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Charles David Allis

April 12, 2024

Charles David Allis (March 22, 1951 – January 8, 2023) was an American molecular biologist, and the Joy and Jack Fishman Professor at the Rockefeller University. He was also the Head of the Laboratory of Chromatin Biology and Epigenetics, and a professor at the Tri-Institutional MD–PhD Program (the other two institutions being the Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine).[4]

Early life and education edit

Allis was born and raised in Cincinnati, Ohio. His father was a city planner and his mother an elementary school teacher.[5] He entered the University of Cincinnati in 1969, majoring in biology. He had his first experience of basic research in his senior (or fourth) year of Bachelor of Science. The experience attracted him to research, and he went to Indiana University Bloomington for graduate studies.[6] He graduated with an MSc in 1975 and a PhD three years later, under the supervision of Anthony Mahowald.[4][6]

Career edit

Allis undertook a postdoctoral fellowship in the University of Rochester after obtaining his PhD.[6] In 1981, he joined the Baylor College of Medicine as an assistant professor in the Department of Biochemistry and Department of Cell Biology, and was promoted to associate professor in 1986 and full professor in 1989.[4] He joined the Department of Biology at Syracuse University College of Arts and Sciences in 1990.[7]

Allis returned to the University of Rochester in 1995, and became the Marie Curran Wilson and Joseph Chamberlain Wilson Professor of Biology two years later.[8] In 1998, Allis went to the Department of Biochemistry and Molecular Genetics at the University of Virginia School of Medicine.[9] He joined the Rockefeller University in 2003 as the Joy and Jack Fishman Professor and Head of the Laboratory of Chromatin Biology and Epigenetics.[4]

Allis had been treated for cancer.[3] He died January 8, 2023, at a hospital in Seattle, Washington.[3]

Research edit

 
Scholia has a profile for Charles David Allis (Q1064064).

Allis was known for his research of histone modifications and their relation to chromatin structure. He started working on Tetrahymena, a ciliated unicellular eukaryote. Tetrahymena is an ideal candidate to study histone acetylation due to its dual nucleus. It has a larger macronucleus that is transcriptionally active and somatic, and a smaller micronucleus that is transcriptionally silent and germline.[10] Chromatin biology at the time was not a popular topic; nor was the use of ciliated organisms.[6]

In 1996, his group isolated the histone acetyltransferase p55 from Tetrahymena, an enzyme that acetylates histones, and found the enzyme was homologous to Gcn5p, a known transcriptional co-activator in yeast.[11][12] This was the first time that histone acetyltransferases were connected to DNA transcription activation,[13] verifying Vincent Allfrey's hypothesis in the 1960s that histone acetylation regulates transcription.[14][15]

Following this seminal report, Allis continued studying histone acetylation, discovering more histone acetyltransferases, including TAF1 (part of the transcription factor TFIID needed to initiate transcription).[16] Allis also branched off to researching histone phosphorylation and histone methylation. He linked histone phosphorylation to mitosis and mitogen stimulation,[17][18] and established a synergistic relationship between histone phosphorylation and acetylation.[19] He also determined the role of methylation at lysine 9 of histone H3,[20] identified SET domain-containing proteins as histone methyltransferase,[21] and found that histone ubiquitylation regulates histone methylation.[22]

In 2000, Allis and Brian Strahl proposed the "histone code hypothesis", which states that DNA transcription is largely regulated by histone modifications.[23] Later, Allis (together with Thomas Jenuwein) explicitly associated the histone code with epigenetics,[24] and recognized the clinical significance of histone modifications, especially in cancers.[25][26]

In more recent years, his attention turned to "oncohistones", which are histones with mutations that distort normal histone modifications, leading to cancers.[27][28]

Honors and awards edit

Allis was a member of Phi Beta Kappa when he graduated from the University of Cincinnati.[8]

The C. David Allis Mentorship Fund for Young Scientists at the Rockefeller University was established in his honor.[46][47]

