Leucine-rich repeat-containing protein 8C is a protein that in humans is encoded by the LRRC8C gene.[5] Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8D, and LRRC8E, is sometimes a subunit of the heteromer protein Volume-Regulated Anion Channel.[6] Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane,[7] and that is not the only function these channels have been linked to.
While LRRC8C is one of many proteins that can be part of VRAC, research has found that it is not as crucial to the activity of the channel in comparison to LRRC8A and LRRC8D.[8][9][10] However, while we know that LRRC8A and LRRC8D are necessary for VRAC function, other studies have found that they are not sufficient for the full range of usual VRAC activity.[11] This is where the other LRRC8 proteins come in, such as LRRC8C, as the different composition of these subunits affects the range of specificity for VRACs.[12][10]
In addition to its role in VRACs, the LRRC8 protein family is also associated with agammaglobulinemia-5.[13]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000171488 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000054720 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Voss F, Ullrich F, Münch J (2014-05-09). "Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC" (PDF). Science (Submitted manuscript). 344 (6184): 634–8. Bibcode:2014Sci...344..634V. doi:10.1126/science.1252826. PMID 24790029. S2CID 24709412.
^Jentsch TJ (2016-05-17). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". Nature Reviews Molecular Cell Biology. 17 (2): 293–3017. doi:10.1038/nrm.2016.29. ISSN 1471-0072. PMID 27033257. S2CID 40565653.[permanent dead link]
^Hyzinski-García MC, Rudkouskaya A, Mongin A (2014-11-15). "LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes". The Journal of Physiology. 592 (22): 4855–62. doi:10.1113/jphysiol.2014.278887. PMC4259531. PMID 25172945.
^Yamada T, Wondergem R, Morrison R (2016-10-04). "Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl− currents and embryonic development in zebrafish". Physiological Reports. 4 (19): e12940. doi:10.14814/phy2.12940. PMC5064130. PMID 27688432.
^ abPlanells-Cases R, Lutter D, Guyader C (2015-12-14). "Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs". EMBO Journal. 34 (24): 2993–3008. doi:10.15252/embj.201592409. PMC4687416. PMID 26530471.
^Okada T, Islam MR, Tsiferova NA (2016-10-20). "Specific and essential but not sufficient roles of LRRC8A in the activity of volume-sensitive outwardly rectifying anion channel (VSOR)". Channels. 11 (2): 109–120. doi:10.1080/19336950.2016.1247133. PMC5398601. PMID 27764579.
^Lutter D, Ullrich F, Lueck JC (2017-03-15). "Selective transport of neurotransmitters and –modulators by distinct volume-regulated LRRC8 anion channels". Journal of Cell Science. 130 (6): 1122–1133. doi:10.1242/jcs.196253. PMID 28193731.
^Sawada A, Takihara Y, Kim JY (December 2003). "A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans". Journal of Clinical Investigation. 112 (11): 1707–13. doi:10.1172/JCI18937. PMC281644. PMID 14660746.
Further readingedit
Jentsch Thomas J (2016). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". Nature Reviews Molecular Cell Biology. 17 (2): 293–307. doi:10.1038/nrm.2016.29. PMID 27033257. S2CID 40565653.
Eggermont D, Trouet I, Carton I, et al. (2001). "Cellular function and control of volume-regulated anion channels". Cell Biochemistry and Biophysics. 35 (3): 263–74. doi:10.1385/CBB:35:3:263. PMID 11894846. S2CID 31821726.
Mongin Alexander (2016). "Volume-regulated anion channel – a frenemy within the brain". Pflügers Archiv. 468 (3): 421–441. doi:10.1007/s00424-015-1765-6. PMC4752865. PMID 26620797.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Sawada A, Takihara Y, Kim JY, et al. (2004). "A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans". J. Clin. Invest. 112 (11): 1707–13. doi:10.1172/JCI18937. PMC281644. PMID 14660746.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kubota K, Kim JY, Sawada A, et al. (2004). "LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins". FEBS Lett. 564 (1–2): 147–52. doi:10.1016/S0014-5793(04)00332-1. PMID 15094057.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC2734081. PMID 15164053.
