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Yoshinori Ohsumi

January 01, 1970

Yoshinori Ohsumi (大隅 良典, Ōsumi Yoshinori, born February 9, 1945) is a Japanese cell biologist specializing in autophagy, the process that cells use to destroy and recycle cellular components. Ohsumi is a professor at Tokyo Institute of Technology's Institute of Innovative Research.[1] He received the Kyoto Prize for Basic Sciences in 2012,[2] the 2016 Nobel Prize in Physiology or Medicine, and the 2017 Breakthrough Prize in Life Sciences[3] for his discoveries of mechanisms for autophagy.[4]

Yoshinori Ohsumi
Ohsumi in 2016
Born (1945-02-09) February 9, 1945 (age 79)
Fukuoka, Japan
Alma materUniversity of Tokyo (BSc, DSc)
Rockefeller University
Known forAutophagy
AwardsKyoto Prize (2012)
Gairdner Foundation International Award (2015)
Nobel Prize in Physiology or Medicine (2016)
Breakthrough Prize in Life Sciences (2017)
Scientific career
FieldsCell biologist
InstitutionsTokyo Institute of Technology
Websitewww.ohsumilab.aro.iri.titech.ac.jp/english.html

Biography edit

 
Ohsumi addressed at Gairdner Foundation International Award Ceremony (at the Royal Ontario Museum in October 2015)
 
with John Dirks, Kenjirō Monji and D. Lorne Tyrrell

Ohsumi was born on February 9, 1945, in Fukuoka. He received a B.Sci. in 1967 and a D.Sci. in 1974, both from the University of Tokyo. In 1974–77 he was a postdoctoral fellow at the Rockefeller University in New York City.[1]

He returned to the University of Tokyo in 1977 as a research associate; he was appointed Lecturer there in 1986, and promoted to Associate Professor in 1988. In 1996, he moved to the National Institute for Basic Biology, Japan in Okazaki City, where he was appointed as a professor. From 2004 to 2009, he was also professor at the Graduate University for Advanced Studies in Hayama. In 2009, he transitioned to a three-way appointment as an emeritus professor at the National Institute for Basic Biology and at the Graduate University for Advanced Studies, and a professorship at the Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology (Tokyo Tech). After his retirement in 2014, he continued to serve as Professor at Institute of Innovative Research, Tokyo Institute of Technology. Currently, he is head of the Cell Biology Research Unit, Institute of Innovative Research, Tokyo Institute of Technology.[5]

Christian de Duve coined the term autophagy in 1963 whereas Ohsumi began his work in 1988. Prior to that time, less than 20 papers per year were published on this subject.[6] During the 1990s, Ohsumi's group described the morphology of autophagy in yeast, and performed mutational screening on yeast cells that identified essential genes for cells to be capable of autophagy.[7][8]

In 2016, he was awarded the Nobel Prize in Physiology or Medicine "for his discoveries of mechanisms for autophagy".[9][10] He is the 25th Japanese person to be awarded a Nobel Prize.[11] Ohsumi's spouse Mariko, a Professor of Teikyo University of Science, collaborated on his research.[12] She is a co-author of many academic papers with him.[13]

Recognition edit

 
Ohsumi in his Tokyo Tech lab

Source:[5]

Selected publications edit

His original findings about autophagy in yeast cells:[17]

  • Takeshige K; Baba M; Tsuboi S; Noda T; Ohsumi Y (October 1992). "Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction". Journal of Cell Biology. 119 (2): 301–11. doi:10.1083/JCB.119.2.301. ISSN 0021-9525. JSTOR 1615399. PMC 2289660. PMID 1400575. Wikidata Q29614187.

Follow up with more research on yeast:[17]

  • Baba M; Takeshige K; Baba N; Ohsumi Y (March 1, 1994). "Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization". Journal of Cell Biology. 124 (6): 903–913. doi:10.1083/JCB.124.6.903. ISSN 0021-9525. JSTOR 1616094. PMC 2119983. PMID 8132712. Wikidata Q34337565.

