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Tony Pawson (biochemist)

January 21, 2023

Anthony James Pawson CH, OC, OOnt, FRS, FRSC (18 October 1952 – 7 August 2013[1]) was a British-born Canadian scientist whose research revolutionised the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 (SH2 domain) as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins.[2][3][4][5][6][7][8][9][10]

Tony Pawson
Born
Anthony James Pawson

(1952-10-18)18 October 1952
Maidstone, England
Died7 August 2013(2013-08-07) (aged 60)
Toronto, Ontario
NationalityBritish-Canadian
Alma materClare College, Cambridge
King's College London (PhD)
Known forCellular signal transduction
AwardsGairdner Foundation International Award (1994)
Flavelle Medal (1998)
Wolf Prize in Medicine (2005)
Royal Medal (2005)
Kyoto Prize (2008)
Fellow of the Royal Society
Scientific career
FieldsGenetics, microbiology
InstitutionsUniversity of Toronto
Mount Sinai Hospital, Toronto
Samuel Lunenfeld Research Institute
ThesisStudies on the Proteins and Nucleic Acids of RNA Tumour Viruses (1976)

Biography

Born in Maidstone, England,[1] the son of the sportsman and writer Tony Pawson, and botanist and high-school teacher Hilarie, he was the eldest of three children.[11] He was educated at Winchester College[12] and Clare College, Cambridge, where he received an MA in biochemistry followed by a PhD from King's College London in 1976. From 1976 to 1980 he pursued postdoctoral work at the University of California, Berkeley. From 1981 to 1985, he was Assistant Professor in microbiology at the University of British Columbia.

Pawson was a Distinguished Investigator and former Director of Research at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Professor in the Department of Molecular Genetics at the University of Toronto both of which he joined in 1985.

Pawson died on 7 August 2013 of unspecified causes at the age of 60.[13][14][15]

Honours and awards

References

  1. ^ a b Bernstein, Alan; Rossant, Janet (2013). "Anthony James Pawson (1952–2013) Biochemist whose vision of cell signalling transformed cancer research". Nature. 501 (7466): 168. Bibcode:2013Natur.501..168B. doi:10.1038/501168a. PMID 24025833.
  2. ^ Pawson, T.; Nash, P. (2003). "Assembly of Cell Regulatory Systems Through Protein Interaction Domains". Science. 300 (5618): 445–452. CiteSeerX 10.1.1.321.3136. doi:10.1126/science.1083653. PMID 12702867. S2CID 14634947.
  3. ^ Nash, P.; Tang, X.; Orlicky, S.; Chen, Q.; Gertler, F. B.; Mendenhall, M. D.; Sicheri, F.; Pawson, T.; Tyers, M. (2001). "Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication". Nature. 414 (6863): 514–521. Bibcode:2001Natur.414..514N. doi:10.1038/35107009. PMID 11734846. S2CID 16924667.
  4. ^ Holland, S. J.; Gale, N. W.; Mbamalu, G.; Yancopoulos, G. D.; Henkemeyer, M.; Pawson, T. (1996). "Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands". Nature. 383 (6602): 722–725. Bibcode:1996Natur.383..722H. doi:10.1038/383722a0. hdl:1807/9444. PMID 8878483. S2CID 4349898.
  5. ^ Salcini, A. E.; McGlade, J.; Pelicci, G.; Nicoletti, I.; Pawson, T.; Pelicci, P. G. (1994). "Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins". Oncogene. 9 (10): 2827–2836. PMID 8084588.
  6. ^ Henkemeyer, M.; Marengere, L. E.; McGlade, J.; Olivier, J. P.; Conlon, R. A.; Holmyard, D. P.; Letwin, K.; Pawson, T. (1994). "Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis". Oncogene. 9 (4): 1001–1014. PMID 8134103.
  7. ^ Stephens, R. M.; Loeb, D. M.; Copeland, T. D.; Pawson, T.; Greene, L. A.; Kaplan, D. R. (1994). "Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses". Neuron. 12 (3): 691–705. doi:10.1016/0896-6273(94)90223-2. PMID 8155326. S2CID 7053584.
  8. ^ Crowe, A. J.; McGlade, J.; Pawson, T.; Hayman, M. J. (1994). "Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase". Oncogene. 9 (2): 537–544. PMID 8290264.
  9. ^ Marengere, L. E. M.; Songyang, Z.; Gish, G. D.; Schaller, M. D.; Parsons, J. T.; Stern, M. J.; Cantley, L. C.; Pawson, T. (1994). "SH2 domain specificity and activity modified by a single residue". Nature. 369 (6480): 502–505. Bibcode:1994Natur.369..502M. doi:10.1038/369502a0. hdl:1807/9433. PMID 7515480. S2CID 22767669.
  10. ^ Moran, M. F. (1990). "Src Homology Region 2 Domains Direct Protein-Protein Interactions in Signal Transduction". Proceedings of the National Academy of Sciences. 87 (21): 8622–8626. Bibcode:1990PNAS...87.8622M. doi:10.1073/pnas.87.21.8622. PMC 55009. PMID 2236073.
  11. ^ Buck, Genna (14 August 2013). "Anthony Pawson helped discover how cells communicate with each other". The Globe and Mail. Retrieved 5 May 2014.
  12. ^ Kyriakis, John M. "Retrospective Tony Pawson (1952–2013)". ASBMB Today. Retrieved 16 January 2015.
  13. ^ "Renowned Toronto genetic researcher Dr. Tony Pawson dies | Toronto Star". Thestar.com. 8 August 2013. Retrieved 9 August 2013.
  14. ^ "Scientific community reels at the loss of the world-renowned Tony Pawson". Maclean's. 9 August 2013. Retrieved 10 August 2013.
  15. ^ Paul Wells (9 August 2013). "RIP Tony Pawson". Maclean's. Retrieved 10 August 2013.
  16. ^ "Past award winners". Canadian National Proteomics Network. Retrieved 16 July 2019.

