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Wikipedia

PRKAR1B

April 14, 2024

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.[5][6][7]

PRKAR1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRKAR1B, PRKAR1, protein kinase cAMP-dependent type I regulatory subunit beta, MASNS
External IDsOMIM: 176911 MGI: 97759 HomoloGene: 37665 GeneCards: PRKAR1B
Orthologs
SpeciesHumanMouse
Entrez

5575

19085

Ensembl

ENSG00000188191

ENSMUSG00000025855

UniProt

P31321

P12849

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 7: 0.55 – 0.73 MbChr 5: 139 – 139.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance edit

Mutations in PRKAR1B cause neurodegenerative disorder.[8]

Interactions edit

PRKAR1B has been shown to interact with AKAP1[9] and PRKAR1A.[9][10]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188191 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025855 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (Dec 1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics. 14 (1): 63–9. doi:10.1016/S0888-7543(05)80284-8. PMID 1358799.
  6. ^ Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T (Dec 1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet. 41 (5): 925–32. PMC 1684338. PMID 3479018.
  7. ^ "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta".
  8. ^ Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J (2014). "PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology". Brain. 137 (Pt 5): 1361–73. doi:10.1093/brain/awu067. PMID 24722252.
  9. ^ a b Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
  10. ^ Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (Oct 1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. doi:10.1016/S0021-9258(19)36921-2. PMID 8407966.

Further reading edit

  • Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID 17168834.
  • Solberg R, Taskén K, Keiserud A, Jahnsen T (1991). "Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases". Biochem. Biophys. Res. Commun. 176 (1): 166–72. doi:10.1016/0006-291X(91)90904-L. PMID 1708242.
  • Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. 145 (11): 3699–705. doi:10.4049/jimmunol.145.11.3699. PMID 1978848.
  • Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. Bibcode:1993PNAS...90.6676H. doi:10.1073/pnas.90.14.6676. PMC 46995. PMID 7688126.
  • Solberg R, Taskén K, Wen W, Coghlan VM, Meinkoth JL, Scott JD, Jahnsen T, Taylor SS (1994). "Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells". Exp. Cell Res. 214 (2): 595–605. doi:10.1006/excr.1994.1297. PMID 7925653.
  • Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016–7. doi:10.1097/00002030-199407000-00025. PMID 7946090.
  • Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. doi:10.1016/S0021-9258(19)36921-2. PMID 8407966.
  • Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix". J. Virol. 71 (6): 4372–7. doi:10.1128/JVI.71.6.4372-4377.1997. PMC 191654. PMID 9151826.
  • Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
  • Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Res. Hum. Retroviruses. 14 (10): 825–33. doi:10.1089/aid.1998.14.825. PMID 9671211.
  • Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685. S2CID 19529677.
  • Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM (1999). "Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes". J. Immunol. 162 (9): 5639–48. doi:10.4049/jimmunol.162.9.5639. PMID 10228048. S2CID 84115936.
  • Adachi M, Lewis EJ (2002). "The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status". J. Biol. Chem. 277 (25): 22915–24. doi:10.1074/jbc.M201695200. PMID 11943777.
  • Oliver CJ, Terry-Lorenzo RT, Elliott E, Bloomer WA, Li S, Brautigan DL, Colbran RJ, Shenolikar S (2002). "Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology". Mol. Cell. Biol. 22 (13): 4690–701. doi:10.1128/MCB.22.13.4690-4701.2002. PMC 133892. PMID 12052877.
  • Nguyen DT, Rovira II, Finkel T (2002). "Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A". FEBS Lett. 521 (1–3): 170–4. doi:10.1016/S0014-5793(02)02868-5. PMID 12067711. S2CID 38098581.
  • Mucignat-Caretta C, Caretta A (2003). "Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain". J. Neurocytol. 30 (11): 885–94. doi:10.1023/A:1020613132648. PMID 12373096. S2CID 30876154.
  • Carlson CR, Ruppelt A, Taskén K (2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.

External links edit

  • Overview of all the structural information available in the PDB for UniProt: P31321 (Human cAMP-dependent protein kinase type I-beta regulatory subunit) at the PDBe-KB.


