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Stephen D. M. Brown

January 01, 1970

For other people called Steve Brown, see Steve Brown.

Steve David Macleod Brown FRS FMedSci[9][1] is director of the Medical Research Council (MRC) Mammalian Genetics Unit, MRC Harwell at Harwell Science and Innovation Campus, Oxfordshire,[9][10][11][12][13] a research centre on mouse genetics. In addition, he leads the Genetics and Pathobiology of Deafness research group.[14]

Steve Brown
FRS FMedSci
Steve Brown at the Royal Society admissions day in London, July 2015
Born
Stephen David Macleod Brown

(1955-05-03) 3 May 1955 (age 69)[8]
Dumfries, Scotland[8]
EducationBelfast Royal Academy
Alma materUniversity of Cambridge (BA, PhD)
Scientific career
Fields
Institutions
ThesisThe molecular organisation and evolution of rodent genomes (1981)
Doctoral advisorGabriel Dover[4][5][6]
Doctoral studentsElizabeth Fisher[7]
Websitehar.mrc.ac.uk/research/lifetime-studies/genetics-and-pathobiology-deafness

Education edit

Brown was educated at Belfast Royal Academy[8] and St Catharine's College, Cambridge, where he was awarded a Bachelor of Arts degree in 1977[8] followed by a PhD in 1981 for research on the molecular organisation and evolution of rodent genomes[15] supervised by Gabriel Dover.[4]

Career and research edit

Brown conducts research in mouse genetics and genomics. He has studied repeated sequences in the DNA of mice and produced molecular maps of mouse chromosomes, which were used to sequence the mouse genome.[4][9][16] He subsequently pioneered efforts to functionally annotate the mouse genome and identify and generate novel disease models through mutagenesis and phenotyping. In particular, he has identified key proteins involved in hearing, contributing to the understanding of the genetics of deafness.[9] For example, research in Brown's laboratory has shown that a mutation in the Evi1 gene increases susceptibility to inflammation of the middle ear (otitis media) in mice, leading to hearing loss.[17]

A particular focus has been the use of mouse models to elucidate the molecular basis of genetic deafness. With Karen Steel, he discovered myosin VIIA as the gene underlying the shaker-1 mutant – one of the first deafness genes to be identified.[18]

Prior to being appointed director of Harwell in 1998, Brown was a professor at Imperial College London.[19] He is chair of the International Mouse Phenotyping Consortium steering committee and joint editor-in-chief of the journal Mammalian Genome.[20][21]

Awards and honours edit

Brown was awarded The Genetics Society Medal in 2009,[citation needed] elected a Fellow of the Academy of Medical Sciences in 2001,[1] and elected a Fellow of the Royal Society (FRS) in 2015.[9][18] His certificate of election reads:

Stephen Brown is distinguished for his research in mouse genetics and genomics. He pioneered studies of repeated sequences in the mouse genome and the use of novel approaches to generate molecular maps of mouse chromosomes, work that underpinned the sequencing of the mouse genome. He has been at the forefront of new approaches in mutagenesis and phenotyping for the functional annotation of the mouse genome and the identification and characterisation of disease models. Notably, in collaboration he has utilised the mouse to study the genetics of deafness, identifying key proteins involved in auditory transduction, which has transformed our understanding in this field.[9]

