Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and is capable of forming a stable complex with elongins B and C. The von Hippel–Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000011007 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028668 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Aso T, Mokady N, Haque D, Conaway RC, Conaway JW (Mar 1996). "Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1". Genomics. 30 (2): 393–4. PMID 8586449.
^Aso T, Lane WS, Conaway JW, Conaway RC (Oct 1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II". Science. 269 (5229): 1439–43. Bibcode:1995Sci...269.1439A. doi:10.1126/science.7660129. PMID 7660129. S2CID 37649908.
Shilatifard A (1998). "Factors regulating the transcriptional elongation activity of RNA polymerase II". FASEB J. 12 (14): 1437–46. doi:10.1096/fasebj.12.14.1437. PMID 9806752. S2CID 17435359.
Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Aso T, Haque D, Fukudome K, et al. (1996). "A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin". Gene. 168 (2): 277–8. doi:10.1016/0378-1119(95)00750-4. PMID 8654961.
Pan G, Aso T, Greenblatt J (1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.
Ohh M, Takagi Y, Aso T, et al. (2000). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. 104 (11): 1583–91. doi:10.1172/JCI8161. PMC481054. PMID 10587522.
Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
Shaheduzzaman S, Krishnan V, Petrovic A, et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". J. Biomed. Sci. 9 (1): 82–96. doi:10.1007/BF02256581. PMID 11810028.
Yamazaki K, Guo L, Sugahara K, et al. (2002). "Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3". J. Biol. Chem. 277 (29): 26444–51. doi:10.1074/jbc.M202859200. PMID 11994304.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Tamura K, Miyata K, Sugahara K, et al. (2003). "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain". Biochem. Biophys. Res. Commun. 309 (1): 189–95. doi:10.1016/S0006-291X(03)01556-0. PMID 12943681.
Stoletov KV, Terman BI (2004). "Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation". Biochem. Biophys. Res. Commun. 320 (1): 70–5. doi:10.1016/j.bbrc.2004.05.134. PMID 15207703.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
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Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC1422157. PMID 16498413.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
eloa, elongin, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4hfxidentifiersaliases, eloa, siii, siii, p110, tceb3a, tceb3, transcription, elongation, factor, subunit, elongin, aexternal, idsomim, 600786, . Elongin A is a protein that in humans is encoded by the ELOA gene 5 6 7 ELOAAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4HFXIdentifiersAliasesELOA EloA SIII SIII p110 TCEB3A TCEB3 transcription elongation factor B subunit 3 elongin AExternal IDsOMIM 600786 MGI 1351315 HomoloGene 37746 GeneCards ELOAGene location Human Chr Chromosome 1 human 1 Band1p36 11Start23 743 448 bp 1 End23 762 059 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 4 D3Start135 730 679 bp 2 End135 749 074 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inlower lobe of lungcardiathoracic diaphragmislet of Langerhanssuperficial temporal arterymucosa of urinary bladderpylorustibialis anterior muscledeltoid muscletriceps brachii muscleTop expressed inmolarplantaris muscleextensor digitorum longus muscletriceps brachii muscleankletemporal musclequadriceps femoris muscletibialis anterior muscleskeletal muscle tissuesoleus muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein bindingCellular componentnucleus nucleoplasm extracellular space elongin complexBiological processtranscription elongation from RNA polymerase II promoter regulation of transcription DNA templated transcription by RNA polymerase II transcription DNA templated regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez692427224EnsemblENSG00000011007ENSMUSG00000028668UniProtQ14241Q8CB77RefSeq mRNA NM 003198NM 013736RefSeq protein NP 003189NP 038764Location UCSC Chr 1 23 74 23 76 MbChr 4 135 73 135 75 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Elongin A is a subunit of the transcription factor B SIII complex The SIII complex is composed of elongins A A2 B and C It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units Elongin A functions as the transcriptionally active component of the SIII complex whereas elongins B and C are regulatory subunits Elongin A2 is specifically expressed in the testis and is capable of forming a stable complex with elongins B and C The von Hippel Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000011007 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028668 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Aso T Mokady N Haque D Conaway RC Conaway JW Mar 1996 Assignment of a human gene encoding the 110 kDa subunit of general transcription factor elongin SIII to chromosome 1p36 1 Genomics 30 2 393 4 PMID 8586449 Aso T Lane WS Conaway JW Conaway RC Oct 1995 Elongin SIII a multisubunit regulator of elongation by RNA polymerase II Science 269 5229 1439 43 Bibcode 1995Sci 269 1439A doi 10 1126 science 7660129 PMID 7660129 S2CID 37649908 a b ELOA elongin A Homo sapiens human Further reading editShilatifard A 1998 Factors regulating the transcriptional elongation activity of RNA polymerase II FASEB J 12 14 1437 46 doi 10 1096 fasebj 12 14 1437 PMID 9806752 S2CID 17435359 Kile BT Schulman BA Alexander WS et al 2002 The SOCS box a tale of destruction and degradation Trends Biochem Sci 27 5 235 41 doi 10 1016 S0968 0004 02 02085 6 PMID 12076535 Aso T Haque D Fukudome K et al 1996 A human cDNA encoding the 110 kDa A subunit of RNA polymerase II transcription factor elongin Gene 168 2 277 8 doi 10 1016 0378 1119 95 00750 4 PMID 8654961 Pan G Aso T Greenblatt J 1997 Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter specific initiation and responsive to transcriptional activators J Biol Chem 272 39 24563 71 doi 10 1074 jbc 272 39 24563 PMID 9305922 Ohh M Takagi Y Aso T et al 2000 Synthetic peptides define critical contacts between elongin C elongin B and the von Hippel Lindau protein J Clin Invest 104 11 1583 91 doi 10 1172 JCI8161 PMC 481054 PMID 10587522 Kamura T Burian D Yan Q et al 2001 Muf1 a novel Elongin BC interacting leucine rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase J Biol Chem 276 32 29748 53 doi 10 1074 jbc M103093200 PMID 11384984 Shaheduzzaman S Krishnan V Petrovic A et al 2002 Effects of HIV 1 Nef on cellular gene expression profiles J Biomed Sci 9 1 82 96 doi 10 1007 BF02256581 PMID 11810028 Yamazaki K Guo L Sugahara K et al 2002 Identification and biochemical characterization of a novel transcription elongation factor Elongin A3 J Biol Chem 277 29 26444 51 doi 10 1074 jbc M202859200 PMID 11994304 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Tamura K Miyata K Sugahara K et al 2003 Identification of EloA BP1 a novel Elongin A binding protein with an exonuclease homology domain Biochem Biophys Res Commun 309 1 189 95 doi 10 1016 S0006 291X 03 01556 0 PMID 12943681 Stoletov KV Terman BI 2004 Bmx is a downstream Rap1 effector in VEGF induced endothelial cell activation Biochem Biophys Res Commun 320 1 70 5 doi 10 1016 j bbrc 2004 05 134 PMID 15207703 Beausoleil SA Jedrychowski M Schwartz D et al 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Woo JS Imm JH Min CK et al 2006 Structural and functional insights into the B30 2 SPRY domain EMBO J 25 6 1353 63 doi 10 1038 sj emboj 7600994 PMC 1422157 PMID 16498413 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ELOA amp oldid 1215893334, wikipedia, wiki, book, books, library,
