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H. Robert Horvitz

October 26, 2023

Howard Robert Horvitz ForMemRS NAS AAA&S APS NAM (born May 8, 1947) is an American biologist best known for his research on the nematode worm Caenorhabditis elegans,[4][1][5] for which he was awarded the 2002 Nobel Prize in Physiology or Medicine, together with Sydney Brenner and John E. Sulston, whose "seminal discoveries concerning the genetic regulation of organ development and programmed cell death" were "important for medical research and have shed new light on the pathogenesis of many diseases".[6]

H. Robert Horvitz
Born
Howard Robert Horvitz

(1947-05-08) May 8, 1947 (age 76)[3]
Chicago, Illinois, US
Alma mater
Known forApoptosis research
SpouseMartha Constantine-Paton
Awards
Scientific career
FieldsBiology
InstitutionsMRC Laboratory of Molecular Biology
Massachusetts Institute of Technology
ThesisModifications of the host RNA polymerase induced by coliphage T4 (1974)
Notable studentsCornelia Bargmann[citation needed]

Michael Hengartner Gary Ruvkun Yishi Jin Andrew Chisholm

Junying Yuan
Websiteweb.mit.edu/horvitz/www/

Education and early life edit

Horvitz was born in Chicago, Illinois to Jewish parents,[3] the son of Mary R. (Savit), a school teacher, and Oscar Freedom Horvitz, a GAO accountant. He majored in mathematics at Massachusetts Institute of Technology, where he joined Alpha Epsilon Pi and spent his summers working for IBM, at first wiring panels for accounting machines and then in his final summer helping to develop IBM's Conversational Programming System.[1]

During his senior year, Horvitz took his first courses in biology and was encouraged by his professors to continue to study biology in graduate school, despite his limited coursework in the field. After he completed his undergraduate studies in 1968, he enrolled in graduate studies in biology at Harvard University, where he studied T4-induced modifications of E. coli RNA polymerase under the direction of Walter Gilbert and James Watson. He completed his PhD in 1974.[7]

Career edit

In 1974, Horvitz took a postdoctoral position at the Laboratory of Molecular Biology (LMB) in Cambridge, England, where he worked with his future Nobel prize co-winners Sydney Brenner and John Sulston on the genetics and cell lineage of C. elegans. In 1978, Horvitz was offered a faculty position at MIT, where he is currently Professor of Biology and a member of the McGovern Institute for Brain Research. He is also an Investigator of the Howard Hughes Medical Institute.

Horvitz serves as the chair of the board of trustees for Society for Science & the Public and is a member of the USA Science and Engineering Festival's Advisory Board.[8]

Research edit

At LMB, Horvitz worked with Sulston to track every non-gonadal cell division that occurred during larval development, and published a complete description of these lineages in 1977.[1][9] Later, in cooperation with Sulston and Martin Chalfie, Horvitz began investigations first characterizing several cell lineage mutants[10][11] and then seeking genes that controlled cell lineage or that controlled specific linages. In 1981, they identified and characterized the gene lin-4, a "heterochronic" mutant that changes the timeline of cell fates.[12]

In his early work at MIT, Horvitz continued his work on cell lineage and cell fate, using C. elegans to investigate whether there was a genetic program controlling cell death, or apoptosis. In 1986, he identified the first "death genes", ced-3 and ced-4. He showed that functional ced-3 and ced-4 genes were a prerequisite for cell death to be executed.[13] He went on to show that another gene, ced-9, protects against cell death by interacting with ced-4 and ced-3, as well as identifying a number of genes that direct how a dead cell is eliminated. Horvitz showed that the human genome contains a ced-3-like gene.[14][15]

Horvitz's later research continued to use C. elegans to analyze the genetic control of animal development and behavior, as well as to link discoveries in the nematode to human diseases, particularly cancer and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). He made further advancements in defining the molecular pathway of programmed cell death, and has identified several key components, including: EGL-1, a protein which activates apoptosis by inhibiting CED-9;[16] transcription factors ces-1 and ces-2,[17][18] and ced-8, which controls the timing of cell death.[19] He has also continued work on heterochronic mutants and other aspects of cell lineage, and established lines of research in signal transduction, morphogenesis, and neural development. Horvitz has collaborated with Victor Ambros and David Bartel on a project to characterize the complete set of the more than 100 microRNAs in the C. elegans genome.[20]

Works edit

 
Scholia has a profile for H. Robert Horvitz (Q295659).

