Alverine is a drug used for functional gastrointestinal disorders. Alverine is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus.
Difficulties in breathing or shortness of breath, wheezing, swelling of the face or other parts of the body (associated with serious allergic reaction)
Yellowing of the whites of the eyes and the skin, due to liver inflammation
It was reported that alverine may induce toxic hepatitis.[3][4]
Mechanism of actionedit
Alverine acts directly on the muscle in the gut, causing it to relax. Alverine is a 5HT1A antagonist, which reduces rectal hypersensitivity.[5] This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease.[6] Diverticular disease is a condition in which small pouches form in the gut lining. These pouches can trap particles of food and become inflamed and painful. In irritable bowel syndrome, the normal activity of the gut muscle is lost. The muscle spasms result in symptoms such as abdominal pain and bloating, constipation or diarrhoea. By relaxing the gut muscle, alverine citrate relieves the symptoms of this condition. Alverine also relaxes the smooth muscle in the womb (uterus). It is therefore also used to treat painful menstruation, which is caused by muscle spasms in the uterus (dysmenorrhea).
Alverine capsules[7] are now available in the market. There are two strengths of capsule - 60 mg and 120 mg. The common dosage for adults and children over 12 years is 60–120 mg taken one, two or three a day, either before or after meals. Alverine is not suitable for those aged under 12 years. Women who are pregnant or breast-feeding should follow the instruction of doctors for the drug.
Development and marketingedit
A combination of alverine citrate and simeticone (ACS) for irritable bowel syndrome therapy were compared with placebo in a phase IV clinical trial.[8] At week 4, the alverine citrate and simeticone group had lower VAS scores for abdominal pain/discomfort (median: 40 mm vs. 50 mm, P = 0.047) and higher responder rate (46.8% vs. 34.3%, OR = 1.3; P = 0.01) as compared with the placebo group.[9]
The drug was firstly authorized for marketing on 03/06/2014. The marketing authorisation holder is Dr. Reddy's Laboratories (UK) Ltd.[10]
^(PDF). Medicines.org.uk. 2014. Archived from the original (PDF) on 2017-12-01.
^Durakoğlu Z, Boztaş G, Sezgil A, Kaymakoğlu S, Dinçer D, Ozdil S, Beşişik F, Mungan Z, Okten A (December 2002). (PDF). The Turkish Journal of Gastroenterology. 13 (4): 226–8. PMID 16378311. Archived from the original (PDF) on 2018-11-23.
^Arhan M, Koklu S, Koksal AS, Yolcu OF, Koruk S, Koruk I, Kayacetin E (August 2004). "Alverine citrate induced acute hepatitis". World Journal of Gastroenterology. 10 (15): 2303–4. doi:10.3748/wjg.v10.i15.2303. PMC4724969. PMID 15259090.
^Coelho, A. M.; Jacob, L.; Fioramonti, J.; Bueno, L. (October 2001). "Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype". The Journal of Pharmacy and Pharmacology. 53 (10): 1419–1426. doi:10.1211/0022357011777783. ISSN 0022-3573. PMID 11697552.
^"Detailed Info About Irritable bowel syndrome". Retrieved 2017-07-26.
^"Alverine Citrate 60 mg Hard Capsules". Drugs.com. Retrieved 2015-12-06.
^Clinical trial number NCT00542295 for "Efficacy and Safety of Meteospasmyl® in Irritable Bowel Syndrome" at ClinicalTrials.gov
^Wittmann T, Paradowski L, Ducrotté P, Bueno L, Andro Delestrain MC (March 2010). "Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome--a randomized, double-blind, placebo-controlled study". Alimentary Pharmacology & Therapeutics. 31 (6): 615–24. doi:10.1111/j.1365-2036.2009.04216.x. PMID 20003095. S2CID 35881469.
^"Alverine citrate 60 mg hard capsules - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. Retrieved 2015-12-06.
