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Biozentrum University of Basel

October 28, 2023

The Biozentrum of the University of Basel specializes in basic molecular and biomedical research and teaching. Research includes the areas of cell growth and development, infection biology, neurobiology, structural biology and biophysics, and computational and systems biology. With 550 employees, the Biozentrum is the largest department at the University of Basel's Faculty of Science. It is home to 32 research groups with scientists from more than 40 nations.[1][2][3]

Logo
Biozentrum, University of Basel

History Edit

In 1971, at the time when the Biozentrum was founded, the concept of developing an interdisciplinary biological research facility was unique in Europe.[4] Scientists from academy and industry as well as representatives of the Canton of Basel-Stadt promoted the Biozentrum's development.[5]

In the winter semester 1972/73 the first students enrolled for the new "Biology II" curriculum. It encompassed a two-year foundation course in mathematics, physics and chemistry as well as a cycle of block courses – a new teaching format. In 1976 the first students received their diplomas. In 1978 the Biozentrum became a department of the University of Basel. In the same year, one of the founding professors, Werner Arber, was awarded the Nobel Prize for Physiology or Medicine[6] for his discovery of the restriction enzymes.[7][8]

With the incorporation of the Maurice E. Müller Institute[9][10] in 1986, the Biozentrum became a competence center for high resolution electron microscopy. It also established a platform for nuclear magnetic resonance spectroscopy.[11] Cooperation with the Institute for Immunology[12] (Hofmann-La Roche) [13] and the Friedrich Miescher Institute[14] (Ciba/Geigy) became ever closer and networking more and more important:[15] In 1996, what is now the "Center of Competence and Excellence in Neuroscience" was founded. Then "Neurex",[16] the largest tri-national alliance of neurobiologists, was set up. The "Basel Signalling Alliance", the "Neuroscience Network Basel",[17] and the "Basel Stem Cell Network"[18] followed. And finally, the Basel Translational Medicine Hub was established to further personalized medicine.[19] The major areas of investigation were also extended: whereas into the 1990s the Biozentrum focused on Cell Growth & Development, Neurobiology and Structural Biology, it was at the beginning of the 21st century that Infection Biology and Computational & Systems Biology were added. Building up a range of Technology Core Facilities which offer highly sophisticated methods of investigation and analysis was also a priority during the last decade.

In 2021, the Biozentrum moved into a 73 m high research tower. The new building offers a state-of the art infrastructure that meets the needs of modern-day research as well as enough room for 400 researchers and 900 students.[20][21] The Biozentrum is headed by its director Alexander F. Schier.[22]

Research Edit

Research at the Biozentrum embraces a wide range of topics, however, one main focus all the research groups share is a strong interest to understand the molecular organization of living organisms.[23]

The major areas of research are concerned with the structure and function of macromolecules,[24][25] the wiring of regulatory circuits,[26] and the general principles underlying complex biological systems and their dynamic interactions.[27]

Currently, the research groups of the Biozentrum are grouped into five major areas of investigation: Growth & Development, Infection Biology, Neurobiology, Structural Biology & Biophysics and Computational & Systems Biology.

Modern research increasingly depends on sophisticated technologies, notably in the fields of genomics, proteomics, imaging, and data analysis. To meet this challenge, the Biozentrum has established a number of so-called Technology Platforms.[28] It has facilities for electron and light microscopy, cell imaging and nanoanalytics,[29] proteomics, biophysics, FACS (Fluorescence Activated Cell Sorting) and Research IT. A microarray and a quantitative genomics facility are being shared with other regional research institute

Degrees awarded Edit

The courses of studies in molecular biology at the Biozentrum are characterized by the early exposure of the students to current research, the offer of all research areas and methods relevant to molecular biology, a modern technical infrastructure and the practical-work-oriented supervision.[30]

BSc Major in Molecular Biology Edit

The bachelor's degree program in Molecular Biology[31] encompasses one year of basic studies followed by two years of immersion in more specialized topics. In the first year, knowledge in mathematics, physics, general chemistry and the basic principles of biology are acquired. In the second year, students attend lectures in biochemistry, developmental biology, genetics, human physiology, immunology, molecular microbiology, neurobiology, structural biology and physics of life and they participate in a practical course in experimental molecular biology. The third year of study has also a practical orientation: in three six-week block courses the students actively engage in research and they work on and write an eight-week theses in Molecular Biology.

