Schuppan was born on 9 August 1954 in Essen, Germany, to Helga Schuppan (née Pahnke) and Senate President Dr. Walther Schuppan. He studied chemistry and medicine at the Ludwig Maximilian University of Munich, and medicine at the Philipp University of Marburg and the Free University of Berlin. In 1982, he received a Ph.D. from the Max Planck Institute of Biochemistry in Martinsried, outside Munich, where he studied the primary structure of basement membranecollagen. In 1986, he received his M.D. from the Free University of Berlin, and three years later, he received his second Ph.D. in medicine summa cum laude after identifying and characterizing undulin/collagen type XIV. He then habilitated in biochemistry (1992) and internal medicine (1996) at the Free University of Berlin. He earned his board certification for internal medicine in 1993 and gastroenterology in 1996.
He is married to Dr. Kristin Gisbert-Schuppan, a psychologist. He has three daughters and a son.
Workedit
From 1997 to 2004, Schuppan worked as a professor, chief medical consultant, and deputy medical director in the Department of Medicine at the Friedrich Alexander University of Erlangen-Nuremberg. From 2004 to 2010, he was a lecturer, first associate, and later full professor of medicine and clinical attending physician/consultant in the Division of Gastroenterology and Hepatology at Beth Israel Deaconess Medical Center, part of Harvard Medical School. In 2011, he became director of the coeliac disease and fibrosis center at the University of Mainz and a senior visiting scientist at Beth Israel Deaconess. Since 2013, he has been the director of the Institute of Translational Immunology at the University of Mainz.
His clinical work and research are focused on the cellular and molecular mechanisms of chronic inflammatory diseases and the translation of these findings into clinical practice. He has helped develop novel diagnostic tools and therapies for inflammatory and fibrotic (scarring) diseases of the liver (cirrhosis), intestine, and other organs, and for coeliac disease, non-coeliac/non-allergy gluten sensitivity, and associated autoimmune and systemic diseases. He has researched the role of the immune system in the defense against cancer, especially of the liver and the gastrointestinal tract, and the role of nutrition in autoimmune and metabolic diseases, especially non-alcoholic fatty liver disease and Type 2 diabetes. His focus is on the development of targeted and individualized therapies—based, for example, on therapeutic nanoparticles[1] as drug carriers in combination with the development of specific disease biomarkers.
Key achievementsedit
Discovered and characterized undulin, or fibril-associated collagen XIV (1990)
Discovered tissue transglutaminase (TG2) as an autoantigen in coeliac disease,[2][3] leading to a paradigm shift in coeliac disease research and the development of a highly reliable diagnostic test (1997)
Identified amylase-trypsin inhibitors from wheat as a cause of non-coeliac/non-allergy wheat sensitivity,[4] leading to a paradigm shift in research on gluten sensitivity (2012)[5]
Developed serum biomarkers of immune-cell inflammatory processes (microparticles), of serum protein biomarkers of liver fibrosis progression, and of antifibrotic agents that, in combination with these biomarkers, may pave the way for the first effective antifibrotic therapies for the liver and other organs.[6][7]
Key publicationsedit
Schuppan has authored more than 70 book chapters and more than 400 PubMed-listed scientific publications.[8]
Schuppan D, et al. (2009). "Celiac Disease: From Pathogenesis to Novel Therapies". Gastroenterology. 137 (6): 1912–1933. doi:10.1053/j.gastro.2009.09.008. PMID 19766641.
Schuppan D.; Zimmer K.-P. (2013). "The Diagnosis and Treatment of Celiac Disease". Dtsch Ärztebl Int. 110 (2): 835–846. doi:10.3238/arztebl.2013.0835. PMC3884535. PMID 24355936.
Schuppan D.; Kim Y.O. (2013). "Evolving therapies for liver fibrosis". J Clin Invest. 123 (5): 1887–1901. doi:10.1172/JCI66028. PMC3635731. PMID 23635787.
He has edited several medical research books and is associate editor of high-ranking scientific journals like Gastroenterology, Journal of Hepatology, American Journal of Physiology and Journal of Clinical Investigation. Since 2011, he has been chair of the Scientific Council of the German Coeliac Society.[9] Schuppan is the only German physician and scientist who has been a full professor of medicine both in the United States and in Germany.
