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Denny (hybrid hominin)

January 01, 1970

Denny (Denisova 11) is an ~90,000 year old fossil specimen belonging to a ~13-year-old Neanderthal-Denisovan hybrid girl.[1][2] To date, she is the only first-generation hybrid hominin ever discovered.[3] Denny’s remains consist of a single fossilized fragment of a long bone discovered among over 2,000 visually unidentifiable fragments excavated at the Denisova Cave in the Altai Mountains, Russia in 2012.[2]

Denny (Denisova 11)
Catalog no.DC1227; GenBank Accession = KU131206
Common nameDenny (Denisova 11)
Species1st generation Neanderthal/Denisovan hybrid
Age90,000 years
Place discoveredDenisova Cave in the Altai Mountains, Siberia, Russia
Date discovered2012
Discovered byViviane Slon, Svante Pääbo, Samantha Brown, Tom Higham, Michael Buckley, Katerina Douka et al.
Denisova 11, genetic tree of ancestors

A team of researchers at Oxford University led by Tom Higham used a method of collagen peptide mass fingerprinting, called Zooarchaeology by Mass Spectrometry (ZooMS), and mitochondrial DNA (mtDNA) analysis to identify the fragment as belonging to an archaic human with Neanderthal ancestry.[4]

Genomic sequencing and analysis led by paleo-geneticists Viviane Slon and Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology revealed that Denny was the offspring of a Neanderthal mother and a Denisovan father.[1][3] Additionally, her genome suggests that her father also carried a small degree of Neanderthal ancestry from 300 to 600 generations prior to his lifetime.[3]

These surprising genomic data has caused some paleontologists to speculate that interspecies mating between Denisovans and Neanderthals could have occurred with some frequency during several periods of contact over many thousands of years.[3] Additionally, these findings lend support to the hypothesis that similar patterns of admixture, or interbreeding between archaic and modern humans, may have resulted in the partial absorption of Denisovans and Neanderthals into modern human populations.[3]

Overview edit

Dating analyses in 2016 determined that Denny (Denisova 11) died about 90,000 years ago, and the bone's cortical thickness indicates an age at death of at least 13 years.[3] An analysis of the whole genome sequence (total mitochondrial and nuclear DNA) indicates she was female, with a Neanderthal mother and a Denisovan father.[1][2][3] While previous analyses of other ancient genomes concluded that Denisovans, Neanderthals, and modern humans interbred during the ice age in Europe and Asia, this find is the most direct evidence yet that various ancient hominins mated with each other and had offspring.[2][5][6]

Previous analyses from other fossils found in this Siberian cave have shown that modern humans, Neanderthals, and Denisovans inhabited this site at various times, and that all three human species interbred with each other.[2][6] The genes of both archaic human species are present in many people today, which suggests that when these groups met, gene flow occurred.[2][5] It is not evident if the mating was consensual or if Denny was fertile.[1] The discovery of Denisova 11 may support the notion that Neanderthals and Denisovans may not have undergone direct extinction but were partly assimilated into modern human populations.[4][6]

Discovery edit

 
 
Denisova Cave
class=notpageimage|
Location of Denisova Cave in the Altai Mountains of Siberia
 
Denisova Cave in the Altai Mountains

The finding consists of a single bone fragment about 2 cm long that was unearthed in 2012 by Russian archeologists at the Denisova Cave from layer 12 of the East Gallery.[7] The cave is located in Denisova valley, Altai Mountains in Siberia, Russia.[2][6] At the time, the origin of the bone fragment remained unknown because it was archived along with thousands of other nondescript bone fragments from the cave.[4]

