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Wikipedia

Concussion

November 23, 2023

For concussion (mild traumatic brain injury) in children and adolescents, see Pediatric concussion.
For other uses, see Concussion (disambiguation).

A concussion, also known as a mild traumatic brain injury (mTBI), is a head injury that temporarily affects brain functioning.[9] Symptoms may include loss of consciousness; memory loss; headaches; difficulty with thinking, concentration, or balance; nausea; blurred vision; dizziness; sleep disturbances, and mood changes.[1] Any of these symptoms may begin immediately, or appear days after the injury.[1] Concussion should be suspected if a person indirectly or directly hits their head and experiences any of the symptoms of concussion.[10] Symptoms of a concussion may be delayed by 1–2 days after the accident. It is not unusual for symptoms to last 2 weeks in adults and 4 weeks in children.[11][2] Fewer than 10% of sports-related concussions among children are associated with loss of consciousness.[12]

Concussion
Other namesMild brain injury, mild traumatic brain injury (mTBI), mild head injury (MHI), minor head trauma
Acceleration (g-forces) can exert rotational forces in the brain, especially the midbrain and diencephalon.
SpecialtyEmergency medicine, neurology
SymptomsHeadache; trouble with thinking, memory, or concentration; nausea; blurry vision; sleep disturbances; mood changes[1]
ComplicationsChronic traumatic encephalopathy, Parkinson's disease, depression, post-concussion syndrome
DurationUp to 4 weeks[2]
CausesMotor vehicle collisions, falls, sports injuries, bicycle accidents[3][4]
Risk factorsphysical violences, drinking alcohol, playing contact sports such as American football, playing martial arts such as muay thai, previous history of concussion[5]
Diagnostic methodBased on symptoms[6]
PreventionHead protection equipment, like hard hats, gridiron football, martial arts, motorcycle, or bicycle helmets [7]
TreatmentPhysical and cognitive rest for a day or two with a gradual return to activities[8][2]
MedicationParacetamol (acetaminophen), NSAIDs[2]
Frequency6 per 1,000 people a year[3]

Common causes include motor vehicle collisions, falls, sports injuries, and bicycle accidents.[3][4] Risk factors include physical violence, drinking alcohol and a prior history of concussion.[11][5] The mechanism of injury involves either a direct blow to the head or forces elsewhere on the body that are transmitted to the head.[11] This is believed to result in neuron dysfunction, as there are increased glucose requirements, but not enough blood supply.[2] A thorough evaluation by a qualified medical provider working in their scope of practice (such as a physician or nurse practitioner) is required to rule out life-threatening head injuries, injuries to the cervical spine, and neurological conditions and to use information obtained from the medical evaluation to diagnose a concussion.[6][13][14] Glasgow coma scale score 13 to 15, loss of consciousness for less than 30 minutes, and memory loss for less than 24 hours may be used to rule out moderate or severe traumatic brain injuries.[6] Diagnostic imaging such as a CT scan or an MRI may be required to rule out severe head injuries.[13] Routine imaging is not required to diagnose concussion.[15]

Prevention of concussions includes the use of a helmet when bicycling or motorbiking.[3] Treatment includes physical and mental rest for 1–2 days, with a gradual step-wise return to activities, school, and work.[8][2][16] Prolonged periods of rest may slow recovery and result in greater depression and anxiety.[2] Paracetamol (acetaminophen) or NSAIDs may be recommended to help with a headache.[2] Prescribed aerobic exercise may improve recovery.[17] Physiotherapy may be useful for persisting balance problems, headache, or whiplash; cognitive behavioral therapy may be useful for mood changes.[2] Evidence to support the use of hyperbaric oxygen therapy and chiropractic therapy is lacking.[2]

Worldwide, concussions are estimated to affect more than 3.5 per 1,000 people a year.[18] Concussions are classified as mild traumatic brain injuries and are the most common type of TBIs.[3][18] Males and young adults are most commonly affected.[3][18] Outcomes are generally good.[19] Another concussion before the symptoms of a prior concussion have resolved is associated with worse outcomes.[20][21] Repeated concussions may also increase the risk in later life of chronic traumatic encephalopathy, Parkinson's disease and depression.[22]

Video explanation of concussions in children[23]

Signs and symptoms

Concussion symptoms vary between people and include physical, cognitive, and emotional symptoms.[10] Symptoms may appear immediately or be delayed by 1–2 days.[10] Delayed onset of symptoms may still be serious and require a medical assessment.[24] Up to one-third of people with concussion experience longer or persisting concussion symptoms, also known as post concussion syndrome or persisting symptoms after concussion, which is defined as concussion symptoms lasting for 4 weeks or longer in children and adolescents, and symptoms lasting for more than 14 days in an adult.[13][11][25] The severity of the initial symptoms is the strongest predictor of recovery time in adults.[11]

Physical

Headaches are the most common mTBI symptom.[26] Others include dizziness, vomiting, nausea, lack of motor coordination, difficulty balancing,[26] or other problems with movement or sensation. Visual symptoms include light sensitivity,[27] seeing bright lights,[28] blurred vision,[29] and double vision.[30] Tinnitus, or a ringing in the ears, is also commonly reported.[29] In one in about seventy concussions, concussive convulsions occur, but seizures that take place during or immediately after a concussion are not "post-traumatic seizures", and, unlike post-traumatic seizures, are not predictive of post-traumatic epilepsy, which requires some form of structural brain damage, not just a momentary disruption in normal brain functioning.[31] Concussive convulsions are thought to result from temporary loss or inhibition of motor function and are not associated either with epilepsy or with more serious structural damage. They are not associated with any particular sequelae and have the same high rate of favorable outcomes as concussions without convulsions.[32]

Cognitive and emotional

Cognitive symptoms include confusion, disorientation, and difficulty focusing attention. Loss of consciousness may occur, but is not necessarily correlated with the severity of the concussion if it is brief.[33] Post-traumatic amnesia, in which events following the injury cannot be recalled, is a hallmark of concussions.[26] Confusion may be present immediately or may develop over several minutes.[26] A person may repeat the same questions,[34] be slow to respond to questions or directions, have a vacant stare, or have slurred[26] or incoherent speech.[35] Other concussion symptoms include changes in sleeping patterns and difficulty with reasoning, concentrating, and performing everyday activities.[26][30][29]

A concussion can result in changes in mood including crankiness, loss of interest in favorite activities or items,[36] tearfulness,[37] and displays of emotion that are inappropriate to the situation.[35] Common symptoms in concussed children include restlessness, lethargy, and irritability.[38]

Mechanism

 
Rotational force is key in a concussion. Punches in boxing can deliver more rotational force to the head than the typical impact in American football.[39]

Forces

The brain is surrounded by cerebrospinal fluid, which protects it from light trauma. More severe impacts, or the forces associated with rapid acceleration, may not be absorbed by this cushion.[40] Concussions, and other head-related injuries, occur when external forces acting on the head are transferred to the brain.[41] Such forces can occur when the head is struck by an object or surface (a 'direct impact'), or when the torso rapidly changes position (i.e. from a body check) and force is transmitted to the head (an 'indirect impact').[41]

Forces may cause linear, rotational, or angular movement of the brain or a combination of them.[37] In rotational movement, the head turns around its center of gravity, and in angular movement, it turns on an axis, not through its center of gravity.[37] The amount of rotational force is thought to be the major component in concussion[42] and its severity.[43] As of 2007, studies with athletes have shown that the amount of force and the location of the impact are not necessarily correlated with the severity of the concussion or its symptoms, and have called into question the threshold for concussion previously thought to exist at around 70–75 g.[44][45]

The parts of the brain most affected by rotational forces are the midbrain and diencephalon.[46][4] It is thought that the forces from the injury disrupt the normal cellular activities in the reticular activating system located in these areas and that this disruption produces the loss of consciousness often seen in concussion.[4] Other areas of the brain that may be affected include the upper part of the brain stem, the fornix, the corpus callosum, the temporal lobe, and the frontal lobe.[47] Angular accelerations of 4600, 5900, or 7900 rad/s2 are estimated to have 25, 50, or 80% risk of mTBI respectively.[48]

Pathophysiology

In both animals and humans, mTBI can alter the brain's physiology for hours to years,[49][50] setting into motion a variety of pathological events.[51] As one example, in animal models, after an initial increase in glucose metabolism, there is a subsequent reduced metabolic state which may persist for up to four weeks after injury.[12] Though these events are thought to interfere with neuronal and brain function, the metabolic processes that follow concussion are reversible in a large majority of affected brain cells; however, a few cells may die after the injury.[52]

Included in the cascade of events unleashed in the brain by concussion is impaired neurotransmission, loss of regulation of ions, deregulation of energy use and cellular metabolism, and a reduction in cerebral blood flow.[52] Excitatory neurotransmitters, chemicals such as glutamate that serve to stimulate nerve cells, are released in excessive amounts.[53] The resulting cellular excitation causes neurons to fire excessively.[54] This creates an imbalance of ions such as potassium and calcium across the cell membranes of neurons (a process like excitotoxicity).[52]

At the same time, cerebral blood flow is relatively reduced for unknown reasons,[27] though the reduction in blood flow is not as severe as it is in ischemia.[52] Thus cells get less glucose than they normally do, which causes an "energy crisis".[27]

Concurrently with these processes, the activity of mitochondria may be reduced, which causes cells to rely on anaerobic metabolism to produce energy, increasing levels of the byproduct lactate.[52]

