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Frances Ashcroft

January 01, 1970

Dame Frances Mary Ashcroft DBE FRS FMedSci (born 1952) is a British ion channel physiologist.[4][1][5] She is Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology at the University of Oxford. She is a fellow of Trinity College, Oxford, and is a director of the Oxford Centre for Gene Function. Her research group has an international reputation for work on insulin secretion, type II diabetes and neonatal diabetes.[6][7] Her work with Andrew Hattersley has helped enable children born with diabetes to switch from insulin injections to tablet therapy.[8][9][4][10]

Dame
Frances Ashcroft
DBE FRS FMedSci
Born
Frances Mary Ashcroft

(1952-02-15) 15 February 1952 (age 72)[2]
NationalityBritish
EducationTalbot Heath School
Alma materUniversity of Cambridge (BA, PhD)
AwardsUNESCO award (2012)
Croonian Lecture (2013)
Scientific career
FieldsPhysiology[1]
Institutions
ThesisCalcium electrogenesis in insect muscle (1978)
Frances Ashcroft's voice
from the BBC programme The Life Scientific, 15 May 2012.[3]
Websitewww.dpag.ox.ac.uk/team/group-leaders/frances-ashcroft

Education edit

Ashcroft was educated at Talbot Heath School and the University of Cambridge where she was awarded a degree in Natural Sciences followed by a PhD in zoology in 1978.[11][12]

Career and research edit

Ashcroft then did postdoctoral research at the University of Leicester and the University of California at Los Angeles.[13] Ashcroft is a director of Oxion: Ion Channels and Disease Initiative, a research and training programme on integrative ion channel research, funded by the Wellcome Trust.[14]

Ashcroft's research focuses on ATP-sensitive potassium (KATP)channels and their role in insulin secretion. Ashcroft is working towards explaining how a rise in the blood glucose concentration stimulates the release of insulin from the pancreatic beta-cells, what goes wrong with this process in type 2 diabetes, and how drugs used to treat this condition exert their beneficial effects.[15] Ashcroft has authored a few science and popular science books based on ion channel physiology:

  • Ion Channels and Disease: Channelopathies on channelopathic diseases[16]
  • Life at the Extremes: The Science of Survival[17]
  • The Spark of Life: Electricity in the Human Body[18]

Her work has helped people with neonatal diabetes, a very rare disease, switch from insulin injections to oral drug therapy.[1]

Honours and awards edit

Ashcroft was elected a Fellow of the Royal Society in 1999.[19] In 2007 Ashcroft was awarded the Walter B. Cannon Award, the highest honour bestowed by the American Physiological Society.[20] She was one of five 2012 winners of the L'Oreal-UNESCO Award for Women in Science.[21]

Ashcroft was awarded an honorary degrees of Doctor of the University from the Open University in 2003 and Doctor of Science from the University of Leicester on 13 July 2007.[12]

Ashcroft was awarded the Croonian Lecture by the Royal Society in 2013.[22]

In the 2015 Birthday Honours, she was appointed a Dame Commander of the Order of the British Empire (DBE) 'for services to Medical Science and the Public Understanding of Science'.[23] She was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 1999.[24]

A. S. Byatt's novel A Whistling Woman is half dedicated to Ashcroft.[25]

Personal life edit

Ashcroft appeared (as a diner) on MasterChef during the 2011 series,[citation needed] along with several other Fellows of the Royal Society.