In 2015, Tom Higham and Katerina Douka, as part of Higham's "PalaeoChron 18 August 2014 at the Wayback Machine" ERC project, decided to try and apply new scientific methods to see whether they could be used to find human remains amongst the thousands of unidentified bone samples in the site. With the collaboration of the head excavators of the Denisova site; Michael Shunkov and Anatoly Derevianko, they took several bags containing thousands of unidentified bone fragments back to the University of Oxford. Samantha Brown, an MSc student at the University of Oxford, worked on the project as part of her dissertation research, screening more than 2000 bone fragments.[4] Using Zooarchaeology by Mass Spectrometry (ZooMS) and working with the laboratory of Michael Buckley at the University of Manchester, they were able to compare the collagen protein fingerprints derived from the Denisova Cave bones to animals and humans of known origin, and they discovered that one of these bones (DC1227) belonged to an archaic human.[4][8][9] A micro-computed tomography (Micro CT) scan of the bone done by Fiona Brock at Cranfield University helped to reveal that the specimen had acid etching and pitting on its surface indicating it may have passed through the digestion system of an animal, likely a hyena.[4] Direct radiocarbon dating estimated the specimen to be more than 50,000 years old, and the sequencing of its mitochondrial DNA (mtDNA) at the Max Planck Institute for Evolutionary Anthropology, showed that Denisova 11 had a sequence consistent with a Neanderthal origin.[4]

Further work by scientists at the Max Planck Institute for Evolutionary Anthropology, where previous samples of Denisovan DNA had been sequenced and analyzed uncovered further key evidence relating the specimen[8] Viviane Slon, Svante Pääbo, and others, uncovered Denny's mixed ancestry by confirming that her mitochondrial DNA, inherited from her mother, came from Neanderthal ancestry and finding that the portion of her nuclear DNA inherited from her father was Denisovan. The publication of their results in 2018 provided the first direct evidence of archaic human interbreeding.[8] It has been called a "landmark find" that is reshaping our understanding of how hominins interacted and could help rewrite the story of archaic and modern humans.[10] According to population geneticist Pontus Skoglund from Harvard Medical School, currently at the Francis Crick Institute in London, "To find a first-generation person of mixed ancestry from [Neanderthal and Denisovan groups] is absolutely extraordinary. ... It’s really great science coupled with a little bit of luck. It’s a really clear-cut case. I think it’s going to go into the textbooks right away.”[1]

The story is told in Tom Higham's book "The World Before Us: How science is revealing a new story of our human origins"[11]

DNA analysis edit

The bone fragment, identified by the code DC1227 (GenBank Accession = KU131206) or as Denisova 11, may have originated from a human arm or leg.[8] Prior to the extraction of material for genetic analysis, DC1227 weighed 1.68 g (0.059 oz), and had maximum dimensions of 24.7 mm (0.97 in) by 8.39 mm (0.330 in).[4] In 2016, a team from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, led by paleogeneticists Viviane Slon and Svante Pääbo, extracted six DNA samples and produced ten libraries of complete genome sequences to an average coverage of 2.6-fold.[3] Isolated mitochondrial DNA and nuclear DNA indicated the archaic human was of nearly equal proportion Neanderthal and Denisovan.[3] A comparison of the specimen's X chromosomes and autosomes showed it belonged to a female.[2][3] The estimated heterozygosity of Denisova 11, found to be comparable to present day Africans suggests that the girl was a first-generation Neanderthal-Denisovan hybrid.[3]

Subsequent analyses showed a high likelihood that her Denisovan father also had some Neanderthal ancestry introduced into his genome hundreds of generations before his lifetime.[2][3] Denisova 11's genome thus constitutes the first direct evidence for at least two instances of interbreeding between Neanderthals and Denisovans.[3][12] Even more surprising, the researchers determined that the girl's mother's genome was more closely related to Western European Neanderthal DNA, excavated thousands of miles away at the Vindija Cave, Croatia, than the Neanderthals who lived in the Siberian cave where her daughter's remains were found.[2][3][8] This finding suggests that Neanderthals migrated in multiple waves from Western Europe to Central Eurasia and encountered the Denisovans several times over a span of tens of thousands of years, and possibly coexisted with them for periods of time.[2][8][10]

Context and implications edit

Further information: Interbreeding between archaic and modern humans

Since the discovery of Neanderthal remains in the 19th century, many scientists have supported the hypothesis of interbreeding between archaic and modern humans, also known as hybridization, admixture, or hybrid-origin theory.[13] The linear view of human evolution came under scrutiny in the 1970s as different species of humans were discovered that made the simplistic concept increasingly unlikely. With the advent of advanced molecular biotechnology, whole-genome sequencing of Neanderthal and human genomes were performed that confirmed recent admixture between various human species.[14] In 2010, evidence was published revealing unambiguous examples of interbreeding between archaic and modern humans during the Middle Paleolithic and early Upper Paleolithic.[citation needed] Research demonstrates that interbreeding occurred in several independent events that included Neanderthals, Denisovans, as well as several unidentified hominins.[citation needed] Modern day Eurasian genomes contain approximately 2% Neanderthal DNA, with traces of Denisovan heritage, while modern Melanesian people have an average of 4–6% Denisovan DNA.[8] Denny represents the first ancient individual discovered whose parents belonged to two discrete species of humans, which will provide a unique opportunity for future comparative genetic studies.[1][2]

