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Wikipedia

AKAP1

April 11, 2024

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.[5][6][7]

AKAP1
Identifiers
AliasesAKAP1, AKAP, AKAP121, AKAP149, AKAP84, D-PPP1R43, PRKA1, SAKAP84, TDRD17, A-kinase anchoring protein 1
External IDsOMIM: 602449 MGI: 104729 HomoloGene: 31165 GeneCards: AKAP1
Orthologs
SpeciesHumanMouse
Entrez

8165

11640

Ensembl

ENSG00000121057

ENSMUSG00000018428

UniProt

Q92667

O08715

RefSeq (mRNA)

NM_001042541
NM_009648

RefSeq (protein)

NP_001036006
NP_033778

Location (UCSC)Chr 17: 57.09 – 57.12 MbChr 11: 88.72 – 88.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.[7]

Interactions edit

AKAP1 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121057 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018428 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Trendelenburg G, Hummel M, Riecken EO, Hanski C (Sep 1996). "Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain". Biochem Biophys Res Commun. 225 (1): 313–9. doi:10.1006/bbrc.1996.1172. PMID 8769136.
  6. ^ Lin RY, Moss SB, Rubin CS (Jan 1996). "Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells". J Biol Chem. 270 (46): 27804–11. doi:10.1074/jbc.270.46.27804. PMID 7499250.
  7. ^ a b "Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1".
  8. ^ a b Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483.
  9. ^ Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. doi:10.1074/jbc.M103885200. PMID 11483602.
  10. ^ a b Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
  11. ^ a b Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K (April 2000). "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. doi:10.1006/jmbi.2000.3662. PMID 10764601.
  12. ^ Kapiloff MS, Schillace RV, Westphal AM, Scott JD (Aug 1999). "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes". J. Cell Sci. 112 (16): 2725–36. doi:10.1242/jcs.112.16.2725. PMID 10413680.

External links edit

Further reading edit

  • Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
  • Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
  • Huang LJ, Durick K, Weiner JA, et al. (1997). "Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits". J. Biol. Chem. 272 (12): 8057–64. doi:10.1074/jbc.272.12.8057. PMID 9065479.
  • Huang LJ, Wang L, Ma Y, et al. (1999). "NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum". J. Cell Biol. 145 (5): 951–9. doi:10.1083/jcb.145.5.951. PMC 2133123. PMID 10352013.
  • Herberg FW, Maleszka A, Eide T, et al. (2000). "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. doi:10.1006/jmbi.2000.3662. PMID 10764601.
  • Steen RL, Martins SB, Taskén K, Collas P (2000). "Recruitment of Protein Phosphatase 1 to the Nuclear Envelope by a-Kinase Anchoring Protein Akap149 Is a Prerequisite for Nuclear Lamina Assembly". J. Cell Biol. 150 (6): 1251–62. doi:10.1083/jcb.150.6.1251. PMC 2150688. PMID 10995432.
  • Furusawa M, Ohnishi T, Taira T, et al. (2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. doi:10.1074/jbc.M103885200. PMID 11483602.
  • Razani B, Lisanti MP (2001). "Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A". Am. J. Physiol., Cell Physiol. 281 (4): C1241–50. doi:10.1152/ajpcell.2001.281.4.C1241. PMID 11546661. S2CID 34190425.
  • Yukitake H, Furusawa M, Taira T, et al. (2003). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483.
  • Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. doi:10.1074/jbc.M206387200. PMID 12414807.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Carlson CR, Ruppelt A, Taskén K (2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
  • Steen RL, Beullens M, Landsverk HB, et al. (2004). "AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase". J. Cell Sci. 116 (Pt 11): 2237–46. doi:10.1242/jcs.00432. PMID 12697839.
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
  • Cardone L, Carlucci A, Affaitati A, et al. (2004). "Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1, a Novel Positive Regulator of src Signaling". Mol. Cell. Biol. 24 (11): 4613–26. doi:10.1128/MCB.24.11.4613-4626.2004. PMC 416429. PMID 15143158.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.