Robert Horvitz has over 255 publications, has been cited over 49,000 times and has an h-index of 108.[21]

  • Sulston, J.E.; Horvitz, H.R. (March 1977). "Post-embryonic cell lineages of the nematode, Caenorhabditis elegans". Developmental Biology. 56 (1): 110–156. doi:10.1016/0012-1606(77)90158-0. PMID 838129.
  • Ellis, Hillary M.; Horvitz, H. Robert (28 March 1986). "Genetic control of programmed cell death in the nematode C. elegans". Cell. 44 (6): 817–829. doi:10.1016/0092-8674(86)90004-8. PMID 3955651. S2CID 44031839.
  • Ellis, R E; Yuan, J; Horvitz, H R (November 1991). "Mechanisms and Functions of Cell Death". Annual Review of Cell Biology. 7 (1): 663–698. doi:10.1146/annurev.cb.07.110191.003311. PMID 1809356.
  • Yuan, J; Shaham, S; Ledoux, S; Ellis, HM; Horvitz, HR (19 November 1993). "The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme". Cell. 75 (4): 641–52. doi:10.1016/0092-8674(93)90485-9. PMID 8242740.
  • Hengartner, MO; Horvitz, HR (25 February 1994). "C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2". Cell. 76 (4): 665–76. doi:10.1016/0092-8674(94)90506-1. PMID 7907274. S2CID 29437409.