The discovery of Denny and other paleogenetic data acquired since 2010 show that human evolution should not be conceptualized as a simple linear or branched progression, but rather, as a complex interaction between related species over various periods of geographical isolation and convergence.[15][16][17][18] Ackermann, Mackay, and Arnold confirm, "Recent genomic research has shown that hybridization between substantially diverged lineages is the rule, not the exception, in human evolution."[19] Acknowledging that there is still debate over how hybridization shaped human genotypes and phenotypes, the evolutionary biologists assert that hybridization was an essential creative force in the emergence of modern humans.[19]

In January 2019, scientists published a chronology for the Pleistocene deposits in the Denisova Cave concluding that at least two groups of humans, including Denisovans, Neanderthals, and related hybrids, occupied the Siberian site from around 300,000 to 20,000 years ago, but more material evidence is needed to prove whether they ever coexisted there.[20][21] Material data collected at the site, including stone tools, bracelets, and other ornaments suggest that Denisovans may have been capable of higher order thought akin to modern humans.[21]

In February 2019, scientists discovered evidence, based on genetics studies using artificial intelligence (AI), that suggest the existence of an unknown human ancestor species, not Neanderthal, Denisovan or human hybrid (like Denny), in the genome of modern humans.[22][23]

See also edit

References edit

  1. ^ a b c d e f Warren, Matthew (22 August 2018). "Mum's a Neanderthal, Dad's a Denisovan: First discovery of an ancient-human hybrid". Nature. 560 (7719): 417–418. Bibcode:2018Natur.560..417W. doi:10.1038/d41586-018-06004-0. PMID 30135540.
  2. ^ a b c d e f g h i j k l Vogel, Gretchen (22 August 2018). "This ancient bone belonged to a child of two extinct human species". Science. doi:10.1126/science.aav1858. S2CID 188160693. Retrieved 22 August 2018.
  3. ^ a b c d e f g h i j k l m n Slon, Viviane; Mafessoni, Fabrizio; Vernot, Benjamin; de Filippo, Cesare; Grote, Steffi; Viola, Bence; Hajdinjak, Mateja; Peyrégne, Stéphane; Nagel, Sarah; Brown, Samantha; Douka, Katerina (6 September 2018). "The genome of the offspring of a Neanderthal mother and a Denisovan father". Nature. 561 (7721): 113–116. Bibcode:2018Natur.561..113S. doi:10.1038/s41586-018-0455-x. ISSN 1476-4687. PMC 6130845. PMID 30135579.
  4. ^ a b c d e f g h Brown, Samantha; Higham, Thomas; Slon, Viviane; Pääbo, Svante; Meyer, Matthias; Douka, Katerina; Brock, Fiona; Comeskey, Daniel; Procopio, Noemi; Shunkov, Michael; Derevianko, Anatoly (29 March 2016). "Identification of a new hominin bone from Denisova Cave, Siberia using collagen fingerprinting and mitochondrial DNA analysis". Scientific Reports. 6 (1): 23559. Bibcode:2016NatSR...623559B. doi:10.1038/srep23559. ISSN 2045-2322. PMC 4810434. PMID 27020421.
  5. ^ a b Zimmer, Carl (22 August 2018). "A Blended Family: Her Mother Was Neanderthal, Her Father Something Else Entirely". The New York Times. Retrieved 22 August 2018.
  6. ^ a b c d Marshall, Michael (22 August 2018). "Prehistoric girl had parents belonging to different human species". New Scientist. Retrieved 22 August 2018.
