LAIR1

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.^[5][6] LAIR1 has also been designated as CD305 (cluster of differentiation 305).

LAIR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KGR, 3RP1
Identifiers
Aliases	LAIR1, CD305, LAIR-1, leukocyte associated immunoglobulin like receptor 1
External IDs	OMIM: 602992 MGI: 105492 HomoloGene: 48097 GeneCards: LAIR1
Gene location (Human) Chr. Chromosome 19 (human)^[1] Band 19q13.42 Start 54,351,384 bp^[1] End 54,370,558 bp^[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)^[2] Band 7 A1|7 2.31 cM Start 4,006,401 bp^[2] End 4,066,203 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix monocyte spleen blood lymph node bone marrow right lung placenta upper lobe of left lung bone marrow cells Top expressed in spleen secondary oocyte blood supraoptic nucleus thymus superior frontal gyrus substantia nigra cerebellar cortex duodenum subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane membrane specific granule membrane tertiary granule membrane Biological process adaptive immune response regulation of immune response immune system process neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3903 52855 Ensembl ENSG00000276053 ENSG00000276163 ENSG00000278154 ENSG00000274110 ENSG00000167613 n/a ENSMUSG00000055541 UniProt Q6GTX8 Q8BG84 RefSeq (mRNA) NM_001289023 NM_001289025 NM_001289026 NM_001289027 NM_002287 NM_021706 NM_021708 NM_001113474 NM_178611 NM_001302675 NM_001302676 NM_001302677 NM_001302681 NM_001302682 NM_001302683 RefSeq (protein) NP_001275952 NP_001275954 NP_001275955 NP_001275956 NP_002278 NP_068352 NP_001106945 NP_001289604 NP_001289605 NP_001289606 NP_001289610 NP_001289611 NP_001289612 NP_848726 Location (UCSC) Chr 19: 54.35 – 54.37 Mb Chr 7: 4.01 – 4.07 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

For 19q13.4, see Chromosome 19 § Cytogenetic band.

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells.^[7] Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.^[6]

Interactions

LAIR1 has been shown to interact with PTPN11^[5][8] and PTPN6.^{[5][8][9][10][11]}

References

1. ENSG00000276163, ENSG00000278154, ENSG00000274110, ENSG00000167613 GRCh38: Ensembl release 89: ENSG00000276053, ENSG00000276163, ENSG00000278154, ENSG00000274110, ENSG00000167613 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055541 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (September 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. hdl:2066/26173. PMID 9285412.
6. "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1".
7. van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (October 1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". European Journal of Immunology. 29 (10): 3160–7. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. PMID 10540327.
8. Fournier N, Chalus L, Durand I, Garcia E, Pin JJ, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates EE, Garrone P (August 2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. 165 (3): 1197–209. doi:10.4049/jimmunol.165.3.1197. PMID 10903717.
9. Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ (February 2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
10. Mousseau DD, Banville D, L'Abbé D, Bouchard P, Shen SH (February 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta" (PDF). J. Biol. Chem. 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. PMID 10660620.
11. Xu Mj, Zhao R, Zhao ZJ (June 2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. doi:10.1074/jbc.M001313200. PMID 10764762.

Further reading

• Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. doi:10.1046/j.1365-3083.1999.00580.x. PMID 10404045. S2CID 10345478.
• Meyaard L (1999). "LAIR-1, a Widely Distributed Human ITIM-Bearing Receptor on Hematopoietic Cells". Immunoreceptor Tyrosine-based Inhibition Motifs. Current Topics in Microbiology 244 and Immunology. Vol. 244. pp. 151–7. doi:10.1007/978-3-642-58537-1_13. ISBN 978-3-540-65789-7. PMID 10453657. {{cite book}}: |journal= ignored (help)
• Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR)". J. Biol. Regul. Homeost. Agents. 17 (4): 330–3. PMID 15065762.
• Poggi A, Tomasello E, Ferrero E, Zocchi MR, Moretta L (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor". Eur. J. Immunol. 28 (7): 2086–91. doi:10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T. PMID 9692876. S2CID 21655416.
• Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. doi:10.4049/jimmunol.162.10.5800. PMID 10229813. S2CID 14882830.
• Poggi A, Pellegatta F, Leone BE, Moretta L, Zocchi MR (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias". Eur. J. Immunol. 30 (10): 2751–8. doi:10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L. PMID 11069054.
• Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
• Saverino D, Fabbi M, Merlo A, Ravera G, Grossi CE, Ciccone E (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions". Hum. Immunol. 63 (7): 534–46. doi:10.1016/S0198-8859(02)00409-3. PMID 12072189.
• Aoukaty A, Lee IF, Wu J, Tan R (2003). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells". J. Clin. Immunol. 23 (2): 141–5. doi:10.1023/A:1022580929226. PMID 12757266. S2CID 31461585.
• Verbrugge A, de Ruiter T, Clevers H, Meyaard L (2003). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment". Int. Immunol. 15 (11): 1349–58. doi:10.1093/intimm/dxg134. PMID 14565933.
• De Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, Narita M, Grutzmeier S, Sönnerborg A, Chiodi F (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection". Blood. 103 (6): 2180–6. doi:10.1182/blood-2003-07-2375. PMID 14604962.

External links

• LAIR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q6GTX8 (Leukocyte-associated immunoglobulin-like receptor 1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.