Thomas A. Bickle studied biology at the University of Geneva. He completed his doctorate in 1972 at the University of California at Davis and subsequently worked there as an assistant. The following year he moved to the Biozentrum at the University of Basel on an EMBO Long-Term Fellowship. Here he was appointed in 1980 to associate professor and in 1990 to full professor.[1] In addition to his duties in research and teaching, he served as Chairman of the Biozentrum[2] and as Dean of the Faculty of Science. He reached emeritus status in 2005.[3]
Thomas A. Bickle mainly investigated the mode of action of bacterialDNA restriction and modification systems. These systems protect bacteria from being invaded by foreign DNA, either free or packaged in bacterial viruses. So-called restriction enzymes (endonucleases) recognize foreign DNA and inactivate these through endonucleolytic cleavage. In Escherichia coli Bickle elucidated the precise method used by these enzymes to distinguish between their own and foreign DNA, He identified the DNA recognition sequences of various restriction enzymes and investigated their structure. Furthermore, he demonstrated that many bacterial viruses have evolved diverse defense mechanisms to avoid restriction.[4]
^Krüger, DH; Bickle, TA (September 1983). "Bacteriophage survival: multiple mechanisms for avoiding the deoxyribonucleic acid restriction systems of their hosts". Microbiol. Rev. 47 (3): 345–60. doi:10.1128/MMBR.47.3.345-360.1983. PMC281580. PMID 6314109.
January 01, 1970
thomas, bickle, thomas, anthony, bickle, british, swiss, microbiologist, 2002nationality, legal, british, swissscientific, careerfieldsmicrobiologyinstitutionsuniversity, geneva, university, california, davis, biozentrum, university, basel, contents, life, wor. Thomas Anthony Bickle is a British Swiss microbiologist Thomas A BickleThomas A Bickle 2002Nationality legal British SwissScientific careerFieldsMicrobiologyInstitutionsUniversity of Geneva University of California Davis Biozentrum University of Basel Contents 1 Life 2 Work 3 Awards and honors 4 External links 5 ReferencesLife editThomas A Bickle studied biology at the University of Geneva He completed his doctorate in 1972 at the University of California at Davis and subsequently worked there as an assistant The following year he moved to the Biozentrum at the University of Basel on an EMBO Long Term Fellowship Here he was appointed in 1980 to associate professor and in 1990 to full professor 1 In addition to his duties in research and teaching he served as Chairman of the Biozentrum 2 and as Dean of the Faculty of Science He reached emeritus status in 2005 3 Work editThis section of a biography of a living person needs additional citations for verification Please help by adding reliable sources Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page especially if potentially libelous Find sources Thomas A Bickle news newspapers books scholar JSTOR October 2014 Learn how and when to remove this message Thomas A Bickle mainly investigated the mode of action of bacterial DNA restriction and modification systems These systems protect bacteria from being invaded by foreign DNA either free or packaged in bacterial viruses So called restriction enzymes endonucleases recognize foreign DNA and inactivate these through endonucleolytic cleavage In Escherichia coli Bickle elucidated the precise method used by these enzymes to distinguish between their own and foreign DNA He identified the DNA recognition sequences of various restriction enzymes and investigated their structure Furthermore he demonstrated that many bacterial viruses have evolved diverse defense mechanisms to avoid restriction 4 Awards and honors edit1980 elected Member of the European Molecular Biology Organization EMBO 1985 member of the Swiss Commission for Molecular BiologyExternal links editWebpage Biozentrum University of Basel Emeriti Researchgate Thomas Bickle Swiss National Science Foundation P3 database Thomas Bickle Google Books Thomas A Bickle Markus Streiff Methods for Purification of Restriction EnzymesReferences edit nbsp Wikimedia Commons has media related to Thomas A Bickle Thomas Bickle in the Biozentrum Biennial Report 2004 2005 Thomas Bickle in the List of former chairs of the Biozentrum Biozentrum emeriti webpage Kruger DH Bickle TA September 1983 Bacteriophage survival multiple mechanisms for avoiding the deoxyribonucleic acid restriction systems of their hosts Microbiol Rev 47 3 345 60 doi 10 1128 MMBR 47 3 345 360 1983 PMC 281580 PMID 6314109 Retrieved from https en wikipedia org w index php title Thomas A Bickle amp oldid 1185744894, wikipedia, wiki, book, books, library,