  7. ^ Hood, Marlowe (22 August 2018). "Neandertal mother, Denisovan father—Newly-sequenced genome sheds light on interactions between ancient hominins". Phys.org. Retrieved 22 August 2018.
  8. ^ a b c d e f g Wei-Haas, Maya (22 August 2018). . National Geographic. Archived from the original on 22 August 2018. Retrieved 22 August 2018.
  9. ^ "Novel collagen fingerprinting identifies a Neanderthal bone among 2,000 fragments". University of Oxford. 29 March 2016. Retrieved 1 April 2016.
  10. ^ a b Zhang, Sarah (22 August 2018). "Scientists Stunned By a Neanderthal Hybrid Discovered in a Siberian Cave". The Atlantic. Retrieved 22 August 2018.
  11. ^ Higham, Tom (2021). The World Before Us: How science is revealing a new story of our human origins. Penguin/RandomHouse. ISBN 978-0241440674.
  12. ^ Scharping, Nathaniel (22 August 2018). "Hybrid Hominin: This Girl's Mother and Father Came From Two Different Species". Discover. Retrieved 22 August 2018.
  13. ^ Huxley, T. (1890). "The Aryan Question and Pre-Historic Man". Collected Essays: Volume VII, Man's Place in Nature.
  14. ^ Green, R.E.; Krause, J.; Briggs, A.W.; Maricic, T.; Stenzel, U.; Kircher, M.; et al. (2010). "A Draft Sequence of the Neandertal Genome". Science. 328 (5979): 710–22. Bibcode:2010Sci...328..710G. doi:10.1126/science.1188021. PMC 5100745. PMID 20448178.
  15. ^ Reich, D.; Green, R.E.; Kircher, M.; et al. (2010). "Genetic history of an archaic hominin group from Denisova Cave in Siberia" (PDF). Nature. 468 (7327): 1053–60. Bibcode:2010Natur.468.1053R. doi:10.1038/nature09710. hdl:10230/25596. PMC 4306417. PMID 21179161.
  16. ^ Antrosio, Jason (2011). "Denisovans & Neandertals". Living Anthropologically.
  17. ^ Hammer, Michael F. (May 2013). (PDF). Scientific American. 308 (5): 66–71. Bibcode:2013SciAm.308e..66H. doi:10.1038/scientificamerican0513-66. PMID 23627222. Archived from the original (PDF) on 24 August 2018 – via grochbiology.org.
  18. ^ Yong, Ed (2011). "Mosaic humans, the hybrid species". New Scientist. 211 (2823): 34–38. Bibcode:2011NewSc.211...34Y. doi:10.1016/S0262-4079(11)61839-3.
  19. ^ a b Rogers Ackermann, Rebecca; Mackay, Alex; Arnold, Michael L. (2016). "The Hybrid Origin of 'Modern' Humans". Evolutionary Biology. 43: 1–11. doi:10.1007/s11692-015-9348-1. S2CID 14329491.
  20. ^ Jacobs, Zenobia; Li, Bo; Shunkov, Michael V.; Kozlikin, Maxim B.; Bolikhovskaya, Nataliya S.; Agadjanian, Alexander K.; Uliyanov, Vladimir A.; Vasiliev, Sergei K.; O’Gorman, Kieran; Derevianko, Anatoly P.; Roberts, Richard G. (2019). "Timing of archaic hominin occupation of Denisova Cave in southern Siberia". Nature. 565 (7741): 594–599. Bibcode:2019Natur.565..594J. doi:10.1038/s41586-018-0843-2. ISSN 1476-4687. PMID 30700870. S2CID 59525956.
  21. ^ a b Zimmer, Carl (30 January 2019). "High Ceilings and a Lovely View: Denisova Cave Was Home to a Lost Branch of Humanity". The New York Times. Retrieved 31 January 2019.
  22. ^ Mondal, Mayukh; Bertranpedt, Jaume; Leo, Oscar (16 January 2019). "Approximate Bayesian computation with deep learning supports a third archaic introgression in Asia and Oceania". Nature Communications. 10 (246): 246. Bibcode:2019NatCo..10..246M. doi:10.1038/s41467-018-08089-7. PMC 6335398. PMID 30651539.
  23. ^ Dockrill, Peter (11 February 2019). "Artificial Intelligence Has Found an Unknown 'Ghost' Ancestor in The Human Genome". ScienceAlert.com. Retrieved 11 February 2019.