References edit

  1. ^ a b c . London: Academy of Medical Sciences. Archived from the original on 4 June 2015.
  2. ^ Brown, S. D.; Hancock, J. M.; Gates, H (2006). "Understanding mammalian genetic systems: The challenge of phenotyping in the mouse". PLOS Genetics. 2 (8): e118. doi:10.1371/journal.pgen.0020118. PMC 1557775. PMID 16933996.
  3. ^ Steel, Karen P.; Brown, Stephen D.M. (1994). "Genes and deafness". Trends in Genetics. 10 (12): 428–35. doi:10.1016/0168-9525(94)90113-9. PMID 7871592.
  4. ^ a b c Brown, S. D. M.; Dover, G. A. (1980). "Conservation of segmental variants of satellite DNA of Mus musculus in a related species: Mus spretus". Nature. 285 (5759): 47–49. Bibcode:1980Natur.285...47B. doi:10.1038/285047a0. ISSN 0028-0836. PMID 7374752. S2CID 4326610.
  5. ^ Dover, G. A.; Strachan, T; Coen, E. S.; Brown, S. D. (1982). "Molecular drive". Science. 218 (4577): 1069. Bibcode:1982Sci...218.1069D. doi:10.1126/science.7146895. PMID 7146894.
  6. ^ Brown, S. D.; Dover, G (1981). "Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes". Journal of Molecular Biology. 150 (4): 441–66. doi:10.1016/0022-2836(81)90374-0. PMID 6276556.
  7. ^ Fisher, Elizabeth Mary Claire (1987). Microcloning and molecular mapping of the mouse X chromosome. london.ac.uk (PhD thesis). University of London. hdl:10044/1/66999. OCLC 1103939662. EThOS uk.bl.ethos.769180.  
  8. ^ a b c d Anon (2016). "Brown, Stephen David Macleod". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U284101. (Subscription or UK public library membership required.)
  9. ^ a b c d e f Anon (2015). . London: Royal Society. Archived from the original on 2 May 2015.
  10. ^ Silver, L. M.; Nadeau, J. H.; Brown, S. D. M.; Eppig, J. T.; Peters, J (1998). "Mammalian Genome, Incorporating Mouse Genome". Mammalian Genome. 9 (1): 1. doi:10.1007/s003359900669. PMID 9435276. S2CID 42368624.
  11. ^ Brown, S. D.; Moore, M. W. (2012). "The International Mouse Phenotyping Consortium: Past and future perspectives on mouse phenotyping". Mammalian Genome. 23 (9–10): 632–40. doi:10.1007/s00335-012-9427-x. PMC 3774932. PMID 22940749.
  12. ^ Brown, S. D. M.; Moore, M. W. (2012). "Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium". Disease Models & Mechanisms. 5 (3): 289–292. doi:10.1242/dmm.009878. ISSN 1754-8403. PMC 3339821. PMID 22566555.
  13. ^ . Medical Research Council. Archived from the original on 4 June 2015.
  14. ^ "Genetics and Pathobiology of Deafness research group". Harwell: MRC Harwell.
  15. ^ Brown, Stephen D. M. (1981). The molecular organisation and evolution of rodent genomes. cam.ac.uk (PhD thesis). University of Cambridge. OCLC 556404448. EThOS uk.bl.ethos.252843.
  16. ^ Brown, S. D.; Dover, G (1981). "Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes". Journal of Molecular Biology. 150 (4): 441–66. doi:10.1016/0022-2836(81)90374-0. PMID 6276556.
  17. ^ Parkinson, N; Hardisty-Hughes, R. E.; Tateossian, H; Tsai, H. T.; Brooker, D; Morse, S; Lalane, Z; MacKenzie, F; Fray, M; Glenister, P; Woodward, A. M.; Polley, S; Barbaric, I; Dear, N; Hough, T. A.; Hunter, A. J.; Cheeseman, M. T.; Brown, S. D. (2006). "Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media". PLOS Genetics. 2 (10): e149. doi:10.1371/journal.pgen.0020149. PMC 1592239. PMID 17029558.
  18. ^ a b Anon (2015). . London: Royal Society. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --. Archived from the original on 25 September 2015. Retrieved 9 March 2016.{{cite web}}: CS1 maint: unfit URL (link)
  19. ^ . Medical Research Council. Archived from the original on 24 September 2014.
  20. ^ "Mammalian Genome: Editorial Board". Springer. Retrieved 14 August 2015.
  21. ^ "IMPC Steering Committee". International Mouse Phenotyping Consortium.