For a period of minutes to days after a concussion, the brain is especially vulnerable to changes in intracranial pressure, blood flow, and anoxia.[27] According to studies performed on animals (which are not always applicable to humans), large numbers of neurons can die during this period in response to slight, normally innocuous changes in blood flow.[27]

Concussion involves diffuse (as opposed to focal) brain injury, meaning that the dysfunction occurs over a widespread area of the brain rather than in a particular spot.[55] It is thought to be a milder type of diffuse axonal injury, because axons may be injured to a minor extent due to stretching.[37] Animal studies in which rodents were concussed have revealed lifelong neuropathological consequences such as ongoing axonal degeneration and neuroinflammation in subcortical white matter tracts.[56] Axonal damage has been found in the brains of concussion patients who died from other causes, but inadequate blood flow to the brain due to other injuries may have contributed.[29] Findings from a study of the brains of deceased NFL athletes who received concussions suggest that lasting damage is done by such injuries. This damage, the severity of which increases with the cumulative number of concussions sustained, can lead to a variety of other health issues.[57]

The debate over whether concussion is a functional or structural phenomenon is ongoing.[58] Structural damage has been found in the mildly traumatically injured brains of animals, but it is not clear whether these findings would apply to humans.[46] Such changes in brain structure could be responsible for certain symptoms such as visual disturbances, but other sets of symptoms, especially those of a psychological nature, are more likely to be caused by reversible pathophysiological changes in cellular function that occur after concussion, such as alterations in neurons' biochemistry.[43] These reversible changes could also explain why dysfunction is frequently temporary.[58] A task force of head injury experts called the Concussion In Sport Group met in 2001 and decided that "concussion may result in neuropathological changes but the acute clinical symptoms largely reflect a functional disturbance rather than structural injury."[59]

Using animal studies, the pathology of a concussion seems to start with mechanical shearing and stretching forces disrupting the cell membrane of nerve cells through "mechanoporation".[60] This results in potassium outflow from within the cell into the extracellular space with the subsequent release of excitatory neurotransmitters including glutamate which leads to enhanced potassium extrusion, in turn resulting in sustained depolarization, impaired nerve activity and potential nerve damage.[60] Human studies have failed to identify changes in glutamate concentration immediately post-mTBI, though disruptions have been seen 3 days to 2 weeks post-injury.[60] In an effort to restore ion balance, the sodium-potassium ion pumps increase activity, which results in excessive ATP (adenosine triphosphate) consumption and glucose utilization, quickly depleting glucose stores within the cells.[61] Simultaneously, inefficient oxidative metabolism leads to anaerobic metabolism of glucose and increased lactate accumulation.[61] There is a resultant local acidosis in the brain and increased cell membrane permeability, leading to local swelling.[61] After this increase in glucose metabolism, there is a subsequent lower metabolic state which may persist for up to 4 weeks after injury. A completely separate pathway involves a large amount of calcium accumulating in cells, which may impair oxidative metabolism and begin further biochemical pathways that result in cell death. Again, both of these main pathways have been established from animal studies and the extent to which they apply to humans is still somewhat unclear.[12]

Diagnosis

Red flags are warning signs that may indicate a more serious problem and require immediate emergency medical attention
Red flag symptoms (emergent assessment required)[24]
Seizure or convulsions
Worsening headache
Difficulty waking up (or loss of consciousness)
Seeing double
Problem recognizing people or places or confusion
Repeated vomiting
Numbness, weakness in extremities, or slurred speech
Not usual self, aggressive, or agitated behaviour
Neck pain or tenderness in the neck
 
Unequal pupil size is not a sign of concussion and can be a sign of a more serious brain injury.

Head trauma recipients are initially assessed to exclude a more severe emergency such as an intracranial hemorrhage or other serious head or neck injuries. This includes the "ABCs" (airway, breathing, circulation) and stabilization of the cervical spine which is assumed to be injured in any athlete who is found to be unconscious after head or neck injury. Indications that screening for more serious injury is needed include 'red flag symptoms' or 'concussion danger signs': worsening headaches, persisting vomiting, increasing disorientation or a deteriorating level of consciousness, seizures, and unequal pupil size.[10][62][63][64] Those with such symptoms, or those who are at higher risk of a more serious brain injury, require an emergency medical assessment.[10] Brain imaging such as a CT scan or MRI may be suggested, but should be avoided unless there are progressive neurological symptoms, focal neurological findings, or concern of skull fracture on exam.[65]

Diagnosis of concussion requires an assessment performed by a physician or nurse practitioner to rule out severe injuries to the brain and cervical spine, mental health conditions, or other medical conditions.[13] Diagnosis is based on physical and neurological examination findings, duration of unconsciousness (usually less than 30 minutes) and post-traumatic amnesia (usually less than 24 hours), and the Glasgow Coma Scale (people with mTBI have scores of 13 to 15).[66] A CT scan or MRI is not required to diagnose concussion.[13][15] Neuropsychological tests such as the SCAT5/child SCAT5 may be suggested measure cognitive function.[11][67][68] Such tests may be administered hours, days, or weeks after the injury, or at different times to demonstrate any trend.[69] Some athletes are also being tested pre-season (pre-season baseline testing) to provide a baseline for comparison in the event of an injury, though this may not reduce risk or affect return to play and baseline testing is not required or suggested for most children and adults.[70][71]

If the Glasgow coma scale is less than 15 at two hours or less than 14 at any time, a CT is recommended.[4] In addition, a CT scan is more likely to be performed if observation after discharge is not assured or intoxication is present, there is suspected increased risk for bleeding, age greater than 60,[4] or less than 16. Most concussions, without complication, cannot be detected with MRI or CT scans.[42] However, changes have been reported on MRI and SPECT imaging in those with concussion and normal CT scans, and post-concussion syndrome may be associated with abnormalities visible on SPECT and PET scans.[52][needs update] Mild head injury may or may not produce abnormal EEG readings.[72][73] A blood test known as the Brain Trauma Indicator was approved in the United States in 2018 and may be able to rule out the risk of intracranial bleeding and thus the need for a CT scan for adults.[74]

Concussion may be under-diagnosed because of the lack of the highly noticeable signs and symptoms while athletes may minimize their injuries to remain in the competition.[75] Direct impact to the head is not required for a concussion diagnosis, as other bodily impacts with a subsequent force transmission to the head are also causes.[76] A retrospective survey in 2005 suggested that more than 88% of concussions are unrecognized.[77] Particularly, many younger athletes struggle with identifying their concussions, which often result in the non-disclosure of concussions and consequently under-representing the incidence of concussions in the context of sport.[78]

Diagnosis can be complex because concussion shares symptoms with other conditions. For example, post-concussion symptoms such as cognitive problems may be misattributed to brain injury when, in fact, due to post-traumatic stress disorder (PTSD).[79]

There are no fluid biomarkers (i.e., blood or urine tests) that are validated for diagnosing concussion in children or adolescents.[80]

Classification

No single definition of concussion, minor head injury,[81] or mild traumatic brain injury is universally accepted.[82] In 2001, the expert Concussion in Sport Group of the first International Symposium on Concussion in Sport[59] defined concussion as "a complex pathophysiological process affecting the brain, induced by traumatic biomechanical forces."[33] It was agreed that concussion typically involves temporary impairment of neurological function that heals by itself within time, and that neuroimaging normally shows no gross structural changes to the brain as the result of the condition.[43]

However, although no structural brain damage occurs according to the classic definition,[83] some researchers have included injuries in which structural damage has occurred, and the National Institute for Health and Clinical Excellence definition includes physiological or physical disruption in the brain's synapses.[84] Also, by definition, concussion has historically involved a loss of consciousness. However, the definition has evolved over time to include a change in consciousness, such as amnesia,[85] although controversy continues about whether the definition should include only those injuries in which loss of consciousness occurs.[46] This debate resurfaces in some of the best-known concussion grading scales, in which those episodes involving loss of consciousness are graded as being more severe than those without.[86]

Definitions of mild traumatic brain injury (mTBI) were inconsistent until the World Health Organization's International Statistical Classification of Diseases and Related Health Problems (ICD-10) provided a consistent, authoritative definition across specialties in 1992.[87] Since then, various organizations such as the American Congress of Rehabilitation Medicine[26] and the American Psychiatric Association in its Diagnostic and Statistical Manual of Mental Disorders[87] have defined mTBI using some combination of loss of consciousness, post-traumatic amnesia, and the Glasgow Coma Scale.

