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Aprobarbital

Aprobarbital (or aprobarbitone), sold as Oramon, Somnifaine, and Allonal, is a barbiturate derivative invented in the 1920s by Ernst Preiswerk. It has sedative, hypnotic and anticonvulsant properties, and was used primarily for the treatment of insomnia.[2] Aprobarbital was never as widely used as more common barbiturate derivatives such as phenobarbital and is now rarely prescribed as it has been replaced by newer drugs with a better safety margin.

Aprobarbital
Clinical data
Other namesaprobarbitone, Oramon, allylpropymal, Alurate, 5-isopropyl- 5-allylbarbituric acid
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
Identifiers
  • 5-propan-2-yl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
CAS Number
  • 77-02-1 Y
PubChem CID
  • 6464
DrugBank
  • DB01352 Y
ChemSpider
  • 6221 Y
UNII
  • Q0YKG9L6RF
KEGG
  • D00698 Y
ChEBI
  • CHEBI:2791 Y
ChEMBL
  • ChEMBL7863 Y
CompTox Dashboard (EPA)
  • DTXSID8022616
ECHA InfoCard100.000.908
Chemical and physical data
FormulaC10H14N2O3
Molar mass210.233 g·mol−1
3D model (JSmol)
  • Interactive image
  • O=C1NC(=O)NC(=O)C1(C(C)C)C\C=C
  • InChI=1S/C10H14N2O3/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15) Y
  • Key:UORJNBVJVRLXMQ-UHFFFAOYSA-N Y
  (verify)

See also edit

References edit

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Reddemann H, Türk E (May 1966). "[Oramon poisoning in infancy and childhood. Observations on 12 aprobarbital poisonings]". Das Deutsche Gesundheitswesen (in German). 21 (19): 878–81. PMID 5973760.

aprobarbital, aprobarbitone, sold, oramon, somnifaine, allonal, barbiturate, derivative, invented, 1920s, ernst, preiswerk, sedative, hypnotic, anticonvulsant, properties, used, primarily, treatment, insomnia, never, widely, used, more, common, barbiturate, de. Aprobarbital or aprobarbitone sold as Oramon Somnifaine and Allonal is a barbiturate derivative invented in the 1920s by Ernst Preiswerk It has sedative hypnotic and anticonvulsant properties and was used primarily for the treatment of insomnia 2 Aprobarbital was never as widely used as more common barbiturate derivatives such as phenobarbital and is now rarely prescribed as it has been replaced by newer drugs with a better safety margin AprobarbitalClinical dataOther namesaprobarbitone Oramon allylpropymal Alurate 5 isopropyl 5 allylbarbituric acidAHFS Drugs comInternational Drug NamesATC codeN05CA05 WHO Legal statusLegal statusBR Class B1 Psychoactive drugs 1 CA Schedule IVIdentifiersIUPAC name 5 propan 2 yl 5 prop 2 enyl 1 3 diazinane 2 4 6 trioneCAS Number77 02 1 YPubChem CID6464DrugBankDB01352 YChemSpider6221 YUNIIQ0YKG9L6RFKEGGD00698 YChEBICHEBI 2791 YChEMBLChEMBL7863 YCompTox Dashboard EPA DTXSID8022616ECHA InfoCard100 000 908Chemical and physical dataFormulaC 10H 14N 2O 3Molar mass210 233 g mol 13D model JSmol Interactive imageSMILES O C1NC O NC O C1 C C C C C CInChI InChI 1S C10H14N2O3 c1 4 5 10 6 2 3 7 13 11 9 15 12 8 10 14 h4 6H 1 5H2 2 3H3 H2 11 12 13 14 15 YKey UORJNBVJVRLXMQ UHFFFAOYSA N Y verify See also editAlphenalReferences edit Anvisa 2023 03 31 RDC Nº 784 Listas de Substancias Entorpecentes Psicotropicas Precursoras e Outras sob Controle Especial Collegiate Board Resolution No 784 Lists of Narcotic Psychotropic Precursor and Other Substances under Special Control in Brazilian Portuguese Diario Oficial da Uniao published 2023 04 04 Archived from the original on 2023 08 03 Retrieved 2023 08 16 Reddemann H Turk E May 1966 Oramon poisoning in infancy and childhood Observations on 12 aprobarbital poisonings Das Deutsche Gesundheitswesen in German 21 19 878 81 PMID 5973760 nbsp This sedative related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Aprobarbital amp oldid 1202781527, wikipedia, wiki, book, books, library,

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