References edit

  1. ^ . Department of Biology, Indiana University Bloomington. September 11, 2018. Archived from the original on February 1, 2023. Retrieved February 1, 2023.
  2. ^ a b . The Cincinnati Enquirer. January 14, 2023. Archived from the original on January 17, 2023. Retrieved January 30, 2023.
  3. ^ a b c Murphy, Brian (January 21, 2023). "David Allis, researcher who explored 'on-off' switch in genes, dies at 71". The Washington Post. Archived from the original on January 23, 2023. Retrieved January 23, 2023.
  4. ^ a b c d . Rockefeller University. Archived from the original on January 30, 2023. Retrieved January 30, 2023.
  5. ^ . Gruber Foundation. Archived from the original on February 7, 2023. Retrieved February 7, 2023.
  6. ^ a b c d Downey, Philip (2006). "Profile of C. David Allis". Proceedings of the National Academy of Sciences. 103 (17): 6425–6427. Bibcode:2006PNAS..103.6425D. doi:10.1073/pnas.0602256103. PMC 1458902. PMID 16618930.
  7. ^ Scalese, Sarah (February 4, 2014). . Syracuse University. Archived from the original on October 19, 2021. Retrieved October 19, 2021.
  8. ^ a b . University of Rochester. July 25, 1997. Archived from the original on October 16, 2019. Retrieved October 16, 2019.
  9. ^ . University of Virginia School of Medicine. January 24, 2023. Archived from the original on February 11, 2023. Retrieved February 11, 2023.
  10. ^ Goldfarb, David S.; Gorovsky, Martin A. (2009). (PDF). Current Biology. 19 (11): R449–R452. doi:10.1016/j.cub.2009.04.023. PMID 19515351. S2CID 9841779. Archived from the original (PDF) on February 14, 2023. Retrieved February 14, 2023.
  11. ^ (PDF). Japan Prize. Archived from the original (PDF) on February 15, 2023. Retrieved February 15, 2023.
  12. ^ Brownell, James E.; Zhou, Jianxin; Ranalli, Tamara; Kobayashi, Ryuji; Edmondson, Diane G.; Roth, Sharon Y.; Allis, C. David (1996). "Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation". Cell. 84 (6): 843–851. doi:10.1016/S0092-8674(00)81063-6. PMID 8601308.
  13. ^ Allis, C. David (2015). ""Modifying" My Career toward Chromatin Biology". Journal of Biological Chemistry. 290 (26): 15904–15908. doi:10.1074/jbc.X115.663229. PMC 4481195. PMID 25944906.
  14. ^ Allfrey, V. G.; Faulkner, R.; Mirsky, A. E. (1964). "Acetylation and methylation of histones and their possible role in the regulation of rna synthesis". Proceedings of the National Academy of Sciences. 51 (5): 786–794. Bibcode:1964PNAS...51..786A. doi:10.1073/pnas.51.5.786. PMC 300163. PMID 14172992.
  15. ^ Allis, C. David (2018). "Pursuing the Secrets of Histone Proteins: An Amazing Journey with a Remarkable Supporting Cast". Cell. 175 (1): 18–21. doi:10.1016/j.cell.2018.08.022. PMID 30217363.
  16. ^ Mizzen, Craig A.; Yang, Xiang-Jiao; Kokubo, Tetsuro; Brownell, James E.; Bannister, Andrew J.; Owen-Hughes, Tom; Workman, Jerry; Wang, Lian; Berger, Shelley L.; Kouzarides, Tony; Nakatani, Yoshihiro; Allis, C. David (1996). (PDF). Cell. 87 (7): 1261–1270. doi:10.1016/S0092-8674(00)81821-8. PMID 8980232. Archived from the original (PDF) on April 15, 2019. Retrieved February 16, 2023.
  17. ^ Hendzel, Michael J.; Wei, Yi; Mancini, Michael A.; Van Hooser, Aaron; Ranalli, Tamara; Brinkley, B. R.; Bazett-Jones, David P.; Allis, C. David (1997). "Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation". Chromosoma. 106 (6): 348–360. doi:10.1007/s004120050256. PMID 9362543. S2CID 29723188. Retrieved February 17, 2023.
  18. ^ Hsu, Jer-Yuan; Sun, Zu-Wen; Li, Xiumin; Reuben, Melanie; Tatchell, Kelly; Bishop, Douglas K.; Grushcow, Jeremy M.; Brame, Cynthia J.; Caldwell, Jennifer A.; Hunt, Donald F.; Lin, Rueyling; Smith, M. Mitchell; Allis, C. David (2000). "Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes". Cell. 102 (3): 279–291. doi:10.1016/S0092-8674(00)00034-9. PMID 10975519.
  19. ^ Cheung, Peter; Tanner, Kirk G.; Cheung, Wang L.; Sassone-Corsi, Paolo; Denu, John M.; Allis, C. David (2000). "Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation". Molecular Cell. 5 (6): 905–915. doi:10.1016/s1097-2765(00)80256-7. PMID 10911985.
  20. ^ Rice, Judd C.; Briggs, Scott D.; Ueberheide, Beatrix; Barber, Cynthia M.; Shabanowitz, Jeffrey; Hunt, Donald F.; Shinkai, Yoichi; Allis, C. David (2003). "Histone Methyltransferases Direct Different Degrees of Methylation to Define Distinct Chromatin Domains". Molecular Cell. 12 (6): 1591–1598. doi:10.1016/s1097-2765(03)00479-9. PMID 14690610.