Further reading edit

  • Viviane Slon; Fabrizio Mafessoni; Benjamin Vernot; et al. (22 August 2018). "The genome of the offspring of a Neanderthal mother and a Denisovan father". Nature. 561 (7721): 1. doi:10.1038/S41586-018-0455-X. ISSN 1476-4687. PMC 6130845. PMID 30135579. Wikidata Q56234568.
  • Tom Higham (2021) The World Before Us: How science is revealing a new story of our human origins. Penguin, London.

External links edit

January 01, 1970
denny, hybrid, hominin, denny, denisova, year, fossil, specimen, belonging, year, neanderthal, denisovan, hybrid, girl, date, only, first, generation, hybrid, hominin, ever, discovered, denny, remains, consist, single, fossilized, fragment, long, bone, discove. Denny Denisova 11 is an 90 000 year old fossil specimen belonging to a 13 year old Neanderthal Denisovan hybrid girl 1 2 To date she is the only first generation hybrid hominin ever discovered 3 Denny s remains consist of a single fossilized fragment of a long bone discovered among over 2 000 visually unidentifiable fragments excavated at the Denisova Cave in the Altai Mountains Russia in 2012 2 Denny Denisova 11 Catalog no DC1227 GenBank Accession KU131206Common nameDenny Denisova 11 Species1st generation Neanderthal Denisovan hybridAge90 000 yearsPlace discoveredDenisova Cave in the Altai Mountains Siberia RussiaDate discovered2012Discovered byViviane Slon Svante Paabo Samantha Brown Tom Higham Michael Buckley Katerina Douka et al Denisova 11 genetic tree of ancestors A team of researchers at Oxford University led by Tom Higham used a method of collagen peptide mass fingerprinting called Zooarchaeology by Mass Spectrometry ZooMS and mitochondrial DNA mtDNA analysis to identify the fragment as belonging to an archaic human with Neanderthal ancestry 4 Genomic sequencing and analysis led by paleo geneticists Viviane Slon and Svante Paabo of the Max Planck Institute for Evolutionary Anthropology revealed that Denny was the offspring of a Neanderthal mother and a Denisovan father 1 3 Additionally her genome suggests that her father also carried a small degree of Neanderthal ancestry from 300 to 600 generations prior to his lifetime 3 These surprising genomic data has caused some paleontologists to speculate that interspecies mating between Denisovans and Neanderthals could have occurred with some frequency during several periods of contact over many thousands of years 3 Additionally these findings lend support to the hypothesis that similar patterns of admixture or interbreeding between archaic and modern humans may have resulted in the partial absorption of Denisovans and Neanderthals into modern human populations 3 Contents 1 Overview 2 Discovery 3 DNA analysis 4 Context and implications 5 See also 6 References 6 1 Further reading 7 External linksOverview editDating analyses in 2016 determined that Denny Denisova 11 died about 90 000 years ago and the bone s cortical thickness indicates an age at death of at least 13 years 3 An analysis of the whole genome sequence total mitochondrial and nuclear DNA indicates she was female with a Neanderthal mother and a Denisovan father 1 2 3 While previous analyses of other ancient genomes concluded that Denisovans Neanderthals and modern humans interbred during the ice age in Europe and Asia this find is the most direct evidence yet that various ancient hominins mated with each other and had offspring 2 5 6 Previous analyses from other fossils found in this Siberian cave have shown that modern humans Neanderthals and Denisovans inhabited this site at various times and that all three human species interbred with each other 2 6 The genes of both archaic human species are present in many people today which suggests that when these groups met gene flow occurred 2 5 It is not evident if the mating was consensual or if Denny was fertile 1 The discovery of Denisova 11 may support the notion that Neanderthals and Denisovans may not have undergone direct extinction but were partly assimilated into modern human populations 4 6 Discovery edit nbsp nbsp Denisova Caveclass notpageimage Location of Denisova Cave in the Altai Mountains of Siberia nbsp Denisova Cave in the Altai Mountains The finding consists of a single bone fragment about 2 cm long that was unearthed in 2012 by Russian archeologists at the Denisova Cave from layer 12 of the East Gallery 7 The cave is located in Denisova valley Altai Mountains in Siberia Russia 2 6 At the time the origin of the bone