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Edward M. De Robertis

March 26, 2023

Edward Michael De Robertis (born June 6, 1947) is an American embryologist and Professor at the University of California, Los Angeles.[1][2] His work has contributed to the finding of conserved molecular processes of embryonic inductions that result in tissue differentiations during animal development.[3] He was elected to the National Academy of Sciences in 2013, worked for the Howard Hughes Medical Institute for 26 years, and holds a Distinguished Professor at the University of California, Los Angeles.[4][5] In 2009 Pope Benedict XVI appointed De Robertis to a lifetime position in the Pontifical Academy of Sciences, and in 2022 Pope Francis appointed him Councillor of the Academy for four years.[6][7]

Edward M. De Robertis
Born(1947-06-06)June 6, 1947
Cambridge, Massachusetts
Alma mater
Known forDorsal-Ventral patterning, Evo-Devo, Xenopus
Scientific career
Fieldsembryology
Institutions
Doctoral advisorJohn Gurdon
Websitehttps://www.hhmi.ucla.edu/derobertis/

Early life and education

Edward De Robertis was born on June 6, 1947, in Cambridge, Massachusetts, while his father, neurobiologist Eduardo Diego De Robertis, was an MIT postdoctoral fellow. From the age of three, he was reared in Uruguay, where he received his medical degree at age 24 from the Universidad de la República del Uruguay. This was followed by the completion of a Ph.D. in chemistry at the Leloir Institute in Buenos Aires, Argentina.[8][9]

Career and research

De Robertis' postdoctoral training (1974-1977) was with Nobel laureate Sir John Gurdon at the Medical Research Council in Cambridge England.

In 1984, De Robertis together with his late colleague Walter Gehring's and their laboratories cloned the first vertebrate development-controlling gene, today known as Hox-C6.[10][11][12][13][14][15] Hox genes are responsible for anterior-to-posterior (head-to-tail) differentiation. The finding that Hox genes are conserved in both vertebrates and fruit flies heralded the beginning of the nascent scientific field of Evolution and Development, or Evo-Devo.[16][17][18]

In the 1990s, the laboratory of De Robertis dissected systematically the molecular pathways that mediate embryonic induction.[19][20] Hans Spemann and Hilde Mangold discovered in 1924 an area of the amphibian embryo that, when transplanted, might promote the creation of Siamese twins.[21] De Robertis identified the genes expressed in Xenopus embryos in this area, beginning with the goosecoid homeobox gene.[22][23]

Together with his colleagues, he discovered Chordin, a protein secreted by dorsal cells that binds Bone Morphogenetic Protein (BMP) growth factors, facilitating their transport to the ventral side of the embryo, where Chordin is digested by a protease called Tolloid, allowing BMPs to signal once more.[24][25][26][27] In most bilateral species, such as fruit flies, spiders, early chordates, and mammals, this flow of growth factors dictates dorsal (back) to ventral (belly) cell and tissue differentiation. The Chordin/BMP/Tolloid biochemical pathway is cross-regulated by interactions with other signalling pathways such as Wnt.[28] His lab has recently established a link between the canonical Wnt pathway, macropinocytosis, multivesicular endosomes, lysosomes, and protein degradation.[29][30][31]

He has also served for over two decades on the scientific board of the Pew Charitable Trusts Latin American Fellows programme.[citation needed]

Honors and awards

  • Member, National Academy of Sciences, 2013.
  • Doctor Honoris Causa, Université Pierre et Marie Curie, Paris, France, 2013.[32]
  • Academician, Pontifical Academy of Sciences, the Vatican, 2009.
  • Ross Harrison Prize in Developmental Biology, 2009.
  • Membre Honoré, Societé de Biologie, Paris, France, 2008.
  • Corresponding Member, Latin American Academy of Sciences, 2002.
  • Fellow, American Academy of Arts and Sciences, 2000.
  • Public lecture series and Medal of the Collège de France, Paris, 1997.
  • Member, European Molecular Biology Organization, 1982.
  • Jane Coffin Childs Memorial Fund postdoctoral fellow, 1976-1977.

