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FLT4

August 29, 2023

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.[5][6]

FLT4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFLT4, FLT41, LMPH1A, PCL, VEGFR3, FLT-4, VEGFR-3, fms related tyrosine kinase 4, LMPHM1, fms related receptor tyrosine kinase 4, CHTD7
External IDsOMIM: 136352 MGI: 95561 HomoloGene: 7321 GeneCards: FLT4
Orthologs
SpeciesHumanMouse
Entrez

2324

14257

Ensembl

ENSG00000037280

ENSMUSG00000020357

UniProt

P35916

P35917

RefSeq (mRNA)

NM_002020
NM_182925
NM_001354989

NM_008029

RefSeq (protein)

NP_002011
NP_891555
NP_001341918

NP_032055

Location (UCSC)Chr 5: 180.6 – 180.65 MbChr 11: 49.5 – 49.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.[5]

Interactions Edit

FLT4 has been shown to interact with SHC1.[7][8][9]

See also Edit

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000037280 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020357 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: FLT4 fms-related tyrosine kinase 4".
  6. ^ Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (June 1992). "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene". Genomics. 13 (2): 475–8. doi:10.1016/0888-7543(92)90277-Y. PMID 1319394.
  7. ^ Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K (December 1994). "Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors". Oncogene. 9 (12): 3545–55. PMID 7970715.
  8. ^ Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP (January 1999). "Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling". Oncogene. 18 (2): 507–14. doi:10.1038/sj.onc.1202315. PMID 9927207.
  9. ^ Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP (May 1996). "Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase". The Journal of Biological Chemistry. 271 (22): 12956–63. doi:10.1074/jbc.271.22.12956. PMID 8662748.

Further reading Edit

  • Petrova TV, Makinen T, Alitalo K (November 1999). "Signaling via vascular endothelial growth factor receptors". Experimental Cell Research. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
  • Aprelikova O, Pajusola K, Partanen J, Armstrong E, Alitalo R, Bailey SK, McMahon J, Wasmuth J, Huebner K, Alitalo K (February 1992). "FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter". Cancer Research. 52 (3): 746–8. PMID 1310071.
  • Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (June 1992). "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene". Genomics. 13 (2): 475–8. doi:10.1016/0888-7543(92)90277-Y. PMID 1319394.
  • Pajusola K, Aprelikova O, Korhonen J, Kaipainen A, Pertovaara L, Alitalo R, Alitalo K (October 1992). "FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines". Cancer Research. 52 (20): 5738–43. PMID 1327515.
  • Fournier E, Dubreuil P, Birnbaum D, Borg JP (September 1995). "Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor". Oncogene. 11 (5): 921–31. PMID 7675451.
  • Pajusola K, Aprelikova O, Armstrong E, Morris S, Alitalo K (November 1993). "Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts". Oncogene. 8 (11): 2931–7. PMID 7692369.
  • Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K (December 1994). "Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors". Oncogene. 9 (12): 3545–55. PMID 7970715.
  • Galland F, Karamysheva A, Pebusque MJ, Borg JP, Rottapel R, Dubreuil P, Rosnet O, Birnbaum D (May 1993). "The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor". Oncogene. 8 (5): 1233–40. PMID 8386825.
  • Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP (May 1996). "Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase". The Journal of Biological Chemistry. 271 (22): 12956–63. doi:10.1074/jbc.271.22.12956. PMID 8662748.
  • Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI (March 1996). "Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4". Proceedings of the National Academy of Sciences of the United States of America. 93 (5): 1988–92. Bibcode:1996PNAS...93.1988L. doi:10.1073/pnas.93.5.1988. PMC 39896. PMID 8700872.
  • Kukk E, Lymboussaki A, Taira S, Kaipainen A, Jeltsch M, Joukov V, Alitalo K (December 1996). "VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development". Development. 122 (12): 3829–37. doi:10.1242/dev.122.12.3829. PMID 9012504.
  • Achen MG, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks AF, Alitalo K, Stacker SA (January 1998). "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proceedings of the National Academy of Sciences of the United States of America. 95 (2): 548–53. Bibcode:1998PNAS...95..548A. doi:10.1073/pnas.95.2.548. PMC 18457. PMID 9435229.
  • Ferrell RE, Levinson KL, Esman JH, Kimak MA, Lawrence EC, Barmada MM, Finegold DN (December 1998). "Hereditary lymphedema: evidence for linkage and genetic heterogeneity". Human Molecular Genetics. 7 (13): 2073–8. doi:10.1093/hmg/7.13.2073. PMID 9817924.
  • Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP (January 1999). "Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling". Oncogene. 18 (2): 507–14. doi:10.1038/sj.onc.1202315. PMID 9927207.
  • Karkkainen MJ, Ferrell RE, Lawrence EC, Kimak MA, Levinson KL, McTigue MA, Alitalo K, Finegold DN (June 2000). "Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema". Nature Genetics. 25 (2): 153–9. doi:10.1038/75997. PMID 10835628. S2CID 38445644.
  • Irrthum A, Karkkainen MJ, Devriendt K, Alitalo K, Vikkula M (August 2000). "Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase". American Journal of Human Genetics. 67 (2): 295–301. doi:10.1086/303019. PMC 1287178. PMID 10856194.
  • Wang JF, Zhang XF, Groopman JE (November 2001). "Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration". The Journal of Biological Chemistry. 276 (45): 41950–7. doi:10.1074/jbc.M101370200. PMID 11553610.
  • Baldwin ME, Roufail S, Halford MM, Alitalo K, Stacker SA, Achen MG (November 2001). "Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis". The Journal of Biological Chemistry. 276 (47): 44307–14. doi:10.1074/jbc.M106188200. PMID 11574540.
  • Walter JW, North PE, Waner M, Mizeracki A, Blei F, Walker JW, Reinisch JF, Marchuk DA (March 2002). "Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma". Genes, Chromosomes & Cancer. 33 (3): 295–303. doi:10.1002/gcc.10028. PMID 11807987. S2CID 33428561.