fragment remained unknown because it was archived along with thousands of other nondescript bone fragments from the cave 4 In 2015 Tom Higham and Katerina Douka as part of Higham s PalaeoChron Archived 18 August 2014 at the Wayback Machine ERC project decided to try and apply new scientific methods to see whether they could be used to find human remains amongst the thousands of unidentified bone samples in the site With the collaboration of the head excavators of the Denisova site Michael Shunkov and Anatoly Derevianko they took several bags containing thousands of unidentified bone fragments back to the University of Oxford Samantha Brown an MSc student at the University of Oxford worked on the project as part of her dissertation research screening more than 2000 bone fragments 4 Using Zooarchaeology by Mass Spectrometry ZooMS and working with the laboratory of Michael Buckley at the University of Manchester they were able to compare the collagen protein fingerprints derived from the Denisova Cave bones to animals and humans of known origin and they discovered that one of these bones DC1227 belonged to an archaic human 4 8 9 A micro computed tomography Micro CT scan of the bone done by Fiona Brock at Cranfield University helped to reveal that the specimen had acid etching and pitting on its surface indicating it may have passed through the digestion system of an animal likely a hyena 4 Direct radiocarbon dating estimated the specimen to be more than 50 000 years old and the sequencing of its mitochondrial DNA mtDNA at the Max Planck Institute for Evolutionary Anthropology showed that Denisova 11 had a sequence consistent with a Neanderthal origin 4 Further work by scientists at the Max Planck Institute for Evolutionary Anthropology where previous samples of Denisovan DNA had been sequenced and analyzed uncovered further key evidence relating the specimen 8 Viviane Slon Svante Paabo and others uncovered Denny s mixed ancestry by confirming that her mitochondrial DNA inherited from her mother came from Neanderthal ancestry and finding that the portion of her nuclear DNA inherited from her father was Denisovan The publication of their results in 2018 provided the first direct evidence of archaic human interbreeding 8 It has been called a landmark find that is reshaping our understanding of how hominins interacted and could help rewrite the story of archaic and modern humans 10 According to population geneticist Pontus Skoglund from Harvard Medical School currently at the Francis Crick Institute in London To find a first generation person of mixed ancestry from Neanderthal and Denisovan groups is absolutely extraordinary It s really great science coupled with a little bit of luck It s a really clear cut case I think it s going to go into the textbooks right away 1 The story is told in Tom Higham s book The World Before Us How science is revealing a new story of our human origins 11 DNA analysis editThe bone fragment identified by the code DC1227 GenBank Accession KU131206 or as Denisova 11 may have originated from a human arm or leg 8 Prior to the extraction of material for genetic analysis DC1227 weighed 1 68 g 0 059 oz and had maximum dimensions of 24 7 mm 0 97 in by 8 39 mm 0 330 in 4 In 2016 a team from the Max Planck Institute for Evolutionary Anthropology in Leipzig Germany led by paleogeneticists Viviane Slon and Svante Paabo extracted six DNA samples and produced ten libraries of complete genome sequences to an average coverage of 2 6 fold 3 Isolated mitochondrial DNA and nuclear DNA indicated the archaic human was of nearly equal proportion Neanderthal and Denisovan 3 A comparison of the specimen s X chromosomes and autosomes showed it belonged to a female 2 3 The estimated heterozygosity of Denisova 11 found to be comparable to present day Africans suggests that the girl was a first generation Neanderthal Denisovan hybrid 3 Subsequent analyses showed a high likelihood that her Denisovan father also had some Neanderthal ancestry introduced into his genome hundreds of generations before his lifetime 2 3 Denisova 11 s genome thus constitutes the first direct evidence for at least two instances of interbreeding between Neanderthals and Denisovans 3 12 Even more surprising the researchers determined that the girl s mother s genome was more closely related to Western European Neanderthal DNA excavated thousands of miles away at the Vindija Cave Croatia than the Neanderthals who lived in the Siberian