Concussion falls under the classification of mild TBI,[88] but it is not clear whether concussion is implied in mild brain injury or mild head injury.[89][needs update] "mTBI" and "concussion" are often treated as synonyms in medical literature[26] but other injuries such as intracranial hemorrhages (e.g. intra-axial hematoma, epidural hematoma, and subdural hematoma) are not necessarily precluded in mTBI[43] or mild head injury,[90][91] as they are in concussion.[92] mTBI associated with abnormal neuroimaging may be considered "complicated mTBI".[52] "Concussion" can be considered to imply a state in which brain function is temporarily impaired and "mTBI" to imply a pathophysiological state, but in practice, few researchers and clinicians distinguish between the terms.[43] Descriptions of the condition, including the severity and the area of the brain affected, are now used more often than "concussion" in clinical neurology.[93]

Prevention

Main article: Prevention of concussions

Prevention of mTBI involves general measures such as wearing seat belts, using airbags in cars, and protective equipment such as helmets for high-risk sports.[26][94] Older people are encouraged to reduce fall risk by keeping floors free of clutter and wearing thin, flat shoes with hard soles that do not interfere with balance.[36]

Protective equipment such as helmets and other headgear and policy changes such as the banning of body checking in youth hockey leagues have been found to reduce the number and severity of concussions in athletes.[95] Secondary prevention such as a Return to Play Protocol for an athlete may reduce the risk of repeat concussions.[96] New "Head Impact Telemetry System" technology is being placed in helmets to study injury mechanisms and may generate knowledge that will potentially help reduce the risk of concussions among American Football players.[97]

Educational interventions, such as handouts, videos, workshops, and lectures, can improve concussion knowledge of diverse groups, particularly youth athletes and coaches.[98] Strong concussion knowledge may be associated with greater recognition of concussion symptoms, higher rates of concussion reporting behaviors, and reduced body checking-related penalties and injuries, thereby lowering risk of mTBI.[98]

Due to the incidence of concussion in sport, younger athletes often do not disclose concussions and their symptoms. Common reasons for non-disclosure include a lack of awareness of the concussion, the belief that the concussion was not serious enough, and not wanting to leave the game or team due to their injury.[78] Self-reported concussion rates among U-20 and elite rugby union players in Ireland are 45–48%, indicating that many concussions go unreported.[39] Changes to the rules or enforcing existing rules in sports, such as those against "head-down tackling", or "spearing", which is associated with a high injury rate, may also prevent concussions.[39]

Treatment

Adults and children with a suspected concussion require a medical assessment with a doctor or nurse practitioner to confirm the diagnosis of concussion and rule out more serious head injuries. After life-threatening head injuries, injuries to the cervical spine, and neurological conditions are ruled out, exclusion of neck or head injury, observation should be continued for several hours. If repeated vomiting, worsening headache, dizziness, seizure activity, excessive drowsiness, double vision, slurred speech, unsteady walk, or weakness or numbness in arms or legs, or signs of basilar skull fracture develop, immediate assessment in an emergency department is needed.[11][12] Observation to monitor for worsening condition is an important part of treatment.[13] People may be released after assessment from their primary care medical clinic, hospital, or emergency room to the care of a trusted person with instructions to return if they display worsening symptoms or those that might indicate an emergent condition ("red flag symptoms") such as change in consciousness, convulsions, severe headache, extremity weakness, vomiting, new bleeding or deafness in either or both ears.[99][24][13] Education about symptoms, their management, and their normal time course, may lead to an improved outcome.[82][needs update]

Rest and return to physical and cognitive activity

Physical and cognitive rest is recommended for the first 24–48 hours following a concussion after which injured persons should gradually start gentle low-risk physical and cognitive activities that do not make current symptoms worse or bring on new symptoms.[11][100] Any activity for which there is a risk of contact, falling, or bumping the head should be avoided until the person has clearance from a doctor or nurse practitioner.[13][11][24] Low-risk activities can be started even while a person has symptoms, as long as the activity does not worsen existing symptoms or bring on new concussion symptoms.[24][15] Resting completely for longer than 24–48 hours follow concussion has been shown to be associated with longer recovery.[101]

Return-to-school

The resumption of low-risk school activities should begin as soon as the student feels ready and has completed an initial period of cognitive rest of no more than 24–48 hours following the acute injury.[101][102] Long absences from school are not suggested, however, the return to school should be gradual and step-wise.[102] Prolonged complete mental or physical rest (beyond 24–48 hours after the accident that lead to the concussion) may worsen outcomes,[102] however, rushing back to full school work load before the person is ready, has also been associated with longer-lasting symptoms and an extended recovery time.[103] Students with a suspected concussion are required to see a doctor for an initial medical assessment and for suggestions on recovery, however, medical clearance is not required for a student to return to school.[24] Since students may appear 'normal', continuing education of relevant school personnel may be needed to ensure appropriate accommodations are made such as part-days and extended deadlines.[101] Accommodations should be based on the monitoring of symptoms that are present during the return-to-school transition including headaches, dizziness, vision problems, memory loss, difficulty concentrating, and abnormal behavior.[101][103] Students must have completely resumed their school activities (without requiring concussion-related academic supports) before returning to full-contact or competitive sports.[24]

Return-to-sport

For persons participating in athletics, it is suggested that participants progress through a series of graded steps.[11] These steps include:

  • Stage 1 (Immediately after injury): 24–48 hours (maximum) of relative physical and cognitive rest.[11] This can include gentle daily activities such as walking in the house, gentle housework, and light school work that do not make symptoms worse. No sports activities.
  • Stage 2: Light aerobic activity such as walking or stationary cycling
  • Stage 3: Sport-specific activities such as running drills and skating drills
  • Stage 4: Non-contact training drills (exercise, coordination, and cognitive load)
  • Stage 5: Full-contact practice (requires medical clearance)
  • Stage 6: Return to full-contact sport or high-risk activities (requires medical clearance)

At each step, the person should not have worsening or new symptoms for at least 24 hours before progressing to the next. If symptoms worsen or new symptoms begin, athletes should drop back to the previous level for at least another 24 hours.[11]

Intercollegiate or professional athletes, are typically followed closely by team athletic trainers during this period but others may not have access to this level of health care and may be sent home with minimal monitoring.

Medications

Medications may be prescribed to treat headaches, sleep problems and depression.[82] Analgesics such as ibuprofen can be taken for headaches,[43] but paracetamol (acetaminophen) is preferred to minimize the risk of intracranial hemorrhage.[104] Concussed individuals are advised not to use alcohol or other drugs that have not been approved by a doctor as they can impede healing.[105] Activation database-guided EEG biofeedback has been shown to return the memory abilities of the concussed individual to levels better than the control group.[106]

About one percent of people who receive treatment for mTBI need surgery for a brain injury.[66]

Return to work

Determining the ideal time for a person to return to work will depend on personal factors and job-related factors including the intensity of the job and the risk of falling or hitting one's head at work during recovery.[13] After the required initial recovery period of complete rest (24–48 hours after the concussion began), gradually and safely returning to the workplace with accommodations and support in place, should be prioritized over staying home and resting for long periods of time, to promote physical recovery and reduce the risk of people becoming socially isolated.[13] The person should work with their employer to design a step-wise "return-to-work" plan.[13] For those with a high-risk job, medical clearance may be required before resuming an activity that could lead to another head injury.[13] Students should have completed the full return-to-school progression with no academic accommodations related to the concussion required before starting to return to part-time work.[24]

Prognosis

The majority of children and adults fully recover from a concussion, however some may experience a prolonged recovery.[107][108] There is no single physical test, blood test (or fluid biomarkers), or imaging test that can be used to determine when a person has fully recovered from concussion.[109]

A person's recovery may be influenced by a variety of factors that include age at the time of injury, intellectual abilities, family environment, social support system, occupational status, coping strategies, and financial circumstances.[110] Factors such as a previous head injury or a coexisting medical condition have been found to predict longer-lasting post-concussion symptoms.[111] Other factors that may lengthen recovery time after mTBI include psychological problems such as substance abuse or clinical depression, poor health before the injury or additional injuries sustained during it, and life stress.[52] Longer periods of amnesia or loss of consciousness immediately after the injury may indicate longer recovery times from residual symptoms.[112] Other strong factors include participation in a contact sport and body mass size.[113]

Pediatric concussion

Most children recover completely from concussion in less than four weeks, however 15–30% of youth may experience symptoms that last longer than a month.[114][115][101]

People aged 65+ with concussion

Mild traumatic brain injury recovery time in people over age 65 may have increased complications due to elevated health concerns, or comorbidities.[116] This often results in longer hospitalization duration, poorer cognitive outcomes, and higher mortality rates.[116]

Repeat concussion

For unknown reasons, having had one concussion significantly increases a person's risk of having another.[69][22] Having previously sustained a sports concussion has been found to be a strong factor increasing the likelihood of a concussion in the future. People who have had a concussion seem more susceptible to another one, particularly if the new injury occurs before symptoms from the previous concussion have completely gone away. It is also a negative process if smaller impacts cause the same symptom severity.[117] Repeated concussions may increase a person's risk in later life for dementia, Parkinson's disease, and depression.[22]

Post-concussion syndrome

Main article: Post-concussion syndrome

In post-concussion syndrome, symptoms do not resolve for weeks, months, or years after a concussion, and may occasionally be permanent.[118] About 10% to 20% of people have post-concussion syndrome for more than a month.[114] Symptoms may include headaches, dizziness, fatigue, anxiety, memory and attention problems, sleep problems, and irritability.[119] Rest, a previously recommended recovery technique, has limited effectiveness.[120] A recommended treatment in both children and adults with symptoms beyond 4 weeks involves an active rehabilitation program with reintroduction of non-contact aerobic activity.[115] Progressive physical exercise has been shown to reduce long-term post-concussive symptoms.[115] Symptoms usually go away on their own within months[92] but may last for years.[121][56] The question of whether the syndrome is due to structural damage or other factors such as psychological ones, or a combination of these, has long been the subject of debate.[79]

Cumulative effects

As of 1999, cumulative effects of concussions were poorly understood, especially the effects on children. The severity of concussions and their symptoms may worsen with successive injuries, even if a subsequent injury occurs months or years after an initial one.[122] Symptoms may be more severe and changes in neurophysiology can occur with the third and subsequent concussions.[69] As of 2006, studies had conflicting findings on whether athletes have longer recovery times after repeat concussions and whether cumulative effects such as impairment in cognition and memory occur.[39]