Awards and membershipsedit
Awards (selection)edit
1990: Lucie Bolte Promotion Award for Research in Liver Diseases
1994: Hermann and Lilly Schilling Professorship, Dept. of Gastroenterology, Benjamin Franklin Hospital, Free University of Berlin
2004: Zetzel Visiting Professor, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School
2010: Gutenberg-Forschungskolleg, University of Mainz
2011: ERC Advanced Grant in Fibroimaging (quantitative imaging of liver fibrosis and fibrogenesis)[10]
2015: Maki Celiac Disease Tampere Prize, University of Tampere
Memberships (selection)edit
German Association for the Study of the Liver (GASL)
^University of Mainz: Nanodimensional polymer therapeutics for tumor therapy. Retrieved 05 August 2014
^W. Dieterich; E. Laag; H. Schöpper; U. Volta; A. Ferguson; H. Gillett; E.O. Riecken; D. Schuppan (Dec 1998). "Autoantibodies to tissue transglutaminase as predictors of celiac disease". Gastroenterology. 115 (6): 1317–1321. doi:10.1016/S0016-5085(98)70007-1. PMID 9834256.
^W. Dieterich; T. Ehnis; M. Bauer; P. Donner; U. Volta; E.O. Riecken; D. Schuppan (Jul 1997). "Identification of tissue transglutaminase as the autoantigen of celiac disease". Nat Med. 3 (7): 797–801. doi:10.1038/nm0797-797. PMID 9212111. S2CID 20033968.
^Y. Junker; S. Zeissig; S.J. Kim; D. Barisani; H. Wieser; D.A. Leffler; V. Zevallos; T.A. Libermann; S. Dillon; T.L. Freitag; C.P. Kelly; D. Schuppan (Dec 2012). "Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4". The Journal of Experimental Medicine. 209 (13): 2395–2408. doi:10.1084/jem.20102660. PMC3526354. PMID 23209313.
^ARD Mittagsmagazin: Beitrag: Protein "ATI" in Weizen macht krank. on YouTube (in German) Retrieved 11 July 2014
^M. Kornek; Y. Popov; T.A. Libermann; N.H. Afdhal; D. Schuppan (Jan 2011). "Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells". Hepatology. 53 (1): 230–242. doi:10.1002/hep.23999. PMC3505073. PMID 20979056.
^M. Kornek; M. Lynch; S.H. Mehta; M. Lai; M. Exley; N.H. Afdhal; D. Schuppan (Aug 2012). "Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis". Gastroenterology. 143 (2): 448–458. doi:10.1053/j.gastro.2012.04.031. PMC3404266. PMID 22537612.
^PubMed: Scientific publications Schuppan. Retrieved 11 July 2014
^German Celiac Society: Members of the Scientific Council. 2014-07-24 at the Wayback Machine (in German). Retrieved 05 August 2014
^University of Mainz: ERC Advanced Grant Fibroimaging Retrieved 07 August 2014
^FZI: The involved scientists. Retrieved 07 August 2014
February 16, 2024
detlef, schuppan, this, article, multiple, issues, please, help, improve, discuss, these, issues, talk, page, learn, when, remove, these, template, messages, major, contributor, this, article, appears, have, close, connection, with, subject, require, cleanup, . This article has multiple issues Please help improve it or discuss these issues on the talk page Learn how and when to remove these template messages A major contributor to this article appears to have a close connection with its subject It may require cleanup to comply with Wikipedia s content policies particularly neutral point of view Please discuss further on the talk page June 2017 Learn how and when to remove this template message This article may require cleanup to meet Wikipedia s quality standards The specific problem is style Please help improve this article if you can June 2017 Learn how and when to remove this template message This article may rely excessively on sources too closely associated with the subject potentially preventing the article from being verifiable and neutral Please help improve it by replacing them with more appropriate citations to reliable independent third party sources June 2017 Learn how and when to remove this template message Learn how and when to remove this template message Detlef Schuppan born 9 August 1954 in Essen West Germany is a German biochemist and physician He focuses on the diagnosis and treatment of coeliac disease and wheat sensitivity fibrotic liver diseases and the immunology of chronic diseases and cancer He is the director of the Institute of Translational Immunology and a professor of internal medicine gastroenterology and hepatology at the Medical Center of the Johannes Gutenberg University of Mainz in Germany He directs the outpatient clinic for coeliac