External links Edit

  • GeneReviews/NCBI/NIH/UW entry on Milroy Disease

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



 

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

 

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

August 29, 2023
flt4, related, tyrosine, kinase, also, known, protein, which, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4bsj, 4bskidentifiersaliases, lmph1a, vegfr3, vegfr, related, tyrosine, kinase, lmphm1, related, receptor, tyros. Fms related tyrosine kinase 4 also known as FLT4 is a protein which in humans is encoded by the FLT4 gene 5 6 FLT4Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4BSJ 4BSKIdentifiersAliasesFLT4 FLT41 LMPH1A PCL VEGFR3 FLT 4 VEGFR 3 fms related tyrosine kinase 4 LMPHM1 fms related receptor tyrosine kinase 4 CHTD7External IDsOMIM 136352 MGI 95561 HomoloGene 7321 GeneCards FLT4Gene location Human Chr Chromosome 5 human 1 Band5q35 3Start180 601 506 bp 1 End180 649 624 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 B1 2 11 29 69 cMStart49 500 090 bp 2 End49 543 566 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of thyroid glandleft lobe of thyroid glandright lungupper lobe of left lungsural nervespleenright uterine tubeleft uterine tuberight adrenal glandsubcutaneous adipose tissueTop expressed ininternal carotid arteryleft lobe of liverexternal carotid arteryleft lungleft lung loberight lungaortic valveright lung lobethoracic diaphragmcarotid bodyMore reference expression dataBioGPSn aGene ontologyMolecular functionvascular endothelial growth factor activated receptor activity transferase activity nucleotide binding protein kinase activity growth factor binding kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity protein phosphatase binding ATP binding protein homodimerization activity receptor tyrosine kinase transmembrane signaling receptor activity vascular endothelial growth factor bindingCellular componentcytoplasm integral component of membrane membrane receptor complex plasma membrane integral component of plasma membrane extracellular region nucleus nucleoplasmBiological processregulation of blood vessel remodeling positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation blood vessel morphogenesis lymphangiogenesis phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of protein kinase C signaling negative regulation of apoptotic process sprouting angiogenesis positive regulation of JNK cascade lymph vessel development positive regulation of endothelial cell migration protein phosphorylation vascular endothelial growth factor receptor signaling pathway vasculature development angiogenesis positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade protein autophosphorylation positive regulation of vascular endothelial growth factor production peptidyl tyrosine phosphorylation cellular response to vascular endothelial growth factor stimulus positive regulation of MAPK cascade lung alveolus development respiratory system process respiratory gaseous exchange by respiratory system vascular endothelial growth factor signaling pathway negative regulation of signal transduction cell differentiation positive regulation of phosphatidylinositol 3 kinase signalingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez232414257EnsemblENSG00000037280ENSMUSG00000020357UniProtP35916P35917RefSeq