January 01, 1970
stephen, brown, other, people, called, steve, brown, steve, brown, steve, david, macleod, brown, fmedsci, director, medical, research, council, mammalian, genetics, unit, harwell, harwell, science, innovation, campus, oxfordshire, research, centre, mouse, gene. For other people called Steve Brown see Steve Brown Steve David Macleod Brown FRS FMedSci 9 1 is director of the Medical Research Council MRC Mammalian Genetics Unit MRC Harwell at Harwell Science and Innovation Campus Oxfordshire 9 10 11 12 13 a research centre on mouse genetics In addition he leads the Genetics and Pathobiology of Deafness research group 14 Steve BrownFRS FMedSciSteve Brown at the Royal Society admissions day in London July 2015BornStephen David Macleod Brown 1955 05 03 3 May 1955 age 69 8 Dumfries Scotland 8 EducationBelfast Royal AcademyAlma materUniversity of Cambridge BA PhD Scientific careerFieldsGenetics Genetic deafness 1 Functional genomics 2 InstitutionsMRC Harwell Imperial College London St Mary s Hospital Medical School 3 ThesisThe molecular organisation and evolution of rodent genomes 1981 Doctoral advisorGabriel Dover 4 5 6 Doctoral studentsElizabeth Fisher 7 Websitehar wbr mrc wbr ac wbr uk wbr research wbr lifetime studies wbr genetics and pathobiology deafness Contents 1 Education 2 Career and research 2 1 Awards and honours 3 ReferencesEducation editBrown was educated at Belfast Royal Academy 8 and St Catharine s College Cambridge where he was awarded a Bachelor of Arts degree in 1977 8 followed by a PhD in 1981 for research on the molecular organisation and evolution of rodent genomes 15 supervised by Gabriel Dover 4 Career and research editBrown conducts research in mouse genetics and genomics He has studied repeated sequences in the DNA of mice and produced molecular maps of mouse chromosomes which were used to sequence the mouse genome 4 9 16 He subsequently pioneered efforts to functionally annotate the mouse genome and identify and generate novel disease models through mutagenesis and phenotyping In particular he has identified key proteins involved in hearing contributing to the understanding of the genetics of deafness 9 For example research in Brown s laboratory has shown that a mutation in the Evi1 gene increases susceptibility to inflammation of the middle ear otitis media in mice leading to hearing loss 17 A particular focus has been the use of mouse models to elucidate the molecular basis of genetic deafness With Karen Steel he discovered myosin VIIA as the gene underlying the shaker 1 mutant one of the first deafness genes to be identified 18 Prior to being appointed director of Harwell in 1998 Brown was a professor at Imperial College London 19 He is chair of the International Mouse Phenotyping Consortium steering committee and joint editor in chief of the journal Mammalian Genome 20 21 Awards and honours editBrown was awarded The Genetics Society Medal in 2009 citation needed elected a Fellow of the Academy of Medical Sciences in 2001 1 and elected a Fellow of the Royal Society FRS in 2015 9 18 His certificate of election reads Stephen Brown is distinguished for his research in mouse genetics and genomics He pioneered studies of repeated sequences in the mouse genome and the use of novel approaches to generate molecular maps of mouse chromosomes work that underpinned the sequencing of the mouse genome He has been at the forefront of new approaches in mutagenesis and phenotyping for the functional annotation of the mouse genome and the identification and characterisation of disease models Notably in collaboration he has utilised the mouse to study the genetics of deafness identifying key proteins involved in auditory transduction which has transformed our understanding in this field 9 References edit a b c Professor Steve Brown FRS FMedSci London Academy of Medical Sciences Archived from the