleles with preferential binding to b2m associated complexes In contrast the activating receptors LILRA1 and LILRA3 prefer b2m independent free heavy chains of MHC class I and in particular HLA C alleles 4 See also editLAIR1 Killer cell immunoglobulin like receptorReferences edit David E Sloane Nicodemus Tedla Muyiwa Awoniyi Donald W MacGlashan Jr Luis Borges K Frank Austen Jonathan P Arm November 2004 Leukocyte immunoglobulin like receptors novel innate receptors for human basophil activation and inhibition PDF Blood 104 9 2832 2839 doi 10 1182 blood 2004 01 0268 PMID 15242876 Damian Brown Rachel L Allen amp John Trowsdale The LILR family modulators of innate and adaptive immune pathways in health and disease Tissue Antigens 2004 64 215 http onlinelibrary wiley com doi 10 1111 j 0001 2815 2004 00290 x pdf Burshtyn Deborah N Morcos Chris 2016 02 01 The Expanding Spectrum of Ligands for Leukocyte Ig like Receptors The Journal of Immunology 196 3 947 955 doi 10 4049 jimmunol 1501937 PMID 26802060 Jones DC Kosmoliaptsis V Apps R Lapaque N Smith I Kono A Chang C Boyle LH Taylor CJ Trowsdale J Allen RL Mar 2011 HLA class I allelic sequence and conformation regulate leukocyte Ig like receptor binding J Immunol 186 5 2990 7 doi 10 4049 jimmunol 1003078 PMID 21270408 nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte nbsp This article about a biochemical receptor is a stub You can help Wikipedia by expanding it vte nbsp This immunology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Leukocyte immunoglobulin like receptors amp oldid 1131219687, wikipedia, wiki, book, books, library,