Smits G, Kajava AV (2004). "LRRC8 extracellular domain is composed of 17 leucine-rich repeats". Mol. Immunol. 41 (5): 561–2. doi:10.1016/j.molimm.2004.04.001. PMID 15183935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
January 01, 1970
lrrc8c, leucine, rich, repeat, containing, protein, protein, that, humans, encoded, gene, researchers, have, found, that, this, protein, along, with, other, lrrc8, proteins, lrrc8a, lrrc8b, lrrc8d, lrrc8e, sometimes, subunit, heteromer, protein, volume, regula. Leucine rich repeat containing protein 8C is a protein that in humans is encoded by the LRRC8C gene 5 Researchers have found out that this protein along with the other LRRC8 proteins LRRC8A LRRC8B LRRC8D and LRRC8E is sometimes a subunit of the heteromer protein Volume Regulated Anion Channel 6 Volume Regulated Anion Channels VRACs are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes such as taurine or glutamate across the plasma membrane 7 and that is not the only function these channels have been linked to LRRC8CIdentifiersAliasesLRRC8C AD158 FAD158 leucine rich repeat containing 8 family member C leucine rich repeat containing 8 family member C leucine rich repeat containing 8 VRAC subunit CExternal IDsOMIM 612889 MGI 2140839 HomoloGene 12997 GeneCards LRRC8C OMA LRRC8C orthologsGene location Human Chr Chromosome 1 human 1 Band1p22 2Start89 633 072 bp 1 End89 769 903 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 E5Start105 667 254 bp 2 End105 760 884 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspermsecondary oocytemonocytelower lobe of lungsuperficial temporal arteryright ventriclesmooth muscle tissuesubcutaneous adipose tissuelymph nodevisceral pleuraTop expressed inleft lung lobecarotid bodyciliary bodyright lung lobebody of femuririsblooddigastric musclefacial motor nucleussemi lunar valveMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding volume sensitive anion channel activityCellular componentcytoplasm integral component of membrane integral component of plasma membrane endoplasmic reticulum membrane membrane endoplasmic reticulum ion channel complex plasma membraneBiological processanion transmembrane transport ion transport fat cell differentiation regulation of anion transport signal transduction transmembrane transport transport cell volume homeostasis inorganic anion transport taurine transport aspartate transmembrane transport protein hexamerization cellular response to osmotic stressSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez84230100604EnsemblENSG00000171488ENSMUSG00000054720UniProtQ8TDW0Q8R502RefSeq mRNA NM 032270NM 133897RefSeq protein NP 115646NP 598658Location UCSC Chr 1 89 63 89 77 MbChr 5 105 67 105 76 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse While LRRC8C is one of many proteins that can be part of VRAC research has found that it is not as crucial to the activity of the channel in comparison to LRRC8A and LRRC8D 8 9 10 However while we know that LRRC8A and LRRC8D are necessary for VRAC function other studies have found that they are not sufficient for the full range of usual VRAC activity 11 This is where the other LRRC8 proteins come in such as LRRC8C as the different composition of these subunits affects the range of specificity for VRACs 12 10 In addition to its role in VRACs the LRRC8 protein family is also associated with agammaglobulinemia 5 13 References edit a b c GRCh38 Ensembl release 89 ENSG00000171488 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000054720 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene LRRC8A leucine rich repeat containing 8 family member A Voss F Ullrich F Munch J 2014 05 09 Identification of LRRC8 heteromers as an essential component of the volume regulated anion channel VRAC PDF Science Submitted manuscript 344 6184 634 8 Bibcode 2014Sci 344 634V doi 10 1126 science 1252826 PMID 24790029 S2CID 24709412 Jentsch TJ 2016 05 17 VRACs and other ion channels and transporters in the regulation of