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Wikipedia

ANAPC1

January 01, 1970

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.[5][6]

ANAPC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANAPC1, APC1, MCPR, TSG24, anaphase promoting complex subunit 1
External IDsOMIM: 608473; MGI: 103097; HomoloGene: 7414; GeneCards: ANAPC1; OMA:ANAPC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

64682

17222

Ensembl

ENSG00000153107

ENSMUSG00000014355

UniProt

Q9H1A4

P53995

RefSeq (mRNA)

NM_022662

NM_008569

RefSeq (protein)

NP_073153

NP_032595

Location (UCSC)Chr 2: 111.61 – 111.88 MbChr 2: 128.45 – 128.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).[6]

Interactions edit

ANAPC1 has been shown to interact with ANAPC5,[7][8] ANAPC4,[7][8] ANAPC2,[7][8] CDC27[7][8] and ANAPC7.[7][8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153107 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014355 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.
  6. ^ a b "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1".
  7. ^ a b c d e Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. S2CID 5942532.
  8. ^ a b c d e Sumara I, Vorlaufer E, Gieffers C, Peters B H, Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.

External links edit

Further reading edit

  • Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.
  • Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi:10.1073/pnas.96.20.11317. PMC 18031. PMID 10500174.
  • Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  • Zur A, Brandeis M (2001). "Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis". EMBO J. 20 (4): 792–801. doi:10.1093/emboj/20.4.792. PMC 145417. PMID 11179223.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
  • Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC 291822. PMID 14657031.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.


 

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January 01, 1970
anapc1, anaphase, promoting, complex, subunit, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4ui9, 5a31, 5g04, 5g05identifiersaliases, apc1, mcpr, tsg24, anaphase, promoting, complex, subunit, 1external, id. Anaphase promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene 5 6 ANAPC1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4UI9 5A31 5G04 5G05IdentifiersAliasesANAPC1 APC1 MCPR TSG24 anaphase promoting complex subunit 1External IDsOMIM 608473 MGI 103097 HomoloGene 7414 GeneCards ANAPC1 OMA ANAPC1 orthologsGene location Human Chr Chromosome 2 human 1 Band2q13Start111 611 639 bp 1 End111 884 690 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 F1Start128 452 024 bp 2 End128 529 311 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpancreatic ductal cellAchilles tendontibialis anterior muscleendothelial cellbone marrow cellsdeltoid musclemiddle temporal gyrusvastus lateralis musclerectumskin of abdomenTop expressed insomiteprimitive streakmaxillary prominencehair follicledermisabdominal wallrenal corpuscleautopod regionhandendocardial cushionMore reference expression dataBioGPSn aGene ontologyMolecular functionubiquitin protein ligase activityCellular componentnucleoplasm cytosol anaphase promoting complex nucleusBiological processcell cycle anaphase promoting complex dependent catabolic process protein ubiquitination protein K11 linked ubiquitination cell division metaphase regulation of mitotic cell cycle phase transition ubiquitin dependent protein catabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6468217222EnsemblENSG00000153107ENSMUSG00000014355UniProtQ9H1A4P53995RefSeq mRNA NM 022662NM 008569RefSeq protein NP 073153NP 032595Location UCSC Chr 2 111 61 111 88 MbChr 2 128 45 128 53 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse ANAPC1 is one of at least ten subunits of the anaphase promoting complex APC which functions at the metaphase to anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome thereby allowing progression through the cell cycle supplied by OMIM 6 Contents 1 Interactions 2 References 3 External links 4 Further readingInteractions editANAPC1 has been shown to interact with ANAPC5 7 8 ANAPC4 7 8 ANAPC2 7 8 CDC27 7 8 and ANAPC7 7 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000153107 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000014355 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Jorgensen PM Graslund S Betz R Stahl S Larsson C Hoog C February 2001 Characterisation of the human APC1 the largest subunit of the anaphase promoting complex Gene 262 1 2 51 9 doi 10 1016 S0378 1119 00 00511 4 PMID 11179667 a b Entrez Gene ANAPC1 anaphase promoting complex subunit 1 a b c d e Vodermaier HC Gieffers C Maurer Stroh S Eisenhaber F Peters JM September 2003 TPR subunits of the anaphase promoting complex mediate binding to the activator protein CDH1 Curr Biol 13 17 1459 68 Bibcode 2003CBio 13 1459V doi 10 1016 S0960 9822 03 00581 5 ISSN 0960 9822 PMID 12956947 S2CID 5942532 a b c d e Sumara I Vorlaufer E Gieffers C Peters B H Peters J M November 2000 Characterization of vertebrate cohesin complexes and their regulation in prophase J Cell Biol 151 4 749 62 doi 10 1083 jcb 151 4 749 ISSN 0021 9525 PMC 2169443 PMID 11076961 External links editHuman ANAPC1 genome location and ANAPC1 gene details page in the UCSC Genome Browser Further reading editGrossberger R Gieffers C Zachariae W et al 1999 Characterization of the DOC1 APC10 subunit of the yeast and the human anaphase promoting complex J Biol Chem 274 20 14500 7 doi 10 1074 jbc 274 20 14500 PMID 10318877 Gieffers C Peters BH Kramer ER et al 1999 Expression of the CDH1 associated form of the anaphase promoting complex in postmitotic neurons Proc Natl Acad Sci U S A 96 20 11317 22 Bibcode 1999PNAS 9611317G doi 10 1073 pnas 96 20 11317 PMC 18031 PMID 10500174 Gmachl M Gieffers C Podtelejnikov AV et al 2000 The RING H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase promoting complex Proc Natl Acad Sci U S A 97 16 8973 8 Bibcode 2000PNAS 97 8973G doi 10 1073 pnas 97 16 8973 PMC 16806 PMID 10922056 Zur A Brandeis M 2001 Securin degradation is mediated by fzy and fzr and is required for complete chromatid separation but not for cytokinesis EMBO J 20 4 792 801 doi 10 1093 emboj 20 4 792 PMC 145417 PMID 11179223 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Vodermaier HC Gieffers C Maurer Stroh S et al 2004 TPR subunits of the anaphase promoting complex mediate binding to the activator protein CDH1 Curr Biol 13 17 1459 68 Bibcode 2003CBio 13 1459V doi 10 1016 S0960 9822 03 00581 5 PMID 12956947 S2CID 5942532 Kraft C Herzog F Gieffers C et al 2004 Mitotic regulation of the human anaphase promoting complex by phosphorylation EMBO J 22 24 6598 609 doi 10 1093 emboj cdg627 PMC 291822 PMID 14657031 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Beausoleil SA Jedrychowski M Schwartz D et al 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Nousiainen M Sillje HH Sauer G et al 2006 Phosphoproteome analysis of the human mitotic spindle Proc Natl Acad Sci U S A 103 14 5391 6 Bibcode 2006PNAS 103 5391N doi 10 1073 pnas 0507066103 PMC 1459365 PMID 16565220 nbsp This enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ANAPC1 amp oldid 1211133792, wikipedia, wiki, book, books, library,

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