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Wikipedia

PRKAR1A

January 01, 1970

cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene.[5]

PRKAR1A
Identifiers
AliasesPRKAR1A, ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1, protein kinase cAMP-dependent type I regulatory subunit alpha
External IDsOMIM: 188830 MGI: 104878 HomoloGene: 37664 GeneCards: PRKAR1A
Orthologs
SpeciesHumanMouse
Entrez

5573

19084

Ensembl

ENSG00000108946

ENSMUSG00000020612

UniProt

P10644

Q9DBC7

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 17: 68.51 – 68.55 MbChr 11: 109.54 – 109.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids Three alternatively spliced transcript variants encoding the same protein have been observed.[6]

Clinical significance edit

Functional null mutations in this gene cause Carney complex (CNC), an autosomal dominant multiple neoplasia syndrome. This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2.[6]

Mutation of PRKAR1A leads to the Carney complex, associating multiple endocrine tumors.[citation needed]

Interactions edit

PRKAR1A has been shown to interact with:

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108946 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020612 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T (December 1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet. 41 (5): 925–32. PMC 1684338. PMID 3479018.
  6. ^ a b "Entrez Gene: PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)".
  7. ^ Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (October 1997). "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11184–9. Bibcode:1997PNAS...9411184J. doi:10.1073/pnas.94.21.11184. PMC 23409. PMID 9326583.
  8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  9. ^ a b Carlson CR, Ruppelt A, Taskén K (March 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/s0022-2836(03)00093-7. PMID 12634056.
  10. ^ Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K (April 2000). "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. doi:10.1006/jmbi.2000.3662. PMID 10764601.
  11. ^ Brown PR, Miki K, Harper DB, Eddy EM (June 2003). "A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum". Biol. Reprod. 68 (6): 2241–8. doi:10.1095/biolreprod.102.013466. PMID 12606363.
  12. ^ Miki K, Eddy EM (December 1998). "Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1". J. Biol. Chem. 273 (51): 34384–90. doi:10.1074/jbc.273.51.34384. PMID 9852104.
  13. ^ a b Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (February 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1627–32. Bibcode:2003PNAS..100.1627L. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.
  14. ^ Tortora G, Damiano V, Bianco C, Baldassarre G, Bianco AR, Lanfrancone L, Pelicci PG, Ciardiello F (February 1997). "The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor". Oncogene. 14 (8): 923–8. doi:10.1038/sj.onc.1200906. PMID 9050991. S2CID 10640461.
  15. ^ Küssel-Andermann P, El-Amraoui A, Safieddine S, Hardelin JP, Nouaille S, Camonis J, Petit C (September 2000). "Unconventional myosin VIIA is a novel A-kinase-anchoring protein". J. Biol. Chem. 275 (38): 29654–9. doi:10.1074/jbc.M004393200. PMID 10889203.
  16. ^ Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (October 1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. doi:10.1016/S0021-9258(19)36921-2. PMID 8407966.
  17. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading edit

