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Trendione

January 23, 2023

Trendione (developmental code name RU-2065; nickname Trenavar), also known as estra-4,9,11-triene-3,17-dione, is an androgen prohormone as well as metabolite of the anabolic steroid trenbolone.[1][2][3][4][5] Trendione is to trenbolone as androstenedione is to testosterone.[6] The compound is inactive itself, showing more than 100-fold lower affinity for the androgen and progesterone receptors than trenbolone.[7][8] It is a designer steroid and has been sold on the internet as a "nutritional supplement".[1] Trendione is listed in the United States Designer Anabolic Steroid Control Act of 2014.[1]

Trendione
Clinical data
Other namesRU-2065; Trenavar; Triendione; Estra-4,9,11-triene-3,17-dione
Drug classAndrogen; Anabolic steroid; Progestogen
Identifiers
  • (8S,13S,14S)-13-Methyl-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
CAS Number
  • 4642-95-9
PubChem CID
  • 160762
ChemSpider
  • 141254
UNII
  • 7M9J4CV848
CompTox Dashboard (EPA)
  • DTXSID80873491
Chemical and physical data
FormulaC18H20O2
Molar mass268.356 g·mol−1
3D model (JSmol)
  • Interactive image
  • C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CCC2=O
  • InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-16H,2-7H2,1H3/t15-,16+,18+/m1/s1
  • Key:KBSXJBBFQODDTQ-RYRKJORJSA-N

See also

References

  1. ^ a b c Liane BJ, Magee C (October 2016). "Guerilla Warfare on the Pancreas? A Case of Acute Pancreatitis From a Supplement Known to Contain Anabolic-Androgenic Steroids". Mil Med. 181 (10): e1395–e1397. doi:10.7205/MILMED-D-15-00575. PMID 27753588.
  2. ^ Yarrow JF, McCoy SC, Borst SE (June 2010). "Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity". Steroids. 75 (6): 377–89. doi:10.1016/j.steroids.2010.01.019. PMID 20138077. S2CID 205253265.
  3. ^ Metzler M (April 1989). "Metabolism of some anabolic agents: toxicological and analytical aspects". J. Chromatogr. 489 (1): 11–21. doi:10.1016/s0378-4347(00)82880-7. PMID 2745641.
  4. ^ Yarrow JF, Conover CF, McCoy SC, Lipinska JA, Santillana CA, Hance JM, Cannady DF, VanPelt TD, Sanchez J, Conrad BP, Pingel JE, Wronski TJ, Borst SE (April 2011). "17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate". Am. J. Physiol. Endocrinol. Metab. 300 (4): E650–60. doi:10.1152/ajpendo.00440.2010. PMC 6189634. PMID 21266670.
  5. ^ Spranger B, Metzler M (April 1991). "Disposition of 17 beta-trenbolone in humans". J. Chromatogr. 564 (2): 485–92. doi:10.1016/0378-4347(91)80517-g. PMID 1874853.
  6. ^ Advances in Agronomy. Elsevier. 13 April 2007. pp. 16–. ISBN 978-0-08-048819-6.
  7. ^ Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH (December 2000). "Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor". APMIS. 108 (12): 838–46. doi:10.1111/j.1600-0463.2000.tb00007.x. PMID 11252818. S2CID 22776408.
  8. ^ Delettré J, Mornon JP, Lepicard G, Ojasoo T, Raynaud JP (January 1980). "Steroid flexibility and receptor specificity". J. Steroid Biochem. 13 (1): 45–59. doi:10.1016/0022-4731(80)90112-0. PMID 7382482.