cell volume and beyond Nature Reviews Molecular Cell Biology 17 2 293 3017 doi 10 1038 nrm 2016 29 ISSN 1471 0072 PMID 27033257 S2CID 40565653 permanent dead link Hyzinski Garcia MC Rudkouskaya A Mongin A 2014 11 15 LRRC8A protein is indispensable for swelling activated and ATP induced release of excitatory amino acids in rat astrocytes The Journal of Physiology 592 22 4855 62 doi 10 1113 jphysiol 2014 278887 PMC 4259531 PMID 25172945 Yamada T Wondergem R Morrison R 2016 10 04 Leucine rich repeat containing protein LRRC8A is essential for swelling activated Cl currents and embryonic development in zebrafish Physiological Reports 4 19 e12940 doi 10 14814 phy2 12940 PMC 5064130 PMID 27688432 a b Planells Cases R Lutter D Guyader C 2015 12 14 Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt based anti cancer drugs EMBO Journal 34 24 2993 3008 doi 10 15252 embj 201592409 PMC 4687416 PMID 26530471 Okada T Islam MR Tsiferova NA 2016 10 20 Specific and essential but not sufficient roles of LRRC8A in the activity of volume sensitive outwardly rectifying anion channel VSOR Channels 11 2 109 120 doi 10 1080 19336950 2016 1247133 PMC 5398601 PMID 27764579 Lutter D Ullrich F Lueck JC 2017 03 15 Selective transport of neurotransmitters and modulators by distinct volume regulated LRRC8 anion channels Journal of Cell Science 130 6 1122 1133 doi 10 1242 jcs 196253 PMID 28193731 Sawada A Takihara Y Kim JY December 2003 A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans Journal of Clinical Investigation 112 11 1707 13 doi 10 1172 JCI18937 PMC 281644 PMID 14660746 Further reading editJentsch Thomas J 2016 VRACs and other ion channels and transporters in the regulation of cell volume and beyond Nature Reviews Molecular Cell Biology 17 2 293 307 doi 10 1038 nrm 2016 29 PMID 27033257 S2CID 40565653 Eggermont D Trouet I Carton I et al 2001 Cellular function and control of volume regulated anion channels Cell Biochemistry and Biophysics 35 3 263 74 doi 10 1385 CBB 35 3 263 PMID 11894846 S2CID 31821726 Mongin Alexander 2016 Volume regulated anion channel a frenemy within the brain Pflugers Archiv 468 3 421 441 doi 10 1007 s00424 015 1765 6 PMC 4752865 PMID 26620797 Nagase T Kikuno R Ishikawa KI et al 2000 Prediction of the coding sequences of unidentified human genes XVI The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro DNA Res 7 1 65 73 doi 10 1093 dnares 7 1 65 PMID 10718198 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Clark HF Gurney AL Abaya E et al 2003 The Secreted Protein Discovery Initiative SPDI a Large Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins A Bioinformatics Assessment Genome Res 13 10 2265 70 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Sawada A Takihara Y Kim JY et al 2004 A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans J Clin Invest 112 11 1707 13 doi 10 1172 JCI18937 PMC 281644 PMID 14660746 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Kubota K Kim JY Sawada A et al 2004 LRRC8 involved in B cell development belongs to a novel family of leucine rich repeat proteins FEBS Lett 564 1 2 147 52 doi 10 1016 S0014 5793 04 00332 1 PMID 15094057 Humphray SJ Oliver K Hunt AR et al 2004 DNA sequence and analysis of human chromosome 9 Nature 429 6990 369 74 Bibcode 2004Natur 429 369H doi 10 1038 nature02465 PMC 2734081 PMID 15164053 Smits G Kajava AV 2004 LRRC8 extracellular domain is composed of 17 leucine rich repeats Mol Immunol 41 5 561 2 doi 10 1016 j molimm 2004 04 001 PMID 15183935 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Otsuki T Ota T Nishikawa T et al 2007 Signal sequence and keyword trap in silico for selection of full length human cDNAs encoding secretion or membrane proteins from oligo capped cDNA libraries DNA Res 12 2 117 26 doi 10 1093 dnares 12 2 117 PMID 16303743 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Retrieved from https en wikipedia org w index php title LRRC8C amp oldid 1217202254, wikipedia, wiki, book, books, library,