  • Stratakis CA (2002). "Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas" (Carney complex)". Ann. N. Y. Acad. Sci. 968 (1): 3–21. Bibcode:2002NYASA.968....3S. doi:10.1111/j.1749-6632.2002.tb04323.x. PMID 12119264. S2CID 26108486.
  • Bourdeau I, Stratakis CA (2002). "Cyclic AMP-dependent signaling aberrations in macronodular adrenal disease". Ann. N. Y. Acad. Sci. 968 (1): 240–55. Bibcode:2002NYASA.968..240B. doi:10.1111/j.1749-6632.2002.tb04339.x. PMID 12119280. S2CID 22397904.
  • Alto N, Carlisle Michel JJ, Dodge KL, Langeberg LK, Scott JD (2003). "Intracellular targeting of protein kinases and phosphatases". Diabetes. 51 (Suppl 3): S385–8. doi:10.2337/diabetes.51.2007.s385. PMID 12475780.
  • Stergiopoulos SG, Stratakis CA (2003). "Human tumors associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease!". FEBS Lett. 546 (1): 59–64. doi:10.1016/S0014-5793(03)00452-6. PMID 12829237. S2CID 37055425.
  • Bossis I, Stratakis CA (2004). "Minireview: PRKAR1A: normal and abnormal functions". Endocrinology. 145 (12): 5452–8. doi:10.1210/en.2004-0900. PMID 15331577.
  • Cho-Chung YS, Nesterova MV (2006). "Tumor reversion: protein kinase A isozyme switching". Ann. N. Y. Acad. Sci. 1058: 76–86. doi:10.1196/annals.1359.014. PMID 16394127. S2CID 45471438.
  • Lytras A, Tolis G (2006). "Growth hormone-secreting tumors: genetic aspects and data from animal models". Neuroendocrinology. 83 (3–4): 166–78. doi:10.1159/000095525. PMID 17047380. S2CID 45606794.
  • Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID 17168834.
  • Boshart M, Weih F, Nichols M, Schütz G (1991). "The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase" (PDF). Cell. 66 (5): 849–59. doi:10.1016/0092-8674(91)90432-X. PMID 1832337. S2CID 8277752.
  • Jones KW, Shapero MH, Chevrette M, Fournier RE (1991). "Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A". Cell. 66 (5): 861–72. doi:10.1016/0092-8674(91)90433-Y. PMID 1889088. S2CID 24273073.
  • Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. 145 (11): 3699–705. doi:10.4049/jimmunol.145.11.3699. PMID 1978848.
  • Sandberg M, Skålhegg B, Jahnsen T (1990). "The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals". Biochem. Biophys. Res. Commun. 167 (1): 323–30. doi:10.1016/0006-291X(90)91768-N. PMID 2310396.
  • Lem J, Chin AC, Thayer MJ, Leach RJ, Fournier RE (1988). "Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7302–6. Bibcode:1988PNAS...85.7302L. doi:10.1073/pnas.85.19.7302. PMC 282174. PMID 2902627.
  • Sandberg M, Taskén K, Oyen O, Hansson V, Jahnsen T (1988). "Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis". Biochem. Biophys. Res. Commun. 149 (3): 939–45. doi:10.1016/0006-291X(87)90499-2. PMID 3426618.
  • Geahlen RL, Carmichael DF, Hashimoto E, Krebs EG (1982). "Phosphorylation of cAMP-dependent protein kinase subunits". Adv. Enzyme Regul. 20: 195–209. doi:10.1016/0065-2571(82)90016-4. PMID 6287816.
  • Guild BC, Strominger JL (1984). "HLA-A2 antigen phosphorylation in vitro by cyclic AMP-dependent protein kinase. Sites of phosphorylation and segmentation in class i major histocompatibility complex gene structure". J. Biol. Chem. 259 (21): 13504–10. doi:10.1016/S0021-9258(18)90722-2. PMID 6333425.
  • Bongarzone I, Monzini N, Borrello MG, Carcano C, Ferraresi G, Arighi E, Mondellini P, Della Porta G, Pierotti MA (1993). "Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A". Mol. Cell. Biol. 13 (1): 358–66. doi:10.1128/MCB.13.1.358. PMC 358915. PMID 7678053.
  • Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. Bibcode:1993PNAS...90.6676H. doi:10.1073/pnas.90.14.6676. PMC 46995. PMID 7688126.
  • Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016–7. doi:10.1097/00002030-199407000-00025. PMID 7946090.