Cumulative effects may include chronic traumatic encephalopathy, psychiatric disorders and loss of long-term memory. For example, the risk of developing clinical depression has been found to be significantly greater for retired American football players with a history of three or more concussions than for those with no concussion history.[123] An experience of three or more concussions is associated with a fivefold greater chance of developing Alzheimer's disease earlier and a threefold greater chance of developing memory deficits.[123]

Chronic traumatic encephalopathy, or "CTE", is an example of the cumulative damage that can occur as the result of multiple concussions or less severe blows to the head. The condition was previously referred to as "dementia pugilistica", or "punch drunk" syndrome, as it was first noted in boxers. The disease can lead to cognitive and physical disabilities such as parkinsonism, speech and memory problems, slowed mental processing, tremor, depression, and inappropriate behavior.[124] It shares features with Alzheimer's disease.[125]

Second-impact syndrome

Main article: Second-impact syndrome

Second-impact syndrome, in which the brain swells dangerously after a minor blow, may occur in very rare cases.[126] The condition may develop in people who receive a second blow days or weeks after an initial concussion before its symptoms have gone away.[27] No one is certain of the cause of this often fatal complication, but it is commonly thought that the swelling occurs because the brain's arterioles lose the ability to regulate their diameter, causing a loss of control over cerebral blood flow.[69] As the brain swells, intracranial pressure rapidly rises.[63] The brain can herniate, and the brain stem can fail within five minutes.[27] Except in boxing, all cases have occurred in athletes under age 20.[53] Due to the very small number of documented cases, the diagnosis is controversial, and doubt exists about its validity.[127] A 2010 Pediatrics review article stated that there is debate whether the brain swelling is due to two separate hits or to just one hit, but in either case, catastrophic football head injuries are three times more likely in high school athletes than in college athletes.[12]

Epidemiology

 
Annual incidence of MTBI by age group in Canada[128]

Most cases of traumatic brain injury are concussions. A World Health Organization (WHO) study estimated that between 70 and 90% of head injuries that receive treatment are mild.[3] However, due to under reporting and to the widely varying definitions of concussion and mTBI, it is difficult to estimate how common the condition is.[87] Estimates of the incidence of concussion may be artificially low, for example, due to under reporting. At least 25% of people with mTBI fail to get assessed by a medical professional.[52] The WHO group reviewed studies on the epidemiology of mTBI and found a hospital treatment rate of 1–3 per 1000 people, but since not all concussions are treated in hospitals, they estimated that the rate per year in the general population is over 6 per 1000 people.[3]

Age

Young children have the highest concussion rate among all age groups.[4] However, most people with a concussion are young adults.[118] A Canadian study found that the yearly incidence of mTBI is lower in older age groups (graph at right).[128] Studies suggest males develop mTBI at about twice the rate of their female counterparts.[3] However, female athletes may be at a higher risk of sustaining a concussion than their male counterparts.[129]

Sports

Up to five percent of sports injuries are concussions.[53] The U.S. Centers for Disease Control and Prevention estimates that 300,000 sports-related concussions occur yearly in the U.S., but that number includes only athletes who lost consciousness.[130] Since loss of consciousness is thought to occur in less than 10% of concussions,[131] the CDC estimate is likely lower than the real number.[130] Sports in which concussion is particularly common include American football, the rugby codes, MMA and boxing (a boxer aims to "knock out", i.e. give a mild traumatic brain injury to, the opponent). The injury is so common in the latter that several medical groups have called for a ban on the sport, including the American Academy of Neurology, the World Medical Association, and the medical associations of the UK, the US, Australia, and Canada.[132]

Workplace

Concussions may also be common and occur in the workplace. According to the US Bureau of Labour Statistics, the most common causes of mTBI-related hospitalizations and deaths from the workplace are falls, force of heavy objects, and vehicular collisions.[133] As a consequence, jobs in the construction, transportation, and natural resource industries (e.g. agriculture, fishing, mining) have more elevated mTBI incidence rates ranging from 10 to 20 cases per 100,000 workers.[133] In particular, as vehicular collisions are the leading cause of workplace mTBI-related injuries, workers from the transportation sector often carry the most risk.[134] Despite these findings, there still remain important gaps in data compilation on workplace-related mTBIs, which has raised questions about increased concussion surveillance and preventive measures in private industry.[134]

History

 
The Hippocratic Corpus mentioned concussion.[112]

The Hippocratic Corpus, a collection of medical works from ancient Greece, mentions concussion, later translated to commotio cerebri, and discusses loss of speech, hearing, and sight that can result from "commotion of the brain".[112] This idea of disruption of mental function by "shaking of the brain" remained the widely accepted understanding of concussion until the 19th century.[112] In the 10th century, the Persian physician Muhammad ibn Zakarīya Rāzi was the first to write about concussion as distinct from other types of head injury.[58] He may have been the first to use the term "cerebral concussion", and his definition of the condition, a transient loss of function with no physical damage, set the stage for the medical understanding of the condition for centuries.[37]

In the 13th century, the physician Lanfranc of Milan's Chiurgia Magna described concussion as brain "commotion", also recognizing a difference between concussion and other types of traumatic brain injury (though many of his contemporaries did not), and discussing the transience of post-concussion symptoms as a result of temporary loss of function from the injury.[58] In the 14th century, the surgeon Guy de Chauliac pointed out the relatively good prognosis of concussion as compared to more severe types of head trauma such as skull fractures and penetrating head trauma.[58] In the 16th-century, the term "concussion" came into use, and symptoms such as confusion, lethargy, and memory problems were described.[58] The 16th century physician Ambroise Paré used the term commotio cerebri,[37] as well as "shaking of the brain", "commotion", and "concussion".[112]

 
Guillaume Dupuytren distinguished between concussion and unconsciousness associated with brain contusion.[112]

Until the 17th century, a concussion was usually described by its clinical features, but after the invention of the microscope, more physicians began exploring underlying physical and structural mechanisms.[58] However, the prevailing view in the 17th century was that the injury did not result from physical damage, and this view continued to be widely held throughout the 18th century.[58] The word "concussion" was used at the time to describe the state of unconsciousness and other functional problems that resulted from the impact, rather than a physiological condition.[58] In 1839, Guillaume Dupuytren described brain contusions, which involve many small hemorrhages, as contusio cerebri and showed the difference between unconsciousness associated with damage to the brain parenchyma and that due to concussion, without such injury.[112] In 1941, animal experiments showed that no macroscopic damage occurs in concussion.[112][135]

Society and culture

Costs

Due to the lack of a consistent definition, the economic costs of mTBI are not known, but they are estimated to be very high.[136] These high costs are due in part to the large percentage of hospital admissions for head injury that is due to mild head trauma,[89] but indirect costs such as lost work time and early retirement account for the bulk of the costs.[136] These direct and indirect costs cause the expense of mild brain trauma to rival that of moderate and severe head injuries.[137]

Terminology

The terms mild brain injury, mild traumatic brain injury (mTBI), mild head injury (MHI), and concussion may be used interchangeably;[138][87] although the term "concussion" is still used in sports literature as interchangeable with "MHI" or "mTBI", the general clinical medical literature uses "mTBI" instead, since a 2003 CDC report outlined it as an important strategy.[75][37] In this article, "concussion" and "mTBI" are used interchangeably.

The term "concussion" is from Latin concutere, "to shake violently"[46] or concussus, "action of striking together".[139]

Research

Minocycline, lithium, and N-acetylcysteine show tentative success in animal models.[140]

Measurement of predictive visual tracking is being studied as a screening technique to identify mild traumatic brain injury. A head-mounted display unit with eye-tracking capability shows a moving object in a predictive pattern for the person to follow with their eyes. People without brain injury will be able to track the moving object with smooth pursuit eye movements and correct trajectory while it is hypothesized that those with mild traumatic brain injury cannot.[141]

Grading systems

Main article: Concussion grading systems

National and international clinical practice guidelines do not recommend a concussion grading system for use by medical professionals.[142][13][115]

Historical information on grading systems

In the past, the decision to allow athletes to return to participation was frequently based on the grade of concussion.[143] However, current research and recommendations by professional organizations including the National Athletic Trainers' Association recommend against such use of these grading systems.[citation needed] Currently, injured athletes are prohibited from returning to play before they are symptom-free during both rest and exertion and until results of the neuropsychological tests have returned to pre-injury levels.[144] Three grading systems have been most widely followed: by Robert Cantu, the Colorado Medical Society, and the American Academy of Neurology.[86] Each employs three grades, as summarized in the following table:[28]

Comparison of historic concussion grading scales – not currently recommended for use by medical professionals
Guidelines  Grade I Grade II Grade III
Cantu Post-traumatic amnesia <30 minutes, no loss of consciousness Loss of consciousness <5 minutes or amnesia lasting 30 minutes–24 hours Loss of consciousness >5 minutes or amnesia >24 hours
Colorado Medical Society Confusion, no loss of consciousness Confusion, post-traumatic amnesia, no loss of consciousness Any loss of consciousness
American Academy of Neurology Confusion, symptoms last <15 minutes, no loss of consciousness Symptoms last >15 minutes, no loss of consciousness Loss of consciousness (IIIa, coma lasts seconds, IIIb for minutes)