References edit

  1. ^ a b c "Women in Physiology" (PDF). Static.physoc.org. Retrieved 21 June 2019.
  2. ^ "Ashcroft, Prof. Frances Mary". Who's Who (online Oxford University Press ed.). A & C Black. 2014. doi:10.1093/ww/9780199540884.013.U5819. (Subscription or UK public library membership required.)
  3. ^ "Frances Ashcroft". The Life Scientific. 15 May 2012. BBC Radio 4. Retrieved 18 January 2014.
  4. ^ a b Wray, Susan; Tansey, Elizabeth, eds. (2015). Women physiologists : centenary celebrations and beyond (PDF). London: The Physiological Society. ISBN 9780993341007. OCLC 922032986.
  5. ^ Frances Ashcroft publications indexed by the Scopus bibliographic database. (subscription required)
  6. ^ Ashcroft, F. M.; Harrison, D. E.; Ashcroft, S. J. H. (1984). "Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells". Nature. 312 (5993): 446–448. Bibcode:1984Natur.312..446A. doi:10.1038/312446a0. PMID 6095103. S2CID 4340710.
  7. ^ Ashcroft, F. M.; Rorsman, P. (1989). "Electrophysiology of the pancreatic β-cell". Progress in Biophysics and Molecular Biology. 54 (2): 87–143. doi:10.1016/0079-6107(89)90013-8. PMID 2484976.
  8. ^ Ashcroft, F. M. (1988). "Adenosine 5'-Triphosphate-Sensitive Potassium Channels". Annual Review of Neuroscience. 11: 97–118. doi:10.1146/annurev.ne.11.030188.000525. PMID 2452599.
  9. ^ "Frances Ashcroft talks to ReAgent about career advice for scientists". reagent.co.uk. 11 June 2014.
  10. ^ Ashcroft, Frances M.; Harrison, Donna E.; Ashcroft, Stephen J. H. (1984). "Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells". Nature. 312 (5993): 446–448. Bibcode:1984Natur.312..446A. doi:10.1038/312446a0. ISSN 0028-0836. PMID 6095103. S2CID 4340710.  
  11. ^ Ashcroft, Frances Mary (1978). Calcium electrogenesis in insect muscle. copac.jisc.ac.uk (PhD thesis). University of Cambridge. OCLC 500372918. EThOS uk.bl.ethos.448200.
  12. ^ a b "Oration for Professor Frances Ashcroft by Professor Gordon Campbell. On the occasion of being awarded Doctor of Science summer 2007". le.ac.uk. University of Leicester. Retrieved 25 June 2012.
  13. ^ "Frances Ashcroft, Professorial Fellow in Physiology". Trinity College, University of Oxford. 2014. Retrieved 21 April 2015.
  14. ^ "Welcome to Oxion". Oxion: Ion Channels and Disease Initiative, Universities of Oxford, Cambridge, London and MRC Hartwell. Retrieved 21 April 2015.
  15. ^ "Frances Ashcroft — GLAXOSMITHKLINE Royal Society Professor". Department of Physiology, Anatomy and Genetics, Medical Sciences Division, University of Oxford. 2015. Retrieved 21 April 2015.
  16. ^ 1999, Academic Press, ISBN 0120653109
  17. ^ 2000, HarperCollins, ISBN 0141046538
  18. ^ 2012, W. W. Norton and Company, ISBN 0006551254
  19. ^ Anon (1999). "Dame Frances Ashcroft DBE FMedSci FRS". royalsociety.org. London: The Royal Society. Retrieved 6 July 2012. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” -- at the Wayback Machine (archived 2016-11-11)
  20. ^ "Oxford physiology professor earns APS' Walter B. Cannon Award" (Press release). American Physiological Society. 27 April 2007. Retrieved 22 March 2015 – via EurekAlert!.
  21. ^ . ox.ac.uk. 8 November 2011. Archived from the original on 8 November 2011. Retrieved 24 October 2017.
  22. ^ "Croonian Lecture—List of lecturers: 21st century". Royal Society. Archived from the original on 14 July 2012. Retrieved 24 October 2017.
  23. ^ "No. 61256". The London Gazette (Supplement). 13 June 2015. p. B8.
  24. ^ "Professor Dame Frances Ashcroft - The Academy of Medical Sciences". Acmedsci.ac.uk. Retrieved 21 June 2019.
  25. ^ Newman, Jenny; Friel, James (2003). "An interview with A. S. Byatt". Cerles Review. Retrieved 11 September 2010. I remember sitting at high table with my friend, Professor Frances Ashcroft, to whom A Whistling Woman is half dedicated.

