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Tomas Lindahl

October 15, 2023

Tomas Robert Lindahl FRS[2] FMedSci[4] (born 28 January 1938) is a Swedish-British scientist specialising in cancer research.[7] In 2015, he was awarded the Nobel Prize in Chemistry[8] jointly with American chemist Paul L. Modrich and Turkish chemist Aziz Sancar for mechanistic studies of DNA repair.[9][10][11]

Tomas Lindahl

FRS FMedSci
Tomas Lindahl at the Royal Swedish Academy of Sciences (2015)
Born
Tomas Robert Lindahl

(1938-01-28) 28 January 1938 (age 85)[6]
Stockholm, Sweden
NationalitySwedish, naturalised British
(dual nationality)
Alma mater
Known forClarification of cellular resistance to carcinogens
Awards
Scientific career
Fields
Institutions
ThesisOn the structure and stability of nucleic acids in solution (1967)
Websitecrick.ac.uk/research/a-z-researchers/emeritus-scientists/tomas-lindahl/

Education Edit

Lindahl was born in Kungsholmen, Stockholm, Sweden to Folke Robert Lindahl and Ethel Hulda Hultberg.[12] He received a PhD degree in 1967,[13] and an MD degree qualification in 1970, from the Karolinska Institutet in Stockholm.[6]

Career and research Edit

After obtaining his research doctorate, Lindahl did postdoctoral research at Princeton University and Rockefeller University.[14] He was professor of medical chemistry at the University of Gothenburg 1978–82. After moving to the United Kingdom he joined the Imperial Cancer Research Fund (now Cancer Research UK) as a researcher in 1981.[14] From 1986 to 2005 he was the first Director of Cancer Research UK's Clare Hall Laboratories in Hertfordshire, since 2015 part of the Francis Crick Institute.[15] He continued to research there until 2009. He has contributed to many papers on DNA repair and the genetics of cancer.[16][17][18][19][20][21][22][23][24]

Awards and honours Edit

Lindahl was elected an EMBO Member in 1974[1] and Fellow of the Royal Society (FRS) in 1988,[3] his certificate of election reads:

Dr. Tomas Lindahl is noted for his contributions to the comprehension of DNA repair at the molecular level in bacterial and mammalian cells. He was the first to isolate a mammalian DNA ligase and to describe a totally unanticipated novel group of DNA glycosylases as mediators of DNA excision repair. He has also discovered a unique class of enzymes in mammalian cells, namely the methyltransferases, which mediate the adaptive response to alkylation of DNA and has shown that the expression of these enzymes is regulated by the ada gene. More recently he has elucidated the molecular defect in Blooms syndrome [sic] to be the lack of DNA ligase I. Apart from providing profound insights into the nature of the DNA repair process his very important contributions promise to facilitate the design of more selective chemotherapeutic drugs for the treatment of cancer. Lindahl has also made a number of significant contributions to understanding at the DNA level the mechanism of transformation of B-lymphocytes by the Epstein-Barr virus. The most notable of these was the first description of the occurrence in lymphoid cells of closed circular duplex viral DNA.[2]

Lindahl received the Royal Society's Royal Medal in 2007 "making fundamental contributions to our understanding of DNA repair. His achievements stand out for their great originality, breadth and lasting influence."[25] He is a member of the Norwegian Academy of Science and Letters.[26] He was awarded the Copley Medal in 2010. He was elected a founding Fellow of the Academy of Medical Sciences (FMedSci) in 1998. In 2018, he was elected a foreign associate of the National Academy of Sciences.

He shared the Nobel Prize in Chemistry in 2015.[9] The Swedish Academy noted that "The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar 'for mechanistic studies of DNA repair'."[27]

