^ abcdLv W, Liu J, Skaar TC, Flockhart DA, Cushman M (March 2015). "Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities". Journal of Medicinal Chemistry. 58 (6): 2623–48. doi:10.1021/jm501218e. PMC4687028. PMID 25751283.
^ abcNagini S (2017). "Breast Cancer: Current Molecular Therapeutic Targets and New Players". Anti-Cancer Agents in Medicinal Chemistry. 17 (2): 152–163. doi:10.2174/1871520616666160502122724. PMID 27137076.
hydroxynorendoxifen, synthetic, nonsteroidal, antiestrogen, triphenylethylene, group, dual, selective, estrogen, receptor, modulator, serm, aromatase, inhibitor, derived, from, tamoxifen, serm, norendoxifen, metabolite, tamoxifen, that, been, found, drug, been. 4 Hydroxynorendoxifen is a synthetic nonsteroidal antiestrogen of the triphenylethylene group 1 2 It is a dual selective estrogen receptor modulator SERM and aromatase inhibitor AI and was derived from tamoxifen a SERM and norendoxifen a metabolite of tamoxifen that has been found to act as an AI 1 2 The drug has been suggested for potential development as a treatment for estrogen receptor ER positive breast cancer 1 2 It was synthesized in 2015 1 4 HydroxynorendoxifenClinical dataOther namesN N Didesmethyl 4 4 dihydroxytamoxifenIdentifiersIUPAC name 4 4 1 4 2 Aminoethoxy phenyl but 1 ene 1 2 diyl diphenolChemSpider58967386Chemical and physical dataFormulaC 24H 25N O 3Molar mass375 468 g mol 13D model JSmol Interactive imageSMILES CCC C C1 CC C O C C1 C1 CC C OCCN C C1 C1 CC C O C C1InChI InChI 1S C24H25NO3 c1 2 23 17 3 9 20 26 10 4 17 24 18 5 11 21 27 12 6 18 19 7 13 22 14 8 19 28 16 15 25 h3 14 26 27H 2 15 16 25H2 1H3Key VYSGWFCGFKTGQC UHFFFAOYSA NReferences edit a b c d Lv W Liu J Skaar TC Flockhart DA Cushman M March 2015 Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities Journal of Medicinal Chemistry 58 6 2623 48 doi 10 1021 jm501218e PMC 4687028 PMID 25751283 a b c Nagini S 2017 Breast Cancer Current Molecular Therapeutic Targets and New Players Anti Cancer Agents in Medicinal Chemistry 17 2 152 163 doi 10 2174 1871520616666160502122724 PMID 27137076 nbsp This antineoplastic or immunomodulatory drug article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 4 27 Hydroxynorendoxifen amp oldid 1130352576, wikipedia, wiki, book, books, library,