External links edit

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

January 01, 1970
prkar1a, camp, dependent, protein, kinase, type, alpha, regulatory, subunit, enzyme, that, humans, encoded, gene, identifiersaliases, acrdys1, adohr, cnc1, pkr1, ppnad1, prkar1, tse1, protein, kinase, camp, dependent, type, regulatory, subunit, alphaexternal, . cAMP dependent protein kinase type I alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene 5 PRKAR1AIdentifiersAliasesPRKAR1A ACRDYS1 ADOHR CAR CNC CNC1 PKR1 PPNAD1 PRKAR1 TSE1 protein kinase cAMP dependent type I regulatory subunit alphaExternal IDsOMIM 188830 MGI 104878 HomoloGene 37664 GeneCards PRKAR1AGene location Human Chr Chromosome 17 human 1 Band17q24 2Start68 511 780 bp 1 End68 551 319 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 E1 11 72 33 cMStart109 540 231 bp 2 End109 560 482 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingerminal epitheliumbronchial epithelial cellsuperficial temporal arterycaput epididymismyocardiumparietal pleuralower lobe of lungponsorbitofrontal cortexvisceral pleuraTop expressed inarcuate nucleusventral tegmental areadorsomedial hypothalamic nucleusparaventricular nucleus of hypothalamusmedian eminencecingulate gyrusventromedial nucleusmammillary bodysubiculummedial vestibular nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding protein kinase A catalytic subunit binding cAMP binding protein binding cAMP dependent protein kinase regulator activity cAMP dependent protein kinase inhibitor activity ubiquitin protein ligase binding protein domain specific binding 3 5 cyclic GMP phosphodiesterase activity kinase activityCellular componentcytoplasm cytosol membrane plasma membrane raft neuromuscular junction plasma membrane ciliary base nucleotide activated protein kinase complex immunological synapse cAMP dependent protein kinase complex axoneme protein containing complex synapse glutamatergic synapseBiological processregulation of protein phosphorylation activation of protein kinase A activity intracellular signal transduction negative regulation of protein kinase activity regulation of transcription by RNA polymerase II cellular response to glucagon stimulus mesoderm formation blood coagulation female meiotic nuclear division negative regulation of meiotic nuclear division cardiac muscle cell proliferation negative regulation of cAMP dependent protein kinase activity negative regulation of activated T cell proliferation heart development renal water homeostasis regulation of protein kinase activity sarcomere organization cGMP mediated signaling phosphorylationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez557319084EnsemblENSG00000108946ENSMUSG00000020612UniProtP10644Q9DBC7RefSeq mRNA NM 001276289NM 001276290NM 001278433NM 002734NM 212471NM 212472NM 001369389NM 001369390NM 021880NM 001313973NM 001313974NM 001313975NM 001313976NM 001362677NM 001373912NM 001373913RefSeq protein NP 001263218NP 001263219NP 001265362NP 002725NP 997636NP 997637NP 001356318NP 001356319NP 001263218 1NP 001265362 1NP 002725 1NP 997636 1NP 997637 1NP 001300902NP 001300903NP 001300904NP 001300905NP 068680NP 001349606NP 001360841NP 001360842Location UCSC Chr 17 68 51 68 55 MbChr 11 109 54 109 56 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Clinical significance 3 Interactions 4 See also 5 References 6 Further reading 7 External linksFunction editcAMP is a signaling molecule important for a variety of cellular functions cAMP exerts its effects by activating the cAMP dependent protein kinase A PKA which transduces the signal through phosphorylation of different target proteins The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans The protein encoded by this gene is one of the regulatory subunits This protein was found to be a tissue specific extinguisher that down regulates the expression of seven liver genes in hepatoma x fibroblast hybrids Three alternatively spliced transcript variants encoding the same protein have been observed 6 Clinical significance editFunctional null mutations in this gene cause Carney complex