References Edit

  1. ^ a b "Tomas Lindahl EMBO profile". people.embo.org. Heidelberg: European Molecular Biology Organization.
  2. ^ a b c . London: The Royal Society. Archived from the original on 10 July 2019.
  3. ^ a b Anon (1988). . royalsociety.org. London: Royal Society. Archived from the original on 22 September 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” -- at the Wayback Machine (archived September 25, 2015)
  4. ^ a b . London: Academy of Medical Sciences. Archived from the original on 8 October 2015.
  5. ^ Lindahl, Tomas (2013). "My Journey to DNA Repair". Genomics, Proteomics & Bioinformatics. 11 (1): 2–7. doi:10.1016/j.gpb.2012.12.001. ISSN 1672-0229. PMC 4357663. PMID 23453014.
  6. ^ a b "LINDAHL, Tomas Robert". Who's Who. Vol. 2015 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
  7. ^ . The Crick. Archived from the original on 1 December 2015.
  8. ^ Tomas Lindahl – Nobel Prize in Chemistry 2015 on Vimeo
  9. ^ a b Broad, William J. (7 October 2015). "Nobel Prize in Chemistry Awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA Studies". The New York Times. ISSN 0362-4331. Retrieved 7 October 2015.
  10. ^ Staff (7 October 2015). "THE NOBEL PRIZE IN CHEMISTRY 2015 – DNA repair – providing chemical stability for life" (PDF). Nobel Prize. Retrieved 7 October 2015.
  11. ^ Cressey, Daniel (2015). "DNA repair sleuths win chemistry Nobel: Tomas Lindahl, Paul Modrich and Aziz Sancar share 2015 prize". Nature. 526 (7573): 307–8. doi:10.1038/nature.2015.18515. ISSN 1476-4687. PMID 26469021.
  12. ^ Sweden, Indexed Birth Records, 1860–1941
  13. ^ Lindahl, Tomas (1967). On the structure and stability of nucleic acids in solution. Stockholm.{{cite book}}: CS1 maint: location missing publisher (link)
  14. ^ a b "Cancer Research UK Grants & Research – Tomas Lindahl". Retrieved 10 November 2008.
  15. ^ "4 ways that Tomas Lindahl’s Nobel Prize for Chemistry revolutionised cancer research", by Emma Smith, CRUK Science blog, 7 October 2015
  16. ^ Gerken, T. is; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2008). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10.1126/science.1151710. PMC 2668859. PMID 17991826.
  17. ^ Tomas Lindahl's publications indexed by the Scopus bibliographic database. (subscription required)
  18. ^ Lindahl, T. (1993). "Instability and decay of the primary structure of DNA". Nature. 362 (6422): 709–15. Bibcode:1993Natur.362..709L. doi:10.1038/362709a0. PMID 8469282. S2CID 4283694.
  19. ^ Wood, R. D. (2001). "Human DNA Repair Genes". Science. 291 (5507): 1284–9. Bibcode:2001Sci...291.1284W. doi:10.1126/science.1056154. PMID 11181991.
  20. ^ Satoh, M. S.; Lindahl, T. (1992). "Role of poly(ADP-ribose) formation in DNA repair". Nature. 356 (6367): 356–8. Bibcode:1992Natur.356..356S. doi:10.1038/356356a0. PMID 1549180. S2CID 4364270.
  21. ^ Trewick, S. C.; Henshaw, T. F.; Hausinger, R. P.; Lindahl, T; Sedgwick, B (2002). "Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage". Nature. 419 (6903): 174–8. Bibcode:2002Natur.419..174T. doi:10.1038/nature00908. PMID 12226667. S2CID 4324333.
  22. ^ Barnes, D. E.; Lindahl, T (2004). "Repair and genetic consequences of endogenous DNA base damage in mammalian cells". Annual Review of Genetics. 38: 445–76. doi:10.1146/annurev.genet.38.072902.092448. PMID 15568983.
  23. ^ Yang, Y. G.; Lindahl, T; Barnes, D. E. (2007). "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease". Cell. 131 (5): 873–86. doi:10.1016/j.cell.2007.10.017. PMID 18045533. S2CID 2332259.
  24. ^ Crow, Y. J.; Hayward, B. E.; Parmar, R; Robins, P; Leitch, A; Ali, M; Black, D. N.; Van Bokhoven, H; Brunner, H. G.; Hamel, B. C.; Corry, P. C.; Cowan, F. M.; Frints, S. G.; Klepper, J; Livingston, J. H.; Lynch, S. A.; Massey, R. F.; Meritet, J. F.; Michaud, J. L.; Ponsot, G; Voit, T; Lebon, P; Bonthron, D. T.; Jackson, A. P.; Barnes, D. E.; Lindahl, T (2006). "Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus". Nature Genetics. 38 (8): 917–20. doi:10.1038/ng1845. PMID 16845398. S2CID 9069106.
  25. ^ "Royal recent winners". Retrieved 10 November 2008.
  26. ^ "Gruppe 6: Cellebiologi og molekylærbiologi" (in Norwegian). Norwegian Academy of Science and Letters. Retrieved 7 October 2010.
  27. ^ "The Nobel Prize in Chemistry 2015". nobelprize.org.