Publications

  • Carrasco, A.E., McGinnis, W., Gehring, W.J. and De Robertis, E.M. (1984). Cloning of an Xenopus laevis gene expressed during early embryogenesis that codes for a peptide region homologous to Drosophila homeotic genes: implications for vertebrate development. Cell 37, 409-414.[33][34]
  • De Robertis, E.M. and Sasai, Y. (1996). A common plan for dorso-ventral patterning in Bilateria. Nature 380, 37-40.[35]
  • De Robertis, E.M. and Tejeda-Muñoz N. (2022). Evo-Devo of Urbilateria and its larval forms. Dev. Biol., 487, 10-20.[36]
  • Cho, K.W.Y, Blumberg, B., Steinbeisser, H. and De Robertis, E.M. (1991). Molecular Nature of Spemann's Organizer: the Role of the Xenopus Homeobox Gene goosecoid. Cell 67, 1111-1120.[37]
  • Sasai, Y., Lu, B., Steinbeisser, H., Geissert, D., Gont, L.K. and De Robertis, E.M. (1994). Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell 79, 779-790.[38]
  • Piccolo, S., Sasai, Y., Lu, B. and De Robertis, E.M. (1996). Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of Chordin to BMP-4. Cell 86, 589-598.[39]
  • Piccolo, S., Agius, E., Lu, B., Goodman, S., Dale, L. and De Robertis, E.M. (1997). Cleavage of Chordin by the Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. Cell 91, 407-416.[40]
  • Lee, H.X., Ambrosio, A.L., Reversade, B. and De Robertis, E.M. (2006). Embryonic dorsal-ventral signaling: secreted Frizzled-related proteins as inhibitors of Tolloid proteinases. Cell 124, 147-159.[41]