External links

  • Elaine Smith (5 July 2006). "Professor named to Order of Companions of Honour". news@UofT. University of Toronto. from the original on 15 September 2007. Retrieved 18 September 2007.
  • . Canadian Institutes of Health Research. 17 April 2007. Archived from the original on 15 February 2005. Retrieved 18 September 2007.
  • Laura Kane (8 August 2013). "Renowned Toronto genetic researcher Dr. Tony Pawson dies". The Toronto Star. Retrieved 8 August 2013.
  • at the Samuel Lunenfeld Research Institute
  • The Official Site of Louisa Gross Horwitz Prize
  • Online Publications (University of Toronto)

January 21, 2023
tony, pawson, biochemist, anthony, james, pawson, oont, frsc, october, 1952, august, 2013, british, born, canadian, scientist, whose, research, revolutionised, understanding, signal, transduction, molecular, mechanisms, which, cells, respond, external, cues, t. Anthony James Pawson CH OC OOnt FRS FRSC 18 October 1952 7 August 2013 1 was a British born Canadian scientist whose research revolutionised the understanding of signal transduction the molecular mechanisms by which cells respond to external cues and how they communicate with each other He identified the phosphotyrosine binding Src homology 2 SH2 domain as the prototypic non catalytic interaction module SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling Since the discovery of SH2 domains hundreds of different modules have been identified in many proteins 2 3 4 5 6 7 8 9 10 Tony PawsonBornAnthony James Pawson 1952 10 18 18 October 1952Maidstone EnglandDied7 August 2013 2013 08 07 aged 60 Toronto OntarioNationalityBritish CanadianAlma materClare College CambridgeKing s College London PhD Known forCellular signal transductionAwardsGairdner Foundation International Award 1994 Flavelle Medal 1998 Wolf Prize in Medicine 2005 Royal Medal 2005 Kyoto Prize 2008 Fellow of the Royal SocietyScientific careerFieldsGenetics microbiologyInstitutionsUniversity of TorontoMount Sinai Hospital TorontoSamuel Lunenfeld Research InstituteThesisStudies on the Proteins and Nucleic Acids of RNA Tumour Viruses 1976 Contents 1 Biography 2 Honours and awards 3 References 4 External linksBiography EditBorn in Maidstone England 1 the son of the sportsman and writer Tony Pawson and botanist and high school teacher Hilarie he was the eldest of three children 11 He was educated at Winchester College 12 and Clare College Cambridge where he received an MA in biochemistry followed by a PhD from King s College London in 1976 From 1976 to 1980 he pursued postdoctoral work at the University of California Berkeley From 1981 to 1985 he was Assistant Professor in microbiology at the University of British Columbia Pawson was a Distinguished Investigator and former Director of Research at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Professor in the Department of Molecular Genetics at the University of Toronto both of which he joined in 1985 Pawson died on 7 August 2013 of unspecified causes at the age of 60 13 14 15 Honours and awards Edit1994 Gairdner Foundation International Award 1994 Fellow of the Royal Society of London and the Royal Society of Canada 1995 Robert L Noble Prize from the National Cancer Institute of Canada 1998 Pezcoller AACR International Award for Cancer Research 1998 Heineken Prize for Biochemistry and Biophysics Royal Netherlands Academy of Arts and Sciences 1998 The Royal Society of Canada Flavelle Medal for meritorious achievement in biological science 2000 J Allyn Taylor International Prize in Medicine 2004 Louisa Gross Horwitz Prize from Columbia University 2004 Poulsson Medal the Norwegian Society of Pharmacology and Toxicology 2004 Associate of the National Academy of Sciences US 2004 Member of the American Academy of Arts and Sciences 2005 Wolf Prize in Medicine for his discovery of protein domains essential for mediating protein protein interactions in cellular signaling pathways and the insights this research has provided into cancer 2005 The Royal Medal The Queen s Medal from The Royal Society of London 2006 Companion of Honour 2007 Premiers Summit Award 2007 Howard Taylor Ricketts Award from University of Chicago 