  21. ^ Strahl, Brian D.; Grant, Patrick A.; Briggs, Scott D.; Sun, Zu-Wen; Bone, James R.; Caldwell, Jennifer A.; Mollah, Sahana; Cook, Richard G.; Shabanowitz, Jeffrey; Hunt, Donald F.; Allis, C. David (2002). "Set2 Is a Nucleosomal Histone H3-Selective Methyltransferase That Mediates Transcriptional Repression". Molecular and Cellular Biology. 22 (5): 1298–1306. doi:10.1128/MCB.22.5.1298-1306.2002. PMC 134702. PMID 11839797.
  22. ^ Sun, Zu-Wen; Allis, C. David (2002). "Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast". Nature. 418 (6893): 104–108. Bibcode:2002Natur.418..104S. doi:10.1038/nature00883. PMID 12077605. S2CID 4338471. Retrieved February 18, 2023.
  23. ^ Strahl, Brian D.; Allis, C. David (2000). "The language of covalent histone modifications". Nature. 403 (6765): 41–45. Bibcode:2000Natur.403...41S. doi:10.1038/47412. PMID 10638745. S2CID 4418993. Retrieved February 19, 2023.
  24. ^ Jenuwein, Thomas; Allis, C. David (2001). . Science. 293 (5532): 1074–1080. CiteSeerX 10.1.1.453.900. doi:10.1126/science.1063127. PMID 11498575. S2CID 1883924. Archived from the original on February 20, 2023. Retrieved February 20, 2023.
  25. ^ Chi, Ping; Allis, C. David; Wang, Gang Greg (2010). "Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers". Nature Reviews Cancer. 10 (7): 457–469. doi:10.1038/nrc2876. PMC 3262678. PMID 20574448.
  26. ^ Dent, Sharon; Grewal, Shiv (2023). "C. David Allis (1951–2023)". Nature. 614 (7948): 409. Bibcode:2023Natur.614..409D. doi:10.1038/d41586-023-00346-0. PMID 36737544. S2CID 256577181.
  27. ^ Nacev, Benjamin A.; Feng, Lijuan; Bagert, John D.; Lemiesz, Agata E.; Gao, JianJiong; Soshnev, Alexey A.; Kundra, Ritika; Schultz, Nikolaus; Muir, Tom W.; Allis, C. David (2019). "The expanding landscape of 'oncohistone' mutations in human cancers". Nature. 567 (7749): 473–478. Bibcode:2019Natur.567..473N. doi:10.1038/s41586-019-1038-1. PMC 6512987. PMID 30894748.
  28. ^ Berger, Shelley L. (2023). "C. David Allis (1951–2023)". Science. 379 (6633): 645. Bibcode:2023Sci...379..645B. doi:10.1126/science.adg7738. PMID 36795814. S2CID 256901502.
  29. ^ . American Academy of Arts and Sciences. Archived from the original on February 3, 2023. Retrieved February 3, 2023.
  30. ^ . Dickson Prize. Archived from the original on December 25, 2022. Retrieved February 3, 2023.
  31. ^ . University of Southern California Keck School of Medicine. Archived from the original on December 5, 2022. Retrieved December 5, 2022.
  32. ^ . Wiley Foundation. January 27, 2004. Archived from the original on February 5, 2023. Retrieved February 5, 2023.
  33. ^ . National Academy of Sciences. Archived from the original on February 5, 2023. Retrieved February 5, 2023.
  34. ^ . University of Cincinnati College of Arts and Sciences. Archived from the original on December 4, 2022. Retrieved February 6, 2023.
  35. ^ . Gairdner Foundation. Archived from the original on December 6, 2021. Retrieved February 6, 2023.
  36. ^ . American Society for Biochemistry and Molecular Biology. Archived from the original on February 6, 2023. Retrieved February 6, 2023.
  37. ^ . Brandeis University. Archived from the original on February 6, 2023. Retrieved February 6, 2023.
  38. ^ . Japan Prize. Archived from the original on February 2, 2023. Retrieved February 6, 2023.
  39. ^ (in French). French Academy of Sciences. Archived from the original on February 7, 2023. Retrieved February 7, 2023.
  40. ^ . Breakthrough Prize Board. Archived from the original on January 16, 2023. Retrieved January 16, 2023.
  41. ^ . Gruber Foundation. Archived from the original on February 1, 2023. Retrieved February 1, 2022.
  42. ^ . March of Dimes. May 8, 2017. Archived from the original on February 8, 2023. Retrieved February 8, 2022.
  43. ^ . Lasker Foundation. Archived from the original on February 8, 2023. Retrieved February 8, 2022.
  44. ^ National Academy of Medicine. Archived from the original on February 8, 2023. Retrieved February 8, 2023.
  45. ^ (Press release). Albany Medical College. October 13, 2022. Archived from the original on October 14, 2022. Retrieved October 14, 2022.
  46. ^ . Rockefeller University. January 14, 2023. Archived from the original on February 16, 2023. Retrieved February 16, 2023.
  47. ^ . Rockefeller University. Archived from the original on February 16, 2023. Retrieved February 16, 2023.