References

  1. ^ "Edward M. De Robertis – Department of Biological Chemistry, UCLA". from the original on 2022-09-20. Retrieved 2022-09-26.
  2. ^ Viegas, Jennifer (2013-12-17). "Profile of Edward M. De Robertis". Proceedings of the National Academy of Sciences. 110 (51): 20349–20351. doi:10.1073/pnas.1320552110. ISSN 0027-8424. PMC 3870733. PMID 24277844.
  3. ^ De Robertis; M, Edward (April 2006). "Spemann's organizer and self-regulation in amphibian embryos". Nature Reviews Molecular Cell Biology. 7 (4): 296–302. doi:10.1038/nrm1855. ISSN 1471-0080. PMC 2464568. PMID 16482093.
  4. ^ "Edward M. De Robertis". www.pas.va. from the original on 2022-07-01. Retrieved 2022-09-26.
  5. ^ "Edward Michael De Robertis". American Academy of Arts & Sciences. from the original on 2022-10-02. Retrieved 2022-09-26.
  6. ^ "Edward M. De Robertis". HHMI. from the original on 2019-12-20. Retrieved 2022-09-26.
  7. ^ "Two UCLA faculty elected to National Academy of Sciences | UCLA Health". www.uclahealth.org. from the original on 2021-10-26. Retrieved 2022-09-26.
  8. ^ "Edward De Robertis – Molecular Biology Institute". from the original on 2022-01-24. Retrieved 2022-09-26.
  9. ^ "Edward De Robertis - Biozentrum". www.biozentrum.unibas.ch. from the original on 2022-10-02. Retrieved 2022-09-26.
  10. ^ "Edward Michael De Robertis". American Academy of Arts & Sciences. from the original on 2022-10-02. Retrieved 2022-09-26.
  11. ^ Hussain, Imran; Bhan, Arunoday; Ansari, Khairul I.; Deb, Paromita; Bobzean, Samara A. M.; Perrotti, Linda I.; Mandal, Subhrangsu S. (2015-06-01). "Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849 (6): 697–708. doi:10.1016/j.bbagrm.2015.02.003. ISSN 1874-9399. PMC 4437882. PMID 25725483.
  12. ^ "Edward M. De Robertis". www.nasonline.org. from the original on 2019-03-24. Retrieved 2022-09-26.
  13. ^ Nolte, Christof; Krumlauf, Robb (2013). Expression of Hox Genes in the Nervous System of Vertebrates. Landes Bioscience. from the original on 2022-10-02. Retrieved 2022-10-02.
  14. ^ "Edward De Robertis - Biozentrum". www.biozentrum.unibas.ch. from the original on 2022-10-02. Retrieved 2022-09-26.
  15. ^ "Edward De Robertis – Molecular Biology Institute". from the original on 2022-01-24. Retrieved 2022-09-26.
  16. ^ "Dr. Edward De Robertis on exploring our ancient genetic toolbox". UCLA. from the original on 2021-10-24. Retrieved 2022-09-26.
  17. ^ "Edward De Robertis – Molecular Biology Institute". from the original on 2022-01-24. Retrieved 2022-09-26.
  18. ^ De Robertis, Eddy M. (April 2008). "Eddy M. De Robertis". Current Biology. 18 (8): R318–R320. doi:10.1016/j.cub.2008.02.037. PMC 2606973. PMID 18561377.
  19. ^ Viegas, Jennifer (2013-12-17). "Profile of Edward M. De Robertis". Proceedings of the National Academy of Sciences. 110 (51): 20349–20351. doi:10.1073/pnas.1320552110. ISSN 0027-8424. PMC 3870733. PMID 24277844.
  20. ^ Niehrs, Christof (2020-08-05). "Lessons from the Organizer - an interview with Edward (Eddy) M. De Robertis". International Journal of Developmental Biology. 65 (1–2–3): 111–122. doi:10.1387/ijdb.190298cn. ISSN 0214-6282. PMID 32813267. S2CID 221180740. from the original on 2022-10-02. Retrieved 2022-10-02.
  21. ^ "Spemann-Mangold Organizer | The Embryo Project Encyclopedia". embryo.asu.edu. from the original on 2022-04-02. Retrieved 2022-09-26.
  22. ^ Niehrs, Christof (2020-08-05). "Lessons from the Organizer - an interview with Edward (Eddy) M. De Robertis". International Journal of Developmental Biology. 65 (1–2–3): 111–122. doi:10.1387/ijdb.190298cn. ISSN 0214-6282. PMID 32813267. S2CID 221180740. from the original on 2022-10-02. Retrieved 2022-10-02.
  23. ^ Robertis, Edward M. De; Gurdon, John B. (2021-03-30). "A Brief History of Xenopus in Biology". Cold Spring Harbor Protocols. 2021 (12): pdb.top107615. doi:10.1101/pdb.top107615. ISSN 1940-3402. PMID 33785561. S2CID 232431470. from the original on 2022-10-02. Retrieved 2022-10-02.
  24. ^ Plouhinec, Jean-Louis; Zakin, Lise; Moriyama, Yuki; De Robertis, Edward M. (2013-12-17). "Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo". Proceedings of the National Academy of Sciences. 110 (51): 20372–20379. doi:10.1073/pnas.1319745110. ISSN 0027-8424. PMC 3870759. PMID 24284174.
  25. ^ "Untitled Document". www.hhmi.ucla.edu. from the original on 2020-10-21. Retrieved 2022-10-02.