 

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April 14, 2024
prkar1b, camp, dependent, protein, kinase, type, beta, regulatory, subunit, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4din, 4f9kidentifiersaliases, prkar1, protein, kinase, camp, dependent, type, regula. cAMP dependent protein kinase type I beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene 5 6 7 PRKAR1BAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4DIN 4F9KIdentifiersAliasesPRKAR1B PRKAR1 protein kinase cAMP dependent type I regulatory subunit beta MASNSExternal IDsOMIM 176911 MGI 97759 HomoloGene 37665 GeneCards PRKAR1BGene location Human Chr Chromosome 7 human 1 Band7p22 3Start549 197 bp 1 End727 650 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 G2 5 77 74 cMStart139 003 061 bp 2 End139 135 756 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inBrodmann area 10cingulate gyrusfrontal poleBrodmann area 9amygdalanucleus accumbenshypothalamusputamencaudate nucleusBrodmann area 46Top expressed insubstantia nigramotor neurondorsal tegmental nucleusventromedial nucleusdorsomedial hypothalamic nucleusprefrontal cortexsubiculumpontine nucleiventral tegmental arealateral hypothalamusMore reference expression dataBioGPSn aGene ontologyMolecular functionnucleotide binding protein kinase A catalytic subunit binding cAMP binding cAMP dependent protein kinase regulator activity cAMP dependent protein kinase inhibitor activity protein binding 3 5 cyclic GMP phosphodiesterase activityCellular componentcytosol membrane plasma membrane ciliary base cAMP dependent protein kinase complex synapse Schaffer collateral CA1 synapse hippocampal mossy fiber to CA3 synapse glutamatergic synapseBiological processregulation of protein phosphorylation activation of protein kinase A activity cellular response to glucagon stimulus blood coagulation negative regulation of cAMP dependent protein kinase activity protein phosphorylation renal water homeostasis learning or memory modulation of chemical synaptic transmission regulation of synaptic vesicle cycle cGMP mediated signalingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez557519085EnsemblENSG00000188191ENSMUSG00000025855UniProtP31321P12849RefSeq mRNA NM 001164758NM 001164759NM 001164760NM 001164761NM 001164762NM 002735NM 001253890NM 008923NM 001359097NM 001359098NM 001359099NM 001359100NM 001359101RefSeq protein NP 001158230NP 001158231NP 001158232NP 001158233NP 001158234NP 002726NP 001240819NP 032949NP 001346026NP 001346027NP 001346028NP 001346029NP 001346030Location UCSC Chr 7 0 55 0 73 MbChr 5 139 139 14 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Clinical significance 2 Interactions 3 References 4 Further reading 5 External linksClinical significance editMutations in PRKAR1B cause neurodegenerative disorder 8 Interactions editPRKAR1B has been shown to interact with AKAP1 9 and PRKAR1A 9 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000188191 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025855 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Solberg R Sistonen P Traskelin AL Berube D Simard J Krajci P Jahnsen T de la Chapelle A Dec 1992 Mapping of the regulatory subunits RI beta and RII beta of cAMP dependent protein kinase genes on human chromosome 7 Genomics 14 1 63 9 doi 10 1016 S0888 7543 05 80284 8 PMID 1358799 Scambler P Oyen O Wainwright B Farrall M Law HY Estivill X Sandberg M Williamson R Jahnsen T Dec 1987 Exclusion of catalytic and regulatory subunits of cAMP dependent protein kinase as candidate genes for the defect causing cystic fibrosis Am J Hum Genet 41 5 925 32 PMC 1684338 PMID 3479018 Entrez Gene PRKAR1B protein kinase cAMP dependent regulatory type I beta Wong TH Chiu WZ Breedveld GJ Li KW Verkerk AJ Hondius D Hukema RK Seelaar H Frick P Severijnen LA Lammers GJ Lebbink JH van Duinen SG Kamphorst W Rozemuller AJ Bakker EB Neumann M Willemsen R Bonifati V Smit AB van Swieten J 2014 PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology Brain 137 Pt 5 1361 73 doi 10 1093 brain awu067 PMID 24722252 a b Carlson CR Ruppelt A Tasken K Mar 2003 A kinase anchoring protein AKAP interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system J Mol Biol 327 3 609 18 doi 10 1016 S0022 2836 03 00093 7 PMID 12634056 Tasken K Skalhegg BS Solberg R Andersson KB Taylor SS Lea T Blomhoff HK Jahnsen T Hansson V Oct 1993 Novel isozymes of cAMP dependent protein kinase exist in human cells due to formation of RI alpha RI beta heterodimeric