Others

  • M Tsukada; Y Ohsumi (October 25, 1993). "Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae". FEBS Letters. 333 (1–2): 169–74. doi:10.1016/0014-5793(93)80398-E. ISSN 0014-5793. PMID 8224160. S2CID 46017791. Wikidata Q27935838.
  • N Mizushima; T Noda; T Yoshimori; et al. (September 24, 1998). "A protein conjugation system essential for autophagy". Nature. 395 (6700): 395–8. Bibcode:1998Natur.395..395M. doi:10.1038/26506. ISSN 1476-4687. PMID 9759731. S2CID 204997310. Wikidata Q27940154.
  • Y Kabeya; N Mizushima; T Ueno; et al. (November 1, 2000). "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing". The EMBO Journal. 19 (21): 5720–8. doi:10.1093/EMBOJ/19.21.5720. ISSN 0261-4189. PMC 305793. PMID 11060023. Wikidata Q24597817.
  • Y Ichimura; T Kirisako; T Takao; et al. (November 23, 2000). "A ubiquitin-like system mediates protein lipidation". Nature. 408 (6811): 488–92. Bibcode:2000Natur.408..488I. doi:10.1038/35044114. ISSN 1476-4687. PMID 11100732. S2CID 4428142. Wikidata Q27934137.
  • Y Ohsumi (March 2001). "Molecular dissection of autophagy: two ubiquitin-like systems". Nature Reviews Molecular Cell Biology. 2 (3): 211–6. doi:10.1038/35056522. ISSN 1471-0072. PMID 11265251. S2CID 38001477. Wikidata Q28206420.
  • Kuma A; Hatano M; Matsui M; et al. (December 23, 2004). "The role of autophagy during the early neonatal starvation period". Nature. 432 (7020): 1032–6. Bibcode:2004Natur.432.1032K. doi:10.1038/NATURE03029. ISSN 1476-4687. PMID 15525940. S2CID 4424974. Wikidata Q29547489.
  • Sho W Suzuki; Jun Onodera; Yoshinori Ohsumi (2011). "Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction". PLOS One. 6 (2): e17412. Bibcode:2011PLoSO...617412S. doi:10.1371/JOURNAL.PONE.0017412. ISSN 1932-6203. PMC 3045454. PMID 21364763. Wikidata Q27077073.
  • Takao Hanada; Nobuo N Noda; Yoshinori Satomi; Yoshinobu Ichimura; Yuko Fujioka; Toshifumi Takao; Fuyuhiko Inagaki; Yoshinori Ohsumi (December 28, 2007). "The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy". Journal of Biological Chemistry. 282 (52): 37298–302. doi:10.1074/JBC.C700195200. ISSN 0021-9258. PMID 17986448. Wikidata Q27933717.
  • Michitaro Shibata; Kazusato Oikawa; Kohki Yoshimoto; et al. (December 24, 2013). "Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis". The Plant Cell. 25 (12): 4967–4983. doi:10.1105/TPC.113.116947. ISSN 1040-4651. JSTOR 43190612. PMC 3903999. PMID 24368788. Wikidata Q34394370.
  • Hayashi Yamamoto; Takayuki Shima; Masaya Yamaguchi; et al. (October 6, 2015). "The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy". Journal of Biological Chemistry. 290 (49): 29506–29518. doi:10.1074/JBC.M115.684233. ISSN 0021-9258. PMC 4705951. PMID 26442587. Wikidata Q34497110.
  • Hayashi Yamamoto; Yuko Fujioka; Sho W Suzuki; et al. (July 11, 2016). "The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes". Developmental Cell. 38 (1): 86–99. doi:10.1016/J.DEVCEL.2016.06.015. ISSN 1534-5807. PMID 27404361. Wikidata Q27718642.