  26. ^ De Robertis, Edward M.; Moriyama, Yuki (2016-01-01), Wassarman, Paul M. (ed.), "Chapter Thirteen - The Chordin Morphogenetic Pathway", Current Topics in Developmental Biology, Essays on Developmental Biology, Part A, Academic Press, 116: 231–245, doi:10.1016/bs.ctdb.2015.10.003, PMID 26970622, S2CID 13919776, retrieved 2022-10-02
  27. ^ De Robertis, Edward M.; Moriyama, Yuki; Colozza, Gabriele (September 2017). "Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson". Development, Growth & Differentiation. 59 (7): 580–592. doi:10.1111/dgd.12388. PMID 28815565. S2CID 22076923.
  28. ^ De Robertis, Edward M.; Moriyama, Yuki; Colozza, Gabriele (September 2017). "Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson". Development, Growth & Differentiation. 59 (7): 580–592. doi:10.1111/dgd.12388. PMID 28815565. S2CID 22076923.
  29. ^ Albrecht, Lauren V.; Tejeda-Muñoz, Nydia; De Robertis, Edward M. (2021-10-06). "Cell Biology of Canonical Wnt Signaling". Annual Review of Cell and Developmental Biology. 37 (1): 369–389. doi:10.1146/annurev-cellbio-120319-023657. ISSN 1081-0706. PMID 34196570. S2CID 235698046. from the original on 2022-08-02. Retrieved 2022-10-02.
  30. ^ "Archived copy". www.hhmi.ucla.edu. from the original on 2017-07-08. Retrieved 2022-10-02.{{cite web}}: CS1 maint: archived copy as title (link)
  31. ^ De Robertis, Edward M.; Moriyama, Yuki; Colozza, Gabriele (September 2017). "Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson". Development, Growth & Differentiation. 59 (7): 580–592. doi:10.1111/dgd.12388. PMID 28815565. S2CID 22076923.
  32. ^ "Sorbonne Université". from the original on 2016-09-21. Retrieved 2016-08-15.
  33. ^ Carrasco, A. E.; McGinnis, W.; Gehring, W. J.; De Robertis, E. M. (June 1984). "Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes". Cell. 37 (2): 409–414. doi:10.1016/0092-8674(84)90371-4. ISSN 0092-8674. PMID 6327066. S2CID 30114443. from the original on 2020-07-21. Retrieved 2022-10-02.
  34. ^ Poli, Stefano; Facchin, Domenico; Rizzetto, Francesca; Rebellato, Luca; Daleffe, Elisabetta; Toniolo, Mauro; Miconi, Antonella; Altinier, Alessandro; Lanera, Corrado; Indrigo, Stefano; Comisso, Jennifer; Proclemer, Alessandro (2019-01-08). "Prognostic role of non-sustained ventricular tachycardia detected with remote interrogation in a pacemaker population". International Journal of Cardiology. Heart & Vasculature. 22: 92–95. doi:10.1016/j.ijcha.2018.12.011. ISSN 2352-9067. PMC 6327066. PMID 30671534.
  35. ^ De Robertis, E. M.; Sasai, Y. (1996-03-07). "A common plan for dorsoventral patterning in Bilateria". Nature. 380 (6569): 37–40. doi:10.1038/380037a0. ISSN 0028-0836. PMID 8598900. S2CID 4355458. from the original on 2022-06-17. Retrieved 2022-10-02.
  36. ^ De Robertis, Edward M.; Tejeda-Muñoz, Nydia (2022-07-01). "Evo-Devo of Urbilateria and its larval forms". Developmental Biology. 487: 10–20. doi:10.1016/j.ydbio.2022.04.003. ISSN 0012-1606. PMID 35443190. S2CID 248234939.
  37. ^ Blum, M.; Gaunt, S. J.; Cho, K. W.; Steinbeisser, H.; Blumberg, B.; Bittner, D.; De Robertis, E. M. (1992-06-26). "Gastrulation in the mouse: the role of the homeobox gene goosecoid". Cell. 69 (7): 1097–1106. doi:10.1016/0092-8674(92)90632-m. ISSN 0092-8674. PMID 1352187. S2CID 16692357. from the original on 2022-01-21. Retrieved 2022-10-02.
  38. ^ Sasai, Y.; Lu, B.; Steinbeisser, H.; Geissert, D.; Gont, L. K.; De Robertis, E. M. (1994-12-02). "Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes". Cell. 79 (5): 779–790. doi:10.1016/0092-8674(94)90068-x. ISSN 0092-8674. PMC 3082463. PMID 8001117.
  39. ^ Piccolo, S.; Sasai, Y.; Lu, B.; De Robertis, E. M. (1996-08-23). "Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4". Cell. 86 (4): 589–598. doi:10.1016/s0092-8674(00)80132-4. ISSN 0092-8674. PMC 3070603. PMID 8752213.
  40. ^ Piccolo, S.; Agius, E.; Lu, B.; Goodman, S.; Dale, L.; De Robertis, E. M. (1997-10-31). "Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity". Cell. 91 (3): 407–416. doi:10.1016/s0092-8674(00)80424-9. ISSN 0092-8674. PMC 3070600. PMID 9363949.
  41. ^ Lee, Hojoon X.; Ambrosio, Andrea L.; Reversade, Bruno; De Robertis, E. M. (2006-01-13). "Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases". Cell. 124 (1): 147–159. doi:10.1016/j.cell.2005.12.018. ISSN 0092-8674. PMC 2486255. PMID 16413488.