complexes J Biol Chem 268 28 21276 83 doi 10 1016 S0021 9258 19 36921 2 PMID 8407966 Further reading editHarrich D McMillan N Munoz L Apolloni A Meredith L 2007 Will diverse Tat interactions lead to novel antiretroviral drug targets Current Drug Targets 7 12 1595 606 doi 10 2174 138945006779025338 PMID 17168834 Solberg R Tasken K Keiserud A Jahnsen T 1991 Molecular cloning cDNA structure and tissue specific expression of the human regulatory subunit RI beta of cAMP dependent protein kinases Biochem Biophys Res Commun 176 1 166 72 doi 10 1016 0006 291X 91 90904 L PMID 1708242 Hofmann B Nishanian P Baldwin RL Insixiengmay P Nel A Fahey JL 1991 HIV inhibits the early steps of lymphocyte activation including initiation of inositol phospholipid metabolism J Immunol 145 11 3699 705 doi 10 4049 jimmunol 145 11 3699 PMID 1978848 Hofmann B Nishanian P Nguyen T Insixiengmay P Fahey JL 1993 Human immunodeficiency virus proteins induce the inhibitory cAMP protein kinase A pathway in normal lymphocytes Proc Natl Acad Sci U S A 90 14 6676 80 Bibcode 1993PNAS 90 6676H doi 10 1073 pnas 90 14 6676 PMC 46995 PMID 7688126 Solberg R Tasken K Wen W Coghlan VM Meinkoth JL Scott JD Jahnsen T Taylor SS 1994 Human regulatory subunit RI beta of cAMP dependent protein kinases expression holoenzyme formation and microinjection into living cells Exp Cell Res 214 2 595 605 doi 10 1006 excr 1994 1297 PMID 7925653 Hofmann B Nishanian P Fan J Nguyen T Fahey JL 1994 HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro AIDS 8 7 1016 7 doi 10 1097 00002030 199407000 00025 PMID 7946090 Tasken K Skalhegg BS Solberg R Andersson KB Taylor SS Lea T Blomhoff HK Jahnsen T Hansson V 1993 Novel isozymes of cAMP dependent protein kinase exist in human cells due to formation of RI alpha RI beta heterodimeric complexes J Biol Chem 268 28 21276 83 doi 10 1016 S0021 9258 19 36921 2 PMID 8407966 Swingler S Gallay P Camaur D Song J Abo A Trono D 1997 The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix J Virol 71 6 4372 7 doi 10 1128 JVI 71 6 4372 4377 1997 PMC 191654 PMID 9151826 Chen P Mayne M Power C Nath A 1997 The Tat protein of HIV 1 induces tumor necrosis factor alpha production Implications for HIV 1 associated neurological diseases J Biol Chem 272 36 22385 8 doi 10 1074 jbc 272 36 22385 PMID 9278385 Zidovetzki R Wang JL Chen P Jeyaseelan R Hofman F 1998 Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C and cAMP dependent protein kinase pathways AIDS Res Hum Retroviruses 14 10 825 33 doi 10 1089 aid 1998 14 825 PMID 9671211 Mayne M Bratanich AC Chen P Rana F Nath A Power C 1998 HIV 1 tat molecular diversity and induction of TNF alpha implications for HIV induced neurological disease Neuroimmunomodulation 5 3 4 184 92 doi 10 1159 000026336 PMID 9730685 S2CID 19529677 Laxminarayana D Khan IU Mishra N Olorenshaw I Tasken K Kammer GM 1999 Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes J Immunol 162 9 5639 48 doi 10 4049 jimmunol 162 9 5639 PMID 10228048 S2CID 84115936 Adachi M Lewis EJ 2002 The paired like homeodomain protein Arix mediates protein kinase A stimulated dopamine beta hydroxylase gene transcription through its phosphorylation status J Biol Chem 277 25 22915 24 doi 10 1074 jbc M201695200 PMID 11943777 Oliver CJ Terry Lorenzo RT Elliott E Bloomer WA Li S Brautigan DL Colbran RJ Shenolikar S 2002 Targeting Protein Phosphatase 1 PP1 to the Actin Cytoskeleton the Neurabin I PP1 Complex Regulates Cell Morphology Mol Cell Biol 22 13 4690 701 doi 10 1128 MCB 22 13 4690 4701 2002 PMC 133892 PMID 12052877 Nguyen DT Rovira II Finkel T 2002 Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A FEBS Lett 521 1 3 170 4 doi 10 1016 S0014 5793 02 02868 5 PMID 12067711 S2CID 38098581 Mucignat Caretta C Caretta A 2003 Localization of Triton insoluble cAMP dependent kinase type RIbeta in rat and mouse brain J Neurocytol 30 11 885 94 doi 10 1023 A 1020613132648 PMID 12373096 S2CID 30876154 Carlson CR Ruppelt A Tasken K 2003 A kinase anchoring protein AKAP interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system J Mol Biol 327 3 609 18 doi 10 1016 S0022 2836 03 00093 7 PMID 12634056 External links editOverview of all the structural information available in the PDB for UniProt P31321 Human cAMP dependent protein kinase type I beta regulatory subunit at the PDBe KB nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PRKAR1B amp oldid 1193531035, wikipedia, wiki, book, books, library,

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