See also edit

References edit

  1. ^ a b Yoshinori Ohsumi's ORCID 0000-0003-2384-2166
  2. ^ Biemiller, Lawrence (November 10, 2012). "Kyoto Prize Is Awarded to 3 Scholars". The Chronicle of Higher Education Blogs: The Ticker. Retrieved October 4, 2016.
  3. ^ "Laureates—Breakthrough Prize". Breakthrough Prize. Retrieved December 5, 2016.
  4. ^ "The Nobel Prize in Physiology or Medicine 2016". The Nobel Foundation. October 3, 2016. Retrieved October 3, 2016.
  5. ^ a b "Yoshinori Ohsumi Biography". Institute of Innovative Research, Tokyo Institute of Technology. Retrieved October 10, 2016.
  6. ^ "Yoshinori Ohsumi: What is autophagy? A dynamic cellular recycling process". Molecular Frontiers Symposium at the Tokyo Institute of Technology, Japan. October 2017. Retrieved January 15, 2018.
  7. ^ Science Staff (October 3, 2016). "Nobel honors discoveries on how cells eat themselves". Science. doi:10.1126/SCIENCE.AAH7373. ISSN 0036-8075. Wikidata Q57407776.
  8. ^ Klionsky DJ (November 2007). "Autophagy: from phenomenology to molecular understanding in less than a decade". Nature Reviews Molecular Cell Biology. 8 (11): 931–7. doi:10.1038/NRM2245. ISSN 1471-0072. PMID 17712358. S2CID 7376303. Wikidata Q29614174.
  9. ^ "Yoshinori Ohsumi – Nobel Lecture: Autophagy – an Intracellular Recycling System". Nobel Prize. December 7, 2016. Retrieved January 15, 2018.
  10. ^ Kolata, Gina; Chan, Sewell (October 3, 2016). "Yoshinori Ohsumi of Japan Wins Nobel Prize for Study of 'Self-Eating' Cells". The New York Times. Retrieved October 10, 2016.
  11. ^ Wanklyn, Alastair (October 3, 2016). "Japanese microbiologist Yoshinori Ohsumi wins Nobel in medicine for autophagy research". The Japan Times. Retrieved October 8, 2016.
  12. ^ "大隅萬里子教授の共同研究がノーベル医学・生理学賞として選定されました" [A joint research of Professor Mariko Ohsumi won Nobel Prize in Physiology or Medicine]. Teikyo University of Science. October 5, 2016.
  13. ^ "Google Scholar". Scholar.google.com.
  14. ^ "Yoshinori Ohsumi". Kyoto Prize. Retrieved October 3, 2016.
  15. ^ "Yoshinori Ohsumi wins Nobel prize in medicine for work on autophagy". The Guardian. Retrieved October 3, 2016.
  16. ^ "Breakthrough Prize – Life Sciences : Breakthrough Prize Laureates – Yoshinori Ohsumi". Breakthroughprize.org. Retrieved October 15, 2018.
  17. ^ a b "Nobel Prize Laureate Yoshinori Ohsumi's Work". Jstor Daily. October 3, 2016.

External links edit

 
Wikimedia Commons has media related to Yoshinori Ōsumi.
  • Yoshinori Ohsumi on Nobelprize.org   inclkuding the Nobel Lecture December 7, 2016 Molecular Mechanisms of Autophagy in Yeast
 
Scholia has an author profile for Yoshinori Ohsumi.