External links

  • De Robertis Laboratory Home Page
  • Howard Hughes Medical Institute
  • UCLA Biological Chemistry
  • Interview with Current Biology
  • Pontifical Academy of Sciences
  • NAS Profile

March 26, 2023
edward, robertis, this, biography, living, person, needs, additional, citations, verification, please, help, adding, reliable, sources, contentious, material, about, living, persons, that, unsourced, poorly, sourced, must, removed, immediately, especially, pot. This biography of a living person needs additional citations for verification Please help by adding reliable sources Contentious material about living persons that is unsourced or poorly sourced must be removed immediately especially if potentially libelous or harmful Find sources Edward M De Robertis news newspapers books scholar JSTOR February 2023 Learn how and when to remove this template message Edward Michael De Robertis born June 6 1947 is an American embryologist and Professor at the University of California Los Angeles 1 2 His work has contributed to the finding of conserved molecular processes of embryonic inductions that result in tissue differentiations during animal development 3 He was elected to the National Academy of Sciences in 2013 worked for the Howard Hughes Medical Institute for 26 years and holds a Distinguished Professor at the University of California Los Angeles 4 5 In 2009 Pope Benedict XVI appointed De Robertis to a lifetime position in the Pontifical Academy of Sciences and in 2022 Pope Francis appointed him Councillor of the Academy for four years 6 7 Edward M De RobertisBorn 1947 06 06 June 6 1947Cambridge MassachusettsAlma materLeloir InstituteKnown forDorsal Ventral patterning Evo Devo XenopusScientific careerFieldsembryologyInstitutionsUniversity of California Los Angeles University of BaselDoctoral advisorJohn GurdonWebsitehttps www hhmi ucla edu derobertis Contents 1 Early life and education 2 Career and research 3 Honors and awards 4 Publications 5 References 6 External linksEarly life and education EditEdward De Robertis was born on June 6 1947 in Cambridge Massachusetts while his father neurobiologist Eduardo Diego De Robertis was an MIT postdoctoral fellow From the age of three he was reared in Uruguay where he received his medical degree at age 24 from the Universidad de la Republica del Uruguay This was followed by the completion of a Ph D in chemistry at the Leloir Institute in Buenos Aires Argentina 8 9 Career and research EditDe Robertis postdoctoral training 1974 1977 was with Nobel laureate Sir John Gurdon at the Medical Research Council in Cambridge England In 1984 De Robertis together with his late colleague Walter Gehring s and their laboratories cloned the first vertebrate development controlling gene today known as Hox C6 10 11 12 13 14 15 Hox genes are responsible for anterior to posterior head to tail differentiation The finding that Hox genes are conserved in both vertebrates and fruit flies heralded the beginning of the nascent scientific field of Evolution and Development or Evo Devo 16 17 18 In the 1990s the laboratory of De Robertis dissected systematically the molecular pathways that mediate embryonic induction 19 20 Hans Spemann and Hilde Mangold discovered in 1924 an area of the amphibian embryo that when transplanted might promote the creation of Siamese twins 21 De Robertis identified the genes expressed in Xenopus embryos in this area beginning with the goosecoid homeobox gene 22 23 Together with his colleagues he discovered Chordin a protein secreted by dorsal cells that binds Bone Morphogenetic Protein BMP growth factors facilitating their transport to the ventral side of the embryo where Chordin is digested by a protease called Tolloid allowing BMPs to signal once more 24 25 26 27 In most