The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolitecortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.[5]
Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and hence may explain why aspirin improves glycemic control in type 2 diabetes.[7]Epigallocatechin gallate from green tea can also potently inhibit this enzyme;[8] green tea is a complex mixture of various phenolics with contents varying with production and processing, and some of the phenolics are known HDAC inhibitors that alter genetic expression. EGCG as usually consumed in green tea is poorly absorbed into the bloodstream. More research is needed to reach firm conclusions.[citation needed]
^Classen-Houben D, Schuster D, Da Cunha T, Odermatt A, Wolber G, Jordis U, Kueenburg B (February 2009). "Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid". The Journal of Steroid Biochemistry and Molecular Biology. 113 (3–5): 248–52. doi:10.1016/j.jsbmb.2009.01.009. PMID 19429429. S2CID 21938309.
^Nixon M, Wake DJ, Livingstone DE, Stimson RH, Esteves CL, Seckl JR, Chapman KE, Andrew R, Walker BR (April 2012). "Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization". Diabetes. 61 (4): 790–6. doi:10.2337/db11-0931. PMC3314355. PMID 22357964.
^Hintzpeter J, Stapelfeld C, Loerz C, Martin HJ, Maser E (3 January 2014). "Green tea and one of its constituents, Epigallocatechine-3-gallate, are potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1". PLOS ONE. 9 (1): e84468. Bibcode:2014PLoSO...984468H. doi:10.1371/journal.pone.0084468. PMC3880318. PMID 24404164.
External linksedit
Human HSD11B1 genome location and HSD11B1 gene details page in the UCSC Genome Browser.
Further readingedit
White PC, Mune T, Agarwal AK (February 1997). "11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess". Endocrine Reviews. 18 (1): 135–56. doi:10.1210/edrv.18.1.0288. PMID 9034789.
Agarwal AK (November 2003). "Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH". Endocrine Research. 29 (4): 411–8. doi:10.1081/ERC-120026947. PMID 14682470. S2CID 32163545.
Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM (October 2004). "11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response". Endocrine Reviews. 25 (5): 831–66. doi:10.1210/er.2003-0031. PMID 15466942.
Wake DJ, Walker BR (February 2006). "Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity". Endocrine. 29 (1): 101–8. doi:10.1385/ENDO:29:1:101. PMID 16622297. S2CID 8906021.
Tannin GM, Agarwal AK, Monder C, New MI, White PC (September 1991). "The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization". The Journal of Biological Chemistry. 266 (25): 16653–8. doi:10.1016/S0021-9258(18)55351-5. PMID 1885595.
Graham DL, Oram JF (June 1987). "Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting". The Journal of Biological Chemistry. 262 (16): 7439–42. doi:10.1016/S0021-9258(18)47584-9. PMID 3034894.
Whorwood CB, Mason JI, Ricketts ML, Howie AJ, Stewart PM (April 1995). "Detection of human 11 beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts". Molecular and Cellular Endocrinology. 110 (1–2): R7–12. doi:10.1016/0303-7207(95)03546-J. PMID 7545619. S2CID 25070635.
Mune T, Rogerson FM, Nikkilä H, Agarwal AK, White PC (August 1995). "Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase". Nature Genetics. 10 (4): 394–9. doi:10.1038/ng0895-394. PMID 7670488. S2CID 30848352.
Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM (April 1998). "Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues". The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1325–35. doi:10.1210/jcem.83.4.4706. PMID 9543163. S2CID 10988572.
Calvo D, Gómez-Coronado D, Suárez Y, Lasunción MA, Vega MA (April 1998). "Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL". Journal of Lipid Research. 39 (4): 777–88. doi:10.1016/S0022-2275(20)32566-9. PMID 9555943.
Odermatt A, Arnold P, Stauffer A, Frey BM, Frey FJ (October 1999). "The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane". The Journal of Biological Chemistry. 274 (40): 28762–70. doi:10.1074/jbc.274.40.28762. PMID 10497248.
Sriskanda V, Schwer B, Ho CK, Shuman S (October 1999). "Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4". Nucleic Acids Research. 27 (20): 3953–63. doi:10.1093/nar/27.20.3953. PMC148661. PMID 10497258.