Awards and honors edit

See also edit

References edit

  1. ^ a b c d H. Robert Horvitz on Nobelprize.org  , accessed 11 October 2020
  2. ^ a b . London: Royal Society. Archived from the original on 2015-03-16.
  3. ^ a b Green, David B. (8 May 2015). "Biologist who discovered death genes' through worm research is born". This Day in Jewish History. Haaretz. Retrieved 18 September 2015.
  4. ^ Horvitz, H. Robert (30 May 2012). "Genetic Control of Nematode Development and Behavior". Our scientists. Howard Hughes Medical Institute. Retrieved 18 September 2015.
  5. ^ "H. Robert Horvitz – Autobiography". Nobel Prizes and Laureates. NobelPrize.org. Retrieved 18 September 2015.[permanent dead link]
  6. ^ Nobelprize pressrelease
  7. ^ "H. Robert Horvitz - Biographical". www.nobelprize.org. Retrieved 2016-01-26.
  8. ^ . Usasciencefestival.org. Archived from the original on 2010-04-21. Retrieved 2013-04-23.
  9. ^ Sulston, J.E.; Horvitz, H.R. (1977). "Post-embryonic Cell Lineages of the Nematode, Caenorhabditis elegans" (PDF). Developmental Biology. 56 (1): 110–156. doi:10.1016/0012-1606(77)90158-0. PMID 838129. Retrieved 26 January 2016.
  10. ^ Horvitz, H. R.; Sulston, J. E. (1980-10-01). "Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans". Genetics. 96 (2): 435–454. doi:10.1093/genetics/96.2.435. ISSN 0016-6731. PMC 1214309. PMID 7262539.
  11. ^ Sulston, John E.; Horvitz, H. Robert (1981-02-01). "Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans". Developmental Biology. 82 (1): 41–55. doi:10.1016/0012-1606(81)90427-9. PMID 7014288.
  12. ^ Chalfie, M.; Horvitz, H. R.; Sulston, J. E. (1981-04-01). "Mutations that lead to reiterations in the cell lineages of C. elegans". Cell. 24 (1): 59–69. doi:10.1016/0092-8674(81)90501-8. ISSN 0092-8674. PMID 7237544. S2CID 33933388.
  13. ^ Ellis, Hilary M.; Horvitz, H. Robert (1986-03-28). "Genetic control of programmed cell death in the nematode C. elegans". Cell. 44 (6): 817–829. doi:10.1016/0092-8674(86)90004-8. PMID 3955651. S2CID 44031839.
  14. ^ Ellis, Ronald E.; Yuan, Junying; Horvitz, H. Robert (1991-01-01). "Mechanisms and Functions of Cell Death". Annual Review of Cell Biology. 7 (1): 663–698. doi:10.1146/annurev.cb.07.110191.003311. PMID 1809356.
  15. ^ "MIT's Horvitz shares Nobel Prize in physiology". MIT News. Retrieved 2016-01-26.
  16. ^ Conradt, B.; Horvitz, H. R. (1998-05-15). "The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9". Cell. 93 (4): 519–529. doi:10.1016/s0092-8674(00)81182-4. ISSN 0092-8674. PMID 9604928. S2CID 1668835.
  17. ^ Metzstein, M. M.; Horvitz, H. R. (1999-09-01). "The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein". Molecular Cell. 4 (3): 309–319. doi:10.1016/s1097-2765(00)80333-0. ISSN 1097-2765. PMID 10518212.
  18. ^ Metzstein, Mark M.; Hengartner, Michael O.; Tsung, Nancy; Ellis, Ronald E.; Horvitz, H. Robert (1996-08-08). "Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2". Nature. 382 (6591): 545–547. Bibcode:1996Natur.382..545M. doi:10.1038/382545a0. PMID 8700229. S2CID 4307474.
  19. ^ Stanfield, G. M.; Horvitz, H. R. (2000-03-01). "The ced-8 gene controls the timing of programmed cell deaths in C. elegans". Molecular Cell. 5 (3): 423–433. doi:10.1016/s1097-2765(00)80437-2. ISSN 1097-2765. PMID 10882128.
  20. ^ "The Horvitz Laboratory". web.mit.edu. Retrieved 2016-01-26.
  21. ^ "Web of Science". Thomson Reuters. Retrieved 19 September 2015.
  22. ^ a b c "H. Robert Horvitz". The Gruber Foundation. Retrieved January 13, 2018.
  23. ^ "NAS award in molecular biology". National Academy of Sciences. Retrieved 20 May 2016.
  24. ^ "Horvitz receives Roche's Mattia Award". MIT News. Massachusetts Institute of Technology. November 3, 1993. Retrieved 17 October 2022.
  25. ^ "Hans Sigrist Prize Winners". University of Bern. Retrieved 20 May 2016.
  26. ^ "Rosenstiel Basic Medical Sciences Research Center - Past Winners". brandeis.edu. Brandeis University. Retrieved 17 October 2022.
  27. ^ "recipients of the passano laureate and physician scientist awards". The Passano Foundation, Inc. Passano Foundation. Retrieved 17 October 2022.
  28. ^ "In recognition of their pioneering contribution to our understanding of apoptosis". gairdner.org. the Canada Gairdner Foundation. Retrieved 17 October 2022.
  29. ^ "Prize Winners of the Paul Ehrlich and Ludwig Darmstaedter Prize" (PDF). goethe-university-frankfurt.de. The Paul Ehrlich Foundation. Retrieved 17 October 2022.
  30. ^ "MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY RECIPIENT LIST" (PDF). marchofdimes.org. Retrieved 17 October 2022.
  31. ^ "Horwitz Prize Goes To MIT's Horvitz, Harvard's Korsmeyer". Columbia University Record. 26 (8). 30 October 2000. Retrieved 19 September 2015.
  32. ^ "The Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research, 2001: H. Robert Horvitz, PhD". The Neuroscientist. 7 (6): 551. December 2001. doi:10.1177/107385840100700611. PMID 11765132. S2CID 41177724. Retrieved 17 October 2022.
  33. ^ "The 2001 Genetics Society of America Medal: H. Robert Horvitz". Genetics Society of America. Retrieved 17 October 2022.
  34. ^ . Superstars of Science. Archived from the original on 2014-08-10. Retrieved 18 September 2015.
  35. ^ "The Wiley Prize in Biomedical Sciences". John Wiley & Sons, Inc. Retrieved 17 October 2022.
  36. ^ "2002 Genetics Prize: H. Robert Horvitz". Gruber prizes. The Gruber Foundation. Retrieved 20 May 2016.
  37. ^ "American Philosophical Society Member History". amphilsoc.org.
  38. ^ "Mendel Medal". The Genetics Society. Retrieved 17 October 2022.