At least 41 systems measure the severity, or grade, of a mild head injury,[43] and there is little agreement about which is best.[28] In an effort to simplify, the 2nd International Conference on Concussion in Sport, meeting in Prague in 2004, decided that these systems should be abandoned in favor of a 'simple' or 'complex' classification.[145] However, the 2008 meeting in Zurich abandoned the simple versus complex terminology, although the participants did agree to keep the concept that most (80–90%) concussions resolve in a short period (7–10 days) and although the recovery time frame may be longer in children and adolescents.[117][146]

See also

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Further reading

  • Harrison, Emily A. "The first concussion crisis: head injury and evidence in early American football." American journal of public health 104.5 (2014): 822-833. online
  • Shurley, Jason P., and Janice S. Todd. "Boxing lessons: An historical review of chronic head trauma in boxing and football." Kinesiology Review 1.3 (2012): 170-184. online

External links

  Share your views on sports-related concussions with Wikiversity

November 23, 2023
concussion, concussion, mild, traumatic, brain, injury, children, adolescents, pediatric, concussion, other, uses, disambiguation, concussion, also, known, mild, traumatic, brain, injury, mtbi, head, injury, that, temporarily, affects, brain, functioning, symp. For concussion mild traumatic brain injury in children and adolescents see Pediatric concussion For other uses see Concussion disambiguation A concussion also known as a mild traumatic brain injury mTBI is a head injury that temporarily affects brain functioning 9 Symptoms may include loss of consciousness memory loss headaches difficulty with thinking concentration or balance nausea blurred vision dizziness sleep disturbances and mood changes 1 Any of these symptoms may begin immediately or appear days after the injury 1 Concussion should be suspected if a person indirectly or directly hits their head and experiences any of the symptoms of concussion 10 Symptoms of a concussion may be delayed by 1 2 days after the accident It is not unusual for symptoms to last 2 weeks in adults and 4 weeks in children 11 2 Fewer than 10 of sports related concussions among children are associated with loss of consciousness 12 ConcussionOther namesMild brain injury mild traumatic brain injury mTBI mild head injury MHI minor head traumaAcceleration g forces can exert rotational forces in the brain especially the midbrain and diencephalon SpecialtyEmergency medicine neurologySymptomsHeadache trouble with thinking memory or concentration nausea blurry vision sleep disturbances mood changes 1 ComplicationsChronic traumatic encephalopathy Parkinson s disease depression post concussion syndromeDurationUp to 4 weeks 2 CausesMotor vehicle collisions falls sports injuries bicycle accidents 3 4 Risk factorsphysical violences drinking alcohol playing contact sports such as American football playing martial arts such as muay thai previous history of concussion 5 Diagnostic methodBased on symptoms 6 PreventionHead protection equipment like hard hats gridiron football martial arts motorcycle or bicycle helmets 7 TreatmentPhysical and cognitive rest for a day or two with a gradual return to activities 8 2 MedicationParacetamol acetaminophen NSAIDs 2 Frequency6 per 1 000 people a year 3 Common causes include motor vehicle collisions falls sports injuries and bicycle accidents 3 4 Risk factors include physical violence drinking alcohol and a prior history of concussion 11 5 The mechanism of injury involves either a direct blow to the head or forces elsewhere on the body that are transmitted to the head 11 This is believed to result in neuron dysfunction as there are increased glucose requirements but not enough blood supply 2 A thorough evaluation by a qualified medical provider working in their scope of practice such as a physician or nurse practitioner is required to rule out life threatening head injuries injuries to the cervical spine and neurological conditions and to use information obtained from the medical evaluation to diagnose a concussion 6 13 14 Glasgow coma scale score 13 to 15 loss of consciousness for less than 30 minutes and memory loss for less than 24 hours may be used to rule out moderate or severe traumatic brain injuries 6 Diagnostic imaging such as a CT scan or an MRI may be required to rule out severe head injuries 13 Routine imaging is not required to diagnose concussion 15 Prevention of concussions includes the use of a helmet when bicycling or motorbiking 3 Treatment includes physical and mental rest for 1 2 days with a gradual step wise return to activities school and work 8 2 16 Prolonged periods of rest may slow recovery and result in greater depression and anxiety 2 Paracetamol acetaminophen or NSAIDs may be recommended to help with a headache 2 Prescribed aerobic exercise may improve recovery 17 Physiotherapy may be useful for persisting balance problems headache or whiplash cognitive behavioral therapy may be useful for mood changes 2 Evidence to support the use of hyperbaric oxygen therapy and chiropractic therapy is lacking 2 Worldwide concussions are estimated to affect more than 3 5 per 1 000 people a year 18 Concussions are classified as mild traumatic brain injuries and are the most common type of TBIs 3 18 Males and young adults are most commonly affected 3 18 Outcomes are generally good 19 Another concussion before the symptoms of a prior concussion have resolved is associated with worse outcomes 20 21 Repeated concussions may also increase the risk in later life of chronic traumatic encephalopathy Parkinson s disease and depression 22 source source source source source source source source track Video explanation of concussions in children 23 Contents 1 Signs and symptoms 1 1 Physical 1 2 Cognitive and emotional 2 Mechanism 2 1 Forces 2 2 Pathophysiology 3 Diagnosis 3 1 Classification 4 Prevention 5 Treatment 5 1 Rest and return to physical and cognitive activity 5 2 Return to school 5 3 Return to sport 5 4 Medications 5 5 Return to work 6 Prognosis 6 1 Pediatric concussion 6 2 People aged 65 with concussion 6 3 Repeat concussion 6 4 Post concussion syndrome 6 5 Cumulative effects 6 6 Second impact syndrome 7 Epidemiology 7 1 Age 7 2 Sports 7 3 Workplace 8 History 9 Society and culture 9 1 Costs 9 2 Terminology 10 Research 10 1 Grading systems 10 1 1 Historical information on grading systems 11 See also 12 References 13 Further reading 14 External linksSigns and symptomsConcussion symptoms vary between people and include physical cognitive and emotional symptoms 10 Symptoms may appear immediately or be delayed by 1 2 days 10 Delayed onset of symptoms may still be serious and require a medical assessment 24 Up to one third of people with concussion experience longer or persisting concussion symptoms also known as post concussion syndrome or persisting symptoms after concussion which is defined as concussion symptoms lasting for 4 weeks or longer in children and adolescents and symptoms lasting for more than 14 days in an adult 13 11 25 The severity of the initial symptoms is the strongest predictor of recovery time in adults 11 Physical Headaches are the most common mTBI symptom 26 Others include dizziness vomiting nausea lack of motor coordination difficulty balancing 26 or other problems with movement or sensation Visual symptoms include light sensitivity 27 seeing bright lights 28 blurred vision 29 and double vision 30 Tinnitus or a ringing in the ears is also commonly reported 29 In one in about seventy concussions concussive convulsions occur but seizures that take place during or immediately after a concussion are not post traumatic seizures and unlike post traumatic seizures are not predictive of post traumatic epilepsy which requires some form of structural brain damage not just a momentary disruption in normal brain functioning 31 Concussive convulsions are thought to result from temporary loss or inhibition of motor function and are not associated either with epilepsy or with more serious structural damage They are not associated with any particular sequelae and have the same high rate of favorable outcomes as concussions without convulsions 32 Cognitive and emotional Cognitive symptoms include confusion disorientation and difficulty focusing attention Loss of consciousness may occur but is not necessarily correlated with the severity of the concussion if it is brief 33 Post traumatic amnesia in which events following the injury cannot be recalled is a hallmark of concussions 26 Confusion may be present immediately or may develop over several minutes 26 A person may repeat the same questions 34 be slow to respond to questions or directions have a vacant stare or have slurred 26 or incoherent speech 35 Other concussion symptoms include changes in sleeping patterns and difficulty with reasoning concentrating and performing everyday activities 26 30 29 A concussion can result in changes in mood including crankiness loss of interest in favorite activities or items 36 tearfulness 37 and displays of emotion that are inappropriate to the situation 35 Common symptoms in concussed children include restlessness lethargy and irritability 38 Mechanism nbsp Rotational force is key in a concussion Punches in boxing can deliver more rotational force to the head than the typical impact in American football 39 Forces The brain is surrounded by cerebrospinal fluid which protects it from light trauma More severe impacts or the forces associated with rapid acceleration may not be absorbed by this cushion 40 Concussions and other head related injuries occur when external forces acting on the head are transferred to the brain 41 Such forces can occur when the head is struck by an object or surface a direct impact or when the torso rapidly changes position i e from a body check and force is transmitted to the head an indirect impact 41 Forces may cause linear rotational or angular movement of the brain or a combination of them 37 In rotational movement the head turns around its center of gravity and in angular movement it turns on an axis not through its center of gravity 37 The amount of rotational force is thought to be the major component in concussion 42 and its severity 43 As of 2007 studies with athletes have shown that the amount of force and the location of the impact are not necessarily correlated with the severity of the concussion or its symptoms and have called into question the threshold for concussion previously thought to exist at around 70 75 g 44 45 The parts of the brain most affected by rotational forces are the midbrain and diencephalon 46 4 It is thought that the forces from the injury disrupt the normal cellular activities in the reticular activating system located in these areas and that this disruption produces the loss of consciousness often seen in concussion 4 Other areas of the brain that may be affected include the upper part of the brain stem the fornix the corpus callosum the temporal lobe and the frontal lobe 47 Angular accelerations of 4600 5900 or 7900 rad s2 are estimated to have 25 50 or 80 risk of mTBI respectively 48 Pathophysiology In both animals and humans mTBI can alter the brain s physiology for hours to years 49 50 setting into motion a variety of pathological events 51 As one example in animal models after an initial increase in glucose metabolism there is a subsequent reduced metabolic state which may persist for up to four weeks after injury 12 Though these events are thought to interfere with neuronal and brain function the metabolic processes that follow concussion are reversible in a large majority of affected brain cells however a few cells may die after the injury 52 Included in the cascade of events unleashed in the brain by concussion is impaired neurotransmission loss of regulation of ions deregulation of energy use and cellular metabolism and a reduction in cerebral blood flow 52 Excitatory