Androgen synthesis inhibitor

March 11, 2023

An androgen synthesis inhibitor is a type of drug which inhibits the enzymatic synthesis of androgens, such as testosterone and dihydrotestosterone (DHT).^[1] They include:

CYP17A1 inhibitors (17α-hydroxylase/17,20-lyase inhibitors): inhibit the synthesis of androgens from pregnanes^[1]
3β-Hydroxysteroid dehydrogenase inhibitors (3β-HSD inhibitors): inhibit the conversion of weaker androgens such as dehydroepiandrosterone (DHEA) and androstenediol into more potent androgens like and testosterone
Cholesterol side-chain cleavage enzyme inhibitors (P450SCC/CYP11A1 inhibitors): inhibit the synthesis of pregnenolone from cholesterol, thereby inhibiting the synthesis of most steroid hormones (which are derived from pregnenolone) including androgens
17β-Hydroxysteroid dehydrogenase inhibitors (17β-HSD inhibitors): inhibit the interconversion of androgens, including the synthesis of testosterone from the less-potent androstenedione
5α-Reductase inhibitors (5α-RIs; SRD5A inhibitors): inhibit the conversion of testosterone into the more-potent DHT
Steroid sulfatase inhibitors (STS inhibitors): inhibit the conversion of inactive androgen sulfates into active androgens like testosterone

Inhibitors of cholesterol synthesis can also reduce androgen production by inhibiting cholesterol production.

Androgen synthesis inhibitors have medical applications in the treatment of benign prostatic hypertrophy, prostate cancer,^[1] androgenetic alopecia, hirsutism, precocious puberty, and hyperandrogenism, among other androgen-dependent conditions.

Because androgens are the endogenous precursors of estrogens, androgen synthesis inhibitors also function as estrogen synthesis inhibitors and can reduce estrogen production and levels.

See also

References

^ ^a ^b ^c Stein MN, Patel N, Bershadskiy A, Sokoloff A, Singer EA (2014). "Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer". Asian J Androl. 16 (3): 387–400. doi:10.4103/1008-682X.129133. PMC 4023364. PMID 24759590.

March 11, 2023

androgen, synthesis, inhibitor, androgen, synthesis, inhibitor, type, drug, which, inhibits, enzymatic, synthesis, androgens, such, testosterone, dihydrotestosterone, they, include, cyp17a1, inhibitors, 17α, hydroxylase, lyase, inhibitors, inhibit, synthesis, . An androgen synthesis inhibitor is a type of drug which inhibits the enzymatic synthesis of androgens such as testosterone and dihydrotestosterone DHT 1 They include CYP17A1 inhibitors 17a hydroxylase 17 20 lyase inhibitors inhibit the synthesis of androgens from pregnanes 1 3b Hydroxysteroid dehydrogenase inhibitors 3b HSD inhibitors inhibit the conversion of weaker androgens such as dehydroepiandrosterone DHEA and androstenediol into more potent androgens like and testosterone Cholesterol side chain cleavage enzyme inhibitors P450SCC CYP11A1 inhibitors inhibit the synthesis of pregnenolone from cholesterol thereby inhibiting the synthesis of most steroid hormones which are derived from pregnenolone including androgens 17b Hydroxysteroid dehydrogenase inhibitors 17b HSD inhibitors inhibit the interconversion of androgens including the synthesis of testosterone from the less potent androstenedione 5a Reductase inhibitors 5a RIs SRD5A inhibitors inhibit the conversion of testosterone into the more potent DHT Steroid sulfatase inhibitors STS inhibitors inhibit the conversion of inactive androgen sulfates into active androgens like testosteroneInhibitors of cholesterol synthesis can also reduce androgen production by inhibiting cholesterol production Androgen synthesis inhibitors have medical applications in the treatment of benign prostatic hypertrophy prostate cancer 1 androgenetic alopecia hirsutism precocious puberty and hyperandrogenism among other androgen dependent conditions Because androgens are the endogenous precursors of estrogens androgen synthesis inhibitors also function as estrogen synthesis inhibitors and can reduce estrogen production and levels See also EditAntiandrogen Androgen synthesis inhibitors Steroidogenesis inhibitor Progesterone synthesis inhibitor Estrogen synthesis inhibitorReferences Edit a b c Stein MN Patel N Bershadskiy A Sokoloff A Singer EA 2014 Androgen synthesis inhibitors in the treatment of castration resistant prostate cancer Asian J Androl 16 3 387 400 doi 10 4103 1008 682X 129133 PMC 4023364 PMID 24759590 Retrieved from https en wikipedia org w index php title Androgen synthesis inhibitor amp oldid 1135428005, wikipedia, wiki, book, books, library,

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