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Sex-hormonal agent

April 14, 2024

A sex-hormonal agent, also known as a sex-hormone receptor modulator, is a type of hormonal agent which specifically modulates the effects of sex hormones and of their biological targets, the sex hormone receptors. The sex hormones include androgens such as testosterone, estrogens such as estradiol, and progestogens such as progesterone.[1] Sex-hormonal agents may be either steroidal or nonsteroidal in chemical structure and may serve to either enhance, inhibit, or have mixed effects on the function of the sex hormone systems.[2]

Sex-hormonal agent
Drug class
Class identifiers
SynonymsSex-steroidal agent; Sex-hormone receptor modulator
UseHormone therapy; Antihormone therapy; Hormonal contraception
Biological targetAndrogen receptor; Estrogen receptor; Progesterone receptor
Chemical classSteroidal; Nonsteroidal
Legal status
In Wikidata

Sex-hormonal agents are used in medicine for a variety of purposes including hormone therapy (e.g., menopausal hormone therapy, androgen replacement therapy, transgender hormone therapy), antihormone therapy (e.g., androgen deprivation therapy, estrogen deprivation therapy), and hormonal contraception, among others.

Types and examples edit

Androgen receptor (AR) modulators edit

See also: Androgen receptor

Estrogen receptor (ER) modulators edit

See also: Estrogen receptor

Progesterone receptor (PR) modulators edit

See also: Progesterone receptor

Indirect sex-hormonal agents edit

Drugs that indirectly influence sex hormone systems, such as antigonadotropins like GnRH analogues and prolactin releasers (e.g., D2 receptor antagonists), progonadotropins like GnRH agonists, and steroidogenesis inhibitors like aromatase inhibitors and androgen synthesis inhibitors, are also sex-hormonal agents.

See also edit

References edit

  1. ^ Thomas L. Lemke; David A. Williams (2008). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 1266–1267. ISBN 978-0-7817-6879-5.
  2. ^ Judi Lindsley Nath (2006). Using Medical Terminology: A Practical Approach. Lippincott Williams & Wilkins. pp. 977–. ISBN 978-0-7817-4868-1.


April 14, 2024
hormonal, agent, hormonal, agent, also, known, hormone, receptor, modulator, type, hormonal, agent, which, specifically, modulates, effects, hormones, their, biological, targets, hormone, receptors, hormones, include, androgens, such, testosterone, estrogens, . A sex hormonal agent also known as a sex hormone receptor modulator is a type of hormonal agent which specifically modulates the effects of sex hormones and of their biological targets the sex hormone receptors The sex hormones include androgens such as testosterone estrogens such as estradiol and progestogens such as progesterone 1 Sex hormonal agents may be either steroidal or nonsteroidal in chemical structure and may serve to either enhance inhibit or have mixed effects on the function of the sex hormone systems 2 Sex hormonal agentDrug classClass identifiersSynonymsSex steroidal agent Sex hormone receptor modulatorUseHormone therapy Antihormone therapy Hormonal contraceptionBiological targetAndrogen receptor Estrogen receptor Progesterone receptorChemical classSteroidal NonsteroidalLegal statusIn WikidataSex hormonal agents are used in medicine for a variety of purposes including hormone therapy e g menopausal hormone therapy androgen replacement therapy transgender hormone therapy antihormone therapy e g androgen deprivation therapy estrogen deprivation therapy and hormonal contraception among others Types and examples editAndrogen receptor AR modulators edit See also Androgen receptor Androgens and anabolic steroids AR agonists Examples testosterone androstanolone dihydrotestosterone prasterone dehydroepiandrosterone nandrolone nortestosterone methyltestosterone metandienone methandrostenolone oxandrolone stanozolol danazol Selective androgen receptor modulators AR mixed agonists antagonists Examples enobosarm ostarine GTx 024 MK 2866 andarine GTx 007 Antiandrogens AR antagonists Examples cyproterone acetate chlormadinone acetate spironolactone flutamide bicalutamide enzalutamide apalutamideEstrogen receptor ER modulators edit See also Estrogen receptor Estrogens ER agonists Examples estradiol estrone estriol estetrol conjugated estrogens Premarin ethinylestradiol diethylstilbestrol stilbestrol chlorotrianisene Selective estrogen receptor modulators ER mixed agonists antagonists Examples tamoxifen clomifene cyclofenil raloxifene toremifene lasofoxifene ospemifene bazedoxifene Antiestrogens ER antagonists Examples fulvestrant ICI 164384 TAS 108 SR 16234 ZB716 fulvestrant 3 boronic acid ethamoxytriphetol MER 25 Progesterone receptor PR modulators edit See also Progesterone receptor Progestogens and progestins PR agonists Examples progesterone medroxyprogesterone acetate norethisterone norethindrone levonorgestrel drospirenone dydrogesterone Selective progesterone receptor modulators PR mixed agonists antagonists Examples mifepristone ulipristal acetate telapristone CDB 4124 vilaprisan BAY 1002670 Antiprogestogens PR antagonists Examples aglepristone onapristone ZK 89299 Indirect sex hormonal agents edit Drugs that indirectly influence sex hormone systems such as antigonadotropins like GnRH analogues and prolactin releasers e g D2 receptor antagonists progonadotropins like GnRH agonists and steroidogenesis inhibitors like aromatase inhibitors and androgen synthesis inhibitors are also sex hormonal agents See also editList of investigational sex hormonal agentsReferences edit Thomas L Lemke David A Williams 2008 Foye s Principles of Medicinal Chemistry Lippincott Williams amp Wilkins pp 1266 1267 ISBN 978 0 7817 6879 5 Judi Lindsley Nath 2006 Using Medical Terminology A Practical Approach Lippincott Williams amp Wilkins pp 977 ISBN 978 0 7817 4868 1 Retrieved from https en wikipedia org w index php title Sex hormonal agent amp oldid 1042305356, wikipedia, wiki, book, books, library,

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