Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.[5][6][7]
The gene was identified in 1998. It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs. The protein is composed of 1,207 amino acids.[5][6]
Functionedit
The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the c-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells.[7][8] Its suppressive role on melanoma development has been reported recently.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000181409 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025375 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abIshikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ abSeki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T, Saito T (Apr 1999). "Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization". Journal of Human Genetics. 44 (2): 141–2. doi:10.1007/s100380050130. PMID 10083745.
^Kos A, Olde Loohuis NF, Wieczorek ML, Glennon JC, Martens GJ, Kolk SM, Aschrafi A (2012). "A potential regulatory role for intronic microRNA-338-3p for its host gene encoding apoptosis-associated tyrosine kinase". PLOS ONE. 7 (2): e31022. Bibcode:2012PLoSO...731022K. doi:10.1371/journal.pone.0031022. PMC3281898. PMID 22363537.
^Ma S, Rubin BP (Apr 2014). "Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma". Laboratory Investigation. 94 (4): 430–438. doi:10.1038/labinvest.2014.13. PMID 24589855.
^Gagnon KB, England R, Diehl L, Delpire E (May 2007). "Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation". American Journal of Physiology. Cell Physiology. 292 (5): C1809–C1815. doi:10.1152/ajpcell.00580.2006. PMID 17267545. S2CID 10258460.
Further readingedit
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Raghunath M, Patti R, Bannerman P, Lee CM, Baker S, Sutton LN, Phillips PC, Damodar Reddy C (May 2000). "A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line". Brain Research. Molecular Brain Research. 77 (2): 151–62. doi:10.1016/S0169-328X(00)00048-6. PMID 10837911.
Tomomura M, Hasegawa Y, Hashikawa T, Tomomura A, Yuzaki M, Furuichi T, Yano R (Apr 2003). "Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain". Brain Research. Molecular Brain Research. 112 (1–2): 103–12. doi:10.1016/S0169-328X(03)00054-8. PMID 12670708.
Honma N, Asada A, Takeshita S, Enomoto M, Yamakawa E, Tsutsumi K, Saito T, Satoh T, Itoh H, Kaziro Y, Kishimoto T, Hisanaga S (Oct 2003). "Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein". Biochemical and Biophysical Research Communications. 310 (2): 398–404. doi:10.1016/j.bbrc.2003.08.143. PMID 14521924.
Piechotta K, Garbarini N, England R, Delpire E (Dec 2003). "Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase". The Journal of Biological Chemistry. 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID 14563843.
aatk, serine, threonine, protein, kinase, lmtk1, also, known, apoptosis, associated, tyrosine, kinase, enzyme, that, humans, encoded, gene, identifiersaliases, aatyk, aatyk1, lmr1, lmtk1, ppp1r77, p35bp, apoptosis, associated, tyrosine, kinase, aatyk1, mkiaa06. Serine threonine protein kinase LMTK1 also known as Apoptosis associated tyrosine kinase is an enzyme that in humans is encoded by the AATK gene 5 6 7 AATKIdentifiersAliasesAATK AATYK AATYK1 LMR1 LMTK1 PPP1R77 p35BP apoptosis associated tyrosine kinase aatyk1 mKIAA0641 apoptosis associated tyrosine kinaseExternal IDsOMIM 605276 MGI 1197518 HomoloGene 74861 GeneCards AATKGene location Human Chr Chromosome 17 human 1 Band17q25 3Start81 110 487 bp 1 End81 166 221 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 E2Start119 898 139 bp 2 End119 937 993 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nerveinferior ganglion of vagus nerveolfactory bulbtrigeminal ganglionsubthalamic nucleusventral tegmental areaputamenBrodmann area 9amygdalaspinal gangliaTop expressed inentorhinal cortexsuperior frontal gyruscerebellar cortexsuperior colliculusinferior colliculuslateral geniculate nucleusmedial geniculate nucleussciatic nervemedulla oblongatamedial dorsal nucleusMore reference expression dataBioGPSn aGene ontologyMolecular functionnucleotide binding protein serine threonine kinase activity protein binding protein kinase activity kinase activity transferase activity ATP bindingCellular componentmembrane perinuclear region of cytoplasm cytoplasm integral component of membrane cellular componentBiological processphosphorylation protein phosphorylation biological processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez962511302EnsemblENSG00000181409ENSMUSG00000025375UniProtQ6ZMQ8Q80YE4RefSeq mRNA NM 001080395NM 004920NM 001198785NM 001198787NM 007377NM 001377503RefSeq protein NP 001073864NP 004911NP 001185714NP 001185716NP 031403NP 001364432NP 001389718Location UCSC Chr 17 81 11 81 17 MbChr 11 119 9 119 94 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Structure and expression 2 Function 3 References 4 Further reading 5 External linksStructure and expression editThe gene was identified in 1998 It is located on chromosome 17 17q25 3 and is expressed in the pancreas kidney brain and lungs The protein is composed of 1 207 amino acids 5 6 Function editThe protein contains a tyrosine kinase domain at the N terminal end and a proline rich domain at the c terminal end Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and or apoptosis of myeloid precursor cells It may also have a role in inducing differentiation in neuronal cells 7 8 Its suppressive role on melanoma development has been reported recently 9 AATK is thought to indirectly inhibit the SPAK WNK4 activation of the Na K Cl cotransporter 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000181409 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000025375 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Ishikawa K Nagase T Suyama M Miyajima N Tanaka A Kotani H Nomura N Ohara O Jun 1998 Prediction of the coding sequences of unidentified human genes X The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro DNA Research 5 3 169 76 doi 10 1093 dnares 5 3 169 PMID 9734811 a b Seki N Hayashi A Hattori A Kozuma S Ohira M Hori T Saito T Apr 1999 Chromosomal assignment of a human apoptosis associated tyrosine kinase gene on chromosome 17q25 3 by somatic hybrid analysis and fluorescence in situ hybridization Journal of Human Genetics 44 2 141 2 doi 10 1007 s100380050130 PMID 10083745 a b Entrez Gene AATK apoptosis associated tyrosine kinase Kos A Olde Loohuis NF Wieczorek ML Glennon JC Martens GJ Kolk SM Aschrafi A 2012 A potential regulatory role for intronic microRNA 338 3p for its host gene encoding apoptosis associated tyrosine kinase PLOS ONE 7 2 e31022 Bibcode 2012PLoSO 731022K doi 10 1371 journal pone 0031022 PMC 3281898 PMID 22363537 Ma S Rubin BP Apr 2014 Apoptosis associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma Laboratory Investigation 94 4 430 438 doi 10 1038 labinvest 2014 13 PMID 24589855 Gagnon KB England R Diehl L Delpire E May 2007 Apoptosis associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na K 2C1 cotransporter regulation American Journal of Physiology Cell Physiology 292 5 C1809 C1815 doi 10 1152 ajpcell 00580 2006 PMID 17267545 S2CID 10258460 Further reading editNakajima D Okazaki N Yamakawa H Kikuno R Ohara O Nagase T Jun 2002 Construction of expression ready cDNA clones for KIAA genes manual curation of 330 KIAA cDNA clones DNA Research 9 3 99 106 doi 10 1093 dnares 9 3 99 PMID 12168954 Raghunath M Patti R Bannerman P Lee CM Baker S Sutton LN Phillips PC Damodar Reddy C May 2000 A novel kinase AATYK induces and promotes neuronal differentiation in a human neuroblastoma SH SY5Y cell line Brain Research Molecular Brain Research 77 2 151 62 doi 10 1016 S0169 328X 00 00048 6 PMID 10837911 Tomomura M Hasegawa Y Hashikawa T Tomomura A Yuzaki M Furuichi T Yano R Apr 2003 Differential expression and function of apoptosis associated tyrosine kinase AATYK in the developing mouse brain Brain Research Molecular Brain Research 112 1 2 103 12 doi 10 1016 S0169 328X 03 00054 8 PMID 12670708 Honma N Asada A Takeshita S Enomoto M Yamakawa E Tsutsumi K Saito T Satoh T Itoh H Kaziro Y Kishimoto T Hisanaga S Oct 2003 Apoptosis associated tyrosine kinase is a Cdk5 activator p35 binding protein Biochemical and Biophysical Research Communications 310 2 398 404 doi 10 1016 j bbrc 2003 08 143 PMID 14521924 Piechotta K Garbarini N England R Delpire E Dec 2003 Characterization of the interaction of the stress kinase SPAK with the Na K 2Cl cotransporter in the nervous system evidence for a scaffolding role of the kinase The Journal of Biological Chemistry 278 52 52848 56 doi 10 1074 jbc M309436200 PMID 14563843 External links editAATK human gene location in the UCSC Genome Browser AATK human gene details in the UCSC Genome Browser Portal nbsp Biology nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title AATK amp oldid 1190101877, wikipedia, wiki, book, books, library,