  This article incorporates text available under the CC BY 4.0 license.

January 01, 1970
frances, ashcroft, dame, frances, mary, ashcroft, fmedsci, born, 1952, british, channel, physiologist, royal, society, glaxosmithkline, research, professor, university, laboratory, physiology, university, oxford, fellow, trinity, college, oxford, director, oxf. Dame Frances Mary Ashcroft DBE FRS FMedSci born 1952 is a British ion channel physiologist 4 1 5 She is Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology at the University of Oxford She is a fellow of Trinity College Oxford and is a director of the Oxford Centre for Gene Function Her research group has an international reputation for work on insulin secretion type II diabetes and neonatal diabetes 6 7 Her work with Andrew Hattersley has helped enable children born with diabetes to switch from insulin injections to tablet therapy 8 9 4 10 DameFrances AshcroftDBE FRS FMedSciBornFrances Mary Ashcroft 1952 02 15 15 February 1952 age 72 2 NationalityBritishEducationTalbot Heath SchoolAlma materUniversity of Cambridge BA PhD AwardsUNESCO award 2012 Croonian Lecture 2013 Scientific careerFieldsPhysiology 1 InstitutionsUniversity of Oxford Trinity College Oxford University of Leicester University of California Los AngelesThesisCalcium electrogenesis in insect muscle 1978 Frances Ashcroft s voice source source source from the BBC programme The Life Scientific 15 May 2012 3 Websitewww wbr dpag wbr ox wbr ac wbr uk wbr team wbr group leaders wbr frances ashcroft Contents 1 Education 2 Career and research 2 1 Honours and awards 3 Personal life 4 ReferencesEducation editAshcroft was educated at Talbot Heath School and the University of Cambridge where she was awarded a degree in Natural Sciences followed by a PhD in zoology in 1978 11 12 Career and research editAshcroft then did postdoctoral research at the University of Leicester and the University of California at Los Angeles 13 Ashcroft is a director of Oxion Ion Channels and Disease Initiative a research and training programme on integrative ion channel research funded by the Wellcome Trust 14 Ashcroft s research focuses on ATP sensitive potassium KATP channels and their role in insulin secretion Ashcroft is working towards explaining how a rise in the blood glucose concentration stimulates the release of insulin from the pancreatic beta cells what goes wrong with this process in type 2 diabetes and how drugs used to treat this condition exert their beneficial effects 15 Ashcroft has authored a few science and popular science books based on ion channel physiology Ion Channels and Disease Channelopathies on channelopathic diseases 16 Life at the Extremes The Science of Survival 17 The Spark of Life Electricity in the Human Body 18 Her work has helped people with neonatal diabetes a very rare disease switch from insulin injections to oral drug therapy 1 Honours and awards edit Ashcroft was elected a Fellow of the Royal Society in 1999 19 In 2007 Ashcroft was awarded the Walter B Cannon Award the highest honour bestowed by the American Physiological Society 20 She was one of five 2012 winners of the L Oreal UNESCO Award for Women in Science 21 Ashcroft was awarded an honorary degrees of Doctor of the University from the Open University in 2003 and Doctor of Science from the University of Leicester on 13 July 2007 12 Ashcroft was awarded the Croonian Lecture by the Royal Society in 2013 22 In the 2015 Birthday Honours she was appointed a Dame Commander of the Order of the British Empire DBE for services to Medical Science and the Public Understanding of Science 23 She was elected a Fellow of the Academy of Medical Sciences FMedSci in 1999 24 A S Byatt s novel A Whistling Woman is half dedicated to Ashcroft 25 Personal life editAshcroft appeared as a diner on MasterChef during the 2011 series citation needed along with several other Fellows of the Royal Society References edit a b c Women in