Further reading edit

  • Altman, Lawrence K. (8 October 2002). "3 Win Nobel for Work on Suicidal Cells". The New York Times. The New York Times. Retrieved 19 September 2015.
  • Badge, Peter; Turner, Nikolaus (2008). Nobel faces : a gallery of Nobel Prize winners. Weinheim [Germany]: Wiley-VCH. pp. 506–507. ISBN 9783527406784.
  • Carey, Jr, Charles W. (2006). "Horvitz, H. Robert". American scientists. New York: Facts on File. pp. 179–180. ISBN 9781438108070.
  • Drogin, Eric (2008). "Programmed cell death". Science for lawyers (1st ed.). Chicago, IL: American Bar Association. pp. 40–41. ISBN 9781590319260.
  • Heemels, Marie-Thérèse (1 July 2004). "131 corpses and a Nobel prize". Nature Milestones: 1–2. doi:10.1038/nrn1463. Retrieved 19 September 2015.
  • Pelengaris, Stella; Khan, Mike (2013-03-13). The Molecular Biology of Cancer: A Bridge from Bench to Bedside. pp. 269–270. ISBN 9781118430859.
  • Stone, Nikki (2010). "Dr. H. Robert Horvitz". When turtles fly the secrets of successful people who know how to stick their necks out. New York: Morgan James. pp. 55–60. ISBN 9781600378010.