 

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

April 11, 2024
akap1, kinase, anchor, protein, mitochondrial, enzyme, that, humans, encoded, gene, identifiersaliases, akap, akap84, ppp1r43, prka1, sakap84, tdrd17, kinase, anchoring, protein, 1external, idsomim, 602449, 104729, homologene, 31165, genecards, gene, location,. A kinase anchor protein 1 mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene 5 6 7 AKAP1IdentifiersAliasesAKAP1 AKAP AKAP121 AKAP149 AKAP84 D PPP1R43 PRKA1 SAKAP84 TDRD17 A kinase anchoring protein 1External IDsOMIM 602449 MGI 104729 HomoloGene 31165 GeneCards AKAP1Gene location Human Chr Chromosome 17 human 1 Band17q22Start57 085 092 bp 1 End57 121 346 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 CStart88 721 618 bp 2 End88 755 412 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytespermbody of tonguethoracic diaphragmcardiasaphenous veinvena cavabiceps brachiivastus lateralis musclerenal medullaTop expressed inseminiferous tubulespermatidbrown adipose tissuedigastric muscleright ventriclesoleus muscleextraocular musclethoracic diaphragmsecondary oocyteinterventricular septumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding protein kinase A regulatory subunit binding nucleic acid binding RNA bindingCellular componentintegral component of membrane mitochondrion mitochondrial outer membrane membrane cytosolBiological processregulation of protein kinase A signaling blood coagulationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez816511640EnsemblENSG00000121057ENSMUSG00000018428UniProtQ92667O08715RefSeq mRNA NM 001242902NM 001242903NM 003488NM 139275NM 001370423NM 001370424NM 001370425NM 001370426NM 001370427NM 001042541NM 009648RefSeq protein NP 001229831NP 001229832NP 003479NP 001357352NP 001357353NP 001357354NP 001357355NP 001357356NP 001036006NP 033778Location UCSC Chr 17 57 09 57 12 MbChr 11 88 72 88 76 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 External links 5 Further readingFunction editThe A kinase anchor proteins AKAPs are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A PKA and confining the holoenzyme to discrete locations within the cell This gene encodes a member of the AKAP family The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion This protein is speculated to be involved in the cAMP dependent signal transduction pathway and in directing RNA to a specific cellular compartment 7 Interactions editAKAP1 has been shown to interact with C3orf15 8 MYCBP 8 9 PRKAR1A 10 11 PRKAR1B 10 and PRKAR2A 11 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000121057 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000018428 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Trendelenburg G Hummel M Riecken EO Hanski C Sep 1996 Molecular characterization of AKAP149 a novel A kinase anchor protein with a KH domain Biochem Biophys Res Commun 225 1 313 9 doi 10 1006 bbrc 1996 1172 PMID 8769136 Lin RY Moss SB Rubin CS Jan 1996 Characterization of S AKAP84 a novel developmentally regulated A kinase anchor protein of male germ cells J Biol Chem 270 46 27804 11 doi 10 1074 jbc 270 46 27804 PMID 7499250 a b Entrez Gene AKAP1 A kinase PRKA anchor protein 1 a b Yukitake H Furusawa M Taira T Iguchi Ariga SM Ariga H Nov 2002 AAT 1 a novel testis specific AMY 1 binding protein forms a quaternary complex with AMY 1 A kinase anchor protein 84 and a regulatory subunit of cAMP dependent protein kinase and is phosphorylated by its kinase J Biol Chem 277 47 45480 92 doi 10 1074 jbc M206201200 PMID 12223483 Furusawa M Ohnishi T Taira T Iguchi Ariga SM Ariga H Sep 2001 AMY 1 a c Myc binding protein is localized in the mitochondria of sperm by association with S AKAP84 an anchor protein of cAMP dependent protein kinase J Biol Chem 276 39 36647 51 doi 10 1074 jbc M103885200 PMID 11483602 a b Carlson CR Ruppelt A Tasken K Mar 2003 A kinase anchoring protein AKAP interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system J Mol Biol 327 3 609 18 doi 10 1016 S0022 2836 03 00093 7 PMID 12634056 a b Herberg FW