disease and small intestinal diseases He is also a professor of medicine and a senior visiting scientist at Harvard Medical School Contents 1 Early life and education 2 Work 2 1 Key achievements 2 2 Key publications 3 Awards and memberships 3 1 Awards selection 3 2 Memberships selection 4 External links 4 1 Original research contributions and cooperations 4 2 Other websites 5 ReferencesEarly life and education editSchuppan was born on 9 August 1954 in Essen Germany to Helga Schuppan nee Pahnke and Senate President Dr Walther Schuppan He studied chemistry and medicine at the Ludwig Maximilian University of Munich and medicine at the Philipp University of Marburg and the Free University of Berlin In 1982 he received a Ph D from the Max Planck Institute of Biochemistry in Martinsried outside Munich where he studied the primary structure of basement membrane collagen In 1986 he received his M D from the Free University of Berlin and three years later he received his second Ph D in medicine summa cum laude after identifying and characterizing undulin collagen type XIV He then habilitated in biochemistry 1992 and internal medicine 1996 at the Free University of Berlin He earned his board certification for internal medicine in 1993 and gastroenterology in 1996 He is married to Dr Kristin Gisbert Schuppan a psychologist He has three daughters and a son Work editFrom 1997 to 2004 Schuppan worked as a professor chief medical consultant and deputy medical director in the Department of Medicine at the Friedrich Alexander University of Erlangen Nuremberg From 2004 to 2010 he was a lecturer first associate and later full professor of medicine and clinical attending physician consultant in the Division of Gastroenterology and Hepatology at Beth Israel Deaconess Medical Center part of Harvard Medical School In 2011 he became director of the coeliac disease and fibrosis center at the University of Mainz and a senior visiting scientist at Beth Israel Deaconess Since 2013 he has been the director of the Institute of Translational Immunology at the University of Mainz Schuppan has had visiting professorships at Columbia University Yale University Duke University the University of Maryland the Mayo Clinic the Weizmann Institute of Science and the University of California at Los Angeles and San Diego His clinical work and research are focused on the cellular and molecular mechanisms of chronic inflammatory diseases and the translation of these findings into clinical practice He has helped develop novel diagnostic tools and therapies for inflammatory and fibrotic scarring diseases of the liver cirrhosis intestine and other organs and for coeliac disease non coeliac non allergy gluten sensitivity and associated autoimmune and systemic diseases He has researched the role of the immune system in the defense against cancer especially of the liver and the gastrointestinal tract and the role of nutrition in autoimmune and metabolic diseases especially non alcoholic fatty liver disease and Type 2 diabetes His focus is on the development of targeted and individualized therapies based for example on therapeutic nanoparticles 1 as drug carriers in combination with the development of specific disease biomarkers Key achievements edit Discovered and characterized undulin or fibril associated collagen XIV 1990 Discovered tissue transglutaminase TG2 as an autoantigen in coeliac disease 2 3 leading to a paradigm shift in coeliac disease research and the development of a highly reliable diagnostic test 1997 Identified amylase trypsin inhibitors from wheat as a cause of non coeliac non allergy wheat sensitivity 4 leading to a paradigm shift in research on gluten sensitivity 2012 5 Developed serum biomarkers of immune cell inflammatory processes microparticles of serum protein biomarkers of liver fibrosis progression and of antifibrotic agents that in combination with these biomarkers may pave the way for the first effective antifibrotic therapies for the liver and other organs 6 7 Key publications edit Schuppan has authored more than 70 book chapters and more than 400 PubMed listed scientific publications 8 Schuppan D et al 2009 Celiac Disease From Pathogenesis to Novel Therapies Gastroenterology 137 6 1912 1933 doi 10 1053 j gastro 2009 09 008 PMID 19766641 Schuppan D Zimmer K P 