BSc Major in Computational Biology Edit

The bachelor's degree program in Computational Sciences[32][33] leading to a Major in Computational Biology also starts with one year of basic studies in mathematics, physics and chemistry and courses in computer science. In the second year, mathematics and computer science are combined with the basic principles of molecular biology. Besides the lectures, the students participate in a practical course in experimental molecular biology. One six-week block course with theoretical and experimental content as well as two research projects are part of the program of the third academic year.

MSc in Molecular Biology Edit

The prerequisite for admission to the master's degree in Molecular Biology[34] is a "Bachelor of Science in Biology" with a "Major in Molecular Biology", in some cases a "Major in Integrative Biology", or a "Bachelor of Science in Computational Sciences" with a "Major in Computational Biology". In general, the program takes three semesters to complete. Students concentrate principally on an own research project. They work at least ten months in the laboratory.

PhD program Edit

The PhD program builds on a university degree in biology or related discipline and requires the student to engage in an independent research project within a period of three to four years. The program is completed by writing a thesis. The students also receive practical training in the latest methods and techniques of molecular biology research and attend courses of the Graduate Teaching Program.[35][36]

Postdoctoral Edit

To expand their knowledge and experience, young researchers often spend a few years in research groups abroad. Accordingly, postdoctoral researchers from all continents are working at the Biozentrum.[37][38]

Notable people Edit

The following notable people work or have worked at the Biozentrum:

Former chairs Edit

Since 1973 the Biozentrum has been led by a chair. In 2009, the position was changed to director. The following persons have occupied this position:[39]