Maleszka A Eide T Vossebein L Tasken K April 2000 Analysis of A kinase anchoring protein AKAP interaction with protein kinase A PKA regulatory subunits PKA isoform specificity in AKAP binding J Mol Biol 298 2 329 39 doi 10 1006 jmbi 2000 3662 PMID 10764601 Kapiloff MS Schillace RV Westphal AM Scott JD Aug 1999 mAKAP an A kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes J Cell Sci 112 16 2725 36 doi 10 1242 jcs 112 16 2725 PMID 10413680 External links editHuman AKAP1 genome location and AKAP1 gene details page in the UCSC Genome Browser Further reading editLester LB Scott JD 1997 Anchoring and scaffold proteins for kinases and phosphatases Recent Prog Horm Res 52 409 29 discussion 429 30 PMID 9238861 Michel JJ Scott JD 2002 AKAP mediated signal transduction Annu Rev Pharmacol Toxicol 42 235 57 doi 10 1146 annurev pharmtox 42 083101 135801 PMID 11807172 Huang LJ Durick K Weiner JA et al 1997 Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits J Biol Chem 272 12 8057 64 doi 10 1074 jbc 272 12 8057 PMID 9065479 Huang LJ Wang L Ma Y et al 1999 NH2 Terminal Targeting Motifs Direct Dual Specificity A Kinase anchoring Protein 1 D AKAP1 to Either Mitochondria or Endoplasmic Reticulum J Cell Biol 145 5 951 9 doi 10 1083 jcb 145 5 951 PMC 2133123 PMID 10352013 Herberg FW Maleszka A Eide T et al 2000 Analysis of A kinase anchoring protein AKAP interaction with protein kinase A PKA regulatory subunits PKA isoform specificity in AKAP binding J Mol Biol 298 2 329 39 doi 10 1006 jmbi 2000 3662 PMID 10764601 Steen RL Martins SB Tasken K Collas P 2000 Recruitment of Protein Phosphatase 1 to the Nuclear Envelope by a Kinase Anchoring Protein Akap149 Is a Prerequisite for Nuclear Lamina Assembly J Cell Biol 150 6 1251 62 doi 10 1083 jcb 150 6 1251 PMC 2150688 PMID 10995432 Furusawa M Ohnishi T Taira T et al 2001 AMY 1 a c Myc binding protein is localized in the mitochondria of sperm by association with S AKAP84 an anchor protein of cAMP dependent protein kinase J Biol Chem 276 39 36647 51 doi 10 1074 jbc M103885200 PMID 11483602 Razani B Lisanti MP 2001 Two distinct caveolin 1 domains mediate the functional interaction of caveolin 1 with protein kinase A Am J Physiol Cell Physiol 281 4 C1241 50 doi 10 1152 ajpcell 2001 281 4 C1241 PMID 11546661 S2CID 34190425 Yukitake H Furusawa M Taira T et al 2003 AAT 1 a novel testis specific AMY 1 binding protein forms a quaternary complex with AMY 1 A kinase anchor protein 84 and a regulatory subunit of cAMP dependent protein kinase and is phosphorylated by its kinase J Biol Chem 277 47 45480 92 doi 10 1074 jbc M206201200 PMID 12223483 Furusawa M Taira T Iguchi Ariga SM Ariga H 2003 AMY 1 interacts with S AKAP84 and AKAP95 in the cytoplasm and the nucleus respectively and inhibits cAMP dependent protein kinase activity by preventing binding of its catalytic subunit to A kinase anchoring protein AKAP complex J Biol Chem 277 52 50885 92 doi 10 1074 jbc M206387200 PMID 12414807 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Carlson CR Ruppelt A Tasken K 2003 A kinase anchoring protein AKAP interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system J Mol Biol 327 3 609 18 doi 10 1016 S0022 2836 03 00093 7 PMID 12634056 Steen RL Beullens M Landsverk HB et al 2004 AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase J Cell Sci 116 Pt 11 2237 46 doi 10 1242 jcs 00432 PMID 12697839 Hillman RT Green RE Brenner SE 2005 An unappreciated role for RNA surveillance Genome Biol 5 2 R8 doi 10 1186 gb 2004 5 2 r8 PMC 395752 PMID 14759258 Cardone L Carlucci A Affaitati A et al 2004 Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1 a Novel Positive Regulator of src Signaling Mol Cell Biol 24 11 4613 26 doi 10 1128 MCB 24 11 4613 4626 2004 PMC 416429 PMID 15143158 Beausoleil SA Jedrychowski M Schwartz D et al 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 nbsp This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title AKAP1 amp oldid 1187414702, wikipedia, wiki, book, books, library,

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