BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and BLyS receptor 3 (BR3), is a membrane protein of the TNF receptor superfamily which recognizes BAFF, an essential factor for B cell maturation and survival.[5][6] In humans it is encoded by the TNFRSF13Cgene.[7]
B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.[7] In B cell maturation, due to regulation by BAFF-R, only a limited amount of B-cell will survive.[8]
Clinical significanceedit
Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells, which are cells that show immune response to normal body cells.[7] Autoreactive B cells are less sensitive toward BAFF and are usually outcompeted by the normal B cells in the maturation process regulated by low BAFF-R expression. An elevated level of BAFF-R can therefore overcome this decreased response and result in accumulation of autoreactive B cells.[8]
BAFF and BAFF-R pair can also down-regulate the cell apoptosis process.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000159958 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000068105 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C (September 2001). "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF". Science. 293 (5537): 2108–11. Bibcode:2001Sci...293.2108T. doi:10.1126/science.1061965. PMID 11509692. S2CID 42673198.
^Yan M, Brady JR, Chan B, Lee WP, Hsu B, Harless S, Cancro M, Grewal IS, Dixit VM (October 2001). "Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency". Current Biology. 11 (19): 1547–52. Bibcode:2001CBio...11.1547Y. doi:10.1016/S0960-9822(01)00481-X. PMID 11591325. S2CID 13925100.
^ abBrink R (October 2006). "Regulation of B cell self-tolerance by BAFF". Seminars in Immunology. 18 (5): 276–83. doi:10.1016/j.smim.2006.04.003. PMID 16916609.
^Rauch M, Tussiwand R, Bosco N, Rolink AG (2009-05-06). "Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells". PLOS ONE. 4 (5): e5456. Bibcode:2009PLoSO...4.5456R. doi:10.1371/journal.pone.0005456. PMC2673681. PMID 19421318.
External linksedit
Human TNFRSF13C genome location and TNFRSF13C gene details page in the UCSC Genome Browser.
Further readingedit
Laâbi Y, Egle A, Strasser A (December 2001). "TNF cytokine family: more BAFF-ling complexities". Current Biology. 11 (24): R1013-6. Bibcode:2001CBio...11R1013L. doi:10.1016/S0960-9822(01)00613-3. PMID 11747837. S2CID 17001236.
Defrance T, Casamayor-Pallejà M, Krammer PH (2003). The life and death of a B cell. Vol. 86. pp. 195–225. doi:10.1016/S0065-230X(02)86006-7. ISBN9780120066865. PMID 12374279. {{cite book}}: |journal= ignored (help)
Ambrose CM (2003). "BAFF-R". Journal of Biological Regulators and Homeostatic Agents. 16 (3): 211–3. PMID 12456020.
Bossen C, Schneider P (October 2006). "BAFF, APRIL and their receptors: structure, function and signaling" (PDF). Seminars in Immunology. 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324.
Treml LS, Crowley JE, Cancro MP (October 2006). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells". Seminars in Immunology. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.
Kalled SL (October 2006). "Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production". Seminars in Immunology. 18 (5): 290–6. doi:10.1016/j.smim.2006.06.002. PMID 16931038.
Mackay F, Leung H (October 2006). "The role of the BAFF/APRIL system on T cell function". Seminars in Immunology. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.
Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P, Werner-Favre C, Zubler RH, Browning JL, Tschopp J (June 1999). "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth". The Journal of Experimental Medicine. 189 (11): 1747–56. doi:10.1084/jem.189.11.1747. PMC2193079. PMID 10359578.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC310948. PMID 11076863.
Yan M, Brady JR, Chan B, Lee WP, Hsu B, Harless S, Cancro M, Grewal IS, Dixit VM (October 2001). "Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency". Current Biology. 11 (19): 1547–52. Bibcode:2001CBio...11.1547Y. doi:10.1016/S0960-9822(01)00481-X. PMID 11591325. S2CID 13925100.
Rolink AG, Melchers F (April 2002). "BAFFled B cells survive and thrive: roles of BAFF in B-cell development". Current Opinion in Immunology. 14 (2): 266–75. doi:10.1016/S0952-7915(02)00332-1. PMID 11869903.
Xu LG, Shu HB (December 2002). "TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production". Journal of Immunology. 169 (12): 6883–9. doi:10.4049/jimmunol.169.12.6883. PMID 12471121.
Kim HM, Yu KS, Lee ME, Shin DR, Kim YS, Paik SG, Yoo OJ, Lee H, Lee JO (May 2003). "Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation". Nature Structural Biology. 10 (5): 342–8. doi:10.1038/nsb925. hdl:10203/11495. PMID 12715002. S2CID 11294267.
Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G (May 2003). "Ligand-receptor binding revealed by the TNF family member TALL-1". Nature. 423 (6935): 49–56. Bibcode:2003Natur.423...49L. doi:10.1038/nature01543. PMID 12721620. S2CID 4373708.
Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA (May 2003). "BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site". Biochemistry. 42 (20): 5977–83. doi:10.1021/bi034017g. PMID 12755599.
baff, receptor, cell, activating, factor, receptor, baff, also, known, tumor, necrosis, factor, receptor, superfamily, member, tnfrsf13c, blys, receptor, membrane, protein, receptor, superfamily, which, recognizes, baff, essential, factor, cell, maturation, su. BAFF receptor B cell activating factor receptor BAFF R also known as tumor necrosis factor receptor superfamily member 13C TNFRSF13C and BLyS receptor 3 BR3 is a membrane protein of the TNF receptor superfamily which recognizes BAFF an essential factor for B cell maturation and survival 5 6 In humans it is encoded by the TNFRSF13C gene 7 TNFRSF13CAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1MPV 1OQE 1OSX 2HFG 3V56 4V46IdentifiersAliasesTNFRSF13C BAFF R BAFFR BROMIX CD268 CVID4 prolixin tumor necrosis factor receptor superfamily member 13C TNF receptor superfamily member 13CExternal IDsOMIM 606269 MGI 1919299 HomoloGene 49897 GeneCards TNFRSF13CGene location Human Chr Chromosome 22 human 1 Band22q13 2Start41 922 032 bp 1 End41 926 806 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 15 E1Start82 105 944 bp 2 End82 108 570 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inspleenlymph nodeappendixbone marrow cellsbloodthymusganglionic eminenceskin of abdomenrectumgallbladderTop expressed inspleenbloodsubmandibular glandsubcutaneous adipose tissuemorulawhite adipose tissuespermatidbone marrowPaneth cellhair follicleMore reference expression dataBioGPSn aOrthologsSpeciesHumanMouseEntrez11565072049EnsemblENSG00000159958ENSMUSG00000068105UniProtQ96RJ3Q9D8D0RefSeq mRNA NM 052945NM 028075NM 001357758RefSeq protein NP 443177NP 082351NP 001344687Location UCSC Chr 22 41 92 41 93 MbChr 15 82 11 82 11 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Clinical significance 3 See also 4 References 5 External links 6 Further readingFunction editB cell activating factor BAFF enhances B cell survival in vitro and is a regulator of the peripheral B cell population The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine rich domain It is thought that this receptor is the principal receptor required for BAFF mediated mature B cell survival 7 In B cell maturation due to regulation by BAFF R only a limited amount of B cell will survive 8 Clinical significance editOverexpression of BAFF in mice results in mature B cell hyperplasia and symptoms of systemic lupus erythematosus SLE Also some SLE patients have increased levels of BAFF in serum Therefore it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells which are cells that show immune response to normal body cells 7 Autoreactive B cells are less sensitive toward BAFF and are usually outcompeted by the normal B cells in the maturation process regulated by low BAFF R expression An elevated level of BAFF R can therefore overcome this decreased response and result in accumulation of autoreactive B cells 8 BAFF and BAFF R pair can also down regulate the cell apoptosis process 9 See also editB cell activating factor B cell maturation antigenReferences edit a b c GRCh38 Ensembl release 89 ENSG00000159958 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000068105 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Thompson JS Bixler SA Qian F Vora K Scott ML Cachero TG Hession C Schneider P Sizing ID Mullen C Strauch K Zafari M Benjamin CD Tschopp J Browning JL Ambrose C September 2001 BAFF R a newly identified TNF receptor that specifically interacts with BAFF Science 293 5537 2108 11 Bibcode 2001Sci 293 2108T doi 10 1126 science 1061965 PMID 11509692 S2CID 42673198 Yan M Brady JR Chan B Lee WP Hsu B Harless S Cancro M Grewal IS Dixit VM October 2001 Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency Current Biology 11 19 1547 52 Bibcode 2001CBio 11 1547Y doi 10 