References Edit

  1. ^ . Archived from the original on May 16, 2021. Retrieved July 10, 2020.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  2. ^ Gross, Michael (31 March 2014). "New barriers to mobility in Europe?". Current Biology. 24 (7): R257–R259. doi:10.1016/j.cub.2014.03.019. PMID 24822251. S2CID 45807911.
  3. ^ "The Biozentrum, University of Basel". biozentrum.unibas.ch. 2023-01-30. Retrieved 2023-01-31.
  4. ^ "Enthusiasmus für Grundlagenforschung". NZZ.ch. Retrieved 2014-07-07.
  5. ^ "History of the Biozentrum Basel". biozentrum.unibas.ch. Retrieved 2020-07-06.
  6. ^ "Nobelprize Werner Arber". nobelprize.org. Retrieved 2020-07-03.
  7. ^ "Restriction enzymes". nature.com. Retrieved 2020-07-03.
  8. ^ Yuan, Robert T. (1987). "Biology II curriculum Biozentrum". Retrieved 2020-07-03.
  9. ^ Müller, Shirley A.; Engel, Andreas (1 January 2012). "Looking back at a quarter-century of research at the Maurice E. Müller Institute for Structural Biology". Journal of Structural Biology. 177 (1): 3–13. doi:10.1016/j.jsb.2011.11.013. PMID 22115996.
  10. ^ MIH Maurice E. Müller Institut for high resolution microscopy. nature.com. 27 October 2015. ISBN 9783319226835. Retrieved 2020-07-03.
  11. ^ "Ein neues Hochleistungs-Spektrometer für das Biozentrum der Universität Basel". unibar.ch. Retrieved 2020-07-03.
  12. ^ Tonegawa, Susumu (January 2004). "That great time in Basel". Cell. 116 (2 Suppl): S99–S101. doi:10.1016/s0092-8674(04)00040-6. PMID 15055594. S2CID 6205504.
  13. ^ "Unprecedented collaboration in autism research". ac.uk. Retrieved 2020-07-03.
  14. ^ "Swiss model". admin.ch. Retrieved 2020-07-03.
  15. ^ Meyer, Jérémie (26 June 2018). "Where the life sciences are concentrated". BaseLaunch.
  16. ^ "Neuroscience Upper Rhine network". neurex.org. Retrieved 2020-07-03.
  17. ^ "Neuroscience Network Basel". unibas.ch. Retrieved 2020-07-03.
  18. ^ "Basel Stem Cell Network". baselstemcells.ch. Retrieved 2020-07-03.
  19. ^ "Roche forms translational medicine research hub". pharmafile.com. Retrieved 2020-07-03.
  20. ^ "Biozentrum Universität Basel, Neubau" (in German). hochbauamt.bs.ch. Retrieved 2021-12-20.
  21. ^ "Bundesrätliches Lob aus der Baugrube heraus für das neue Biozentrum" (in German). basellandschaftlichezeitung.ch. Retrieved 2021-12-20.
  22. ^ "Alex Schier Appointed New Director of the Biozentrum". www.unibas.ch. Retrieved 2018-03-28.
  23. ^ "Basel Night 2018: Basel to Harvard and Back Again". swissnexboston.org. Retrieved 2020-07-06.
  24. ^ Waterhouse, Andrew; Bertoni, Martino; Bienert, Stefan; Studer, Gabriel; Tauriello, Gerardo; Gumienny, Rafal; Heer, Florian T; de Beer, Tjaart A P; Rempfer, Christine; Bordoli, Lorenza; Lepore, Rosalba; Schwede, Torsten (2 July 2018). "SWISS-MODEL: homology modelling of protein structures and complexes". Nucleic Acids Research. 46 (W1): W296–W303. doi:10.1093/nar/gky427. PMC 6030848. PMID 29788355.
  25. ^ Nazarov, Sergey; Schneider, Johannes P; Brackmann, Maximilian; Goldie, Kenneth N; Stahlberg, Henning; Basler, Marek (15 February 2018). "Cryo‐ EM reconstruction of Type VI secretion system baseplate and sheath distal end". The EMBO Journal. 37 (4). doi:10.15252/embj.201797103. PMC 5813253. PMID 29255010.
  26. ^ Shimobayashi, Mitsugu; Hall, Michael N. (March 2014). "Making new contacts: the mTOR network in metabolism and signalling crosstalk". Nature Reviews Molecular Cell Biology. 15 (3): 155–162. doi:10.1038/nrm3757. PMID 24556838. S2CID 26780852.
  27. ^ Tintignac, Lionel A.; Brenner, Hans-Rudolf; Rüegg, Markus A. (July 2015). "Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting". Physiological Reviews. 95 (3): 809–852. doi:10.1152/physrev.00033.2014. PMID 26109340.
  28. ^ "Technology Platforms". biozentrum.unibas.ch. Retrieved 2020-07-06.
  29. ^ Imaging Core Facility (IMCF) swissbioimaging.ch. Retrieved 2014-07-07
  30. ^ Gladfelter, Amy (December 2002). "A Lab with a View: American Postdocs Abroad". Cell Biology Education. 1 (4): 128–131. doi:10.1187/cbe.02-07-0015. PMC 149801. PMID 12669104.
  31. ^ "Bachelor's degree program in Molecular Biology". biozentrum.unibas.ch. Retrieved 2020-07-06.
  32. ^ "Bachelor of Science in Computational Sciences, Major in Computational Biology". biozentrum.unibas.ch. Retrieved 2022-01-17.
  33. ^ "Computational Sciences, Degree:Bachelor". unibas.ch. Retrieved 2022-01-17.
  34. ^ "Molecular Biology, Degree:Master". unibas.ch. Retrieved 2022-01-17.
  35. ^ "Graduate Teaching Program". biozentrum.unibas.ch. Retrieved 2020-07-06.
  36. ^ "Biozentrum PhD Fellowships Program 2020". armacad.info. Retrieved 2020-07-10.
  37. ^ "Basel Travel Guide 2020". Turner Travel Guide. Retrieved 2020-07-06.
  38. ^ "Grants and Scholarships". swissnexbrazil.org. Retrieved 2020-07-06.
  39. ^ "The Biozentrum – its history and role - Former chairs". biozentrum.unibas.ch. Retrieved 2020-07-06.