January 01, 1970
yoshinori, ohsumi, 大隅, 良典, Ōsumi, yoshinori, born, february, 1945, japanese, cell, biologist, specializing, autophagy, process, that, cells, destroy, recycle, cellular, components, ohsumi, professor, tokyo, institute, technology, institute, innovative, researc. Yoshinori Ohsumi 大隅 良典 Ōsumi Yoshinori born February 9 1945 is a Japanese cell biologist specializing in autophagy the process that cells use to destroy and recycle cellular components Ohsumi is a professor at Tokyo Institute of Technology s Institute of Innovative Research 1 He received the Kyoto Prize for Basic Sciences in 2012 2 the 2016 Nobel Prize in Physiology or Medicine and the 2017 Breakthrough Prize in Life Sciences 3 for his discoveries of mechanisms for autophagy 4 Yoshinori OhsumiOhsumi in 2016Born 1945 02 09 February 9 1945 age 79 Fukuoka JapanAlma materUniversity of Tokyo BSc DSc Rockefeller UniversityKnown forAutophagyAwardsKyoto Prize 2012 Gairdner Foundation International Award 2015 Nobel Prize in Physiology or Medicine 2016 Breakthrough Prize in Life Sciences 2017 Scientific careerFieldsCell biologistInstitutionsTokyo Institute of TechnologyWebsitewww wbr ohsumilab wbr aro wbr iri wbr titech wbr ac wbr jp wbr english wbr html Contents 1 Biography 2 Recognition 3 Selected publications 4 See also 5 References 6 External linksBiography edit nbsp Ohsumi addressed at Gairdner Foundation International Award Ceremony at the Royal Ontario Museum in October 2015 nbsp with John Dirks Kenjirō Monji and D Lorne Tyrrell Ohsumi was born on February 9 1945 in Fukuoka He received a B Sci in 1967 and a D Sci in 1974 both from the University of Tokyo In 1974 77 he was a postdoctoral fellow at the Rockefeller University in New York City 1 He returned to the University of Tokyo in 1977 as a research associate he was appointed Lecturer there in 1986 and promoted to Associate Professor in 1988 In 1996 he moved to the National Institute for Basic Biology Japan in Okazaki City where he was appointed as a professor From 2004 to 2009 he was also professor at the Graduate University for Advanced Studies in Hayama In 2009 he transitioned to a three way appointment as an emeritus professor at the National Institute for Basic Biology and at the Graduate University for Advanced Studies and a professorship at the Advanced Research Organization Integrated Research Institute Tokyo Institute of Technology Tokyo Tech After his retirement in 2014 he continued to serve as Professor at Institute of Innovative Research Tokyo Institute of Technology Currently he is head of the Cell Biology Research Unit Institute of Innovative Research Tokyo Institute of Technology 5 Christian de Duve coined the term autophagy in 1963 whereas Ohsumi began his work in 1988 Prior to that time less than 20 papers per year were published on this subject 6 During the 1990s Ohsumi s group described the morphology of autophagy in yeast and performed mutational screening on yeast cells that identified essential genes for cells to be capable of autophagy 7 8 In 2016 he was awarded the Nobel Prize in Physiology or Medicine for his discoveries of mechanisms for autophagy 9 10 He is the 25th Japanese person to be awarded a Nobel Prize 11 Ohsumi s spouse Mariko a Professor of Teikyo University of Science collaborated on his research 12 She is a co author of many academic papers with him 13 Recognition edit nbsp Ohsumi in his Tokyo Tech lab Source 5 2005 Fujihara Award Fujihara Foundation of Science 2006 Japan Academy Prize Japan Academy 2007 Science Award Botanical Society of Japan ja 2008 Asahi Prize Asahi Shimbun 2012 Kyoto Prize in Basic Sciences 14 2013 Thomson Reuters Citation Laureate 2015 Gairdner Foundation International Award 2015 International Prize for Biology 2015 Keio Medical Science Prize 2015 Person of Cultural Merit 2015 Rosenstiel Award 2016 Wiley Prize in Biomedical Sciences 2016 Dr Paul Janssen Award for Biomedical Research 2016 Nobel Prize in Physiology or Medicine 15 2017 Breakthrough Prize in Life Sciences 16 Selected publications editHis original findings about autophagy in yeast cells 17 Takeshige K Baba M Tsuboi S Noda T Ohsumi Y October 1992 Autophagy in yeast demonstrated with proteinase deficient mutants and conditions for its induction Journal of Cell Biology 119 2 301 11 doi 10 1083 JCB 119 2 301 ISSN 0021 9525 JSTOR 1615399 PMC 2289660 PMID 1400575 Wikidata Q29614187 Follow up with more research on yeast 17 Baba M Takeshige K Baba N Ohsumi Y March 1 1994 Ultrastructural analysis of the autophagic process in yeast detection of autophagosomes and their characterization Journal of Cell Biology 124 6 903 913 doi 10 1083 JCB 124 6 903 ISSN 0021 9525 JSTOR 1616094 PMC 2119983 PMID 8132712 Wikidata Q34337565 Others M Tsukada Y Ohsumi October 25 1993 Isolation and characterization of autophagy defective mutants of Saccharomyces cerevisiae FEBS Letters 333 1 2 169 74 doi 10 1016 0014 5793 93 80398 E ISSN 0014 5793 PMID 8224160 S2CID 46017791 Wikidata Q27935838 N Mizushima T Noda T Yoshimori et al September 24 1998 A protein conjugation system essential for autophagy Nature 395 6700 395 8 Bibcode 