bilateral species such as fruit flies spiders early chordates and mammals this flow of growth factors dictates dorsal back to ventral belly cell and tissue differentiation The Chordin BMP Tolloid biochemical pathway is cross regulated by interactions with other signalling pathways such as Wnt 28 His lab has recently established a link between the canonical Wnt pathway macropinocytosis multivesicular endosomes lysosomes and protein degradation 29 30 31 He has also served for over two decades on the scientific board of the Pew Charitable Trusts Latin American Fellows programme citation needed Honors and awards EditMember National Academy of Sciences 2013 Doctor Honoris Causa Universite Pierre et Marie Curie Paris France 2013 32 Academician Pontifical Academy of Sciences the Vatican 2009 Ross Harrison Prize in Developmental Biology 2009 Membre Honore Societe de Biologie Paris France 2008 Corresponding Member Latin American Academy of Sciences 2002 Fellow American Academy of Arts and Sciences 2000 Public lecture series and Medal of the College de France Paris 1997 Member European Molecular Biology Organization 1982 Jane Coffin Childs Memorial Fund postdoctoral fellow 1976 1977 Publications EditCarrasco A E McGinnis W Gehring W J and De Robertis E M 1984 Cloning of an Xenopus laevis gene expressed during early embryogenesis that codes for a peptide region homologous to Drosophila homeotic genes implications for vertebrate development Cell 37 409 414 33 34 De Robertis E M and Sasai Y 1996 A common plan for dorso ventral patterning in Bilateria Nature 380 37 40 35 De Robertis E M and Tejeda Munoz N 2022 Evo Devo of Urbilateria and its larval forms Dev Biol 487 10 20 36 Cho K W Y Blumberg B Steinbeisser H and De Robertis E M 1991 Molecular Nature of Spemann s Organizer the Role of the Xenopus Homeobox Gene goosecoid Cell 67 1111 1120 37 Sasai Y Lu B Steinbeisser H Geissert D Gont L K and De Robertis E M 1994 Xenopus chordin a novel dorsalizing factor activated by organizer specific homeobox genes Cell 79 779 790 38 Piccolo S Sasai Y Lu B and De Robertis E M 1996 Dorsoventral patterning in Xenopus Inhibition of ventral signals by direct binding of Chordin to BMP 4 Cell 86 589 598 39 Piccolo S Agius E Lu B Goodman S Dale L and De Robertis E M 1997 Cleavage of Chordin by the Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity Cell 91 407 416 40 Lee H X Ambrosio A L Reversade B and De Robertis E M 2006 Embryonic dorsal ventral signaling secreted Frizzled related proteins as inhibitors of Tolloid proteinases Cell 124 147 159 41 References Edit Edward M De Robertis Department of Biological Chemistry UCLA Archived from the original on 2022 09 20 Retrieved 2022 09 26 Viegas Jennifer 2013 12 17 Profile of Edward M De Robertis Proceedings of the National Academy of Sciences 110 51 20349 20351 doi 10 1073 pnas 1320552110 ISSN 0027 8424 PMC 3870733 PMID 24277844 De Robertis M Edward April 2006 Spemann s organizer and self regulation in amphibian embryos Nature Reviews Molecular Cell Biology 7 4 296 302 doi 10 1038 nrm1855 ISSN 1471 0080 PMC 2464568 PMID 16482093 Edward M De Robertis www pas va Archived from the original on 2022 07 01 Retrieved 2022 09 26 Edward Michael De Robertis American Academy of Arts amp Sciences Archived from the original on 2022 10 02 Retrieved 2022 09 26 Edward M De Robertis HHMI Archived from the original on 2019 12 20 Retrieved 2022 09 26 Two UCLA faculty elected to National Academy of Sciences UCLA Health www uclahealth org Archived from the original on 2021 10 26 Retrieved 2022 09 26 Edward De Robertis Molecular Biology Institute Archived from the original on 2022 01 24 Retrieved 2022 09 26 Edward De Robertis Biozentrum www biozentrum unibas ch Archived from the original on 2022 10 02 Retrieved 2022 09 26 Edward Michael De