neurotransmitters chemicals such as glutamate that serve to stimulate nerve cells are released in excessive amounts 53 The resulting cellular excitation causes neurons to fire excessively 54 This creates an imbalance of ions such as potassium and calcium across the cell membranes of neurons a process like excitotoxicity 52 At the same time cerebral blood flow is relatively reduced for unknown reasons 27 though the reduction in blood flow is not as severe as it is in ischemia 52 Thus cells get less glucose than they normally do which causes an energy crisis 27 Concurrently with these processes the activity of mitochondria may be reduced which causes cells to rely on anaerobic metabolism to produce energy increasing levels of the byproduct lactate 52 For a period of minutes to days after a concussion the brain is especially vulnerable to changes in intracranial pressure blood flow and anoxia 27 According to studies performed on animals which are not always applicable to humans large numbers of neurons can die during this period in response to slight normally innocuous changes in blood flow 27 Concussion involves diffuse as opposed to focal brain injury meaning that the dysfunction occurs over a widespread area of the brain rather than in a particular spot 55 It is thought to be a milder type of diffuse axonal injury because axons may be injured to a minor extent due to stretching 37 Animal studies in which rodents were concussed have revealed lifelong neuropathological consequences such as ongoing axonal degeneration and neuroinflammation in subcortical white matter tracts 56 Axonal damage has been found in the brains of concussion patients who died from other causes but inadequate blood flow to the brain due to other injuries may have contributed 29 Findings from a study of the brains of deceased NFL athletes who received concussions suggest that lasting damage is done by such injuries This damage the severity of which increases with the cumulative number of concussions sustained can lead to a variety of other health issues 57 The debate over whether concussion is a functional or structural phenomenon is ongoing 58 Structural damage has been found in the mildly traumatically injured brains of animals but it is not clear whether these findings would apply to humans 46 Such changes in brain structure could be responsible for certain symptoms such as visual disturbances but other sets of symptoms especially those of a psychological nature are more likely to be caused by reversible pathophysiological changes in cellular function that occur after concussion such as alterations in neurons biochemistry 43 These reversible changes could also explain why dysfunction is frequently temporary 58 A task force of head injury experts called the Concussion In Sport Group met in 2001 and decided that concussion may result in neuropathological changes but the acute clinical symptoms largely reflect a functional disturbance rather than structural injury 59 Using animal studies the pathology of a concussion seems to start with mechanical shearing and stretching forces disrupting the cell membrane of nerve cells through mechanoporation 60 This results in potassium outflow from within the cell into the extracellular space with the subsequent release of excitatory neurotransmitters including glutamate which leads to enhanced potassium extrusion in turn resulting in sustained depolarization impaired nerve activity and potential nerve damage 60 Human studies have failed to identify changes in glutamate concentration immediately post mTBI though disruptions have been seen 3 days to 2 weeks post injury 60 In an effort to restore ion balance the sodium potassium ion pumps increase activity which results in excessive ATP adenosine triphosphate consumption and glucose utilization quickly depleting glucose stores within the cells 61 Simultaneously inefficient oxidative metabolism leads to anaerobic metabolism of glucose and increased lactate accumulation 61 There is a resultant local acidosis in the brain and increased cell membrane permeability leading to local swelling 61 After this increase in glucose metabolism there is a subsequent lower metabolic state which may persist for up to 4 weeks after injury A completely separate pathway involves a large amount of calcium accumulating in cells which may impair oxidative metabolism and begin further biochemical pathways that result in cell death Again both of these main pathways have been established from animal studies and the extent to which they apply to humans is still somewhat unclear 12 DiagnosisRed flags are warning signs that may indicate a more serious problem and require immediate emergency medical attention Red flag symptoms emergent assessment required 24 Seizure or convulsionsWorsening headacheDifficulty waking up or loss of consciousness Seeing doubleProblem recognizing people or places or confusionRepeated vomitingNumbness weakness in extremities or slurred speechNot usual self aggressive or agitated behaviourNeck pain or tenderness in the neck nbsp Unequal pupil size is not a sign of concussion and can be a sign of a more serious brain injury Head trauma recipients are initially assessed to exclude a more severe emergency such as an intracranial hemorrhage or other serious head or neck injuries This includes the ABCs airway breathing circulation and stabilization of the cervical spine which is assumed to be injured in any athlete who is found to be unconscious after head or neck injury Indications that screening for more serious injury is needed include red flag symptoms or concussion danger signs worsening headaches persisting vomiting increasing disorientation or a deteriorating level of consciousness seizures and unequal pupil size 10 62 63 64 Those with such symptoms or those who are at higher risk of a more serious brain injury require an emergency medical assessment 10 Brain imaging such as a CT scan or MRI may be suggested but should be avoided unless there are progressive neurological symptoms focal neurological findings or concern of skull fracture on exam 65 Diagnosis of concussion requires an assessment performed by a physician or nurse practitioner to rule out severe injuries to the brain and cervical spine mental health conditions or other medical conditions 13 Diagnosis is based on physical and neurological examination findings duration of unconsciousness usually less than 30 minutes and post traumatic amnesia usually less than 24 hours and the Glasgow Coma Scale people with mTBI have scores of 13 to 15 66 A CT scan or MRI is not required to diagnose concussion 13 15 Neuropsychological tests such as the SCAT5 child SCAT5 may be suggested measure cognitive function 11 67 68 Such tests may be administered hours days or weeks after the injury or at different times to demonstrate any trend 69 Some athletes are also being tested pre season pre season baseline testing to provide a baseline for comparison in the event of an injury though this may not reduce risk or affect return to play and baseline testing is not required or suggested for most children and adults 70 71 If the Glasgow coma scale is less than 15 at two hours or less than 14 at any time a CT is recommended 4 In addition a CT scan is more likely to be performed if observation after discharge is not assured or intoxication is present there is suspected increased risk for bleeding age greater than 60 4 or less than 16 Most concussions without complication cannot be detected with MRI or CT scans 42 However changes have been reported on MRI and SPECT imaging in those with concussion and normal CT scans and post concussion syndrome may be associated with abnormalities visible on SPECT and PET scans 52 needs update Mild head injury may or may not produce abnormal EEG readings 72 73 A blood test known as the Brain Trauma Indicator was approved in the United States in 2018 and may be able to rule out the risk of intracranial bleeding and thus the need for a CT scan for adults 74 Concussion may be under diagnosed because of the lack of the highly noticeable signs and symptoms while athletes may minimize their injuries to remain in the competition 75 Direct impact to the head is not required for a concussion diagnosis as other bodily impacts with a subsequent force transmission to the head are also causes 76 A retrospective survey in 2005 suggested that more than 88 of concussions are unrecognized 77 Particularly many younger athletes struggle with identifying their concussions which often result in the non disclosure of concussions and consequently under representing the incidence of concussions in the context of sport 78 Diagnosis can be complex because concussion shares symptoms with other conditions For example post concussion symptoms such as cognitive problems may be misattributed to brain injury when in fact due to post traumatic stress disorder PTSD 79 There are no fluid biomarkers i e blood or urine tests that are validated for diagnosing concussion in children or adolescents 80 Classification No single definition of concussion minor head injury 81 or mild traumatic brain injury is universally accepted 82 In 2001 the expert Concussion in Sport Group of the first International Symposium on Concussion in Sport 59 defined concussion as a complex pathophysiological process affecting the brain induced by traumatic biomechanical forces 33 It was agreed that concussion typically involves temporary impairment of neurological function that heals by itself within time and that neuroimaging normally shows no gross structural changes to the brain as the result of the condition 43 However although no structural brain damage occurs according to the classic definition 83 some researchers have included injuries in which structural damage has occurred and the National Institute for Health and Clinical Excellence definition includes physiological or physical disruption in the brain s synapses 84 Also by definition concussion has historically involved a loss of consciousness However the definition has evolved over time to include a change in consciousness such as amnesia 85 although controversy continues about whether the definition should include only those injuries in which loss of consciousness occurs 46 This debate resurfaces in some of the best known concussion grading scales in which those episodes involving loss of consciousness are graded as being more severe than those without 86 Definitions of mild traumatic brain injury mTBI were inconsistent until the World Health Organization s International Statistical Classification of Diseases and Related Health Problems ICD 10 provided a consistent authoritative definition across specialties in 1992 87 Since then various organizations such as the American Congress of Rehabilitation Medicine 26 and the American Psychiatric Association in its Diagnostic and Statistical Manual of Mental Disorders 87 have defined mTBI using some combination of loss of consciousness post traumatic amnesia and the Glasgow Coma Scale Concussion falls under the classification of mild TBI 88 but it is not clear whether concussion is implied in mild brain injury or mild head injury 89 needs update mTBI and concussion are often treated as synonyms in medical literature 26 but other injuries such as intracranial hemorrhages e g intra axial hematoma epidural hematoma and subdural hematoma are not necessarily precluded in mTBI 43 or mild head injury 90 91 as they are in concussion 92 mTBI associated with abnormal neuroimaging may be considered complicated mTBI 52 Concussion can be considered to imply a state in which brain function is temporarily impaired and mTBI to imply a pathophysiological state but in practice few researchers and clinicians distinguish between the terms 43 Descriptions of the condition including the severity and the area of the brain affected are now used more often than concussion in clinical neurology 93 PreventionMain article Prevention of concussions Prevention of mTBI involves general measures such as wearing seat belts using airbags in