Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7gene.[5] Multiple transcript variants encoding different isoforms have been found for this gene.
This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.[5]
^ abcdVodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
^Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC2169443. PMID 11076961.
^Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC16806. PMID 10922056.
^Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC2635557. PMID 18997788.
External linksedit
Human ANAPC7 genome location and ANAPC7 gene details page in the UCSC Genome Browser.
Further readingedit
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu H, Peters JM, King RW, et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.
Chan GK, Jablonski SA, Sudakin V, et al. (1999). "Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC". J. Cell Biol. 146 (5): 941–54. doi:10.1083/jcb.146.5.941. PMC2169490. PMID 10477750.
Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi:10.1073/pnas.96.20.11317. PMC18031. PMID 10500174.
Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC16806. PMID 10922056.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Park KH, Choi SE, Eom M, Kang Y (2006). "Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships". Breast Cancer Res. 7 (2): R238–47. doi:10.1186/bcr978. PMC1064132. PMID 15743504.
Turnell AS, Stewart GS, Grand RJ, et al. (2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature. 438 (7068): 690–5. Bibcode:2005Natur.438..690T. doi:10.1038/nature04151. PMID 16319895. S2CID 4432156.
This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.
anapc7, anaphase, promoting, complex, subunit, enzyme, that, humans, encoded, gene, multiple, transcript, variants, encoding, different, isoforms, have, been, found, this, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes3ffl, 4ui9, 5a31, 5. Anaphase promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene 5 Multiple transcript variants encoding different isoforms have been found for this gene ANAPC7Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3FFL 4UI9 5A31 5G04 5G05IdentifiersAliasesANAPC7 APC7 anaphase promoting complex subunit 7 FERBONExternal IDsOMIM 606949 MGI 1929711 HomoloGene 10512 GeneCards ANAPC7Gene location Human Chr Chromosome 12 human 1 Band12q24 11Start110 372 900 bp 1 End110 403 730 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 FStart122 559 756 bp 2 End122 582 975 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpancreatic ductal cellcerebellar hemisphereright uterine tubevaginaright lobe of thyroid glandminor salivary glandskin of abdomencaudate nucleusganglionic eminenceleft uterine tubeTop expressed insacculeotic placodeinterventricular septumexternal carotid arteryinternal carotid arterymedullary collecting ducttrigeminal ganglionmaxillary prominencerenal corpusclePaneth cellMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein phosphatase binding protein bindingCellular componentnucleoplasm cytosol anaphase promoting complex nucleusBiological processcell cycle anaphase promoting complex dependent catabolic process protein ubiquitination protein K11 linked ubiquitination cell division regulation of mitotic cell cycle phase transition ubiquitin dependent protein catabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5143456317EnsemblENSG00000196510ENSMUSG00000029466UniProtQ9UJX3Q9WVM3RefSeq mRNA NM 001137664NM 016238NM 001385208NM 001385209NM 001385210NM 001385211NM 001385212NM 019805RefSeq protein NP 001131136NP 057322NP 057322 2NP 062779Location UCSC Chr 12 110 37 110 4 MbChr 5 122 56 122 58 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 External links 5 Further readingFunction editThis gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex cyclosome APC C a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B type cyclins for 26S proteasome mediated degradation through ubiquitination The encoded protein is required for proper protein ubiquitination function of APC C and for the interaction of APC C with certain transcription coactivators 5 Interactions editANAPC7 has been shown to interact with ANAPC1 6 7 ANAPC4 6 CDC27 6 8 and CDC20 6 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000196510 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029466 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene ANAPC7 anaphase promoting complex subunit 7 a b c d Vodermaier HC Gieffers C Maurer Stroh S Eisenhaber F Peters JM September 2003 TPR subunits of the anaphase promoting complex mediate binding to the activator protein CDH1 Curr Biol 13 17 1459 68 Bibcode 2003CBio 13 1459V doi 10 1016 S0960 9822 03 00581 5 PMID 12956947 S2CID 5942532 Sumara I Vorlaufer E Gieffers C Peters BH Peters JM November 2000 Characterization of vertebrate cohesin complexes and their regulation in prophase J Cell Biol 151 4 749 62 doi 10 1083 jcb 151 4 749 PMC 2169443 PMID 11076961 Gmachl M Gieffers C Podtelejnikov AV Mann M Peters JM August 2000 The RING H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase promoting complex Proc Natl Acad Sci U S A 97 16 8973 8 Bibcode 2000PNAS 97 8973G doi 10 1073 pnas 97 16 8973 PMC 16806 PMID 10922056 Nilsson J Yekezare M Minshull J Pines J December 2008 The APC C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction Nat Cell Biol 10 12 1411 20 doi 10 1038 ncb1799 PMC 2635557 PMID 18997788 External links editHuman ANAPC7 genome location and ANAPC7 gene details page in the UCSC Genome Browser Further reading editAndersson B Wentland MA Ricafrente JY et al 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 13 doi 10 1006 abio 1996 0138 PMID 8619474 Yu W Andersson B Worley KC et al 1997 Large Scale Concatenation cDNA Sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Yu H Peters JM King RW et al 1998 Identification of a cullin homology region in a subunit of the anaphase promoting complex Science 279 5354 1219 22 Bibcode 1998Sci 279 1219Y doi 10 1126 science 279 5354 1219 PMID 9469815 Grossberger R Gieffers C Zachariae W et al 1999 Characterization of the DOC1 APC10 subunit of the yeast and the human anaphase promoting complex J Biol Chem 274 20 14500 7 doi 10 1074 jbc 274 20 14500 PMID 10318877 Chan GK Jablonski SA Sudakin V et al 1999 Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp E Functions at Kinetochores and Binds the Cyclosome APC J Cell Biol 146 5 941 54 doi 10 1083 jcb 146 5 941 PMC 2169490 PMID 10477750 Gieffers C Peters BH Kramer ER et al 1999 Expression of the CDH1 associated form of the anaphase promoting complex in postmitotic neurons Proc Natl Acad Sci U S A 96 20 11317 22 Bibcode 1999PNAS 9611317G doi 10 1073 pnas 96 20 11317 PMC 18031 PMID 10500174 Gmachl M Gieffers C Podtelejnikov AV et al 2000 The RING H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase promoting complex Proc Natl Acad Sci U S A 97 16 8973 8 Bibcode 2000PNAS 97 8973G doi 10 1073 pnas 97 16 8973 PMC 16806 PMID 10922056 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Vodermaier HC Gieffers C Maurer Stroh S et al 2004 TPR subunits of the anaphase promoting complex mediate binding to the activator protein CDH1 Curr Biol 13 17 1459 68 Bibcode 2003CBio 13 1459V doi 10 1016 S0960 9822 03 00581 5 PMID 12956947 S2CID 5942532 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Park KH Choi SE Eom M Kang Y 2006 Downregulation of the anaphase promoting complex APC 7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships Breast Cancer Res 7 2 R238 47 doi 10 1186 bcr978 PMC 1064132 PMID 15743504 Turnell AS Stewart GS Grand RJ et al 2005 The APC C and CBP p300 cooperate to regulate transcription and cell cycle progression Nature 438 7068 690 5 Bibcode 2005Natur 438 690T doi 10 1038 nature04151 PMID 16319895 S2CID 4432156 nbsp This article on a gene on human chromosome 12 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ANAPC7 amp oldid 1211134282, wikipedia, wiki, book, books, library,