External links edit

  • H. Robert Horvitz on Nobelprize.org  

October 26, 2023
robert, horvitz, howard, robert, horvitz, formemrs, born, 1947, american, biologist, best, known, research, nematode, worm, caenorhabditis, elegans, which, awarded, 2002, nobel, prize, physiology, medicine, together, with, sydney, brenner, john, sulston, whose. Howard Robert Horvitz ForMemRS NAS AAA amp S APS NAM born May 8 1947 is an American biologist best known for his research on the nematode worm Caenorhabditis elegans 4 1 5 for which he was awarded the 2002 Nobel Prize in Physiology or Medicine together with Sydney Brenner and John E Sulston whose seminal discoveries concerning the genetic regulation of organ development and programmed cell death were important for medical research and have shed new light on the pathogenesis of many diseases 6 H Robert HorvitzBornHoward Robert Horvitz 1947 05 08 May 8 1947 age 76 3 Chicago Illinois USAlma materMassachusetts Institute of Technology BS Harvard University PhD Known forApoptosis researchSpouseMartha Constantine PatonAwardsNAS Award in Molecular Biology 1988 Nobel Prize in Physiology or Medicine 2002 1 Gruber Prize in Genetics 2002 Wiley Prize 2002 ForMemRS 2009 2 Scientific careerFieldsBiologyInstitutionsMRC Laboratory of Molecular BiologyMassachusetts Institute of TechnologyThesisModifications of the host RNA polymerase induced by coliphage T4 1974 Notable studentsCornelia Bargmann citation needed Michael Hengartner Gary Ruvkun Yishi Jin Andrew Chisholm Junying YuanWebsiteweb wbr mit wbr edu wbr horvitz wbr www wbr Contents 1 Education and early life 2 Career 3 Research 4 Works 5 Awards and honors 6 See also 7 References 8 Further reading 9 External linksEducation and early life editHorvitz was born in Chicago Illinois to Jewish parents 3 the son of Mary R Savit a school teacher and Oscar Freedom Horvitz a GAO accountant He majored in mathematics at Massachusetts Institute of Technology where he joined Alpha Epsilon Pi and spent his summers working for IBM at first wiring panels for accounting machines and then in his final summer helping to develop IBM s Conversational Programming System 1 During his senior year Horvitz took his first courses in biology and was encouraged by his professors to continue to study biology in graduate school despite his limited coursework in the field After he completed his undergraduate studies in 1968 he enrolled in graduate studies in biology at Harvard University where he studied T4 induced modifications of E coli RNA polymerase under the direction of Walter Gilbert and James Watson He completed his PhD in 1974 7 Career editIn 1974 Horvitz took a postdoctoral position at the Laboratory of Molecular Biology LMB in Cambridge England where he worked with his future Nobel prize co winners Sydney Brenner and John Sulston on the genetics and cell lineage of C elegans In 1978 Horvitz was offered a faculty position at MIT where he is currently Professor of Biology and a member of the McGovern Institute for Brain Research He is also an Investigator of the Howard Hughes Medical Institute Horvitz serves as the chair of the board of trustees for Society for Science amp the Public and is a member of the USA Science and Engineering Festival s Advisory Board 8 Research editAt LMB Horvitz worked with Sulston to track every non gonadal cell division that occurred during larval development and published a complete description of these lineages in 1977 1 9 Later in cooperation with Sulston and Martin Chalfie Horvitz began investigations first characterizing several cell lineage mutants 10 11 and then seeking genes that controlled cell lineage or that controlled specific linages In 1981 they identified and characterized the gene lin 4 a heterochronic mutant that changes the timeline of cell fates 12 In his early work at MIT Horvitz continued his work on cell lineage and cell fate using C elegans to investigate whether there was a genetic program controlling cell death or apoptosis In 1986 he identified the first death genes ced 3 and ced 4 He showed that functional ced 3 and ced 4 genes were a prerequisite for cell death to be executed 13 He went on to show that another gene ced 9 protects against cell death by interacting with ced 4 and ced 3 as well as identifying a number of genes that direct how a dead cell is eliminated Horvitz showed that the human genome contains a ced 3 like gene 14 15 Horvitz s later research continued to use C elegans to analyze the genetic control of animal development and behavior as well as to link discoveries in the nematode to human diseases particularly cancer and neurodegenerative diseases such as amyotrophic lateral sclerosis ALS He made further advancements in defining the molecular pathway of programmed cell death and has identified several key components