Robertis American Academy of Arts amp Sciences Archived from the original on 2022 10 02 Retrieved 2022 09 26 Hussain Imran Bhan Arunoday Ansari Khairul I Deb Paromita Bobzean Samara A M Perrotti Linda I Mandal Subhrangsu S 2015 06 01 Bisphenol A induces expression of HOXC6 an estrogen regulated homeobox containing gene associated with breast cancer Biochimica et Biophysica Acta BBA Gene Regulatory Mechanisms 1849 6 697 708 doi 10 1016 j bbagrm 2015 02 003 ISSN 1874 9399 PMC 4437882 PMID 25725483 Edward M De Robertis www nasonline org Archived from the original on 2019 03 24 Retrieved 2022 09 26 Nolte Christof Krumlauf Robb 2013 Expression of Hox Genes in the Nervous System of Vertebrates Landes Bioscience Archived from the original on 2022 10 02 Retrieved 2022 10 02 Edward De Robertis Biozentrum www biozentrum unibas ch Archived from the original on 2022 10 02 Retrieved 2022 09 26 Edward De Robertis Molecular Biology Institute Archived from the original on 2022 01 24 Retrieved 2022 09 26 Dr Edward De Robertis on exploring our ancient genetic toolbox UCLA Archived from the original on 2021 10 24 Retrieved 2022 09 26 Edward De Robertis Molecular Biology Institute Archived from the original on 2022 01 24 Retrieved 2022 09 26 De Robertis Eddy M April 2008 Eddy M De Robertis Current Biology 18 8 R318 R320 doi 10 1016 j cub 2008 02 037 PMC 2606973 PMID 18561377 Viegas Jennifer 2013 12 17 Profile of Edward M De Robertis Proceedings of the National Academy of Sciences 110 51 20349 20351 doi 10 1073 pnas 1320552110 ISSN 0027 8424 PMC 3870733 PMID 24277844 Niehrs Christof 2020 08 05 Lessons from the Organizer an interview with Edward Eddy M De Robertis International Journal of Developmental Biology 65 1 2 3 111 122 doi 10 1387 ijdb 190298cn ISSN 0214 6282 PMID 32813267 S2CID 221180740 Archived from the original on 2022 10 02 Retrieved 2022 10 02 Spemann Mangold Organizer The Embryo Project Encyclopedia embryo asu edu Archived from the original on 2022 04 02 Retrieved 2022 09 26 Niehrs Christof 2020 08 05 Lessons from the Organizer an interview with Edward Eddy M De Robertis International Journal of Developmental Biology 65 1 2 3 111 122 doi 10 1387 ijdb 190298cn ISSN 0214 6282 PMID 32813267 S2CID 221180740 Archived from the original on 2022 10 02 Retrieved 2022 10 02 Robertis Edward M De Gurdon John B 2021 03 30 A Brief History of Xenopus in Biology Cold Spring Harbor Protocols 2021 12 pdb top107615 doi 10 1101 pdb top107615 ISSN 1940 3402 PMID 33785561 S2CID 232431470 Archived from the original on 2022 10 02 Retrieved 2022 10 02 Plouhinec Jean Louis Zakin Lise Moriyama Yuki De Robertis Edward M 2013 12 17 Chordin forms a self organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo Proceedings of the National Academy of Sciences 110 51 20372 20379 doi 10 1073 pnas 1319745110 ISSN 0027 8424 PMC 3870759 PMID 24284174 Untitled Document www hhmi ucla edu Archived from the original on 2020 10 21 Retrieved 2022 10 02 De Robertis Edward M Moriyama Yuki 2016 01 01 Wassarman Paul M ed Chapter Thirteen The Chordin Morphogenetic Pathway Current Topics in Developmental Biology Essays on Developmental Biology Part A Academic Press 116 231 245 doi 10 1016 bs ctdb 2015 10 003 PMID 26970622 S2CID 13919776 retrieved 2022 10 02 De Robertis Edward M Moriyama Yuki Colozza Gabriele September 2017 Generation of animal form by the Chordin Tolloid BMP gradient 100 years after D Arcy Thompson Development Growth amp Differentiation 59 7 580 592 doi 10 1111 dgd 12388 PMID 28815565 S2CID 22076923 De Robertis Edward M Moriyama Yuki Colozza Gabriele September 2017 Generation of animal form by the Chordin Tolloid BMP gradient 100 years after D Arcy Thompson Development Growth amp Differentiation 59 7 580 592 doi 10 1111 dgd 12388 PMID 28815565 S2CID 22076923 Albrecht