cave where her daughter s remains were found 2 3 8 This finding suggests that Neanderthals migrated in multiple waves from Western Europe to Central Eurasia and encountered the Denisovans several times over a span of tens of thousands of years and possibly coexisted with them for periods of time 2 8 10 Context and implications editFurther information Interbreeding between archaic and modern humans Since the discovery of Neanderthal remains in the 19th century many scientists have supported the hypothesis of interbreeding between archaic and modern humans also known as hybridization admixture or hybrid origin theory 13 The linear view of human evolution came under scrutiny in the 1970s as different species of humans were discovered that made the simplistic concept increasingly unlikely With the advent of advanced molecular biotechnology whole genome sequencing of Neanderthal and human genomes were performed that confirmed recent admixture between various human species 14 In 2010 evidence was published revealing unambiguous examples of interbreeding between archaic and modern humans during the Middle Paleolithic and early Upper Paleolithic citation needed Research demonstrates that interbreeding occurred in several independent events that included Neanderthals Denisovans as well as several unidentified hominins citation needed Modern day Eurasian genomes contain approximately 2 Neanderthal DNA with traces of Denisovan heritage while modern Melanesian people have an average of 4 6 Denisovan DNA 8 Denny represents the first ancient individual discovered whose parents belonged to two discrete species of humans which will provide a unique opportunity for future comparative genetic studies 1 2 The discovery of Denny and other paleogenetic data acquired since 2010 show that human evolution should not be conceptualized as a simple linear or branched progression but rather as a complex interaction between related species over various periods of geographical isolation and convergence 15 16 17 18 Ackermann Mackay and Arnold confirm Recent genomic research has shown that hybridization between substantially diverged lineages is the rule not the exception in human evolution 19 Acknowledging that there is still debate over how hybridization shaped human genotypes and phenotypes the evolutionary biologists assert that hybridization was an essential creative force in the emergence of modern humans 19 In January 2019 scientists published a chronology for the Pleistocene deposits in the Denisova Cave concluding that at least two groups of humans including Denisovans Neanderthals and related hybrids occupied the Siberian site from around 300 000 to 20 000 years ago but more material evidence is needed to prove whether they ever coexisted there 20 21 Material data collected at the site including stone tools bracelets and other ornaments suggest that Denisovans may have been capable of higher order thought akin to modern humans 21 In February 2019 scientists discovered evidence based on genetics studies using artificial intelligence AI that suggest the existence of an unknown human ancestor species not Neanderthal Denisovan or human hybrid like Denny in the genome of modern humans 22 23 See also editArdi Dawn of Humanity 2015 PBS documentary Homo naledi an early human species hypothesized to possibly be a Homo Australopithecus hybrid Human evolution Interbreeding between archaic and modern humans List of human evolution fossils Lucy Prehistoric Autopsy 2012 BBC documentary Selam Taung ChildReferences edit a b c d e f Warren Matthew 22 August 2018 Mum s a Neanderthal Dad s a Denisovan First discovery of an ancient human hybrid Nature 560 7719 417 418 Bibcode 2018Natur 560 417W doi 10 1038 d41586 018 06004 0 PMID 30135540 a b c d e f g h i j k l Vogel Gretchen 22 August 2018 This ancient bone belonged to a child of two extinct human species Science doi 10 1126 science aav1858 S2CID 188160693 Retrieved 22 August 2018 a b c d e f g h i j k l m n Slon Viviane Mafessoni Fabrizio Vernot Benjamin de Filippo Cesare Grote Steffi Viola Bence Hajdinjak Mateja Peyregne Stephane Nagel Sarah Brown Samantha Douka Katerina 6 September 2018 The genome of the offspring of a Neanderthal mother and a Denisovan father Nature 561 7721 113 116 Bibcode 2018Natur 561 113S doi 10 1038 s41586 018 0455 x ISSN 1476 4687 PMC 6130845 PMID 30135579 a b c d e f g h Brown Samantha Higham Thomas Slon Viviane Paabo Svante Meyer Matthias Douka Katerina