2013 The Diagnosis and Treatment of Celiac Disease Dtsch Arztebl Int 110 2 835 846 doi 10 3238 arztebl 2013 0835 PMC 3884535 PMID 24355936 Schuppan D Afdhal N H 2008 Liver Cirrhosis The Lancet 371 9615 838 851 doi 10 1016 S0140 6736 08 60383 9 PMC 2271178 PMID 18328931 Schuppan D Kim Y O 2013 Evolving therapies for liver fibrosis J Clin Invest 123 5 1887 1901 doi 10 1172 JCI66028 PMC 3635731 PMID 23635787 He has edited several medical research books and is associate editor of high ranking scientific journals like Gastroenterology Journal of Hepatology American Journal of Physiology and Journal of Clinical Investigation Since 2011 he has been chair of the Scientific Council of the German Coeliac Society 9 Schuppan is the only German physician and scientist who has been a full professor of medicine both in the United States and in Germany Awards and memberships editAwards selection edit 1990 Lucie Bolte Promotion Award for Research in Liver Diseases 1994 Hermann and Lilly Schilling Professorship Dept of Gastroenterology Benjamin Franklin Hospital Free University of Berlin 2004 Zetzel Visiting Professor Division of Gastroenterology Beth Israel Deaconess Medical Center Harvard Medical School 2010 Gutenberg Forschungskolleg University of Mainz 2011 ERC Advanced Grant in Fibroimaging quantitative imaging of liver fibrosis and fibrogenesis 10 2015 Maki Celiac Disease Tampere Prize University of TampereMemberships selection edit German Association for the Study of the Liver GASL European Association for the Study of the Liver EASL American Association for the Study of Liver Diseases AASLD German Society for Digestive and Metabolic Diseases DGVS United European Gastroenterology Foundation UEGF American Gastroenterological Association AGA American Physiological Society APA Research Center for Immune Therapy University Medical Center Mainz FZI 11 External links editOriginal research contributions and cooperations edit https web archive org web 20140725195111 http www biomedexperts com Profile bme 1644943 Detlef SchuppanOther websites edit Curriculum vitae http www fzi uni mainz de Dateien ENCV Prof Schuppan pdfCoeliac disease wheat sensitivity http www apotheken umschau de Zoeliakie in German https web archive org web 20140717050102 http zedira com medicine celiacdisease de in German http zedira com data newsletter Zoeliakie 20Medikament 20aus 20Aktuell 203 2012 pdf in German References edit University of Mainz Nanodimensional polymer therapeutics for tumor therapy Retrieved 05 August 2014 W Dieterich E Laag H Schopper U Volta A Ferguson H Gillett E O Riecken D Schuppan Dec 1998 Autoantibodies to tissue transglutaminase as predictors of celiac disease Gastroenterology 115 6 1317 1321 doi 10 1016 S0016 5085 98 70007 1 PMID 9834256 W Dieterich T Ehnis M Bauer P Donner U Volta E O Riecken D Schuppan Jul 1997 Identification of tissue transglutaminase as the autoantigen of celiac disease Nat Med 3 7 797 801 doi 10 1038 nm0797 797 PMID 9212111 S2CID 20033968 Y Junker S Zeissig S J Kim D Barisani H Wieser D A Leffler V Zevallos T A Libermann S Dillon T L Freitag C P Kelly D Schuppan Dec 2012 Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll like receptor 4 The Journal of Experimental Medicine 209 13 2395 2408 doi 10 1084 jem 20102660 PMC 3526354 PMID 23209313 ARD Mittagsmagazin Beitrag Protein ATI in Weizen macht krank on YouTube in German Retrieved 11 July 2014 M Kornek Y Popov T A Libermann N H Afdhal D Schuppan Jan 2011 Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells Hepatology 53 1 230 242 doi 10 1002 hep 23999 PMC 3505073 PMID 20979056 M Kornek M Lynch S H Mehta M Lai M Exley N H Afdhal D Schuppan Aug 2012 Circulating microparticles as disease specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis Gastroenterology 143 2 448 458 doi 10 1053 j gastro 2012 04 031 PMC 3404266 PMID 22537612 PubMed Scientific publications Schuppan Retrieved 11 July 2014 German Celiac Society Members of the Scientific Council Archived 2014 07 24 at the Wayback Machine in German Retrieved 05 August 2014 University of Mainz ERC Advanced Grant Fibroimaging Retrieved 07 August 2014 FZI The involved scientists Retrieved 07 August 2014 Retrieved from https en wikipedia org w index php title Detlef Schuppan amp oldid 1136089604, wikipedia, wiki, book, books, library,