mRNA NM 002020NM 182925NM 001354989NM 008029RefSeq protein NP 002011NP 891555NP 001341918NP 032055Location UCSC Chr 5 180 6 180 65 MbChr 11 49 5 49 54 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium Mutations in this gene cause hereditary lymphedema type IA 5 Contents 1 Interactions 2 See also 3 References 4 Further reading 5 External linksInteractions EditFLT4 has been shown to interact with SHC1 7 8 9 See also EditVEGF receptorsReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000037280 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020357 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene FLT4 fms related tyrosine kinase 4 Galland F Karamysheva A Mattei MG Rosnet O Marchetto S Birnbaum D June 1992 Chromosomal localization of FLT4 a novel receptor type tyrosine kinase gene Genomics 13 2 475 8 doi 10 1016 0888 7543 92 90277 Y PMID 1319394 Pajusola K Aprelikova O Pelicci G Weich H Claesson Welsh L Alitalo K December 1994 Signalling properties of FLT4 a proteolytically processed receptor tyrosine kinase related to two VEGF receptors Oncogene 9 12 3545 55 PMID 7970715 Fournier E Blaikie P Rosnet O Margolis B Birnbaum D Borg JP January 1999 Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling Oncogene 18 2 507 14 doi 10 1038 sj onc 1202315 PMID 9927207 Fournier E Rosnet O Marchetto S Turck CW Rottapel R Pelicci PG Birnbaum D Borg JP May 1996 Interaction with the phosphotyrosine binding domain phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4 VEGFR3 receptor tyrosine kinase The Journal of Biological Chemistry 271 22 12956 63 doi 10 1074 jbc 271 22 12956 PMID 8662748 Further reading EditPetrova TV Makinen T Alitalo K November 1999 Signaling via vascular endothelial growth factor receptors Experimental Cell Research 253 1 117 30 doi 10 1006 excr 1999 4707 PMID 10579917 Aprelikova O Pajusola K Partanen J Armstrong E Alitalo R Bailey SK McMahon J Wasmuth J Huebner K Alitalo K February 1992 FLT4 a novel class III receptor tyrosine kinase in chromosome 5q33 qter Cancer Research 52 3 746 8 PMID 1310071 Galland F Karamysheva A Mattei MG Rosnet O Marchetto S Birnbaum D June 1992 Chromosomal localization of FLT4 a novel receptor type tyrosine kinase gene Genomics 13 2 475 8 doi 10 1016 0888 7543 92 90277 Y PMID 1319394 Pajusola K Aprelikova O Korhonen J Kaipainen A Pertovaara L Alitalo R Alitalo K October 1992 FLT4 receptor tyrosine kinase contains seven immunoglobulin like loops and is expressed in multiple human tissues and cell lines Cancer Research 52 20 5738 43 PMID 1327515 Fournier E Dubreuil P Birnbaum D Borg JP September 1995 Mutation at tyrosine residue 1337 abrogates ligand dependent transforming capacity of the FLT4 receptor Oncogene 11 5 921 31 PMID 7675451 Pajusola K Aprelikova O Armstrong E Morris S Alitalo K November 1993 Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts Oncogene 8 11 2931 7 PMID 7692369 Pajusola K Aprelikova O Pelicci G Weich H Claesson Welsh L Alitalo K December 1994 Signalling properties of FLT4 a proteolytically processed receptor tyrosine kinase related to two VEGF receptors Oncogene 9 12 3545 55 PMID 7970715 Galland F Karamysheva A Pebusque MJ Borg JP Rottapel R Dubreuil P Rosnet O Birnbaum D May 1993 The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor Oncogene 8 5 1233 40 PMID 