External links Edit

  • Official website

47°33′51″N 7°34′51″E / 47.56417°N 7.58083°E / 47.56417; 7.58083

October 28, 2023
biozentrum, university, basel, biozentrum, university, basel, specializes, basic, molecular, biomedical, research, teaching, research, includes, areas, cell, growth, development, infection, biology, neurobiology, structural, biology, biophysics, computational,. The Biozentrum of the University of Basel specializes in basic molecular and biomedical research and teaching Research includes the areas of cell growth and development infection biology neurobiology structural biology and biophysics and computational and systems biology With 550 employees the Biozentrum is the largest department at the University of Basel s Faculty of Science It is home to 32 research groups with scientists from more than 40 nations 1 2 3 LogoBiozentrum University of Basel Contents 1 History 2 Research 3 Degrees awarded 3 1 BSc Major in Molecular Biology 3 2 BSc Major in Computational Biology 3 3 MSc in Molecular Biology 3 4 PhD program 3 5 Postdoctoral 4 Notable people 4 1 Former chairs 5 References 6 External linksHistory EditIn 1971 at the time when the Biozentrum was founded the concept of developing an interdisciplinary biological research facility was unique in Europe 4 Scientists from academy and industry as well as representatives of the Canton of Basel Stadt promoted the Biozentrum s development 5 In the winter semester 1972 73 the first students enrolled for the new Biology II curriculum It encompassed a two year foundation course in mathematics physics and chemistry as well as a cycle of block courses a new teaching format In 1976 the first students received their diplomas In 1978 the Biozentrum became a department of the University of Basel In the same year one of the founding professors Werner Arber was awarded the Nobel Prize for Physiology or Medicine 6 for his discovery of the restriction enzymes 7 8 With the incorporation of the Maurice E Muller Institute 9 10 in 1986 the Biozentrum became a competence center for high resolution electron microscopy It also established a platform for nuclear magnetic resonance spectroscopy 11 Cooperation with the Institute for Immunology 12 Hofmann La Roche 13 and the Friedrich Miescher Institute 14 Ciba Geigy became ever closer and networking more and more important 15 In 1996 what is now the Center of Competence and Excellence in Neuroscience was founded Then Neurex 16 the largest tri national alliance of neurobiologists was set up The Basel Signalling Alliance the Neuroscience Network Basel 17 and the Basel Stem Cell Network 18 followed And finally the Basel Translational Medicine Hub was established to further personalized medicine 19 The major areas of investigation were also extended whereas into the 1990s the Biozentrum focused on Cell Growth amp Development Neurobiology and Structural Biology it was at the beginning of the 21st century that Infection Biology and Computational amp Systems Biology were added Building up a range of Technology Core Facilities which offer highly sophisticated methods of investigation and analysis was also a priority during the last decade In 2021 the Biozentrum moved into a 73 m high research tower The new building offers a state of the art infrastructure that meets the needs of modern day research as well as enough room for 400 researchers and 900 students 20 21 The Biozentrum is headed by its director Alexander F Schier 22 Research EditResearch at the Biozentrum embraces a wide range of topics however one main focus all the research groups share is a strong interest to understand the molecular organization of living organisms 23 The major areas of research are concerned with the structure and function of macromolecules 24 25 the wiring of regulatory circuits 26 and the general principles underlying complex biological systems and their dynamic interactions 27 Currently the research groups of the Biozentrum are grouped into five major areas of investigation Growth amp Development Infection Biology Neurobiology Structural Biology amp Biophysics and Computational amp Systems Biology Modern research increasingly depends on sophisticated technologies notably in the fields of genomics proteomics imaging and data analysis To meet this challenge the Biozentrum has established a number of so called Technology Platforms 28 It has facilities for electron and light