Schutte BC, Bjork BC, Coppage KB, Malik MI, Gregory SG, Scott DJ, Brentzell LM, Watanabe Y, Dixon MJ, Murray JC (January 2000). "A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41". Genome Research. 10 (1): 81–94. doi:10.1101/gr.10.1.81 (inactive 31 January 2024). PMC310500. PMID 10645953.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)
Cooper MS, Walker EA, Bland R, Fraser WD, Hewison M, Stewart PM (September 2000). "Expression and functional consequences of 11beta-hydroxysteroid dehydrogenase activity in human bone". Bone. 27 (3): 375–81. doi:10.1016/S8756-3282(00)00344-6. PMID 10962348.
Reddy ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, Gangopadhyay A, Shih DM, Lusis AJ, Navab M, Fogelman AM (April 2001). "Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (4): 542–7. doi:10.1161/01.ATV.21.4.542. PMID 11304470.
Pácha J, Lisá V, Miksík I (February 2002). "Effect of cellular differentiation on 11beta-hydroxysteroid dehydrogenase activity in the intestine". Steroids. 67 (2): 119–26. doi:10.1016/S0039-128X(01)00143-X. PMID 11755176. S2CID 568790.
Albertin G, Tortorella C, Malendowicz LK, Aragona F, Neri G, Nussdorfer GG (May 2002). "Human adrenal cortex and aldosterone secreting adenomas express both 11beta-hydroxysteroid dehydrogenase type 1 and type 2 genes". International Journal of Molecular Medicine. 9 (5): 495–8. doi:10.3892/ijmm.9.5.495. PMID 11956655.
Mazzocchi G, Malendowicz LK, Aragona F, Tortorella C, Gottardo L, Nussdorfer GG (July 2002). "11beta-Hydroxysteroid dehydrogenase types 1 and 2 are up- and downregulated in cortisol-secreting adrenal adenomas". Journal of Investigative Medicine. 50 (4): 288–92. PMID 12109593.
11β, hydroxysteroid, dehydrogenase, type, also, known, cortisone, reductase, nadph, dependent, enzyme, highly, expressed, metabolic, tissues, including, liver, adipose, tissue, central, nervous, system, these, tissues, hsd11b1, reduces, cortisone, active, horm. 11b Hydroxysteroid dehydrogenase type 1 also known as cortisone reductase is an NADPH dependent enzyme highly expressed in key metabolic tissues including liver adipose tissue and the central nervous system In these tissues HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors It belongs to the family of short chain dehydrogenases It is encoded by the HSD11B1 gene HSD11B1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4P38 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FCO 3FRJ 3H6K 3HFG 3OQ1 3PDJ 3QQP 3TFQ 4BB5 4BB6 4C7J 4C7K 4HFR 4HX5 4IJU 4IJV 4IJW 4K1L 4YYZ 1XU7IdentifiersAliasesHSD11B1 11 DH 11 beta HSD1 CORTRD2 HDL HSD11 HSD11B HSD11L SDR26C1 hydroxysteroid 11 beta dehydrogenase 1 hydroxysteroid 11 beta dehydrogenase 1External IDsOMIM 600713 MGI 103562 HomoloGene 68471 GeneCards HSD11B1EC number1 1 1 146Gene location Human Chr Chromosome 1 human 1 Band1q32 2Start209 686 178 bp 1 End209 734 949 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 H6Start192 903 942 bp 2 End192 946 383 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of liverislet of Langerhansurethraright lungstromal cell of endometriumupper lobe of left lungskin of abdomenvulvasubcutaneous adipose tissueleft coronary arteryTop expressed inleft lobe of liverright lung lobeleft lungbelly cordleft lung lobewhite adipose tissuegallbladdersubmandibular glandsubcutaneous adipose tissuekidneyMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular function11 beta hydroxysteroid dehydrogenase NADP activity oxidoreductase activity 11 beta hydroxysteroid dehydrogenase NAD P activity steroid bindingCellular componentintegral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membraneBiological processglucocorticoid biosynthetic process lung development lipid metabolism steroid metabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez329015483EnsemblENSG00000117594ENSMUSG00000016194UniProtP28845P50172RefSeq mRNA NM 181755NM 001206741NM 005525NM 