including EGL 1 a protein which activates apoptosis by inhibiting CED 9 16 transcription factors ces 1 and ces 2 17 18 and ced 8 which controls the timing of cell death 19 He has also continued work on heterochronic mutants and other aspects of cell lineage and established lines of research in signal transduction morphogenesis and neural development Horvitz has collaborated with Victor Ambros and David Bartel on a project to characterize the complete set of the more than 100 microRNAs in the C elegans genome 20 Works edit nbsp Scholia has a profile for H Robert Horvitz Q295659 Robert Horvitz has over 255 publications has been cited over 49 000 times and has an h index of 108 21 Sulston J E Horvitz H R March 1977 Post embryonic cell lineages of the nematode Caenorhabditis elegans Developmental Biology 56 1 110 156 doi 10 1016 0012 1606 77 90158 0 PMID 838129 Ellis Hillary M Horvitz H Robert 28 March 1986 Genetic control of programmed cell death in the nematode C elegans Cell 44 6 817 829 doi 10 1016 0092 8674 86 90004 8 PMID 3955651 S2CID 44031839 Ellis R E Yuan J Horvitz H R November 1991 Mechanisms and Functions of Cell Death Annual Review of Cell Biology 7 1 663 698 doi 10 1146 annurev cb 07 110191 003311 PMID 1809356 Yuan J Shaham S Ledoux S Ellis HM Horvitz HR 19 November 1993 The C elegans cell death gene ced 3 encodes a protein similar to mammalian interleukin 1 beta converting enzyme Cell 75 4 641 52 doi 10 1016 0092 8674 93 90485 9 PMID 8242740 Hengartner MO Horvitz HR 25 February 1994 C elegans cell survival gene ced 9 encodes a functional homolog of the mammalian proto oncogene bcl 2 Cell 76 4 665 76 doi 10 1016 0092 8674 94 90506 1 PMID 7907274 S2CID 29437409 Awards and honors edit1986 Spencer Award in Neurobiology from Columbia University 22 1986 Warren Triennial Prize from the Massachusetts General Hospital 22 1988 U S Steel Foundation Award in Molecular Biology from the U S National Academy of Sciences 23 22 1991 Member U S National Academy of Sciences 1993 V D Mattia Award Roche Institute of Molecular Biology 24 1994 Member American Academy of Arts and Sciences 1994 Hans Sigrist Prize from the University of Bern Switzerland 25 1995 Charles A Dana Award 1995 President of the Genetics Society of America 1996 Ciba Drew Award for Biomedical Science 1997 Rosenstiel Award 26 1998 Fellow American Academy of Microbiology 1998 Passano Award for the Advancement of Medical Science 27 1998 Alfred P Sloan Jr Prize General Motors Research Foundation 1999 Gairdner Foundation International Award 28 2000 Paul Ehrlich and Ludwig Darmstaedter Prize 29 2000 Segerfalk Award 2000 March of Dimes Prize in Developmental Biology 30 2000 Louisa Gross Horwitz Prize for Biology or Biochemistry 31 2000 Grand Prix Charles Leopold Mayer French Academy of Sciences 2001 Bristol Myers Squibb Award for Distinguished Achievement in Neuroscience 32 2001 Genetics Society of America Medal 33 2002 Nobel Prize in Physiology or Medicine with Sydney Brenner and John Sulston 34 2002 Wiley Prize in Biomedical Sciences 35 2002 Gruber Prize in Geneticsgrom the Gruber Foundation 36 2004 Member American Philosophical Society 37 2003 Member Institute of Medicine 2007 UK Genetics Society Mendel Medal 38 2009 Elected a Foreign Member of the Royal Society ForMemRS 2 See also editHistory of apoptosis research List of Jewish Nobel laureatesReferences edit a b c d H Robert Horvitz on Nobelprize org nbsp accessed 11 October 2020 a b Fellows of the Royal Society London Royal Society Archived from the original on 2015 03 16 a b Green David B 8 May 2015 Biologist who discovered death genes through worm research is born This Day in Jewish History Haaretz Retrieved 18 September 2015 Horvitz H Robert 30 May 2012 Genetic Control of Nematode Development and Behavior Our scientists Howard Hughes Medical Institute Retrieved 18 September 2015 H Robert Horvitz Autobiography Nobel Prizes and Laureates NobelPrize org Retrieved 18 September 2015 permanent dead link Nobelprize pressrelease H Robert Horvitz Biographical www nobelprize org Retrieved 2016 01 26 USA Science and Engineering Festival Advisors Usasciencefestival org Archived from the original on 2010 04 21 Retrieved 2013 04 23 Sulston J E Horvitz H R 1977 Post embryonic Cell Lineages of the Nematode Caenorhabditis elegans PDF Developmental Biology 56 1 110 156 doi 10 1016 0012 1606 77 90158 0 PMID 838129 Retrieved 26 January 2016 Horvitz H R Sulston J E 1980 10 01 Isolation and genetic characterization of cell lineage mutants of the nematode Caenorhabditis elegans Genetics 96 2 435 454 doi 10 1093 genetics 96 2 435 ISSN 0016 6731 PMC 1214309 PMID 7262539 Sulston John E Horvitz H Robert 1981 02 01 Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans Developmental Biology 82 1 41 55 doi 10 1016 0012 1606 81 90427 9 PMID 7014288 Chalfie M