A study at the University of California, San Diego School of Medicine has shown that LTB4 promotes insulin resistance in obese mice.[3]Obesity is the major cause of insulin resistance in type 2 diabetes.[4]
^. UC San Diego Health. Archived from the original on 2022-02-18.
^Li, P; Oh, DY; Bandyopadhyay, G; Lagakos, WS; Talukdar, S; Osborn, O; Johnson, A; Chung, H; Maris, M; Ofrecio, JM; Taguchi, S; Lu, M; Olefsky, JM (2015). "LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes". Nature Medicine. 21 (3): 239–247. doi:10.1038/nm.3800. PMC4429798. PMID 25706874.
May 07, 2024
leukotriene, leukotriene, ltb4, leukotriene, involved, inflammation, been, shown, promote, insulin, resistance, obese, mice, leukotriene, names, preferred, iupac, name, dihydroxyicosa, tetraenoic, acid, identifiers, number, 71160, model, jsmol, interactive, im. Leukotriene B4 LTB4 is a leukotriene involved in inflammation It has been shown to promote insulin resistance in obese mice Leukotriene B4 Names Preferred IUPAC name 5S 6Z 8E 10E 12R 14Z 5 12 Dihydroxyicosa 6 8 10 14 tetraenoic acid Identifiers CAS Number 71160 24 2 Y 3D model JSmol Interactive image ChEBI CHEBI 15647 N ChEMBL ChEMBL65061 N ChemSpider 4444132 N IUPHAR BPS 2487 KEGG C02165 N PubChem CID 5280492 UNII 1HGW4DR56D Y CompTox Dashboard EPA DTXSID4037162 InChI InChI 1S C20H32O4 c1 2 3 4 5 6 9 13 18 21 14 10 7 8 11 15 19 22 16 12 17 20 23 24 h6 11 14 15 18 19 21 22H 2 5 12 13 16 17H2 1H3 H 23 24 b8 7 9 6 14 10 15 11 t18 19 m1 s1 NKey VNYSSYRCGWBHLG AMOLWHMGSA N NInChI 1 C20H32O4 c1 2 3 4 5 6 9 13 18 21 14 10 7 8 11 15 19 22 16 12 17 20 23 24 h6 11 14 15 18 19 21 22H 2 5 12 13 16 17H2 1H3 H 23 24 b8 7 9 6 14 10 15 11 t18 19 m1 s1Key VNYSSYRCGWBHLG AMOLWHMGBE SMILES CCCCC C C C C H C C C C C C C H CCCC O O O O Properties Chemical formula C 20H 32O 4 Molar mass 336 472 g mol 1 Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox referencesBiochemistry editLTB4 is a leukotriene involved in inflammation It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium allowing them to bind to and cross it into the tissue 1 In neutrophils it is also a potent chemoattractant and is able to induce the formation of reactive oxygen species and the release of lysosomal enzymes by these cells 1 It is synthesized by leukotriene A4 hydrolase from leukotriene A4 2 nbsp Eicosanoid synthesis leukotrienes at right Diabetes editA study at the University of California San Diego School of Medicine has shown that LTB4 promotes insulin resistance in obese mice 3 Obesity is the major cause of insulin resistance in type 2 diabetes 4 References edit a b Cotran Kumar Collins 1999 Robbins Pathologic Basis of Disease Philadelphia W B Saunders Company ISBN 0 7216 7335 X LTA4H uniprot Retrieved 9 April 2013 Molecular Link between Obesity and Type 2 Diabetes Reveals Potential Therapy UC San Diego Health Archived from the original on 2022 02 18 Li P Oh DY Bandyopadhyay G Lagakos WS Talukdar S Osborn O Johnson A Chung H Maris M Ofrecio JM Taguchi S Lu M Olefsky JM 2015 LTB4 promotes insulin resistance in obese mice by acting on macrophages hepatocytes and myocytes Nature Medicine 21 3 239 247 doi 10 1038 nm 3800 PMC 4429798 PMID 25706874 Retrieved from https en wikipedia org w index php title Leukotriene B4 amp oldid 1218790149, wikipedia, wiki, book, books, library,