1998Natur 395 395M doi 10 1038 26506 ISSN 1476 4687 PMID 9759731 S2CID 204997310 Wikidata Q27940154 Y Kabeya N Mizushima T Ueno et al November 1 2000 LC3 a mammalian homologue of yeast Apg8p is localized in autophagosome membranes after processing The EMBO Journal 19 21 5720 8 doi 10 1093 EMBOJ 19 21 5720 ISSN 0261 4189 PMC 305793 PMID 11060023 Wikidata Q24597817 Y Ichimura T Kirisako T Takao et al November 23 2000 A ubiquitin like system mediates protein lipidation Nature 408 6811 488 92 Bibcode 2000Natur 408 488I doi 10 1038 35044114 ISSN 1476 4687 PMID 11100732 S2CID 4428142 Wikidata Q27934137 Y Ohsumi March 2001 Molecular dissection of autophagy two ubiquitin like systems Nature Reviews Molecular Cell Biology 2 3 211 6 doi 10 1038 35056522 ISSN 1471 0072 PMID 11265251 S2CID 38001477 Wikidata Q28206420 Kuma A Hatano M Matsui M et al December 23 2004 The role of autophagy during the early neonatal starvation period Nature 432 7020 1032 6 Bibcode 2004Natur 432 1032K doi 10 1038 NATURE03029 ISSN 1476 4687 PMID 15525940 S2CID 4424974 Wikidata Q29547489 Sho W Suzuki Jun Onodera Yoshinori Ohsumi 2011 Starvation induced cell death in autophagy defective yeast mutants is caused by mitochondria dysfunction PLOS One 6 2 e17412 Bibcode 2011PLoSO 617412S doi 10 1371 JOURNAL PONE 0017412 ISSN 1932 6203 PMC 3045454 PMID 21364763 Wikidata Q27077073 Takao Hanada Nobuo N Noda Yoshinori Satomi Yoshinobu Ichimura Yuko Fujioka Toshifumi Takao Fuyuhiko Inagaki Yoshinori Ohsumi December 28 2007 The Atg12 Atg5 conjugate has a novel E3 like activity for protein lipidation in autophagy Journal of Biological Chemistry 282 52 37298 302 doi 10 1074 JBC C700195200 ISSN 0021 9258 PMID 17986448 Wikidata Q27933717 Michitaro Shibata Kazusato Oikawa Kohki Yoshimoto et al December 24 2013 Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis The Plant Cell 25 12 4967 4983 doi 10 1105 TPC 113 116947 ISSN 1040 4651 JSTOR 43190612 PMC 3903999 PMID 24368788 Wikidata Q34394370 Hayashi Yamamoto Takayuki Shima Masaya Yamaguchi et al October 6 2015 The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy Journal of Biological Chemistry 290 49 29506 29518 doi 10 1074 JBC M115 684233 ISSN 0021 9258 PMC 4705951 PMID 26442587 Wikidata Q34497110 Hayashi Yamamoto Yuko Fujioka Sho W Suzuki et al July 11 2016 The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes Developmental Cell 38 1 86 99 doi 10 1016 J DEVCEL 2016 06 015 ISSN 1534 5807 PMID 27404361 Wikidata Q27718642 See also editList of Japanese Nobel laureates List of Nobel laureates affiliated with the University of TokyoReferences edit a b Yoshinori Ohsumi s ORCID 0000 0003 2384 2166 Biemiller Lawrence November 10 2012 Kyoto Prize Is Awarded to 3 Scholars The Chronicle of Higher Education Blogs The Ticker Retrieved October 4 2016 Laureates Breakthrough Prize Breakthrough Prize Retrieved December 5 2016 The Nobel Prize in Physiology or Medicine 2016 The Nobel Foundation October 3 2016 Retrieved October 3 2016 a b Yoshinori Ohsumi Biography Institute of Innovative Research Tokyo Institute of Technology Retrieved October 10 2016 Yoshinori Ohsumi What is autophagy A dynamic cellular recycling process Molecular Frontiers Symposium at the Tokyo Institute of Technology Japan October 2017 Retrieved January 15 2018 Science Staff October 3 2016 Nobel honors discoveries on how cells eat themselves Science doi 10 1126 SCIENCE AAH7373 ISSN 0036 8075 Wikidata Q57407776 Klionsky DJ November 2007 Autophagy from phenomenology to molecular understanding in less than a decade Nature Reviews Molecular Cell Biology 8 11 931 7 doi 10 1038 NRM2245 ISSN 1471 0072 PMID 17712358 S2CID 7376303 Wikidata Q29614174 Yoshinori Ohsumi Nobel Lecture Autophagy an Intracellular Recycling System Nobel Prize December 7 2016 Retrieved January 15 2018 Kolata Gina Chan Sewell October 3 2016 Yoshinori Ohsumi of Japan Wins Nobel Prize for Study of Self Eating Cells The New York Times Retrieved October 10 2016 Wanklyn Alastair October 3 2016 Japanese microbiologist Yoshinori Ohsumi wins Nobel in medicine for autophagy research The Japan Times Retrieved October 8 2016 大隅萬里子教授の共同研究がノーベル医学 生理学賞として選定されました A joint research of Professor Mariko Ohsumi won Nobel Prize in Physiology or Medicine Teikyo University of Science October 5 2016 Google Scholar Scholar google com Yoshinori Ohsumi Kyoto Prize Retrieved October 3 2016 Yoshinori Ohsumi wins Nobel prize in medicine for work on autophagy The Guardian Retrieved October 3 2016 Breakthrough Prize Life Sciences Breakthrough Prize Laureates Yoshinori Ohsumi Breakthroughprize org Retrieved October 15 2018 a b Nobel Prize Laureate Yoshinori Ohsumi s Work Jstor Daily October 3 2016 External links edit nbsp Wikimedia Commons has media related to Yoshinori Ōsumi Yoshinori Ohsumi on Nobelprize org nbsp inclkuding the Nobel Lecture December 7 2016 Molecular Mechanisms of Autophagy in Yeast nbsp Scholia has an author profile for Yoshinori Ohsumi Retrieved from https en wikipedia org w index php title Yoshinori Ohsumi amp oldid 1219812111, wikipedia, wiki, book, books, library,

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