cars and protective equipment such as helmets for high risk sports 26 94 Older people are encouraged to reduce fall risk by keeping floors free of clutter and wearing thin flat shoes with hard soles that do not interfere with balance 36 Protective equipment such as helmets and other headgear and policy changes such as the banning of body checking in youth hockey leagues have been found to reduce the number and severity of concussions in athletes 95 Secondary prevention such as a Return to Play Protocol for an athlete may reduce the risk of repeat concussions 96 New Head Impact Telemetry System technology is being placed in helmets to study injury mechanisms and may generate knowledge that will potentially help reduce the risk of concussions among American Football players 97 Educational interventions such as handouts videos workshops and lectures can improve concussion knowledge of diverse groups particularly youth athletes and coaches 98 Strong concussion knowledge may be associated with greater recognition of concussion symptoms higher rates of concussion reporting behaviors and reduced body checking related penalties and injuries thereby lowering risk of mTBI 98 Due to the incidence of concussion in sport younger athletes often do not disclose concussions and their symptoms Common reasons for non disclosure include a lack of awareness of the concussion the belief that the concussion was not serious enough and not wanting to leave the game or team due to their injury 78 Self reported concussion rates among U 20 and elite rugby union players in Ireland are 45 48 indicating that many concussions go unreported 39 Changes to the rules or enforcing existing rules in sports such as those against head down tackling or spearing which is associated with a high injury rate may also prevent concussions 39 TreatmentAdults and children with a suspected concussion require a medical assessment with a doctor or nurse practitioner to confirm the diagnosis of concussion and rule out more serious head injuries After life threatening head injuries injuries to the cervical spine and neurological conditions are ruled out exclusion of neck or head injury observation should be continued for several hours If repeated vomiting worsening headache dizziness seizure activity excessive drowsiness double vision slurred speech unsteady walk or weakness or numbness in arms or legs or signs of basilar skull fracture develop immediate assessment in an emergency department is needed 11 12 Observation to monitor for worsening condition is an important part of treatment 13 People may be released after assessment from their primary care medical clinic hospital or emergency room to the care of a trusted person with instructions to return if they display worsening symptoms or those that might indicate an emergent condition red flag symptoms such as change in consciousness convulsions severe headache extremity weakness vomiting new bleeding or deafness in either or both ears 99 24 13 Education about symptoms their management and their normal time course may lead to an improved outcome 82 needs update Rest and return to physical and cognitive activity Physical and cognitive rest is recommended for the first 24 48 hours following a concussion after which injured persons should gradually start gentle low risk physical and cognitive activities that do not make current symptoms worse or bring on new symptoms 11 100 Any activity for which there is a risk of contact falling or bumping the head should be avoided until the person has clearance from a doctor or nurse practitioner 13 11 24 Low risk activities can be started even while a person has symptoms as long as the activity does not worsen existing symptoms or bring on new concussion symptoms 24 15 Resting completely for longer than 24 48 hours follow concussion has been shown to be associated with longer recovery 101 Return to school The resumption of low risk school activities should begin as soon as the student feels ready and has completed an initial period of cognitive rest of no more than 24 48 hours following the acute injury 101 102 Long absences from school are not suggested however the return to school should be gradual and step wise 102 Prolonged complete mental or physical rest beyond 24 48 hours after the accident that lead to the concussion may worsen outcomes 102 however rushing back to full school work load before the person is ready has also been associated with longer lasting symptoms and an extended recovery time 103 Students with a suspected concussion are required to see a doctor for an initial medical assessment and for suggestions on recovery however medical clearance is not required for a student to return to school 24 Since students may appear normal continuing education of relevant school personnel may be needed to ensure appropriate accommodations are made such as part days and extended deadlines 101 Accommodations should be based on the monitoring of symptoms that are present during the return to school transition including headaches dizziness vision problems memory loss difficulty concentrating and abnormal behavior 101 103 Students must have completely resumed their school activities without requiring concussion related academic supports before returning to full contact or competitive sports 24 Return to sport For persons participating in athletics it is suggested that participants progress through a series of graded steps 11 These steps include Stage 1 Immediately after injury 24 48 hours maximum of relative physical and cognitive rest 11 This can include gentle daily activities such as walking in the house gentle housework and light school work that do not make symptoms worse No sports activities Stage 2 Light aerobic activity such as walking or stationary cycling Stage 3 Sport specific activities such as running drills and skating drills Stage 4 Non contact training drills exercise coordination and cognitive load Stage 5 Full contact practice requires medical clearance Stage 6 Return to full contact sport or high risk activities requires medical clearance At each step the person should not have worsening or new symptoms for at least 24 hours before progressing to the next If symptoms worsen or new symptoms begin athletes should drop back to the previous level for at least another 24 hours 11 Intercollegiate or professional athletes are typically followed closely by team athletic trainers during this period but others may not have access to this level of health care and may be sent home with minimal monitoring Medications Medications may be prescribed to treat headaches sleep problems and depression 82 Analgesics such as ibuprofen can be taken for headaches 43 but paracetamol acetaminophen is preferred to minimize the risk of intracranial hemorrhage 104 Concussed individuals are advised not to use alcohol or other drugs that have not been approved by a doctor as they can impede healing 105 Activation database guided EEG biofeedback has been shown to return the memory abilities of the concussed individual to levels better than the control group 106 About one percent of people who receive treatment for mTBI need surgery for a brain injury 66 Return to work Determining the ideal time for a person to return to work will depend on personal factors and job related factors including the intensity of the job and the risk of falling or hitting one s head at work during recovery 13 After the required initial recovery period of complete rest 24 48 hours after the concussion began gradually and safely returning to the workplace with accommodations and support in place should be prioritized over staying home and resting for long periods of time to promote physical recovery and reduce the risk of people becoming socially isolated 13 The person should work with their employer to design a step wise return to work plan 13 For those with a high risk job medical clearance may be required before resuming an activity that could lead to another head injury 13 Students should have completed the full return to school progression with no academic accommodations related to the concussion required before starting to return to part time work 24 PrognosisThe majority of children and adults fully recover from a concussion however some may experience a prolonged recovery 107 108 There is no single physical test blood test or fluid biomarkers or imaging test that can be used to determine when a person has fully recovered from concussion 109 A person s recovery may be influenced by a variety of factors that include age at the time of injury intellectual abilities family environment social support system occupational status coping strategies and financial circumstances 110 Factors such as a previous head injury or a coexisting medical condition have been found to predict longer lasting post concussion symptoms 111 Other factors that may lengthen recovery time after mTBI include psychological problems such as substance abuse or clinical depression poor health before the injury or additional injuries sustained during it and life stress 52 Longer periods of amnesia or loss of consciousness immediately after the injury may indicate longer recovery times from residual symptoms 112 Other strong factors include participation in a contact sport and body mass size 113 Pediatric concussion Most children recover completely from concussion in less than four weeks however 15 30 of youth may experience symptoms that last longer than a month 114 115 101 People aged 65 with concussion Mild traumatic brain injury recovery time in people over age 65 may have increased complications due to elevated health concerns or comorbidities 116 This often results in longer hospitalization duration poorer cognitive outcomes and higher mortality rates 116 Repeat concussion For unknown reasons having had one concussion significantly increases a person s risk of having another 69 22 Having previously sustained a sports concussion has been found to be a strong factor increasing the likelihood of a concussion in the future People who have had a concussion seem more susceptible to another one particularly if the new injury occurs before symptoms from the previous concussion have completely gone away It is also a negative process if smaller impacts cause the same symptom severity 117 Repeated concussions may increase a person s risk in later life for dementia Parkinson s disease and depression 22 Post concussion syndrome Main article Post concussion syndrome In post concussion syndrome symptoms do not resolve for weeks months or years after a concussion and may occasionally be permanent 118 About 10 to 20 of people have post concussion syndrome for more than a month 114 Symptoms may include headaches dizziness fatigue anxiety memory and attention problems sleep problems and irritability 119 Rest a previously recommended recovery technique has limited effectiveness 120 A recommended treatment in both children and adults with symptoms beyond 4 weeks involves an active rehabilitation program with reintroduction of non contact aerobic activity 115 Progressive physical exercise has been shown to reduce long term post concussive symptoms 115 Symptoms usually go away on their own within months 92 but may last for years 121 56 The question of whether the syndrome is due to structural damage or other factors such as psychological ones or a combination of these has long been the subject of debate 79 Cumulative effects As of 1999 cumulative effects of concussions were poorly understood especially the effects on children The severity of concussions and their symptoms may worsen with successive injuries even if a subsequent injury occurs months or years after an initial one 122 Symptoms may be more severe and changes in neurophysiology can occur with the third and subsequent concussions 69 As of 2006 studies had conflicting findings on whether athletes have longer recovery times after repeat concussions and whether cumulative effects such as impairment in cognition and memory occur 39 Cumulative effects