External links Edit

  • Tomas Lindahl on Nobelprize.org   including the Nobel Lecture 8 December 2015 The Intrinsic Fragility of DNA

October 15, 2023
tomas, lindahl, tomas, robert, lindahl, fmedsci, born, january, 1938, swedish, british, scientist, specialising, cancer, research, 2015, awarded, nobel, prize, chemistry, jointly, with, american, chemist, paul, modrich, turkish, chemist, aziz, sancar, mechanis. Tomas Robert Lindahl FRS 2 FMedSci 4 born 28 January 1938 is a Swedish British scientist specialising in cancer research 7 In 2015 he was awarded the Nobel Prize in Chemistry 8 jointly with American chemist Paul L Modrich and Turkish chemist Aziz Sancar for mechanistic studies of DNA repair 9 10 11 Tomas LindahlFRS FMedSciTomas Lindahl at the Royal Swedish Academy of Sciences 2015 BornTomas Robert Lindahl 1938 01 28 28 January 1938 age 85 6 Stockholm SwedenNationalitySwedish naturalised British dual nationality Alma materKarolinska Institutet PhD Known forClarification of cellular resistance to carcinogensAwardsEMBO Membership 1974 1 FRS 1988 2 3 FMedSci 1998 4 Royal Medal 2007 Copley Medal 2010 Nobel Prize in Chemistry 2015 Scientific careerFieldsCancer research DNA repair 5 InstitutionsFrancis Crick Institute London Research Institute University of Gothenburg Princeton University Rockefeller UniversityThesisOn the structure and stability of nucleic acids in solution 1967 Websitecrick wbr ac wbr uk wbr research wbr a z researchers wbr emeritus scientists wbr tomas lindahl wbr Contents 1 Education 2 Career and research 3 Awards and honours 4 References 5 External linksEducation EditLindahl was born in Kungsholmen Stockholm Sweden to Folke Robert Lindahl and Ethel Hulda Hultberg 12 He received a PhD degree in 1967 13 and an MD degree qualification in 1970 from the Karolinska Institutet in Stockholm 6 Career and research EditAfter obtaining his research doctorate Lindahl did postdoctoral research at Princeton University and Rockefeller University 14 He was professor of medical chemistry at the University of Gothenburg 1978 82 After moving to the United Kingdom he joined the Imperial Cancer Research Fund now Cancer Research UK as a researcher in 1981 14 From 1986 to 2005 he was the first Director of Cancer Research UK s Clare Hall Laboratories in Hertfordshire since 2015 part of the Francis Crick Institute 15 He continued to research there until 2009 He has contributed to many papers on DNA repair and the genetics of cancer 16 17 18 19 20 21 22 23 24 Awards and honours EditLindahl was elected an EMBO Member in 1974 1 and Fellow of the Royal Society FRS in 1988 3 his certificate of election reads Dr Tomas Lindahl is noted for his contributions to the comprehension of DNA repair at the molecular level in bacterial and mammalian cells He was the first to isolate a mammalian DNA ligase and to describe a totally unanticipated novel group of DNA glycosylases as mediators of DNA excision repair He has also discovered a unique class of enzymes in mammalian cells namely the methyltransferases which mediate the adaptive response to alkylation of DNA and has shown that the expression of these enzymes is regulated by the ada gene More recently he has elucidated the molecular defect in Blooms syndrome sic to be the lack of DNA ligase I Apart from providing profound insights into the nature of the DNA repair process his very important contributions promise to facilitate the design of more selective chemotherapeutic drugs for the treatment of cancer Lindahl has also made a number of significant contributions to understanding at the DNA level the mechanism of transformation of B lymphocytes by the Epstein Barr virus The most notable of these was the first description of the occurrence in lymphoid cells of closed circular duplex viral DNA 2 Lindahl received the Royal Society s Royal Medal in 2007 making fundamental contributions to our understanding of DNA repair His achievements stand out for their great originality breadth and lasting influence 25 He is a member of the Norwegian Academy of Science and Letters 26 He was awarded the Copley Medal in 2010 He was elected a founding Fellow of the Academy of Medical Sciences FMedSci in 1998 In 2018 he was elected a foreign associate of the National Academy of Sciences He shared the Nobel Prize in Chemistry in 2015 9 The Swedish Academy noted that The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl Paul Modrich and Aziz Sancar for mechanistic studies of DNA repair 27 References Edit a b Tomas Lindahl EMBO profile people embo org Heidelberg European Molecular Biology Organization a b c Lindahl Tomas Robert EC 1988 20 London The Royal Society Archived from