April 12, 2024
charles, david, allis, march, 1951, january, 2023, american, molecular, biologist, jack, fishman, professor, rockefeller, university, also, head, laboratory, chromatin, biology, epigenetics, professor, institutional, program, other, institutions, being, memori. Charles David Allis March 22 1951 January 8 2023 was an American molecular biologist and the Joy and Jack Fishman Professor at the Rockefeller University He was also the Head of the Laboratory of Chromatin Biology and Epigenetics and a professor at the Tri Institutional MD PhD Program the other two institutions being the Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine 4 Charles David AllisBorn 1951 03 22 March 22 1951 2 Cincinnati OhioDiedJanuary 8 2023 2023 01 08 aged 71 2 Seattle Washington 3 EducationUniversity of Cincinnati BSc Indiana University MSc PhD Known forResearch of histone modificationsAwardsCanada Gairdner International Award Japan Prize Grand Prix Charles Leopold Mayer Breakthrough Prize in Life Sciences Gruber Prize in Genetics Albert Lasker Award for Basic Medical Research Albany Medical Center PrizeScientific careerFieldsEpigeneticsInstitutionsRockefeller University University of Virginia University of Rochester Baylor College of MedicineThesisIsolation and characterization of pole cells and polar granules from embryos ofDrosophila melanogaster 1978 Doctoral advisorAnthony Mahowald 1 Contents 1 Early life and education 2 Career 3 Research 4 Honors and awards 5 ReferencesEarly life and education editAllis was born and raised in Cincinnati Ohio His father was a city planner and his mother an elementary school teacher 5 He entered the University of Cincinnati in 1969 majoring in biology He had his first experience of basic research in his senior or fourth year of Bachelor of Science The experience attracted him to research and he went to Indiana University Bloomington for graduate studies 6 He graduated with an MSc in 1975 and a PhD three years later under the supervision of Anthony Mahowald 4 6 Career editAllis undertook a postdoctoral fellowship in the University of Rochester after obtaining his PhD 6 In 1981 he joined the Baylor College of Medicine as an assistant professor in the Department of Biochemistry and Department of Cell Biology and was promoted to associate professor in 1986 and full professor in 1989 4 He joined the Department of Biology at Syracuse University College of Arts and Sciences in 1990 7 Allis returned to the University of Rochester in 1995 and became the Marie Curran Wilson and Joseph Chamberlain Wilson Professor of Biology two years later 8 In 1998 Allis went to the Department of Biochemistry and Molecular Genetics at the University of Virginia School of Medicine 9 He joined the Rockefeller University in 2003 as the Joy and Jack Fishman Professor and Head of the Laboratory of Chromatin Biology and Epigenetics 4 Allis had been treated for cancer 3 He died January 8 2023 at a hospital in Seattle Washington 3 Research edit nbsp Scholia has a profile for Charles David Allis Q1064064 Allis was known for his research of histone modifications and their relation to chromatin structure He started working on Tetrahymena a ciliated unicellular eukaryote Tetrahymena is an ideal candidate to study histone acetylation due to its dual nucleus It has a larger macronucleus that is transcriptionally active and somatic and a smaller micronucleus that is transcriptionally silent and germline 10 Chromatin biology at the time was not a popular topic nor was the use of ciliated organisms 6 In 1996 his group isolated the histone acetyltransferase p55 from Tetrahymena an enzyme that acetylates histones and found the enzyme was homologous to Gcn5p a known transcriptional co activator in yeast 11 12 This was the first time that histone acetyltransferases were connected to DNA transcription