The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.[6]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020377 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lam BK, Penrose JF, Freeman GJ, Austen KF (Sep 1994). "Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4". Proc Natl Acad Sci U S A. 91 (16): 7663–7. Bibcode:1994PNAS...91.7663L. doi:10.1073/pnas.91.16.7663. PMC44462. PMID 8052639.
Penrose JF, Austen KF (2000). "The biochemical, molecular, and genomic aspects of leukotriene C4 synthase". Proc. Assoc. Am. Physicians. 111 (6): 537–46. doi:10.1046/j.1525-1381.1999.99212.x. PMID 10591082.
Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221.
Bigby TD (2000). "The leukotriene C(4) synthase gene and asthma". Am. J. Respir. Cell Mol. Biol. 23 (3): 273–6. doi:10.1165/ajrcmb.23.3.f197. PMID 10970815.
Penrose JF, Gagnon L, Goppelt-Struebe M, et al. (1993). "Purification of human leukotriene C4 synthase". Proc. Natl. Acad. Sci. U.S.A. 89 (23): 11603–6. doi:10.1073/pnas.89.23.11603. PMC50601. PMID 1454853.
Nicholson DW, Ali A, Klemba MW, et al. (1992). "Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells". J. Biol. Chem. 267 (25): 17849–57. doi:10.1016/S0021-9258(19)37121-2. PMID 1517222.
Penrose JF, Spector J, Lam BK, et al. (1995). "Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody". Am. J. Respir. Crit. Care Med. 152 (1): 283–9. doi:10.1164/ajrccm.152.1.7599836. PMID 7599836.
Söderström M, Morgenstern R, Hammarström S (1995). "Protein-protein interaction affinity chromatography of leukotriene C4 synthase". Protein Expr. Purif. 6 (3): 352–6. doi:10.1006/prep.1995.1046. PMID 7663172.
Welsch DJ, Creely DP, Hauser SD, et al. (1994). "Molecular cloning and expression of human leukotriene-C4 synthase". Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9745–9. Bibcode:1994PNAS...91.9745W. doi:10.1073/pnas.91.21.9745. PMC44893. PMID 7937884.
Nicholson DW, Ali A, Vaillancourt JP, et al. (1993). "Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits". Proc. Natl. Acad. Sci. U.S.A. 90 (5): 2015–9. Bibcode:1993PNAS...90.2015N. doi:10.1073/pnas.90.5.2015. PMC46011. PMID 8446623.
Penrose JF, Spector J, Baldasaro M, et al. (1996). "Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35". J. Biol. Chem. 271 (19): 11356–61. doi:10.1074/jbc.271.19.11356. PMID 8626689.
Bigby TD, Hodulik CR, Arden KC, Fu L (1997). "Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35". Mol. Med. 2 (5): 637–46. doi:10.1007/BF03401647. PMC2230200. PMID 8898379.
Scoggan KA, Jakobsson PJ, Ford-Hutchinson AW (1997). "Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes". J. Biol. Chem. 272 (15): 10182–7. doi:10.1074/jbc.272.15.10182. PMID 9092565.
Sala A, Folco G, Henson PM, Murphy RC (1997). "Pharmacological modulation of human platelet leukotriene C4-synthase". Biochem. Pharmacol. 53 (6): 905–8. doi:10.1016/S0006-2952(96)00819-2. PMID 9113110.
Spanbroek R, Stark HJ, Janssen-Timmen U, et al. (1998). "5-Lipoxygenase expression in Langerhans cells of normal human epidermis". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 663–8. Bibcode:1998PNAS...95..663S. doi:10.1073/pnas.95.2.663. PMC18477. PMID 9435249.
External linksedit
leukotriene-C4+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
leukotriene, synthase, enzyme, that, humans, encoded, ltc4s, gene, ltc4savailable, structurespdbortholog, search, pdbe, rcsblist, codes4jrz, 2pno, 2uuh, 2uui, 3b29, 3hkk, 3leo, 3pcv, 4j7t, 4j7y, 4jc7, 4jcz, 5hv9, 4wabidentifiersaliasesltc4s, entrez, 4056, exte. Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene 5 6 LTC4SAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4JRZ 2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4J7T 4J7Y 4JC7 4JCZ 5HV9 4WABIdentifiersAliasesLTC4S entrez 4056 Leukotriene C4 synthaseExternal IDsOMIM 246530 MGI 107498 HomoloGene 7406 GeneCards LTC4SGene location Human Chr Chromosome 5 human 1 Band5q35 3Start179 793 980 bp 1 End179 796 647 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 B1 3Start50 127 288 bp 2 End50 129 443 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright uterine tuberight coronary arteryleft uterine tubeleft coronary arteryright lungtibial nerveascending aortaspleenbloodmyometriumTop expressed inwhite adipose tissuesubcutaneous adipose tissuebrown adipose tissueankle jointsecondary oocytelipsuperior frontal gyrusentorhinal cortexthymusduodenumMore reference expression dataBioGPSn aGene ontologyMolecular functionleukotriene C4 synthase activity glutathione peroxidase activity protein binding lyase activity enzyme activator activity lipid binding identical protein binding glutathione transferase activityCellular componentintegral component of membrane membrane nuclear envelope endoplasmic reticulum nuclear outer membrane nucleus intracellular membrane bounded organelle endoplasmic reticulum membraneBiological processpositive regulation of catalytic activity leukotriene biosynthetic process cellular oxidant detoxification leukotriene metabolic process long chain fatty acid biosynthetic process lipoxygenase pathway lipoxin biosynthetic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez405617001EnsemblENSG00000283887ENSG00000213316ENSMUSG00000020377UniProtQ16873Q60860RefSeq