1016 S0960 9822 01 00481 X PMID 11591325 S2CID 13925100 a b c Entrez Gene TNFRSF13C tumor necrosis factor receptor superfamily member 13C a b Brink R October 2006 Regulation of B cell self tolerance by BAFF Seminars in Immunology 18 5 276 83 doi 10 1016 j smim 2006 04 003 PMID 16916609 Rauch M Tussiwand R Bosco N Rolink AG 2009 05 06 Crucial role for BAFF BAFF R signaling in the survival and maintenance of mature B cells PLOS ONE 4 5 e5456 Bibcode 2009PLoSO 4 5456R doi 10 1371 journal pone 0005456 PMC 2673681 PMID 19421318 External links editHuman TNFRSF13C genome location and TNFRSF13C gene details page in the UCSC Genome Browser Further reading editLaabi Y Egle A Strasser A December 2001 TNF cytokine family more BAFF ling complexities Current Biology 11 24 R1013 6 Bibcode 2001CBio 11R1013L doi 10 1016 S0960 9822 01 00613 3 PMID 11747837 S2CID 17001236 Defrance T Casamayor Palleja M Krammer PH 2003 The life and death of a B cell Vol 86 pp 195 225 doi 10 1016 S0065 230X 02 86006 7 ISBN 9780120066865 PMID 12374279 a href Template Cite book html title Template Cite book cite book a journal ignored help Ambrose CM 2003 BAFF R Journal of Biological Regulators and Homeostatic Agents 16 3 211 3 PMID 12456020 Bossen C Schneider P October 2006 BAFF APRIL and their receptors structure function and signaling PDF Seminars in Immunology 18 5 263 75 doi 10 1016 j smim 2006 04 006 PMID 16914324 Treml LS Crowley JE Cancro MP October 2006 BLyS receptor signatures resolve homeostatically independent compartments among naive and antigen experienced B cells Seminars in Immunology 18 5 297 304 doi 10 1016 j smim 2006 07 001 PMID 16919470 Kalled SL October 2006 Impact of the BAFF BR3 axis on B cell survival germinal center maintenance and antibody production Seminars in Immunology 18 5 290 6 doi 10 1016 j smim 2006 06 002 PMID 16931038 Mackay F Leung H October 2006 The role of the BAFF APRIL system on T cell function Seminars in Immunology 18 5 284 9 doi 10 1016 j smim 2006 04 005 PMID 16931039 Schneider P MacKay F Steiner V Hofmann K Bodmer JL Holler N Ambrose C Lawton P Bixler S Acha Orbea H Valmori D Romero P Werner Favre C Zubler RH Browning JL Tschopp J June 1999 BAFF a novel ligand of the tumor necrosis factor family stimulates B cell growth The Journal of Experimental Medicine 189 11 1747 56 doi 10 1084 jem 189 11 1747 PMC 2193079 PMID 10359578 Hartley JL Temple GF Brasch MA November 2000 DNA cloning using in vitro site specific recombination Genome Research 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Yan M Brady JR Chan B Lee WP Hsu B Harless S Cancro M Grewal IS Dixit VM October 2001 Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency Current Biology 11 19 1547 52 Bibcode 2001CBio 11 1547Y doi 10 1016 S0960 9822 01 00481 X PMID 11591325 S2CID 13925100 Rolink AG Melchers F April 2002 BAFFled B cells survive and thrive roles of BAFF in B cell development Current Opinion in Immunology 14 2 266 75 doi 10 1016 S0952 7915 02 00332 1 PMID 11869903 Xu LG Shu HB December 2002 TNFR associated factor 3 is associated with BAFF R and negatively regulates BAFF R mediated NF kappa B activation and IL 10 production Journal of Immunology 169 12 6883 9 doi 10 4049 jimmunol 169 12 6883 PMID 12471121 Kim HM Yu KS Lee ME Shin DR Kim YS Paik SG Yoo OJ Lee H Lee JO May 2003 Crystal structure of the BAFF BAFF R complex and its implications for receptor activation Nature Structural Biology 10 5 342 8 doi 10 1038 nsb925 hdl 10203 11495 PMID 12715002 S2CID 11294267 Liu Y Hong X Kappler J Jiang L Zhang R Xu L Pan CH Martin WE Murphy RC Shu HB Dai S Zhang G May 2003 Ligand receptor binding revealed by the TNF family member TALL 1 Nature 423 6935 49 56 Bibcode 2003Natur 423 49L doi 10 1038 nature01543 PMID 12721620 S2CID 4373708 Gordon NC Pan B Hymowitz SG Yin J Kelley RF Cochran AG Yan M Dixit VM Fairbrother WJ Starovasnik MA May 2003 BAFF BLyS receptor 3 comprises a minimal TNF receptor like module that encodes a highly focused ligand binding site Biochemistry 42 20 5977 83 doi 10 1021 bi034017g PMID 12755599 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title BAFF receptor amp oldid 1220789585, wikipedia, wiki, book, books, library,