2008 Kyoto Prize Japan s Nobel for Proposing and Proving the Concept of Adapter Molecules in the Signal Transduction 2012 Thomson Reuters Citation Laureates candidate for Nobel Prize in Medicine for identification of the phosphotyrosine binding SH2 domain and demonstrating its function in protein protein interactions 2013 Annual award of the Canadian National Proteomics Network thereafter named the CNPN Tony Pawson Proteomics Award 16 References Edit a b Bernstein Alan Rossant Janet 2013 Anthony James Pawson 1952 2013 Biochemist whose vision of cell signalling transformed cancer research Nature 501 7466 168 Bibcode 2013Natur 501 168B doi 10 1038 501168a PMID 24025833 Pawson T Nash P 2003 Assembly of Cell Regulatory Systems Through Protein Interaction Domains Science 300 5618 445 452 CiteSeerX 10 1 1 321 3136 doi 10 1126 science 1083653 PMID 12702867 S2CID 14634947 Nash P Tang X Orlicky S Chen Q Gertler F B Mendenhall M D Sicheri F Pawson T Tyers M 2001 Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication Nature 414 6863 514 521 Bibcode 2001Natur 414 514N doi 10 1038 35107009 PMID 11734846 S2CID 16924667 Holland S J Gale N W Mbamalu G Yancopoulos G D Henkemeyer M Pawson T 1996 Bidirectional signalling through the EPH family receptor Nuk and its transmembrane ligands Nature 383 6602 722 725 Bibcode 1996Natur 383 722H doi 10 1038 383722a0 hdl 1807 9444 PMID 8878483 S2CID 4349898 Salcini A E McGlade J Pelicci G Nicoletti I Pawson T Pelicci P G 1994 Formation of Shc Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins Oncogene 9 10 2827 2836 PMID 8084588 Henkemeyer M Marengere L E McGlade J Olivier J P Conlon R A Holmyard D P Letwin K Pawson T 1994 Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis Oncogene 9 4 1001 1014 PMID 8134103 Stephens R M Loeb D M Copeland T D Pawson T Greene L A Kaplan D R 1994 Trk receptors use redundant signal transduction pathways involving SHC and PLC gamma 1 to mediate NGF responses Neuron 12 3 691 705 doi 10 1016 0896 6273 94 90223 2 PMID 8155326 S2CID 7053584 Crowe A J McGlade J Pawson T Hayman M J 1994 Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v sea tyrosine kinase Oncogene 9 2 537 544 PMID 8290264 Marengere L E M Songyang Z Gish G D Schaller M D Parsons J T Stern M J Cantley L C Pawson T 1994 SH2 domain specificity and activity modified by a single residue Nature 369 6480 502 505 Bibcode 1994Natur 369 502M doi 10 1038 369502a0 hdl 1807 9433 PMID 7515480 S2CID 22767669 Moran M F 1990 Src Homology Region 2 Domains Direct Protein Protein Interactions in Signal Transduction Proceedings of the National Academy of Sciences 87 21 8622 8626 Bibcode 1990PNAS 87 8622M doi 10 1073 pnas 87 21 8622 PMC 55009 PMID 2236073 Buck Genna 14 August 2013 Anthony Pawson helped discover how cells communicate with each other The Globe and Mail Retrieved 5 May 2014 Kyriakis John M Retrospective Tony Pawson 1952 2013 ASBMB Today Retrieved 16 January 2015 Renowned Toronto genetic researcher Dr Tony Pawson dies Toronto Star Thestar com 8 August 2013 Retrieved 9 August 2013 Scientific community reels at the loss of the world renowned Tony Pawson Maclean s 9 August 2013 Retrieved 10 August 2013 Paul Wells 9 August 2013 RIP Tony Pawson Maclean s Retrieved 10 August 2013 Past award winners Canadian National Proteomics Network Retrieved 16 July 2019 External links EditElaine Smith 5 July 2006 Professor named to Order of Companions of Honour news UofT University of Toronto Archived from the original on 15 September 2007 Retrieved 18 September 2007 Anthony Pawson OC O Ont PhD FRS FRSC Canadian Institutes of Health Research 17 April 2007 Archived from the original on 15 February 2005 Retrieved 18 September 2007 Laura Kane 8 August 2013 Renowned Toronto genetic researcher Dr Tony Pawson dies The Toronto Star Retrieved 8 August 2013 Anthony Pawson official website at the Samuel Lunenfeld Research Institute The Official Site of Louisa Gross Horwitz Prize Online Publications University of Toronto Retrieved from https en wikipedia org w index php title Tony Pawson biochemist amp oldid 1090506787, wikipedia, wiki, book, books, library,

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