April 15, 2024
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Not to be confused with Alvameline This article needs additional citations for verification Please help improve this article by adding citations to reliable sources Unsourced material may be challenged and removed Find sources Alverine news newspapers books scholar JSTOR January 2016 Learn how and when to remove this template message Alverine is a drug used for functional gastrointestinal disorders Alverine is a smooth muscle relaxant Smooth muscle is a type of muscle that is not under voluntary control it is the muscle present in places such as the gut and uterus AlverineClinical dataAHFS Drugs comInternational Drug NamesATC codeA03AX08 WHO Legal statusLegal statusUK General sales list GSL OTC IdentifiersIUPAC name N Ethyl 3 phenyl N 3 phenylpropyl propan 1 amineCAS Number150 59 4 YPubChem CID3678DrugBankDB01616 YChemSpider3550 YUNII46TIR1560OKEGGD07440 YChEBICHEBI 518413 YChEMBLChEMBL253371 YCompTox Dashboard EPA DTXSID0048557ECHA InfoCard100 005 240Chemical and physical dataFormulaC 20H 27NMolar mass281 443 g mol 13D model JSmol Interactive imageSMILES c1ccccc1CCCN CC CCCc2ccccc2InChI InChI 1S C20H27N c1 2 21 17 9 15 19 11 5 3 6 12 19 18 10 16 20 13 7 4 8 14 20 h3 8 11 14H 2 9 10 15 18H2 1H3 YKey ZPFXAOWNKLFJDN UHFFFAOYSA N Y verify Contents 1 Adverse effects 2 Mechanism of action 3 Development and marketing 4 ReferencesAdverse effects editThe side effects of alverine include 1 2 Difficulties in breathing or shortness of breath wheezing swelling of the face or other parts of the body associated with serious allergic reaction Yellowing of the whites of the eyes and the skin due to liver inflammation A feeling of nausea or dizziness Headache Minor allergic reaction skin rash itching It was reported that alverine may induce toxic hepatitis 3 4 Mechanism of action editAlverine acts directly on the muscle in the gut causing it to relax Alverine is a 5HT1A antagonist which reduces rectal hypersensitivity 5 This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease 6 Diverticular disease is a condition in which small pouches form in the gut lining These pouches can trap particles of food and become inflamed and painful In irritable bowel syndrome the normal activity of the gut muscle is lost The muscle spasms result in symptoms such as abdominal pain and bloating constipation or diarrhoea By relaxing the gut muscle alverine citrate relieves the symptoms of this condition Alverine also relaxes the smooth muscle in the womb uterus It is therefore also used to treat painful menstruation which is caused by muscle spasms in the uterus dysmenorrhea Alverine capsules 7 are now available in the market There are two strengths of capsule 60 mg and 120 mg The common dosage for adults and children over 12 years is 60 120 mg taken one two or three a day either before or after meals Alverine is not suitable for those aged under 12 years Women who are pregnant or breast feeding should follow the instruction of doctors for the drug Development and marketing editA combination of alverine citrate and simeticone ACS for irritable bowel syndrome therapy were compared with placebo in a phase IV clinical trial 8 At week 4 the alverine citrate and simeticone group had lower VAS scores for abdominal pain discomfort median 40 mm vs 50 mm P 0 047 and higher responder rate 46 8 vs 34 3 OR 1 3 P 0 01 as compared with the placebo group 9 The drug was firstly authorized for marketing on 03 06 2014 The marketing authorisation holder is Dr Reddy s Laboratories UK Ltd 10 References edit Alverine capsules Spasmonal Audmonal Side effects dosage Patient Patient Retrieved 2015 12 06 Alverine Citrate Patient Information Leaflet PDF Medicines org uk 2014 Archived from the original PDF on 2017 12 01 Durakoglu Z Boztas G Sezgil A Kaymakoglu S Dincer D Ozdil S Besisik F Mungan Z Okten A December 2002 Alverine induced toxic hepatitis a case report PDF The Turkish Journal of Gastroenterology 13 4 226 8 PMID 16378311 Archived from the original PDF on 2018 11 23 Arhan M Koklu S Koksal AS Yolcu OF Koruk S Koruk I Kayacetin E August 2004 Alverine citrate induced acute hepatitis World Journal of Gastroenterology 10 15 2303 4 doi 10 3748 wjg v10 i15 2303 PMC 4724969 PMID 15259090 Coelho A M Jacob L Fioramonti J Bueno L October 2001 Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5 HT1A receptor subtype The Journal of Pharmacy and Pharmacology 53 10 1419 1426 doi 10 1211 0022357011777783 ISSN 0022 3573 PMID 11697552 Detailed Info About Irritable bowel syndrome Retrieved 2017 07 26 Alverine Citrate 60 mg Hard Capsules Drugs com Retrieved 2015 12 06 Clinical trial number NCT00542295 for Efficacy and Safety of Meteospasmyl in Irritable Bowel Syndrome at ClinicalTrials gov Wittmann T Paradowski L Ducrotte P Bueno L Andro Delestrain MC March 2010 Clinical trial the efficacy of alverine citrate simeticone combination on abdominal pain discomfort in irritable bowel syndrome a randomized double blind placebo controlled study Alimentary Pharmacology amp Therapeutics 31 6 615 24 doi 10 1111 j 1365 2036 2009 04216 x PMID 20003095 S2CID 35881469 Alverine citrate 60 mg hard capsules Summary of Product Characteristics SPC eMC www medicines org uk Retrieved 2015 12 06 Retrieved from https en wikipedia org w index php title Alverine amp oldid 1212694410, wikipedia, wiki, book, books, library,