original on 4 June 2015 Brown S D Hancock J M Gates H 2006 Understanding mammalian genetic systems The challenge of phenotyping in the mouse PLOS Genetics 2 8 e118 doi 10 1371 journal pgen 0020118 PMC 1557775 PMID 16933996 Steel Karen P Brown Stephen D M 1994 Genes and deafness Trends in Genetics 10 12 428 35 doi 10 1016 0168 9525 94 90113 9 PMID 7871592 a b c Brown S D M Dover G A 1980 Conservation of segmental variants of satellite DNA of Mus musculus in a related species Mus spretus Nature 285 5759 47 49 Bibcode 1980Natur 285 47B doi 10 1038 285047a0 ISSN 0028 0836 PMID 7374752 S2CID 4326610 Dover G A Strachan T Coen E S Brown S D 1982 Molecular drive Science 218 4577 1069 Bibcode 1982Sci 218 1069D doi 10 1126 science 7146895 PMID 7146894 Brown S D Dover G 1981 Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes Journal of Molecular Biology 150 4 441 66 doi 10 1016 0022 2836 81 90374 0 PMID 6276556 Fisher Elizabeth Mary Claire 1987 Microcloning and molecular mapping of the mouse X chromosome london ac uk PhD thesis University of London hdl 10044 1 66999 OCLC 1103939662 EThOS uk bl ethos 769180 nbsp a b c d Anon 2016 Brown Stephen David Macleod Who s Who online Oxford University Press ed Oxford A amp C Black doi 10 1093 ww 9780199540884 013 U284101 Subscription or UK public library membership required a b c d e f Anon 2015 Professor Stephen Brown FMedSci FRS London Royal Society Archived from the original on 2 May 2015 Silver L M Nadeau J H Brown S D M Eppig J T Peters J 1998 Mammalian Genome Incorporating Mouse Genome Mammalian Genome 9 1 1 doi 10 1007 s003359900669 PMID 9435276 S2CID 42368624 Brown S D Moore M W 2012 The International Mouse Phenotyping Consortium Past and future perspectives on mouse phenotyping Mammalian Genome 23 9 10 632 40 doi 10 1007 s00335 012 9427 x PMC 3774932 PMID 22940749 Brown S D M Moore M W 2012 Towards an encyclopaedia of mammalian gene function the International Mouse Phenotyping Consortium Disease Models amp Mechanisms 5 3 289 292 doi 10 1242 dmm 009878 ISSN 1754 8403 PMC 3339821 PMID 22566555 Profile Steve Brown Medical Research Council Archived from the original on 4 June 2015 Genetics and Pathobiology of Deafness research group Harwell MRC Harwell Brown Stephen D M 1981 The molecular organisation and evolution of rodent genomes cam ac uk PhD thesis University of Cambridge OCLC 556404448 EThOS uk bl ethos 252843 Brown S D Dover G 1981 Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes Journal of Molecular Biology 150 4 441 66 doi 10 1016 0022 2836 81 90374 0 PMID 6276556 Parkinson N Hardisty Hughes R E Tateossian H Tsai H T Brooker D Morse S Lalane Z MacKenzie F Fray M Glenister P Woodward A M Polley S Barbaric I Dear N Hough T A Hunter A J Cheeseman M T Brown S D 2006 Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media PLOS Genetics 2 10 e149 doi 10 1371 journal pgen 0020149 PMC 1592239 PMID 17029558 a b Anon 2015 Professor Steve Brown FMedSci FRS London Royal Society Archived from the original on 17 November 2015 One or more of the preceding sentences incorporates text from the royalsociety org website where All text published under the heading Biography on Fellow profile pages is available under Creative Commons Attribution 4 0 International License Royal Society Terms conditions and policies Archived from the original on 25 September 2015 Retrieved 9 March 2016 a href Template Cite web html title Template Cite web cite web a CS1 maint unfit URL link MRC Harwell Timeline Medical Research Council Archived from the original on 24 September 2014 Mammalian Genome Editorial Board Springer Retrieved 14 August 2015 IMPC Steering Committee International Mouse Phenotyping Consortium Retrieved from https en wikipedia org w index php title Stephen D M Brown amp oldid 1188101797, wikipedia, wiki, book, books, library,

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