microscopy cell imaging and nanoanalytics 29 proteomics biophysics FACS Fluorescence Activated Cell Sorting and Research IT A microarray and a quantitative genomics facility are being shared with other regional research instituteDegrees awarded EditThe courses of studies in molecular biology at the Biozentrum are characterized by the early exposure of the students to current research the offer of all research areas and methods relevant to molecular biology a modern technical infrastructure and the practical work oriented supervision 30 BSc Major in Molecular Biology Edit The bachelor s degree program in Molecular Biology 31 encompasses one year of basic studies followed by two years of immersion in more specialized topics In the first year knowledge in mathematics physics general chemistry and the basic principles of biology are acquired In the second year students attend lectures in biochemistry developmental biology genetics human physiology immunology molecular microbiology neurobiology structural biology and physics of life and they participate in a practical course in experimental molecular biology The third year of study has also a practical orientation in three six week block courses the students actively engage in research and they work on and write an eight week theses in Molecular Biology BSc Major in Computational Biology Edit The bachelor s degree program in Computational Sciences 32 33 leading to a Major in Computational Biology also starts with one year of basic studies in mathematics physics and chemistry and courses in computer science In the second year mathematics and computer science are combined with the basic principles of molecular biology Besides the lectures the students participate in a practical course in experimental molecular biology One six week block course with theoretical and experimental content as well as two research projects are part of the program of the third academic year MSc in Molecular Biology Edit The prerequisite for admission to the master s degree in Molecular Biology 34 is a Bachelor of Science in Biology with a Major in Molecular Biology in some cases a Major in Integrative Biology or a Bachelor of Science in Computational Sciences with a Major in Computational Biology In general the program takes three semesters to complete Students concentrate principally on an own research project They work at least ten months in the laboratory PhD program Edit The PhD program builds on a university degree in biology or related discipline and requires the student to engage in an independent research project within a period of three to four years The program is completed by writing a thesis The students also receive practical training in the latest methods and techniques of molecular biology research and attend courses of the Graduate Teaching Program 35 36 Postdoctoral Edit To expand their knowledge and experience young researchers often spend a few years in research groups abroad Accordingly postdoctoral researchers from all continents are working at the Biozentrum 37 38 Notable people EditThe following notable people work or have worked at the Biozentrum Jan Pieter Abrahams Ueli Aebi Markus Affolter Silvia Arber Werner Arber Attila Becskei Thomas A Bickle Dirk Bumann Guy R Cornelis Christoph Dehio Fiona Doetsch Andreas Engel Walter Gehring Stephan Grzesiek Michael N Hall Christoph Handschin Sebastian Hiller Urs Jenal Roderick Lim Timm Maier Susan Mango Urs A Meyer John Graham Nicholls Erich Nigg Jean Pieters Heinrich Reichert Markus Ruegg Gottfried Schatz Peter Scheiffele Alexander F Schier Tilman Schirmer Torsten Schwede Anna Seelig Loffler Joachim Seelig Anne Spang Martin Spiess Henning Stahlberg Erik van Nimwegen Mihaela Zavolan Former chairs Edit Since 1973 the Biozentrum has been led by a chair In 2009 the position was changed to director The following persons have occupied this position 39 Max M Burger 1973 77 Jurgen Engel 1977 79 Werner Arber 1979 83 Gottfried Schatz 1983 85 Kasper Kirschner 1985 87 Walter J Gehring 1987 89 Johan N Jansonius 1989 91 Thomas A Bickle 1991 93 Urs A Meyer 1993 95 Walter Keller 1995 97 Joachim Seelig 1997 99 and 2000 09 Andreas Engel 1999 2000 Erich Nigg 2009 2018 Alexander F Schier 2018 present References Edit Excellence in Research Archived from the original on May 16 2021 Retrieved July 10 2020 a href Template Cite web html title Template Cite web cite web a CS1 maint bot