mRNA NM 145867NM 000897NM 008521NM 001313968RefSeq protein NP 665874NP 001300897NP 032547Location UCSC Chr 5 179 79 179 8 MbChr 11 50 13 50 13 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe protein encoded by this gene LTC4S or glutathione S transferase II is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4 This is a member of MAPEG family of transmembrane proteins A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum where it forms a complex with 5 Lipoxygenase activating protein This protein is remotely related to microsomal glutathione S transferase Contents 1 Function 2 References 3 Further reading 4 External linksFunction editThe MAPEG Membrane Associated Proteins in Eicosanoid and Glutathione metabolism family includes a number of human proteins several of which are involved the production of leukotrienes This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes potent biological compounds derived from arachidonic acid Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum 6 nbsp Eicosanoid synthesis Leukotrienes at right References edit a b c ENSG00000213316 GRCh38 Ensembl release 89 ENSG00000283887 ENSG00000213316 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020377 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lam BK Penrose JF Freeman GJ Austen KF Sep 1994 Expression cloning of a cDNA for human leukotriene C4 synthase an integral membrane protein conjugating reduced glutathione to leukotriene A4 Proc Natl Acad Sci U S A 91 16 7663 7 Bibcode 1994PNAS 91 7663L doi 10 1073 pnas 91 16 7663 PMC 44462 PMID 8052639 a b Entrez Gene LTC4S leukotriene C4 synthase Further reading editPenrose JF 1999 LTC4 synthase Enzymology biochemistry and molecular characterization Clinical Reviews in Allergy amp Immunology 17 1 2 133 52 doi 10 1007 BF02737601 PMID 10436863 S2CID 34121294 Penrose JF Austen KF 2000 The biochemical molecular and genomic aspects of leukotriene C4 synthase Proc Assoc Am Physicians 111 6 537 46 doi 10 1046 j 1525 1381 1999 99212 x PMID 10591082 Jakobsson PJ Morgenstern R Mancini J et al 2000 Membrane associated proteins in eicosanoid and glutathione metabolism MAPEG A widespread protein superfamily Am J Respir Crit Care Med 161 2 Pt 2 S20 4 doi 10 1164 ajrccm 161 supplement 1 ltta 5 PMID 10673221 Bigby TD 2000 The leukotriene C 4 synthase gene and asthma Am J Respir Cell Mol Biol 23 3 273 6 doi 10 1165 ajrcmb 23 3 f197 PMID 10970815 Penrose JF Gagnon L Goppelt Struebe M et al 1993 Purification of human leukotriene C4 synthase Proc Natl Acad Sci U S A 89 23 11603 6 doi 10 1073 pnas 89 23 11603 PMC 50601 PMID 1454853 Nicholson DW Ali A Klemba MW et al 1992 Human leukotriene C4 synthase expression in dimethyl sulfoxide differentiated U937 cells J Biol Chem 267 25 17849 57 doi 10 1016 S0021 9258 19 37121 2 PMID 1517222 Penrose JF Spector J Lam BK et al 1995 Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody Am J Respir Crit Care Med 152 1 283 9 doi 10 1164 ajrccm 152 1 7599836 PMID 7599836 Soderstrom M Morgenstern R Hammarstrom S 1995 Protein protein interaction affinity chromatography of leukotriene C4 synthase Protein Expr Purif 6 3 352 6 doi 10 1006 prep 1995 1046 PMID 7663172 Welsch DJ Creely DP Hauser SD et al 1994 Molecular cloning and expression of human leukotriene C4 synthase Proc Natl Acad Sci U S A 91 21 9745 9 Bibcode 1994PNAS 91 9745W doi 10 1073 pnas 91 21 9745 PMC 44893 PMID 7937884 Nicholson DW Ali A Vaillancourt JP et al 1993 Purification to homogeneity and the N terminal sequence of human leukotriene C4 synthase a homodimeric glutathione S transferase composed of 18 kDa subunits Proc Natl Acad Sci U S A 90 5 2015 9 Bibcode 1993PNAS 90 2015N doi 10 1073 pnas 90 5 2015 PMC 46011 PMID 8446623 Penrose JF Spector J Baldasaro M et al 1996 Molecular cloning of the gene for human leukotriene C4 synthase Organization nucleotide sequence and chromosomal localization to 5q35 J Biol Chem 271 19 11356 61 doi 10 1074 jbc 271 19 11356 PMID 8626689 Bigby TD Hodulik CR Arden KC Fu L 1997 Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35 Mol Med 2 5 637 46 doi 10 1007 BF03401647 PMC 2230200 PMID 8898379 Scoggan KA Jakobsson PJ Ford Hutchinson AW 1997 Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes J Biol Chem 272 15 10182 7 doi 10 1074 jbc 272 15 10182 PMID 9092565 Sala A Folco G Henson PM Murphy RC 1997 Pharmacological modulation of human platelet leukotriene C4 synthase Biochem Pharmacol 53 6 905 8 doi 10 1016 S0006 2952 96 00819 2 PMID 9113110 Spanbroek R Stark HJ Janssen Timmen U et al 1998 5 Lipoxygenase expression in Langerhans cells of normal human epidermis Proc Natl Acad Sci U S A 95 2 663 8 Bibcode 1998PNAS 95 663S doi 10 1073 pnas 95 2 663 PMC 18477 PMID 9435249 External links editleukotriene C4 synthase at the U S National Library of Medicine Medical Subject Headings MeSH UMich Orientation of Proteins in Membranes families superfamily 199 Eicosanoid and Glutathione metabolism protein family MAPEG This lyase article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Leukotriene C4 synthase amp oldid 1116591408, wikipedia, wiki, book, books, library,