001044751NM 008288RefSeq protein NP 001193670NP 005516NP 861420NP 001193670 1NP 005516 1NP 861420 1NP 001038216NP 032314Location UCSC Chr 1 209 69 209 73 MbChr 1 192 9 192 95 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Clinical significance 3 See also 4 References 5 External links 6 Further readingFunction editThe protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone In addition the encoded protein can catalyze the reverse reaction the conversion of cortisone to cortisol Too much cortisol can lead to central obesity and a particular variation in this gene has been associated with obesity and insulin resistance in children Two transcript variants encoding the same protein have been found for this gene 5 nbsp Cortisol cortisone equilibriumClinical significance edit11b HSD1 is inhibited by carbenoxolone a drug typically used in the treatment of peptic ulcers Moreover 18alpha glycyrrhizic acid from the root of glycyrrhiza glabra was discovered as an inhibitor 6 Salicylate downregulates 11b HSD1 expression in adipose tissue in obese mice and hence may explain why aspirin improves glycemic control in type 2 diabetes 7 Epigallocatechin gallate from green tea can also potently inhibit this enzyme 8 green tea is a complex mixture of various phenolics with contents varying with production and processing and some of the phenolics are known HDAC inhibitors that alter genetic expression EGCG as usually consumed in green tea is poorly absorbed into the bloodstream More research is needed to reach firm conclusions citation needed See also editCortisone reductase deficiency 11b hydroxysteroid dehydrogenase type 2References edit a b c GRCh38 Ensembl release 89 ENSG00000117594 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000016194 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene HSD11B1 hydroxysteroid 11 beta dehydrogenase 1 Classen Houben D Schuster D Da Cunha T Odermatt A Wolber G Jordis U Kueenburg B February 2009 Selective inhibition of 11beta hydroxysteroid dehydrogenase 1 by 18alpha glycyrrhetinic acid but not 18beta glycyrrhetinic acid The Journal of Steroid Biochemistry and Molecular Biology 113 3 5 248 52 doi 10 1016 j jsbmb 2009 01 009 PMID 19429429 S2CID 21938309 Nixon M Wake DJ Livingstone DE Stimson RH Esteves CL Seckl JR Chapman KE Andrew R Walker BR April 2012 Salicylate downregulates 11b HSD1 expression in adipose tissue in obese mice and in humans mediating insulin sensitization Diabetes 61 4 790 6 doi 10 2337 db11 0931 PMC 3314355 PMID 22357964 Hintzpeter J Stapelfeld C Loerz C Martin HJ Maser E 3 January 2014 Green tea and one of its constituents Epigallocatechine 3 gallate are potent inhibitors of human 11b hydroxysteroid dehydrogenase type 1 PLOS ONE 9 1 e84468 Bibcode 2014PLoSO 984468H doi 10 1371 journal pone 0084468 PMC 3880318 PMID 24404164 External links editHuman HSD11B1 genome location and HSD11B1 gene details page in the UCSC Genome Browser Further reading editWhite PC Mune T Agarwal AK February 1997 11 beta Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess Endocrine Reviews 18 1 135 56 doi 10 1210 edrv 18 1 0288 PMID 9034789 Agarwal AK November 2003 Cortisol metabolism and visceral obesity role of 11beta hydroxysteroid dehydrogenase type I enzyme and reduced co factor NADPH Endocrine Research 29 4 411 8 doi 10 1081 ERC 120026947 PMID 14682470 S2CID 32163545 Tomlinson JW Walker EA Bujalska IJ Draper N Lavery GG Cooper MS Hewison M Stewart PM October 2004 11beta hydroxysteroid dehydrogenase type 1 a tissue specific regulator of glucocorticoid response Endocrine Reviews 25 5 831 66 doi 10 1210 er 2003 0031 PMID 15466942 Wake DJ Walker BR February 2006 Inhibition of 11beta hydroxysteroid dehydrogenase type 1 in obesity Endocrine 29 1 101 8 doi 10 1385 ENDO 29 1 101 PMID 16622297 S2CID 8906021 Tannin GM Agarwal AK Monder C New MI White PC September 1991 The human gene for 11 beta