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Formiminoglutamic acid

Formiminoglutamic acid (FIGLU; conjugate base, formiminoglutamate) is an intermediate in the catabolism of L-histidine to L-glutamic acid. It thus is also a biomarker for intracellular levels of folate. The FIGLU test is used to identify vitamin B₁₂ deficiency, folate deficiency, and liver failure or liver disease.[1][2] It is elevated with folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate and a decrease in homocysteine.[3]

Formiminoglutamic acid
Names
IUPAC name
N-(aminomethylidene)-L-glutamic acid
Other names
FIGLU
Identifiers
  • 816-90-0 Y
3D model (JSmol)
  • Interactive image
ChemSpider
  • 388370 N
ECHA InfoCard 100.011.308
MeSH Formiminoglutamic+acid
  • 909
UNII
  • YV703N7VOG Y
  • C(CC(=O)O)C(C(=O)O)N=CN
Properties
C6H10N2O4
Molar mass 174.156 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)

See also edit

References edit

  1. ^ Lascelles, P. T.; Donaldson, D. (1989). "Formiminoglutamic Acid (FIGLU) Test". Diagnostic Function Tests in Chemical Pathology. pp. 59–60. doi:10.1007/978-94-009-1846-7_31. ISBN 978-0-7462-0107-7.
  2. ^ FIGLU+Test at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  3. ^ Scott, JohnM.; Weir, DonaldG. (15 August 1981). "THE METHYL FOLATE TRAP: A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid-induced exacerbation of subacute combined degeneration in pernicious anaemia". The Lancet. 318 (8242): 337–340. doi:10.1016/S0140-6736(81)90650-4. ISSN 0140-6736. PMID 6115113. S2CID 29977127.


formiminoglutamic, acid, figlu, conjugate, base, formiminoglutamate, intermediate, catabolism, histidine, glutamic, acid, thus, also, biomarker, intracellular, levels, folate, figlu, test, used, identify, vitamin, deficiency, folate, deficiency, liver, failure. Formiminoglutamic acid FIGLU conjugate base formiminoglutamate is an intermediate in the catabolism of L histidine to L glutamic acid It thus is also a biomarker for intracellular levels of folate The FIGLU test is used to identify vitamin B deficiency folate deficiency and liver failure or liver disease 1 2 It is elevated with folate trapping where it is accompanied by decreased methylmalonic acid increased folate and a decrease in homocysteine 3 Formiminoglutamic acid Names IUPAC name N aminomethylidene L glutamic acid Other names FIGLU Identifiers CAS Number 816 90 0 Y 3D model JSmol Interactive image ChemSpider 388370 N ECHA InfoCard 100 011 308 MeSH Formiminoglutamic acid PubChem CID 909 UNII YV703N7VOG Y SMILES C CC O O C C O O N CN Properties Chemical formula C 6H 10N 2O 4 Molar mass 174 156 g mol 1 Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox referencesSee also editFormiminotransferase cyclodeaminase Glutamate 1 semialdehyde Glutamic acid Imidazol 4 one 5 propionic acidReferences edit Lascelles P T Donaldson D 1989 Formiminoglutamic Acid FIGLU Test Diagnostic Function Tests in Chemical Pathology pp 59 60 doi 10 1007 978 94 009 1846 7 31 ISBN 978 0 7462 0107 7 FIGLU Test at the U S National Library of Medicine Medical Subject Headings MeSH Scott JohnM Weir DonaldG 15 August 1981 THE METHYL FOLATE TRAP A physiological response in man to prevent methyl group deficiency in kwashiorkor methionine deficiency and an explanation for folic acid induced exacerbation of subacute combined degeneration in pernicious anaemia The Lancet 318 8242 337 340 doi 10 1016 S0140 6736 81 90650 4 ISSN 0140 6736 PMID 6115113 S2CID 29977127 nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte nbsp This article about a base chemistry is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Formiminoglutamic acid amp oldid 1175945042, wikipedia, wiki, book, books, library,

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