Physiology PDF Static physoc org Retrieved 21 June 2019 Ashcroft Prof Frances Mary Who s Who online Oxford University Press ed A amp C Black 2014 doi 10 1093 ww 9780199540884 013 U5819 Subscription or UK public library membership required Frances Ashcroft The Life Scientific 15 May 2012 BBC Radio 4 Retrieved 18 January 2014 a b Wray Susan Tansey Elizabeth eds 2015 Women physiologists centenary celebrations and beyond PDF London The Physiological Society ISBN 9780993341007 OCLC 922032986 Frances Ashcroft publications indexed by the Scopus bibliographic database subscription required Ashcroft F M Harrison D E Ashcroft S J H 1984 Glucose induces closure of single potassium channels in isolated rat pancreatic b cells Nature 312 5993 446 448 Bibcode 1984Natur 312 446A doi 10 1038 312446a0 PMID 6095103 S2CID 4340710 Ashcroft F M Rorsman P 1989 Electrophysiology of the pancreatic b cell Progress in Biophysics and Molecular Biology 54 2 87 143 doi 10 1016 0079 6107 89 90013 8 PMID 2484976 Ashcroft F M 1988 Adenosine 5 Triphosphate Sensitive Potassium Channels Annual Review of Neuroscience 11 97 118 doi 10 1146 annurev ne 11 030188 000525 PMID 2452599 Frances Ashcroft talks to ReAgent about career advice for scientists reagent co uk 11 June 2014 Ashcroft Frances M Harrison Donna E Ashcroft Stephen J H 1984 Glucose induces closure of single potassium channels in isolated rat pancreatic b cells Nature 312 5993 446 448 Bibcode 1984Natur 312 446A doi 10 1038 312446a0 ISSN 0028 0836 PMID 6095103 S2CID 4340710 nbsp Ashcroft Frances Mary 1978 Calcium electrogenesis in insect muscle copac jisc ac uk PhD thesis University of Cambridge OCLC 500372918 EThOS uk bl ethos 448200 a b Oration for Professor Frances Ashcroft by Professor Gordon Campbell On the occasion of being awarded Doctor of Science summer 2007 le ac uk University of Leicester Retrieved 25 June 2012 Frances Ashcroft Professorial Fellow in Physiology Trinity College University of Oxford 2014 Retrieved 21 April 2015 Welcome to Oxion Oxion Ion Channels and Disease Initiative Universities of Oxford Cambridge London and MRC Hartwell Retrieved 21 April 2015 Frances Ashcroft GLAXOSMITHKLINE Royal Society Professor Department of Physiology Anatomy and Genetics Medical Sciences Division University of Oxford 2015 Retrieved 21 April 2015 1999 Academic Press ISBN 0120653109 2000 HarperCollins ISBN 0141046538 2012 W W Norton and Company ISBN 0006551254 Anon 1999 Dame Frances Ashcroft DBE FMedSci FRS royalsociety org London The Royal Society Retrieved 6 July 2012 One or more of the preceding sentences incorporates text from the royalsociety org website where All text published under the heading Biography on Fellow profile pages is available under Creative Commons Attribution 4 0 International License Royal Society Terms conditions and policies at the Wayback Machine archived 2016 11 11 Oxford physiology professor earns APS Walter B Cannon Award Press release American Physiological Society 27 April 2007 Retrieved 22 March 2015 via EurekAlert Ashcroft receives L oreal UNESCO Award for Women in Science ox ac uk 8 November 2011 Archived from the original on 8 November 2011 Retrieved 24 October 2017 Croonian Lecture List of lecturers 21st century Royal Society Archived from the original on 14 July 2012 Retrieved 24 October 2017 No 61256 The London Gazette Supplement 13 June 2015 p B8 Professor Dame Frances Ashcroft The Academy of Medical Sciences Acmedsci ac uk Retrieved 21 June 2019 Newman Jenny Friel James 2003 An interview with A S Byatt Cerles Review Retrieved 11 September 2010 I remember sitting at high table with my friend Professor Frances Ashcroft to whom A Whistling Woman is half dedicated nbsp This article incorporates text available under the CC BY 4 0 license Retrieved from https en wikipedia org w index php title Frances Ashcroft amp oldid 1169357513, wikipedia, wiki, book, books, library,

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