original URL status unknown link Gross Michael 31 March 2014 New barriers to mobility in Europe Current Biology 24 7 R257 R259 doi 10 1016 j cub 2014 03 019 PMID 24822251 S2CID 45807911 The Biozentrum University of Basel biozentrum unibas ch 2023 01 30 Retrieved 2023 01 31 Enthusiasmus fur Grundlagenforschung NZZ ch Retrieved 2014 07 07 History of the Biozentrum Basel biozentrum unibas ch Retrieved 2020 07 06 Nobelprize Werner Arber nobelprize org Retrieved 2020 07 03 Restriction enzymes nature com Retrieved 2020 07 03 Yuan Robert T 1987 Biology II curriculum Biozentrum Retrieved 2020 07 03 Muller Shirley A Engel Andreas 1 January 2012 Looking back at a quarter century of research at the Maurice E Muller Institute for Structural Biology Journal of Structural Biology 177 1 3 13 doi 10 1016 j jsb 2011 11 013 PMID 22115996 MIH Maurice E Muller Institut for high resolution microscopy nature com 27 October 2015 ISBN 9783319226835 Retrieved 2020 07 03 Ein neues Hochleistungs Spektrometer fur das Biozentrum der Universitat Basel unibar ch Retrieved 2020 07 03 Tonegawa Susumu January 2004 That great time in Basel Cell 116 2 Suppl S99 S101 doi 10 1016 s0092 8674 04 00040 6 PMID 15055594 S2CID 6205504 Unprecedented collaboration in autism research ac uk Retrieved 2020 07 03 Swiss model admin ch Retrieved 2020 07 03 Meyer Jeremie 26 June 2018 Where the life sciences are concentrated BaseLaunch Neuroscience Upper Rhine network neurex org Retrieved 2020 07 03 Neuroscience Network Basel unibas ch Retrieved 2020 07 03 Basel Stem Cell Network baselstemcells ch Retrieved 2020 07 03 Roche forms translational medicine research hub pharmafile com Retrieved 2020 07 03 Biozentrum Universitat Basel Neubau in German hochbauamt bs ch Retrieved 2021 12 20 Bundesratliches Lob aus der Baugrube heraus fur das neue Biozentrum in German basellandschaftlichezeitung ch Retrieved 2021 12 20 Alex Schier Appointed New Director of the Biozentrum www unibas ch Retrieved 2018 03 28 Basel Night 2018 Basel to Harvard and Back Again swissnexboston org Retrieved 2020 07 06 Waterhouse Andrew Bertoni Martino Bienert Stefan Studer Gabriel Tauriello Gerardo Gumienny Rafal Heer Florian T de Beer Tjaart A P Rempfer Christine Bordoli Lorenza Lepore Rosalba Schwede Torsten 2 July 2018 SWISS MODEL homology modelling of protein structures and complexes Nucleic Acids Research 46 W1 W296 W303 doi 10 1093 nar gky427 PMC 6030848 PMID 29788355 Nazarov Sergey Schneider Johannes P Brackmann Maximilian Goldie Kenneth N Stahlberg Henning Basler Marek 15 February 2018 Cryo EM reconstruction of Type VI secretion system baseplate and sheath distal end The EMBO Journal 37 4 doi 10 15252 embj 201797103 PMC 5813253 PMID 29255010 Shimobayashi Mitsugu Hall Michael N March 2014 Making new contacts the mTOR network in metabolism and signalling crosstalk Nature Reviews Molecular Cell Biology 15 3 155 162 doi 10 1038 nrm3757 PMID 24556838 S2CID 26780852 Tintignac Lionel A Brenner Hans Rudolf Ruegg Markus A July 2015 Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting Physiological Reviews 95 3 809 852 doi 10 1152 physrev 00033 2014 PMID 26109340 Technology Platforms biozentrum unibas ch Retrieved 2020 07 06 Imaging Core Facility IMCF swissbioimaging ch Retrieved 2014 07 07 Gladfelter Amy December 2002 A Lab with a View American Postdocs Abroad Cell Biology Education 1 4 128 131 doi 10 1187 cbe 02 07 0015 PMC 149801 PMID 12669104 Bachelor s degree program in Molecular Biology biozentrum unibas ch Retrieved 2020 07 06 Bachelor of Science in Computational Sciences Major in Computational Biology biozentrum unibas ch Retrieved 2022 01 17 Computational Sciences Degree Bachelor unibas ch Retrieved 2022 01 17 Molecular Biology Degree Master unibas ch Retrieved 2022 01 17 Graduate Teaching Program biozentrum unibas ch Retrieved 2020 07 06 Biozentrum PhD Fellowships Program 2020 armacad info Retrieved 2020 07 10 Basel Travel Guide 2020 Turner Travel Guide Retrieved 2020 07 06 Grants and Scholarships swissnexbrazil org Retrieved 2020 07 06 The Biozentrum its history and role Former chairs biozentrum unibas ch Retrieved 2020 07 06 External links EditOfficial website47 33 51 N 7 34 51 E 47 56417 N 7 58083 E 47 56417 7 58083 Retrieved from https en wikipedia org w index php title Biozentrum University of Basel amp oldid 1169999745, wikipedia, wiki, book, books, library,

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