CNC an autosomal dominant multiple neoplasia syndrome This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor specific chimeric oncogene known as PTC2 6 Mutation of PRKAR1A leads to the Carney complex associating multiple endocrine tumors citation needed Interactions editPRKAR1A has been shown to interact with AKAP10 7 8 AKAP1 9 10 AKAP4 11 12 ARFGEF1 13 ARFGEF2 13 Grb2 14 MYO7A 15 PRKAR1B 9 16 and UBE2M 17 See also editcAMP dependent protein kinaseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000108946 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020612 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Scambler P Oyen O Wainwright B Farrall M Law HY Estivill X Sandberg M Williamson R Jahnsen T December 1987 Exclusion of catalytic and regulatory subunits of cAMP dependent protein kinase as candidate genes for the defect causing cystic fibrosis Am J Hum Genet 41 5 925 32 PMC 1684338 PMID 3479018 a b Entrez Gene PRKAR1A protein kinase cAMP dependent regulatory type I alpha tissue specific extinguisher 1 Huang LJ Durick K Weiner JA Chun J Taylor SS October 1997 D AKAP2 a novel protein kinase A anchoring protein with a putative RGS domain Proc Natl Acad Sci U S A 94 21 11184 9 Bibcode 1997PNAS 9411184J doi 10 1073 pnas 94 21 11184 PMC 23409 PMID 9326583 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 a b Carlson CR Ruppelt A Tasken K March 2003 A kinase anchoring protein AKAP interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system J Mol Biol 327 3 609 18 doi 10 1016 s0022 2836 03 00093 7 PMID 12634056 Herberg FW Maleszka A Eide T Vossebein L Tasken K April 2000 Analysis of A kinase anchoring protein AKAP interaction with protein kinase A PKA regulatory subunits PKA isoform specificity in AKAP binding J Mol Biol 298 2 329 39 doi 10 1006 jmbi 2000 3662 PMID 10764601 Brown PR Miki K Harper DB Eddy EM June 2003 A kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum Biol Reprod 68 6 2241 8 doi 10 1095 biolreprod 102 013466 PMID 12606363 Miki K Eddy EM December 1998 Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1 J Biol Chem 273 51 34384 90 doi 10 1074 jbc 273 51 34384 PMID 9852104 a b Li H Adamik R Pacheco Rodriguez G Moss J Vaughan M February 2003 Protein kinase A anchoring AKAP domains in brefeldin A inhibited guanine nucleotide exchange protein 2 BIG2 Proc Natl Acad Sci U S A 100 4 1627 32 Bibcode 2003PNAS 100 1627L doi 10 1073 pnas 0337678100 PMC 149883 PMID 12571360 Tortora G Damiano V Bianco C Baldassarre G Bianco AR Lanfrancone L Pelicci PG Ciardiello F February 1997 The RIalpha subunit of protein kinase A PKA binds to Grb2 and allows PKA interaction with the activated EGF receptor Oncogene 14 8 923 8 doi 10 1038 sj onc 1200906 PMID 9050991 S2CID 10640461 Kussel Andermann P El Amraoui A Safieddine S Hardelin JP Nouaille S Camonis J Petit C September 2000 Unconventional myosin VIIA is a novel A kinase anchoring protein J Biol Chem 275 38 29654 9 doi 10 1074 jbc M004393200 PMID 10889203 Tasken K Skalhegg BS Solberg R Andersson KB Taylor SS Lea T Blomhoff HK Jahnsen T Hansson V October 1993 Novel isozymes of cAMP dependent protein kinase exist in human cells due to formation of RI alpha RI beta heterodimeric complexes J Biol Chem 268 28 21276 83 doi 10 1016 S0021 9258 19 36921 2 PMID 8407966 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 Further reading editStratakis CA 2002 Mutations of the gene encoding the protein kinase A type I alpha regulatory subunit PRKAR1A in patients with the complex of spotty skin pigmentation myxomas endocrine overactivity and schwannomas Carney complex Ann N Y Acad Sci 968 1 3 21 Bibcode 2002NYASA 968 3S doi 10 1111 j 1749 6632 2002 tb04323 x PMID 12119264 S2CID 26108486 Bourdeau I Stratakis CA 2002 Cyclic AMP dependent signaling aberrations in macronodular adrenal disease Ann N Y Acad Sci 968 1 240 55 Bibcode 2002NYASA 968 240B doi 10 1111 j 1749 6632 2002 tb04339 x PMID 12119280 S2CID 22397904 Alto N Carlisle Michel JJ Dodge KL Langeberg LK Scott JD 2003 Intracellular targeting of protein kinases and phosphatases Diabetes 51 Suppl 3 S385 