hydroxysteroid dehydrogenase Structure tissue distribution and chromosomal localization The Journal of Biological Chemistry 266 25 16653 8 doi 10 1016 S0021 9258 18 55351 5 PMID 1885595 Graham DL Oram JF June 1987 Identification and characterization of a high density lipoprotein binding protein in cell membranes by ligand blotting The Journal of Biological Chemistry 262 16 7439 42 doi 10 1016 S0021 9258 18 47584 9 PMID 3034894 Whorwood CB Mason JI Ricketts ML Howie AJ Stewart PM April 1995 Detection of human 11 beta hydroxysteroid dehydrogenase isoforms using reverse transcriptase polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts Molecular and Cellular Endocrinology 110 1 2 R7 12 doi 10 1016 0303 7207 95 03546 J PMID 7545619 S2CID 25070635 Mune T Rogerson FM Nikkila H Agarwal AK White PC August 1995 Human hypertension caused by mutations in the kidney isozyme of 11 beta hydroxysteroid dehydrogenase Nature Genetics 10 4 394 9 doi 10 1038 ng0895 394 PMID 7670488 S2CID 30848352 Ricketts ML Verhaeg JM Bujalska I Howie AJ Rainey WE Stewart PM April 1998 Immunohistochemical localization of type 1 11beta hydroxysteroid dehydrogenase in human tissues The Journal of Clinical Endocrinology and Metabolism 83 4 1325 35 doi 10 1210 jcem 83 4 4706 PMID 9543163 S2CID 10988572 Calvo D Gomez Coronado D Suarez Y Lasuncion MA Vega MA April 1998 Human CD36 is a high affinity receptor for the native lipoproteins HDL LDL and VLDL Journal of Lipid Research 39 4 777 88 doi 10 1016 S0022 2275 20 32566 9 PMID 9555943 Odermatt A Arnold P Stauffer A Frey BM Frey FJ October 1999 The N terminal anchor sequences of 11beta hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane The Journal of Biological Chemistry 274 40 28762 70 doi 10 1074 jbc 274 40 28762 PMID 10497248 Sriskanda V Schwer B Ho CK Shuman S October 1999 Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4 Nucleic Acids Research 27 20 3953 63 doi 10 1093 nar 27 20 3953 PMC 148661 PMID 10497258 Schutte BC Bjork BC Coppage KB Malik MI Gregory SG Scott DJ Brentzell LM Watanabe Y Dixon MJ Murray JC January 2000 A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32 q41 Genome Research 10 1 81 94 doi 10 1101 gr 10 1 81 inactive 31 January 2024 PMC 310500 PMID 10645953 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint DOI inactive as of January 2024 link Cooper MS Walker EA Bland R Fraser WD Hewison M Stewart PM September 2000 Expression and functional consequences of 11beta hydroxysteroid dehydrogenase activity in human bone Bone 27 3 375 81 doi 10 1016 S8756 3282 00 00344 6 PMID 10962348 Reddy ST Wadleigh DJ Grijalva V Ng C Hama S Gangopadhyay A Shih DM Lusis AJ Navab M Fogelman AM April 2001 Human paraoxonase 3 is an HDL associated enzyme with biological activity similar to paraoxonase 1 protein but is not regulated by oxidized lipids Arteriosclerosis Thrombosis and Vascular Biology 21 4 542 7 doi 10 1161 01 ATV 21 4 542 PMID 11304470 Pacha J Lisa V Miksik I February 2002 Effect of cellular differentiation on 11beta hydroxysteroid dehydrogenase activity in the intestine Steroids 67 2 119 26 doi 10 1016 S0039 128X 01 00143 X PMID 11755176 S2CID 568790 Albertin G Tortorella C Malendowicz LK Aragona F Neri G Nussdorfer GG May 2002 Human adrenal cortex and aldosterone secreting adenomas express both 11beta hydroxysteroid dehydrogenase type 1 and type 2 genes International Journal of Molecular Medicine 9 5 495 8 doi 10 3892 ijmm 9 5 495 PMID 11956655 Mazzocchi G Malendowicz LK Aragona F Tortorella C Gottardo L Nussdorfer GG July 2002 11beta Hydroxysteroid dehydrogenase types 1 and 2 are up and downregulated in cortisol secreting adrenal adenomas Journal of Investigative Medicine 50 4 288 92 PMID 12109593 Portal nbsp Biology This EC 1 1 1 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 11b Hydroxysteroid dehydrogenase type 1 amp oldid 1201593745, wikipedia, wiki, book, books, library,