Horvitz H R Sulston J E 1981 04 01 Mutations that lead to reiterations in the cell lineages of C elegans Cell 24 1 59 69 doi 10 1016 0092 8674 81 90501 8 ISSN 0092 8674 PMID 7237544 S2CID 33933388 Ellis Hilary M Horvitz H Robert 1986 03 28 Genetic control of programmed cell death in the nematode C elegans Cell 44 6 817 829 doi 10 1016 0092 8674 86 90004 8 PMID 3955651 S2CID 44031839 Ellis Ronald E Yuan Junying Horvitz H Robert 1991 01 01 Mechanisms and Functions of Cell Death Annual Review of Cell Biology 7 1 663 698 doi 10 1146 annurev cb 07 110191 003311 PMID 1809356 MIT s Horvitz shares Nobel Prize in physiology MIT News Retrieved 2016 01 26 Conradt B Horvitz H R 1998 05 15 The C elegans protein EGL 1 is required for programmed cell death and interacts with the Bcl 2 like protein CED 9 Cell 93 4 519 529 doi 10 1016 s0092 8674 00 81182 4 ISSN 0092 8674 PMID 9604928 S2CID 1668835 Metzstein M M Horvitz H R 1999 09 01 The C elegans cell death specification gene ces 1 encodes a snail family zinc finger protein Molecular Cell 4 3 309 319 doi 10 1016 s1097 2765 00 80333 0 ISSN 1097 2765 PMID 10518212 Metzstein Mark M Hengartner Michael O Tsung Nancy Ellis Ronald E Horvitz H Robert 1996 08 08 Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces 2 Nature 382 6591 545 547 Bibcode 1996Natur 382 545M doi 10 1038 382545a0 PMID 8700229 S2CID 4307474 Stanfield G M Horvitz H R 2000 03 01 The ced 8 gene controls the timing of programmed cell deaths in C elegans Molecular Cell 5 3 423 433 doi 10 1016 s1097 2765 00 80437 2 ISSN 1097 2765 PMID 10882128 The Horvitz Laboratory web mit edu Retrieved 2016 01 26 Web of Science Thomson Reuters Retrieved 19 September 2015 a b c H Robert Horvitz The Gruber Foundation Retrieved January 13 2018 NAS award in molecular biology National Academy of Sciences Retrieved 20 May 2016 Horvitz receives Roche s Mattia Award MIT News Massachusetts Institute of Technology November 3 1993 Retrieved 17 October 2022 Hans Sigrist Prize Winners University of Bern Retrieved 20 May 2016 Rosenstiel Basic Medical Sciences Research Center Past Winners brandeis edu Brandeis University Retrieved 17 October 2022 recipients of the passano laureate and physician scientist awards The Passano Foundation Inc Passano Foundation Retrieved 17 October 2022 In recognition of their pioneering contribution to our understanding of apoptosis gairdner org the Canada Gairdner Foundation Retrieved 17 October 2022 Prize Winners of the Paul Ehrlich and Ludwig Darmstaedter Prize PDF goethe university frankfurt de The Paul Ehrlich Foundation Retrieved 17 October 2022 MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY RECIPIENT LIST PDF marchofdimes org Retrieved 17 October 2022 Horwitz Prize Goes To MIT s Horvitz Harvard s Korsmeyer Columbia University Record 26 8 30 October 2000 Retrieved 19 September 2015 The Bristol Myers Squibb Award for Distinguished Achievement in Neuroscience Research 2001 H Robert Horvitz PhD The Neuroscientist 7 6 551 December 2001 doi 10 1177 107385840100700611 PMID 11765132 S2CID 41177724 Retrieved 17 October 2022 The 2001 Genetics Society of America Medal H Robert Horvitz Genetics Society of America Retrieved 17 October 2022 H Robert Horvits Superstars of Science Archived from the original on 2014 08 10 Retrieved 18 September 2015 The Wiley Prize in Biomedical Sciences John Wiley amp Sons Inc Retrieved 17 October 2022 2002 Genetics Prize H Robert Horvitz Gruber prizes The Gruber Foundation Retrieved 20 May 2016 American Philosophical Society Member History amphilsoc org Mendel Medal The Genetics Society Retrieved 17 October 2022 Further reading editAltman Lawrence K 8 October 2002 3 Win Nobel for Work on Suicidal Cells The New York Times The New York Times Retrieved 19 September 2015 Badge Peter Turner Nikolaus 2008 Nobel faces a gallery of Nobel Prize winners Weinheim Germany Wiley VCH pp 506 507 ISBN 9783527406784 Carey Jr Charles W 2006 Horvitz H Robert American scientists New York Facts on File pp 179 180 ISBN 9781438108070 Drogin Eric 2008 Programmed cell death Science for lawyers 1st ed Chicago IL American Bar Association pp 40 41 ISBN 9781590319260 Heemels Marie Therese 1 July 2004 131 corpses and a Nobel prize Nature Milestones 1 2 doi 10 1038 nrn1463 Retrieved 19 September 2015 Pelengaris Stella Khan Mike 2013 03 13 The Molecular Biology of Cancer A Bridge from Bench to Bedside pp 269 270 ISBN 9781118430859 Stone Nikki 2010 Dr H Robert Horvitz When turtles fly the secrets of successful people who know how to stick their necks out New York Morgan James pp 55 60 ISBN 9781600378010 External links editH Robert Horvitz on Nobelprize org nbsp Retrieved from https en wikipedia org w index php title H Robert Horvitz amp oldid 1171101480, wikipedia, wiki, book, books, library,

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