 

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January 23, 2023
trendione, developmental, code, name, 2065, nickname, trenavar, also, known, estra, triene, dione, androgen, prohormone, well, metabolite, anabolic, steroid, trenbolone, trenbolone, androstenedione, testosterone, compound, inactive, itself, showing, more, than. Trendione developmental code name RU 2065 nickname Trenavar also known as estra 4 9 11 triene 3 17 dione is an androgen prohormone as well as metabolite of the anabolic steroid trenbolone 1 2 3 4 5 Trendione is to trenbolone as androstenedione is to testosterone 6 The compound is inactive itself showing more than 100 fold lower affinity for the androgen and progesterone receptors than trenbolone 7 8 It is a designer steroid and has been sold on the internet as a nutritional supplement 1 Trendione is listed in the United States Designer Anabolic Steroid Control Act of 2014 1 TrendioneClinical dataOther namesRU 2065 Trenavar Triendione Estra 4 9 11 triene 3 17 dioneDrug classAndrogen Anabolic steroid ProgestogenIdentifiersIUPAC name 8S 13S 14S 13 Methyl 1 2 6 7 8 14 15 16 octahydrocyclopenta a phenanthrene 3 17 dioneCAS Number4642 95 9PubChem CID160762ChemSpider141254UNII7M9J4CV848CompTox Dashboard EPA DTXSID80873491Chemical and physical dataFormulaC 18H 20O 2Molar mass268 356 g mol 13D model JSmol Interactive imageSMILES C C 12C CC3 C4CCC O C C4CC C H 3 C H 1CCC2 OInChI InChI 1S C18H20O2 c1 18 9 8 14 13 5 3 12 19 10 11 13 2 4 15 14 16 18 6 7 17 18 20 h8 10 15 16H 2 7H2 1H3 t15 16 18 m1 s1Key KBSXJBBFQODDTQ RYRKJORJSA NSee also EditList of androgens anabolic steroidsReferences Edit a b c Liane BJ Magee C October 2016 Guerilla Warfare on the Pancreas A Case of Acute Pancreatitis From a Supplement Known to Contain Anabolic Androgenic Steroids Mil Med 181 10 e1395 e1397 doi 10 7205 MILMED D 15 00575 PMID 27753588 Yarrow JF McCoy SC Borst SE June 2010 Tissue selectivity and potential clinical applications of trenbolone 17beta hydroxyestra 4 9 11 trien 3 one A potent anabolic steroid with reduced androgenic and estrogenic activity Steroids 75 6 377 89 doi 10 1016 j steroids 2010 01 019 PMID 20138077 S2CID 205253265 Metzler M April 1989 Metabolism of some anabolic agents toxicological and analytical aspects J Chromatogr 489 1 11 21 doi 10 1016 s0378 4347 00 82880 7 PMID 2745641 Yarrow JF Conover CF McCoy SC Lipinska JA Santillana CA Hance JM Cannady DF VanPelt TD Sanchez J Conrad BP Pingel JE Wronski TJ Borst SE April 2011 17b Hydroxyestra 4 9 11 trien 3 one trenbolone exhibits tissue selective anabolic activity effects on muscle bone adiposity hemoglobin and prostate Am J Physiol Endocrinol Metab 300 4 E650 60 doi 10 1152 ajpendo 00440 2010 PMC 6189634 PMID 21266670 Spranger B Metzler M April 1991 Disposition of 17 beta trenbolone in humans J Chromatogr 564 2 485 92 doi 10 1016 0378 4347 91 80517 g PMID 1874853 Advances in Agronomy Elsevier 13 April 2007 pp 16 ISBN 978 0 08 048819 6 Bauer ER Daxenberger A Petri T Sauerwein H Meyer HH December 2000 Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor human sex hormone binding globulin and to the bovine progestin receptor APMIS 108 12 838 46 doi 10 1111 j 1600 0463 2000 tb00007 x PMID 11252818 S2CID 22776408 Delettre J Mornon JP Lepicard G Ojasoo T Raynaud JP January 1980 Steroid flexibility and receptor specificity J Steroid Biochem 13 1 45 59 doi 10 1016 0022 4731 80 90112 0 PMID 7382482 This article about a steroid is a stub You can help Wikipedia by expanding it vte This drug article relating to the genito urinary system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Trendione amp oldid 1088539414, wikipedia, wiki, book, books, library,

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