Brock Fiona Comeskey Daniel Procopio Noemi Shunkov Michael Derevianko Anatoly 29 March 2016 Identification of a new hominin bone from Denisova Cave Siberia using collagen fingerprinting and mitochondrial DNA analysis Scientific Reports 6 1 23559 Bibcode 2016NatSR 623559B doi 10 1038 srep23559 ISSN 2045 2322 PMC 4810434 PMID 27020421 a b Zimmer Carl 22 August 2018 A Blended Family Her Mother Was Neanderthal Her Father Something Else Entirely The New York Times Retrieved 22 August 2018 a b c d Marshall Michael 22 August 2018 Prehistoric girl had parents belonging to different human species New Scientist Retrieved 22 August 2018 Hood Marlowe 22 August 2018 Neandertal mother Denisovan father Newly sequenced genome sheds light on interactions between ancient hominins Phys org Retrieved 22 August 2018 a b c d e f g Wei Haas Maya 22 August 2018 Ancient Girl s Parents Were Two Different Human Species National Geographic Archived from the original on 22 August 2018 Retrieved 22 August 2018 Novel collagen fingerprinting identifies a Neanderthal bone among 2 000 fragments University of Oxford 29 March 2016 Retrieved 1 April 2016 a b Zhang Sarah 22 August 2018 Scientists Stunned By a Neanderthal Hybrid Discovered in a Siberian Cave The Atlantic Retrieved 22 August 2018 Higham Tom 2021 The World Before Us How science is revealing a new story of our human origins Penguin RandomHouse ISBN 978 0241440674 Scharping Nathaniel 22 August 2018 Hybrid Hominin This Girl s Mother and Father Came From Two Different Species Discover Retrieved 22 August 2018 Huxley T 1890 The Aryan Question and Pre Historic Man Collected Essays Volume VII Man s Place in Nature Green R E Krause J Briggs A W Maricic T Stenzel U Kircher M et al 2010 A Draft Sequence of the Neandertal Genome Science 328 5979 710 22 Bibcode 2010Sci 328 710G doi 10 1126 science 1188021 PMC 5100745 PMID 20448178 Reich D Green R E Kircher M et al 2010 Genetic history of an archaic hominin group from Denisova Cave in Siberia PDF Nature 468 7327 1053 60 Bibcode 2010Natur 468 1053R doi 10 1038 nature09710 hdl 10230 25596 PMC 4306417 PMID 21179161 Antrosio Jason 2011 Denisovans amp Neandertals Living Anthropologically Hammer Michael F May 2013 Human Hybrids PDF Scientific American 308 5 66 71 Bibcode 2013SciAm 308e 66H doi 10 1038 scientificamerican0513 66 PMID 23627222 Archived from the original PDF on 24 August 2018 via grochbiology org Yong Ed 2011 Mosaic humans the hybrid species New Scientist 211 2823 34 38 Bibcode 2011NewSc 211 34Y doi 10 1016 S0262 4079 11 61839 3 a b Rogers Ackermann Rebecca Mackay Alex Arnold Michael L 2016 The Hybrid Origin of Modern Humans Evolutionary Biology 43 1 11 doi 10 1007 s11692 015 9348 1 S2CID 14329491 Jacobs Zenobia Li Bo Shunkov Michael V Kozlikin Maxim B Bolikhovskaya Nataliya S Agadjanian Alexander K Uliyanov Vladimir A Vasiliev Sergei K O Gorman Kieran Derevianko Anatoly P Roberts Richard G 2019 Timing of archaic hominin occupation of Denisova Cave in southern Siberia Nature 565 7741 594 599 Bibcode 2019Natur 565 594J doi 10 1038 s41586 018 0843 2 ISSN 1476 4687 PMID 30700870 S2CID 59525956 a b Zimmer Carl 30 January 2019 High Ceilings and a Lovely View Denisova Cave Was Home to a Lost Branch of Humanity The New York Times Retrieved 31 January 2019 Mondal Mayukh Bertranpedt Jaume Leo Oscar 16 January 2019 Approximate Bayesian computation with deep learning supports a third archaic introgression in Asia and Oceania Nature Communications 10 246 246 Bibcode 2019NatCo 10 246M doi 10 1038 s41467 018 08089 7 PMC 6335398 PMID 30651539 Dockrill Peter 11 February 2019 Artificial Intelligence Has Found an Unknown Ghost Ancestor in The Human Genome ScienceAlert com Retrieved 11 February 2019 Further reading edit Viviane Slon Fabrizio Mafessoni Benjamin Vernot et al 22 August 2018 The genome of the offspring of a Neanderthal mother and a Denisovan father Nature 561 7721 1 doi 10 1038 S41586 018 0455 X ISSN 1476 4687 PMC 6130845 PMID 30135579 Wikidata Q56234568 Tom Higham 2021 The World Before Us How science is revealing a new story of our human origins Penguin London External links editHuman Timeline Interactive Smithsonian National Museum of Natural History August 2016 Portals nbsp Evolutionary biology nbsp Biology nbsp Paleontology nbsp Science Retrieved from https en wikipedia org w index php title Denny hybrid hominin amp oldid 1198803177, wikipedia, wiki, book, books, library,

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