activation 13 verifying Vincent Allfrey s hypothesis in the 1960s that histone acetylation regulates transcription 14 15 Following this seminal report Allis continued studying histone acetylation discovering more histone acetyltransferases including TAF1 part of the transcription factor TFIID needed to initiate transcription 16 Allis also branched off to researching histone phosphorylation and histone methylation He linked histone phosphorylation to mitosis and mitogen stimulation 17 18 and established a synergistic relationship between histone phosphorylation and acetylation 19 He also determined the role of methylation at lysine 9 of histone H3 20 identified SET domain containing proteins as histone methyltransferase 21 and found that histone ubiquitylation regulates histone methylation 22 In 2000 Allis and Brian Strahl proposed the histone code hypothesis which states that DNA transcription is largely regulated by histone modifications 23 Later Allis together with Thomas Jenuwein explicitly associated the histone code with epigenetics 24 and recognized the clinical significance of histone modifications especially in cancers 25 26 In more recent years his attention turned to oncohistones which are histones with mutations that distort normal histone modifications leading to cancers 27 28 Honors and awards editMember of the American Academy of Arts and Sciences 2001 29 Dickson Prize in Medicine 2002 30 Massry Prize 2003 31 Wiley Prize in Biomedical Sciences 2004 32 Member of the National Academy of Sciences 2005 33 Distinguished Alumnus Award University of Cincinnati College of Arts and Sciences 2007 34 Gairdner Foundation International Award 2007 35 American Society for Biochemistry and Molecular Biology Merck Award 2008 36 Lewis S Rosenstiel Award for Distinguished Work in Basic Medical Research 2010 37 Japan Prize 2014 38 Grand Prix Charles Leopold Mayer 2014 39 Breakthrough Prize in Life Sciences 2015 40 Gruber Prize in Genetics 2016 41 March of Dimes Prize in Developmental Biology 2017 42 Albert Lasker Award for Basic Medical Research 2018 43 Member of the National Academy of Medicine 2019 44 Albany Medical Center Prize 2022 45 Allis was a member of Phi Beta Kappa when he graduated from the University of Cincinnati 8 The C David Allis Mentorship Fund for Young Scientists at the Rockefeller University was established in his honor 46 47 References edit Alum C David Allis wins 2018 Lasker Award Department of Biology Indiana University Bloomington September 11 2018 Archived from the original on February 1 2023 Retrieved February 1 2023 a b Charles David Allis Dave The Cincinnati Enquirer January 14 2023 Archived from the original on January 17 2023 Retrieved January 30 2023 a b c Murphy Brian January 21 2023 David Allis researcher who explored on off switch in genes dies at 71 The Washington Post Archived from the original on January 23 2023 Retrieved January 23 2023 a b c d C David Allis Ph D 1951 2023 Rockefeller University Archived from the original on January 30 2023 Retrieved January 30 2023 C David Allis Gruber Foundation Archived from the original on February 7 2023 Retrieved February 7 2023 a b c d Downey Philip 2006 Profile of C David Allis Proceedings of the National Academy of Sciences 103 17 6425 6427 Bibcode 2006PNAS 103 6425D doi 10 1073 pnas 0602256103 PMC 1458902 PMID 16618930 Scalese Sarah February 4 2014 Former SU professor named Japan Prize Laureate Syracuse University Archived from the original on October 19 2021 Retrieved October 19 2021 a b C David Allis Named Wilson Professor of Biology University of Rochester July 25 1997 Archived from the original on October 16 2019 Retrieved October 16 2019 A Tribute to C David Allis PhD Professor in the Department of Biochemistry and Molecular Genetics from 1998 2003 University of Virginia School of Medicine January 24 2023 Archived