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Alphenal

Alphenal (Alphenal, Efrodal, Prophenal, Sanudorm), also known as 5-allyl-5-phenylbarbituric acid, is a barbiturate derivative developed in the 1920s.[1] It has primarily anticonvulsant properties, and was used occasionally for the treatment of epilepsy or convulsions, although not as commonly, as better known barbiturates such as phenobarbital.[2][3] [4][5]

Alphenal
Clinical data
Other names5-Phenyl-5-allylbarbituric acid
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
Identifiers
  • 5-phenyl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
CAS Number
  • 115-43-5 Y
PubChem CID
  • 8274
ChemSpider
  • 7975 Y
UNII
  • 7T7L08Q9JI
CompTox Dashboard (EPA)
  • DTXSID60150919
ECHA InfoCard100.003.718
Chemical and physical data
FormulaC13H12N2O3
Molar mass244.250 g·mol−1
3D model (JSmol)
  • Interactive image
  • O=C1NC(=O)NC(=O)C1(c2ccccc2)C\C=C
  • InChI=1S/C13H12N2O3/c1-2-8-13(9-6-4-3-5-7-9)10(16)14-12(18)15-11(13)17/h2-7H,1,8H2,(H2,14,15,16,17,18) Y
  • Key:WOIGZSBYKGQJGL-UHFFFAOYSA-N Y
  (verify)

LD50: Mouse (Oral): 280 mg/kg

References edit

  1. ^ DE 526854, "Verfahren zur Darstellung von C,C-disubstituierten Barbitursaeuren", issued 11 June 1931, assigned to Hoffmann La Roche 
  2. ^ Carissimi M (1962). "Nuovi Barbiturici Alogenati Farmaco". Ediozione Scientifica. 17 (6): 390–413.
  3. ^ Martin JR, Godel T, Hunkeler W, Jenck F, Moreau JL, Sleight AJ, Widmer U (December 2000). "Psychopharmacological Agents". Kirk-Othmer Encyclopedia of Chemical Technology. doi:10.1002/0471238961.1619250313011820.a01. ISBN 0471238961.
  4. ^ Brandenberger H, Maes RA (1997). Analytical Toxicology: For Clinical, Forensic, and Pharmaceutical Chemists. Walter de Gruyter. p. 348. ISBN 978-3-11-010731-9. Retrieved 19 May 2012.
  5. ^ García PC, Cruz SV, Mirón CE (28 January 2005). Fundamentos de síntesis de fármacos. Edicions Universitat Barcelona. p. 161. ISBN 978-84-475-2876-9. Retrieved 19 May 2012.



alphenal, efrodal, prophenal, sanudorm, also, known, allyl, phenylbarbituric, acid, barbiturate, derivative, developed, 1920s, primarily, anticonvulsant, properties, used, occasionally, treatment, epilepsy, convulsions, although, commonly, better, known, barbi. Alphenal Alphenal Efrodal Prophenal Sanudorm also known as 5 allyl 5 phenylbarbituric acid is a barbiturate derivative developed in the 1920s 1 It has primarily anticonvulsant properties and was used occasionally for the treatment of epilepsy or convulsions although not as commonly as better known barbiturates such as phenobarbital 2 3 4 5 AlphenalClinical dataOther names5 Phenyl 5 allylbarbituric acidRoutes ofadministrationOralATC codenoneLegal statusLegal statusCA Schedule IV US Schedule III Rx onlyIdentifiersIUPAC name 5 phenyl 5 prop 2 enyl 1 3 diazinane 2 4 6 trioneCAS Number115 43 5 YPubChem CID8274ChemSpider7975 YUNII7T7L08Q9JICompTox Dashboard EPA DTXSID60150919ECHA InfoCard100 003 718Chemical and physical dataFormulaC 13H 12N 2O 3Molar mass244 250 g mol 13D model JSmol Interactive imageSMILES O C1NC O NC O C1 c2ccccc2 C C CInChI InChI 1S C13H12N2O3 c1 2 8 13 9 6 4 3 5 7 9 10 16 14 12 18 15 11 13 17 h2 7H 1 8H2 H2 14 15 16 17 18 YKey WOIGZSBYKGQJGL UHFFFAOYSA N Y verify LD50 Mouse Oral 280 mg kgReferences edit DE 526854 Verfahren zur Darstellung von C C disubstituierten Barbitursaeuren issued 11 June 1931 assigned to Hoffmann La Roche Carissimi M 1962 Nuovi Barbiturici Alogenati Farmaco Ediozione Scientifica 17 6 390 413 Martin JR Godel T Hunkeler W Jenck F Moreau JL Sleight AJ Widmer U December 2000 Psychopharmacological Agents Kirk Othmer Encyclopedia of Chemical Technology doi 10 1002 0471238961 1619250313011820 a01 ISBN 0471238961 Brandenberger H Maes RA 1997 Analytical Toxicology For Clinical Forensic and Pharmaceutical Chemists Walter de Gruyter p 348 ISBN 978 3 11 010731 9 Retrieved 19 May 2012 Garcia PC Cruz SV Miron CE 28 January 2005 Fundamentos de sintesis de farmacos Edicions Universitat Barcelona p 161 ISBN 978 84 475 2876 9 Retrieved 19 May 2012 nbsp This anticonvulsant related article is a stub You can help Wikipedia by expanding it vte nbsp This sedative related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Alphenal amp oldid 1202781235, wikipedia, wiki, book, books, library,

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