8386825 Fournier E Rosnet O Marchetto S Turck CW Rottapel R Pelicci PG Birnbaum D Borg JP May 1996 Interaction with the phosphotyrosine binding domain phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4 VEGFR3 receptor tyrosine kinase The Journal of Biological Chemistry 271 22 12956 63 doi 10 1074 jbc 271 22 12956 PMID 8662748 Lee J Gray A Yuan J Luoh SM Avraham H Wood WI March 1996 Vascular endothelial growth factor related protein a ligand and specific activator of the tyrosine kinase receptor Flt4 Proceedings of the National Academy of Sciences of the United States of America 93 5 1988 92 Bibcode 1996PNAS 93 1988L doi 10 1073 pnas 93 5 1988 PMC 39896 PMID 8700872 Kukk E Lymboussaki A Taira S Kaipainen A Jeltsch M Joukov V Alitalo K December 1996 VEGF C receptor binding and pattern of expression with VEGFR 3 suggests a role in lymphatic vascular development Development 122 12 3829 37 doi 10 1242 dev 122 12 3829 PMID 9012504 Achen MG Jeltsch M Kukk E Makinen T Vitali A Wilks AF Alitalo K Stacker SA January 1998 Vascular endothelial growth factor D VEGF D is a ligand for the tyrosine kinases VEGF receptor 2 Flk1 and VEGF receptor 3 Flt4 Proceedings of the National Academy of Sciences of the United States of America 95 2 548 53 Bibcode 1998PNAS 95 548A doi 10 1073 pnas 95 2 548 PMC 18457 PMID 9435229 Ferrell RE Levinson KL Esman JH Kimak MA Lawrence EC Barmada MM Finegold DN December 1998 Hereditary lymphedema evidence for linkage and genetic heterogeneity Human Molecular Genetics 7 13 2073 8 doi 10 1093 hmg 7 13 2073 PMID 9817924 Fournier E Blaikie P Rosnet O Margolis B Birnbaum D Borg JP January 1999 Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling Oncogene 18 2 507 14 doi 10 1038 sj onc 1202315 PMID 9927207 Karkkainen MJ Ferrell RE Lawrence EC Kimak MA Levinson KL McTigue MA Alitalo K Finegold DN June 2000 Missense mutations interfere with VEGFR 3 signalling in primary lymphoedema Nature Genetics 25 2 153 9 doi 10 1038 75997 PMID 10835628 S2CID 38445644 Irrthum A Karkkainen MJ Devriendt K Alitalo K Vikkula M August 2000 Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase American Journal of Human Genetics 67 2 295 301 doi 10 1086 303019 PMC 1287178 PMID 10856194 Wang JF Zhang XF Groopman JE November 2001 Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor 3 and modulates cell migration The Journal of Biological Chemistry 276 45 41950 7 doi 10 1074 jbc M101370200 PMID 11553610 Baldwin ME Roufail S Halford MM Alitalo K Stacker SA Achen MG November 2001 Multiple forms of mouse vascular endothelial growth factor D are generated by RNA splicing and proteolysis The Journal of Biological Chemistry 276 47 44307 14 doi 10 1074 jbc M106188200 PMID 11574540 Walter JW North PE Waner M Mizeracki A Blei F Walker JW Reinisch JF Marchuk DA March 2002 Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma Genes Chromosomes amp Cancer 33 3 295 303 doi 10 1002 gcc 10028 PMID 11807987 S2CID 33428561 External links EditGeneReviews NCBI NIH UW entry on Milroy DiseaseThis article incorporates text from the United States National Library of Medicine which is in the public domain Portal Biology This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title FLT4 amp oldid 1170990834, wikipedia, wiki, book, books, library,

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