from the original on February 11 2023 Retrieved February 11 2023 Goldfarb David S Gorovsky Martin A 2009 Nuclear Dimorphism Two Peas in a Pod PDF Current Biology 19 11 R449 R452 doi 10 1016 j cub 2009 04 023 PMID 19515351 S2CID 9841779 Archived from the original PDF on February 14 2023 Retrieved February 14 2023 2014 Japan Prize Achievement Life Science field PDF Japan Prize Archived from the original PDF on February 15 2023 Retrieved February 15 2023 Brownell James E Zhou Jianxin Ranalli Tamara Kobayashi Ryuji Edmondson Diane G Roth Sharon Y Allis C David 1996 Tetrahymena Histone Acetyltransferase A A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation Cell 84 6 843 851 doi 10 1016 S0092 8674 00 81063 6 PMID 8601308 Allis C David 2015 Modifying My Career toward Chromatin Biology Journal of Biological Chemistry 290 26 15904 15908 doi 10 1074 jbc X115 663229 PMC 4481195 PMID 25944906 Allfrey V G Faulkner R Mirsky A E 1964 Acetylation and methylation of histones and their possible role in the regulation of rna synthesis Proceedings of the National Academy of Sciences 51 5 786 794 Bibcode 1964PNAS 51 786A doi 10 1073 pnas 51 5 786 PMC 300163 PMID 14172992 Allis C David 2018 Pursuing the Secrets of Histone Proteins An Amazing Journey with a Remarkable Supporting Cast Cell 175 1 18 21 doi 10 1016 j cell 2018 08 022 PMID 30217363 Mizzen Craig A Yang Xiang Jiao Kokubo Tetsuro Brownell James E Bannister Andrew J Owen Hughes Tom Workman Jerry Wang Lian Berger Shelley L Kouzarides Tony Nakatani Yoshihiro Allis C David 1996 The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity PDF Cell 87 7 1261 1270 doi 10 1016 S0092 8674 00 81821 8 PMID 8980232 Archived from the original PDF on April 15 2019 Retrieved February 16 2023 Hendzel Michael J Wei Yi Mancini Michael A Van Hooser Aaron Ranalli Tamara Brinkley B R Bazett Jones David P Allis C David 1997 Mitosis specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation Chromosoma 106 6 348 360 doi 10 1007 s004120050256 PMID 9362543 S2CID 29723188 Retrieved February 17 2023 Hsu Jer Yuan Sun Zu Wen Li Xiumin Reuben Melanie Tatchell Kelly Bishop Douglas K Grushcow Jeremy M Brame Cynthia J Caldwell Jennifer A Hunt Donald F Lin Rueyling Smith M Mitchell Allis C David 2000 Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1 aurora Kinase and Glc7 PP1 Phosphatase in Budding Yeast and Nematodes Cell 102 3 279 291 doi 10 1016 S0092 8674 00 00034 9 PMID 10975519 Cheung Peter Tanner Kirk G Cheung Wang L Sassone Corsi Paolo Denu John M Allis C David 2000 Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation Molecular Cell 5 6 905 915 doi 10 1016 s1097 2765 00 80256 7 PMID 10911985 Rice Judd C Briggs Scott D Ueberheide Beatrix Barber Cynthia M Shabanowitz Jeffrey Hunt Donald F Shinkai Yoichi Allis C David 2003 Histone Methyltransferases Direct Different Degrees of Methylation to Define Distinct Chromatin Domains Molecular Cell 12 6 1591 1598 doi 10 1016 s1097 2765 03 00479 9 PMID 14690610 Strahl Brian D Grant Patrick A Briggs Scott D Sun Zu Wen Bone James R Caldwell Jennifer A Mollah Sahana Cook Richard G Shabanowitz Jeffrey Hunt Donald F Allis C David 2002 Set2 Is a Nucleosomal Histone H3 Selective Methyltransferase That Mediates Transcriptional Repression Molecular and Cellular Biology 22 5 1298 1306 doi 10 1128 MCB 22 5 1298 1306 2002 PMC 134702 PMID 11839797 Sun Zu Wen Allis C David 2002 Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast Nature 418 6893 104 108 Bibcode 2002Natur 418 104S doi 10 1038 nature00883 PMID 12077605 S2CID 4338471 Retrieved February 18 2023 Strahl Brian D Allis C David 2000 The language of covalent histone modifications Nature 403 6765 41 45 Bibcode 2000Natur 403 41S doi 10 1038 47412 PMID 10638745 S2CID 4418993 Retrieved February 19 2023 Jenuwein Thomas Allis C David 2001 Translating the histone code Science 293 