may include chronic traumatic encephalopathy psychiatric disorders and loss of long term memory For example the risk of developing clinical depression has been found to be significantly greater for retired American football players with a history of three or more concussions than for those with no concussion history 123 An experience of three or more concussions is associated with a fivefold greater chance of developing Alzheimer s disease earlier and a threefold greater chance of developing memory deficits 123 Chronic traumatic encephalopathy or CTE is an example of the cumulative damage that can occur as the result of multiple concussions or less severe blows to the head The condition was previously referred to as dementia pugilistica or punch drunk syndrome as it was first noted in boxers The disease can lead to cognitive and physical disabilities such as parkinsonism speech and memory problems slowed mental processing tremor depression and inappropriate behavior 124 It shares features with Alzheimer s disease 125 Second impact syndrome Main article Second impact syndrome Second impact syndrome in which the brain swells dangerously after a minor blow may occur in very rare cases 126 The condition may develop in people who receive a second blow days or weeks after an initial concussion before its symptoms have gone away 27 No one is certain of the cause of this often fatal complication but it is commonly thought that the swelling occurs because the brain s arterioles lose the ability to regulate their diameter causing a loss of control over cerebral blood flow 69 As the brain swells intracranial pressure rapidly rises 63 The brain can herniate and the brain stem can fail within five minutes 27 Except in boxing all cases have occurred in athletes under age 20 53 Due to the very small number of documented cases the diagnosis is controversial and doubt exists about its validity 127 A 2010 Pediatrics review article stated that there is debate whether the brain swelling is due to two separate hits or to just one hit but in either case catastrophic football head injuries are three times more likely in high school athletes than in college athletes 12 Epidemiology nbsp Annual incidence of MTBI by age group in Canada 128 Most cases of traumatic brain injury are concussions A World Health Organization WHO study estimated that between 70 and 90 of head injuries that receive treatment are mild 3 However due to under reporting and to the widely varying definitions of concussion and mTBI it is difficult to estimate how common the condition is 87 Estimates of the incidence of concussion may be artificially low for example due to under reporting At least 25 of people with mTBI fail to get assessed by a medical professional 52 The WHO group reviewed studies on the epidemiology of mTBI and found a hospital treatment rate of 1 3 per 1000 people but since not all concussions are treated in hospitals they estimated that the rate per year in the general population is over 6 per 1000 people 3 Age Young children have the highest concussion rate among all age groups 4 However most people with a concussion are young adults 118 A Canadian study found that the yearly incidence of mTBI is lower in older age groups graph at right 128 Studies suggest males develop mTBI at about twice the rate of their female counterparts 3 However female athletes may be at a higher risk of sustaining a concussion than their male counterparts 129 Sports Up to five percent of sports injuries are concussions 53 The U S Centers for Disease Control and Prevention estimates that 300 000 sports related concussions occur yearly in the U S but that number includes only athletes who lost consciousness 130 Since loss of consciousness is thought to occur in less than 10 of concussions 131 the CDC estimate is likely lower than the real number 130 Sports in which concussion is particularly common include American football the rugby codes MMA and boxing a boxer aims to knock out i e give a mild traumatic brain injury to the opponent The injury is so common in the latter that several medical groups have called for a ban on the sport including the American Academy of Neurology the World Medical Association and the medical associations of the UK the US Australia and Canada 132 Workplace Concussions may also be common and occur in the workplace According to the US Bureau of Labour Statistics the most common causes of mTBI related hospitalizations and deaths from the workplace are falls force of heavy objects and vehicular collisions 133 As a consequence jobs in the construction transportation and natural resource industries e g agriculture fishing mining have more elevated mTBI incidence rates ranging from 10 to 20 cases per 100 000 workers 133 In particular as vehicular collisions are the leading cause of workplace mTBI related injuries workers from the transportation sector often carry the most risk 134 Despite these findings there still remain important gaps in data compilation on workplace related mTBIs which has raised questions about increased concussion surveillance and preventive measures in private industry 134 History nbsp The Hippocratic Corpus mentioned concussion 112 The Hippocratic Corpus a collection of medical works from ancient Greece mentions concussion later translated to commotio cerebri and discusses loss of speech hearing and sight that can result from commotion of the brain 112 This idea of disruption of mental function by shaking of the brain remained the widely accepted understanding of concussion until the 19th century 112 In the 10th century the Persian physician Muhammad ibn Zakariya Razi was the first to write about concussion as distinct from other types of head injury 58 He may have been the first to use the term cerebral concussion and his definition of the condition a transient loss of function with no physical damage set the stage for the medical understanding of the condition for centuries 37 In the 13th century the physician Lanfranc of Milan s Chiurgia Magna described concussion as brain commotion also recognizing a difference between concussion and other types of traumatic brain injury though many of his contemporaries did not and discussing the transience of post concussion symptoms as a result of temporary loss of function from the injury 58 In the 14th century the surgeon Guy de Chauliac pointed out the relatively good prognosis of concussion as compared to more severe types of head trauma such as skull fractures and penetrating head trauma 58 In the 16th century the term concussion came into use and symptoms such as confusion lethargy and memory problems were described 58 The 16th century physician Ambroise Pare used the term commotio cerebri 37 as well as shaking of the brain commotion and concussion 112 nbsp Guillaume Dupuytren distinguished between concussion and unconsciousness associated with brain contusion 112 Until the 17th century a concussion was usually described by its clinical features but after the invention of the microscope more physicians began exploring underlying physical and structural mechanisms 58 However the prevailing view in the 17th century was that the injury did not result from physical damage and this view continued to be widely held throughout the 18th century 58 The word concussion was used at the time to describe the state of unconsciousness and other functional problems that resulted from the impact rather than a physiological condition 58 In 1839 Guillaume Dupuytren described brain contusions which involve many small hemorrhages as contusio cerebri and showed the difference between unconsciousness associated with damage to the brain parenchyma and that due to concussion without such injury 112 In 1941 animal experiments showed that no macroscopic damage occurs in concussion 112 135 Society and cultureCosts Due to the lack of a consistent definition the economic costs of mTBI are not known but they are estimated to be very high 136 These high costs are due in part to the large percentage of hospital admissions for head injury that is due to mild head trauma 89 but indirect costs such as lost work time and early retirement account for the bulk of the costs 136 These direct and indirect costs cause the expense of mild brain trauma to rival that of moderate and severe head injuries 137 Terminology The terms mild brain injury mild traumatic brain injury mTBI mild head injury MHI and concussion may be used interchangeably 138 87 although the term concussion is still used in sports literature as interchangeable with MHI or mTBI the general clinical medical literature uses mTBI instead since a 2003 CDC report outlined it as an important strategy 75 37 In this article concussion and mTBI are used interchangeably The term concussion is from Latin concutere to shake violently 46 or concussus action of striking together 139 ResearchMinocycline lithium and N acetylcysteine show tentative success in animal models 140 Measurement of predictive visual tracking is being studied as a screening technique to identify mild traumatic brain injury A head mounted display unit with eye tracking capability shows a moving object in a predictive pattern for the person to follow with their eyes People without brain injury will be able to track the moving object with smooth pursuit eye movements and correct trajectory while it is hypothesized that those with mild traumatic brain injury cannot 141 Grading systems Main article Concussion grading systems National and international clinical practice guidelines do not recommend a concussion grading system for use by medical professionals 142 13 115 Historical information on grading systems In the past the decision to allow athletes to return to participation was frequently based on the grade of concussion 143 However current research and recommendations by professional organizations including the National Athletic Trainers Association recommend against such use of these grading systems citation needed Currently injured athletes are prohibited from returning to play before they are symptom free during both rest and exertion and until results of the neuropsychological tests have returned to pre injury levels 144 Three grading systems have been most widely followed by Robert Cantu the Colorado Medical Society and the American Academy of Neurology 86 Each employs three grades as summarized in the following table 28 Comparison of historic concussion grading scales not currently recommended for use by medical professionals Guidelines Grade I Grade II Grade IIICantu Post traumatic amnesia lt 30 minutes no loss of consciousness Loss of consciousness lt 5 minutes or amnesia lasting 30 minutes 24 hours Loss of consciousness gt 5 minutes or amnesia gt 24 hoursColorado Medical Society Confusion no loss of consciousness Confusion post traumatic amnesia no loss of consciousness Any loss of consciousnessAmerican Academy of Neurology Confusion symptoms last lt 15 minutes no loss of consciousness Symptoms last gt 15 minutes no 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International Conference on Concussion in Sport Zurich November 2012 Journal of Athletic Training 48 4 554 575 doi 10 4085 1062 6050 48 4 05 PMC 3715021 PMID 23855364 Further readingHarrison Emily A The first concussion crisis head injury and evidence in early American football American journal of public health 104 5 2014 822 833 onlineShurley Jason P and Janice S Todd Boxing lessons An historical review of chronic head trauma in boxing and football Kinesiology Review 1 3 2012 170 184 onlineExternal links nbsp Share your views on sports related concussions with Wikiversity Facts about Concussion and Brain Injury and Where to Get Help US Centers for Disease Control and Prevention Concussion in High School Sports US Centers for Disease Control and Prevention 2018 CDC Guideline on MTBI in children Retrieved from https en wikipedia org w index php title Concussion amp oldid 1182734395, wikipedia, wiki, book, books, library,

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