8 doi 10 2337 diabetes 51 2007 s385 PMID 12475780 Stergiopoulos SG Stratakis CA 2003 Human tumors associated with Carney complex and germline PRKAR1A mutations a protein kinase A disease FEBS Lett 546 1 59 64 doi 10 1016 S0014 5793 03 00452 6 PMID 12829237 S2CID 37055425 Bossis I Stratakis CA 2004 Minireview PRKAR1A normal and abnormal functions Endocrinology 145 12 5452 8 doi 10 1210 en 2004 0900 PMID 15331577 Cho Chung YS Nesterova MV 2006 Tumor reversion protein kinase A isozyme switching Ann N Y Acad Sci 1058 76 86 doi 10 1196 annals 1359 014 PMID 16394127 S2CID 45471438 Lytras A Tolis G 2006 Growth hormone secreting tumors genetic aspects and data from animal models Neuroendocrinology 83 3 4 166 78 doi 10 1159 000095525 PMID 17047380 S2CID 45606794 Harrich D McMillan N Munoz L Apolloni A Meredith L 2007 Will diverse Tat interactions lead to novel antiretroviral drug targets Current Drug Targets 7 12 1595 606 doi 10 2174 138945006779025338 PMID 17168834 Boshart M Weih F Nichols M Schutz G 1991 The tissue specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP dependent protein kinase PDF Cell 66 5 849 59 doi 10 1016 0092 8674 91 90432 X PMID 1832337 S2CID 8277752 Jones KW Shapero MH Chevrette M Fournier RE 1991 Subtractive hybridization cloning of a tissue specific extinguisher TSE1 encodes a regulatory subunit of protein kinase A Cell 66 5 861 72 doi 10 1016 0092 8674 91 90433 Y PMID 1889088 S2CID 24273073 Hofmann B Nishanian P Baldwin RL Insixiengmay P Nel A Fahey JL 1991 HIV inhibits the early steps of lymphocyte activation including initiation of inositol phospholipid metabolism J Immunol 145 11 3699 705 doi 10 4049 jimmunol 145 11 3699 PMID 1978848 Sandberg M Skalhegg B Jahnsen T 1990 The two mRNA forms for the type I alpha regulatory subunit of cAMP dependent protein kinase from human testis are due to the use of different polyadenylation site signals Biochem Biophys Res Commun 167 1 323 30 doi 10 1016 0006 291X 90 91768 N PMID 2310396 Lem J Chin AC Thayer MJ Leach RJ Fournier RE 1988 Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans dominant locus Tse 1 Proc Natl Acad Sci U S A 85 19 7302 6 Bibcode 1988PNAS 85 7302L doi 10 1073 pnas 85 19 7302 PMC 282174 PMID 2902627 Sandberg M Tasken K Oyen O Hansson V Jahnsen T 1988 Molecular cloning cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP dependent protein kinase from human testis Biochem Biophys Res Commun 149 3 939 45 doi 10 1016 0006 291X 87 90499 2 PMID 3426618 Geahlen RL Carmichael DF Hashimoto E Krebs EG 1982 Phosphorylation of cAMP dependent protein kinase subunits Adv Enzyme Regul 20 195 209 doi 10 1016 0065 2571 82 90016 4 PMID 6287816 Guild BC Strominger JL 1984 HLA A2 antigen phosphorylation in vitro by cyclic AMP dependent protein kinase Sites of phosphorylation and segmentation in class i major histocompatibility complex gene structure J Biol Chem 259 21 13504 10 doi 10 1016 S0021 9258 18 90722 2 PMID 6333425 Bongarzone I Monzini N Borrello MG Carcano C Ferraresi G Arighi E Mondellini P Della Porta G Pierotti MA 1993 Molecular characterization of a thyroid tumor specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP dependent protein kinase A Mol Cell Biol 13 1 358 66 doi 10 1128 MCB 13 1 358 PMC 358915 PMID 7678053 Hofmann B Nishanian P Nguyen T Insixiengmay P Fahey JL 1993 Human immunodeficiency virus proteins induce the inhibitory cAMP protein kinase A pathway in normal lymphocytes Proc Natl Acad Sci U S A 90 14 6676 80 Bibcode 1993PNAS 90 6676H doi 10 1073 pnas 90 14 6676 PMC 46995 PMID 7688126 Hofmann B Nishanian P Fan J Nguyen T Fahey JL 1994 HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro AIDS 8 7 1016 7 doi 10 1097 00002030 199407000 00025 PMID 7946090 External links editPDBe KB provides an overview of all the structure information available in the PDB for Human cAMP dependent protein kinase type I alpha regulatory subunit PRKAR1A This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title PRKAR1A amp oldid 1191692359, wikipedia, wiki, book, books, library,

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