5532 1074 1080 CiteSeerX 10 1 1 453 900 doi 10 1126 science 1063127 PMID 11498575 S2CID 1883924 Archived from the original on February 20 2023 Retrieved February 20 2023 Chi Ping Allis C David Wang Gang Greg 2010 Covalent histone modifications miswritten misinterpreted and mis erased in human cancers Nature Reviews Cancer 10 7 457 469 doi 10 1038 nrc2876 PMC 3262678 PMID 20574448 Dent Sharon Grewal Shiv 2023 C David Allis 1951 2023 Nature 614 7948 409 Bibcode 2023Natur 614 409D doi 10 1038 d41586 023 00346 0 PMID 36737544 S2CID 256577181 Nacev Benjamin A Feng Lijuan Bagert John D Lemiesz Agata E Gao JianJiong Soshnev Alexey A Kundra Ritika Schultz Nikolaus Muir Tom W Allis C David 2019 The expanding landscape of oncohistone mutations in human cancers Nature 567 7749 473 478 Bibcode 2019Natur 567 473N doi 10 1038 s41586 019 1038 1 PMC 6512987 PMID 30894748 Berger Shelley L 2023 C David Allis 1951 2023 Science 379 6633 645 Bibcode 2023Sci 379 645B doi 10 1126 science adg7738 PMID 36795814 S2CID 256901502 C David Allis American Academy of Arts and Sciences Archived from the original on February 3 2023 Retrieved February 3 2023 2002 Dickson Prize Winner Dickson Prize Archived from the original on December 25 2022 Retrieved February 3 2023 Massry Prize Winners 1996 Present University of Southern California Keck School of Medicine Archived from the original on December 5 2022 Retrieved December 5 2022 C David Allis to Receive the Third Annual Wiley Prize in the Biomedical Sciences Wiley Foundation January 27 2004 Archived from the original on February 5 2023 Retrieved February 5 2023 C David Allis National Academy of Sciences Archived from the original on February 5 2023 Retrieved February 5 2023 Past A amp S Alumni Award Winners 2002 2019 University of Cincinnati College of Arts and Sciences Archived from the original on December 4 2022 Retrieved February 6 2023 C David Allis Gairdner Foundation Archived from the original on December 6 2021 Retrieved February 6 2023 ASBMB Merck Award American Society for Biochemistry and Molecular Biology Archived from the original on February 6 2023 Retrieved February 6 2023 Past Winners Brandeis University Archived from the original on February 6 2023 Retrieved February 6 2023 The 2014 Japan Prize Japan Prize Archived from the original on February 2 2023 Retrieved February 6 2023 Laureat 2014 du prix Charles Leopold Mayer C David Allis in French French Academy of Sciences Archived from the original on February 7 2023 Retrieved February 7 2023 C David Allis Breakthrough Prize Board Archived from the original on January 16 2023 Retrieved January 16 2023 C David Allis Gruber Foundation Archived from the original on February 1 2023 Retrieved February 1 2022 2017 March of Dimes Prize awarded to Dr C David Allis for groundbreaking research March of Dimes May 8 2017 Archived from the original on February 8 2023 Retrieved February 8 2022 2018 Albert Lasker Basic Medical Research Award Lasker Foundation Archived from the original on February 8 2023 Retrieved February 8 2022 C David Allis Ph D National Academy of Medicine Archived from the original on February 8 2023 Retrieved February 8 2023 2022 Albany Prize Awarded for Pivotal Discoveries in Gene Regulation Press release Albany Medical College October 13 2022 Archived from the original on October 14 2022 Retrieved October 14 2022 Remembering a pioneer of chromatin biology Rockefeller University January 14 2023 Archived from the original on February 16 2023 Retrieved February 16 2023 C David Allis Mentorship Fund for Young Scientists Rockefeller University Archived from the original on February 16 2023 Retrieved February 16 2023 Retrieved from https en wikipedia org w index php title Charles David Allis amp oldid 1202280987, wikipedia, wiki, book, books, library,

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