the original on 10 July 2019 a b Anon 1988 Dr Tomas Lindahl FMedSci FRS royalsociety org London Royal Society Archived from the original on 22 September 2015 One or more of the preceding sentences incorporates text from the royalsociety org website where All text published under the heading Biography on Fellow profile pages is available under Creative Commons Attribution 4 0 International License Royal Society Terms conditions and policies at the Wayback Machine archived September 25 2015 a b Dr Tomas Lindahl FRS FMedSci London Academy of Medical Sciences Archived from the original on 8 October 2015 Lindahl Tomas 2013 My Journey to DNA Repair Genomics Proteomics amp Bioinformatics 11 1 2 7 doi 10 1016 j gpb 2012 12 001 ISSN 1672 0229 PMC 4357663 PMID 23453014 a b LINDAHL Tomas Robert Who s Who Vol 2015 online Oxford University Press ed A amp C Black Subscription or UK public library membership required Emeritus Scientist Tomas Lindahl The Crick Archived from the original on 1 December 2015 Tomas Lindahl Nobel Prize in Chemistry 2015 on Vimeo a b Broad William J 7 October 2015 Nobel Prize in Chemistry Awarded to Tomas Lindahl Paul Modrich and Aziz Sancar for DNA Studies The New York Times ISSN 0362 4331 Retrieved 7 October 2015 Staff 7 October 2015 THE NOBEL PRIZE IN CHEMISTRY 2015 DNA repair providing chemical stability for life PDF Nobel Prize Retrieved 7 October 2015 Cressey Daniel 2015 DNA repair sleuths win chemistry Nobel Tomas Lindahl Paul Modrich and Aziz Sancar share 2015 prize Nature 526 7573 307 8 doi 10 1038 nature 2015 18515 ISSN 1476 4687 PMID 26469021 Sweden Indexed Birth Records 1860 1941 Lindahl Tomas 1967 On the structure and stability of nucleic acids in solution Stockholm a href Template Cite book html title Template Cite book cite book a CS1 maint location missing publisher link a b Cancer Research UK Grants amp Research Tomas Lindahl Retrieved 10 November 2008 4 ways that Tomas Lindahl s Nobel Prize for Chemistry revolutionised cancer research by Emma Smith CRUK Science blog 7 October 2015 Gerken T is Girard C A Tung Y C L Webby C J Saudek V Hewitson K S Yeo G S H McDonough M A Cunliffe S McNeill L A Galvanovskis J Rorsman P Robins P Prieur X Coll A P Ma M Jovanovic Z Farooqi I S Sedgwick B Barroso I Lindahl T Ponting C P Ashcroft F M O Rahilly S Schofield C J 2008 The Obesity Associated FTO Gene Encodes a 2 Oxoglutarate Dependent Nucleic Acid Demethylase Science 318 5855 1469 1472 Bibcode 2007Sci 318 1469G doi 10 1126 science 1151710 PMC 2668859 PMID 17991826 Tomas Lindahl s publications indexed by the Scopus bibliographic database subscription required Lindahl T 1993 Instability and decay of the primary structure of DNA Nature 362 6422 709 15 Bibcode 1993Natur 362 709L doi 10 1038 362709a0 PMID 8469282 S2CID 4283694 Wood R D 2001 Human DNA Repair Genes Science 291 5507 1284 9 Bibcode 2001Sci 291 1284W doi 10 1126 science 1056154 PMID 11181991 Satoh M S Lindahl T 1992 Role of poly ADP ribose formation in DNA repair Nature 356 6367 356 8 Bibcode 1992Natur 356 356S doi 10 1038 356356a0 PMID 1549180 S2CID 4364270 Trewick S C Henshaw T F Hausinger R P Lindahl T Sedgwick B 2002 Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage Nature 419 6903 174 8 Bibcode 2002Natur 419 174T doi 10 1038 nature00908 PMID 12226667 S2CID 4324333 Barnes D E Lindahl T 2004 Repair and genetic consequences of endogenous DNA base damage in mammalian cells Annual Review of Genetics 38 445 76 doi 10 1146 annurev genet 38 072902 092448 PMID 15568983 Yang Y G Lindahl T Barnes D E 2007 Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease Cell 131 5 873 86 doi 10 1016 j cell 2007 10 017 PMID 18045533 S2CID 2332259 Crow Y J Hayward B E Parmar R Robins P Leitch A Ali M Black D N Van Bokhoven H Brunner H G Hamel B C Corry P C Cowan F M Frints S G Klepper J Livingston J H Lynch S A Massey R F Meritet J F Michaud J L Ponsot G Voit T Lebon P Bonthron D T Jackson A P Barnes D E Lindahl T 2006 Mutations in the gene encoding the 3 5 DNA exonuclease TREX1 cause Aicardi Goutieres syndrome at the AGS1 locus Nature Genetics 38 8 917 20 doi 10 1038 ng1845 PMID 16845398 S2CID 9069106 Royal recent winners Retrieved 10 November 2008 Gruppe 6 Cellebiologi og molekylaerbiologi in Norwegian Norwegian Academy of Science and Letters Retrieved 7 October 2010 The Nobel Prize in Chemistry 2015 nobelprize org External links EditTomas Lindahl on Nobelprize org nbsp including the Nobel Lecture 8 December 2015 The Intrinsic Fragility of DNA Retrieved from https en wikipedia org w index php title Tomas Lindahl amp oldid 1179860293, wikipedia, wiki, book, books, library,

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