Lauren V Tejeda Munoz Nydia De Robertis Edward M 2021 10 06 Cell Biology of Canonical Wnt Signaling Annual Review of Cell and Developmental Biology 37 1 369 389 doi 10 1146 annurev cellbio 120319 023657 ISSN 1081 0706 PMID 34196570 S2CID 235698046 Archived from the original on 2022 08 02 Retrieved 2022 10 02 Archived copy www hhmi ucla edu Archived from the original on 2017 07 08 Retrieved 2022 10 02 a href Template Cite web html title Template Cite web cite web a CS1 maint archived copy as title link De Robertis Edward M Moriyama Yuki Colozza Gabriele September 2017 Generation of animal form by the Chordin Tolloid BMP gradient 100 years after D Arcy Thompson Development Growth amp Differentiation 59 7 580 592 doi 10 1111 dgd 12388 PMID 28815565 S2CID 22076923 Sorbonne Universite Archived from the original on 2016 09 21 Retrieved 2016 08 15 Carrasco A E McGinnis W Gehring W J De Robertis E M June 1984 Cloning of an X laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes Cell 37 2 409 414 doi 10 1016 0092 8674 84 90371 4 ISSN 0092 8674 PMID 6327066 S2CID 30114443 Archived from the original on 2020 07 21 Retrieved 2022 10 02 Poli Stefano Facchin Domenico Rizzetto Francesca Rebellato Luca Daleffe Elisabetta Toniolo Mauro Miconi Antonella Altinier Alessandro Lanera Corrado Indrigo Stefano Comisso Jennifer Proclemer Alessandro 2019 01 08 Prognostic role of non sustained ventricular tachycardia detected with remote interrogation in a pacemaker population International Journal of Cardiology Heart amp Vasculature 22 92 95 doi 10 1016 j ijcha 2018 12 011 ISSN 2352 9067 PMC 6327066 PMID 30671534 De Robertis E M Sasai Y 1996 03 07 A common plan for dorsoventral patterning in Bilateria Nature 380 6569 37 40 doi 10 1038 380037a0 ISSN 0028 0836 PMID 8598900 S2CID 4355458 Archived from the original on 2022 06 17 Retrieved 2022 10 02 De Robertis Edward M Tejeda Munoz Nydia 2022 07 01 Evo Devo of Urbilateria and its larval forms Developmental Biology 487 10 20 doi 10 1016 j ydbio 2022 04 003 ISSN 0012 1606 PMID 35443190 S2CID 248234939 Blum M Gaunt S J Cho K W Steinbeisser H Blumberg B Bittner D De Robertis E M 1992 06 26 Gastrulation in the mouse the role of the homeobox gene goosecoid Cell 69 7 1097 1106 doi 10 1016 0092 8674 92 90632 m ISSN 0092 8674 PMID 1352187 S2CID 16692357 Archived from the original on 2022 01 21 Retrieved 2022 10 02 Sasai Y Lu B Steinbeisser H Geissert D Gont L K De Robertis E M 1994 12 02 Xenopus chordin a novel dorsalizing factor activated by organizer specific homeobox genes Cell 79 5 779 790 doi 10 1016 0092 8674 94 90068 x ISSN 0092 8674 PMC 3082463 PMID 8001117 Piccolo S Sasai Y Lu B De Robertis E M 1996 08 23 Dorsoventral patterning in Xenopus inhibition of ventral signals by direct binding of chordin to BMP 4 Cell 86 4 589 598 doi 10 1016 s0092 8674 00 80132 4 ISSN 0092 8674 PMC 3070603 PMID 8752213 Piccolo S Agius E Lu B Goodman S Dale L De Robertis E M 1997 10 31 Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity Cell 91 3 407 416 doi 10 1016 s0092 8674 00 80424 9 ISSN 0092 8674 PMC 3070600 PMID 9363949 Lee Hojoon X Ambrosio Andrea L Reversade Bruno De Robertis E M 2006 01 13 Embryonic dorsal ventral signaling secreted frizzled related proteins as inhibitors of tolloid proteinases Cell 124 1 147 159 doi 10 1016 j cell 2005 12 018 ISSN 0092 8674 PMC 2486255 PMID 16413488 External links EditDe Robertis Laboratory Home Page Howard Hughes Medical Institute UCLA Biological Chemistry Interview with Current Biology Pope Appoints Cancer Researcher to Prestigious Scientific Academy Pontifical Academy of Sciences NAS Profile Retrieved from https en wikipedia org w index php title Edward M De Robertis amp oldid 1138971166, wikipedia, wiki, book, books, library,

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