Semenogelin-1 is a protein that in humans is encoded by the SEMG1gene.[3][4][5] The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000124233 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lilja H, Abrahamsson PA, Lundwall A (Mar 1989). "Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa". J Biol Chem. 264 (3): 1894–900. doi:10.1016/S0021-9258(18)94272-9. PMID 2912989.
^Jonsson M, Linse S, Frohm B, Lundwall A, Malm J (Apr 2005). "Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen". Biochem J. 387 (Pt 2): 447–53. doi:10.1042/BJ20041424. PMC1134973. PMID 15563730.
Robert M, Gagnon C (1999). "Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein". Cell. Mol. Life Sci. 55 (6–7): 944–60. doi:10.1007/s000180050346. PMID 10412373. S2CID 31516685.
Ulvsbäck M, Lazure C, Lilja H, et al. (1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20". J. Biol. Chem. 267 (25): 18080–4. doi:10.1016/S0021-9258(19)37155-8. PMID 1517240.
Schneider K, Kausler W, Tripier D, et al. (1989). "[Isolation and structure determination of two peptides occurring in human seminal plasma]". Biol. Chem. Hoppe-Seyler. 370 (4): 353–6. doi:10.1515/bchm3.1989.370.1.353. PMID 2757795.
Li CH, Hammonds RG, Ramasharma K, Chung D (1985). "Human seminal alpha inhibins: isolation, characterization, and structure". Proc. Natl. Acad. Sci. U.S.A. 82 (12): 4041–4. Bibcode:1985PNAS...82.4041L. doi:10.1073/pnas.82.12.4041. PMC397930. PMID 3889920.
Lilja H, Jeppsson JO (1985). "Amino acid sequence of the predominant basic protein in human seminal plasma". FEBS Lett. 182 (1): 181–4. doi:10.1016/0014-5793(85)81179-0. PMID 3972122. S2CID 31277428.
Ramasharma K, Sairam MR, Seidah NG, et al. (1984). "Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity". Science. 223 (4641): 1199–202. Bibcode:1984Sci...223.1199R. doi:10.1126/science.6422553. PMID 6422553.
Lilja H, Laurell CB, Jeppsson JO (1984). "Characterization of the predominant basic protein in human seminal plasma, one cleavage product of the major seminal vesicle protein". Scand. J. Clin. Lab. Invest. 44 (5): 439–46. doi:10.3109/00365518409083835. PMID 6484484.
Seidah NG, Ramasharma K, Sairam MR, Chrétien M (1984). "Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity". FEBS Lett. 167 (1): 98–102. doi:10.1016/0014-5793(84)80840-6. PMID 6698208. S2CID 27647296.
Khan Z, Smyth DG (1993). "Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen". Eur. J. Biochem. 212 (1): 35–40. doi:10.1111/j.1432-1033.1993.tb17629.x. PMID 8444163.
Lundwall A (1996). "The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA". Eur. J. Biochem. 235 (3): 466–70. doi:10.1111/j.1432-1033.1996.00466.x. PMID 8654389.
Malm J, Hellman J, Magnusson H, et al. (1996). "Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II". Eur. J. Biochem. 238 (1): 48–53. doi:10.1111/j.1432-1033.1996.0048q.x. PMID 8665951.
Bjartell A, Malm J, Moller C, et al. (1997). "Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry". J. Androl. 17 (1): 17–26. doi:10.1002/j.1939-4640.1996.tb00582.x. PMID 8833737. S2CID 20337870.
Robert M, Gibbs BF, Jacobson E, Gagnon C (1997). "Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I.". Biochemistry. 36 (13): 3811–9. doi:10.1021/bi9626158. PMID 9092810.
Peter A, Lilja H, Lundwall A, Malm J (1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase". Eur. J. Biochem. 252 (2): 216–21. doi:10.1046/j.1432-1327.1998.2520216.x. PMID 9523691.
Lövgren J, Airas K, Lilja H (1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". Eur. J. Biochem. 262 (3): 781–9. doi:10.1046/j.1432-1327.1999.00433.x. PMID 10411640.
Malm J, Hellman J, Hogg P, Lilja H (2000). "Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor". Prostate. 45 (2): 132–9. doi:10.1002/1097-0045(20001001)45:2<132::AID-PROS7>3.0.CO;2-3. PMID 11027412. S2CID 35309283.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Brillard-Bourdet M, Réhault S, Juliano L, et al. (2002). "Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates". Eur. J. Biochem. 269 (1): 390–5. doi:10.1046/j.0014-2956.2001.02667.x. PMID 11784334.
This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.
semenogelin, semenogelin, protein, that, humans, encoded, semg1, gene, protein, encoded, this, gene, predominant, protein, semen, encoded, secreted, protein, involved, formation, matrix, that, encases, ejaculated, spermatozoa, prostate, specific, antigen, prot. Semenogelin 1 is a protein that in humans is encoded by the SEMG1 gene 3 4 5 The protein encoded by this gene is the predominant protein in semen The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa The prostate specific antigen PSA protease processes this protein into smaller peptides with each possibly having a separate function The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely Two transcript variants encoding different isoforms have been found for this gene 5 SEMG1IdentifiersAliasesSEMG1 CT103 SEMG SGI dJ172H20 2 Semenogelin I semenogelin 1External IDsOMIM 182140 HomoloGene 130511 GeneCards SEMG1 OMA SEMG1 orthologsGene location Human Chr Chromosome 20 human 1 Band20q13 12Start45 207 033 bp 1 End45 209 768 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inseminal vesiculaspermprostategallbladderthymussynovial jointbloodislet of Langerhansurinary bladderpharynxn aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding metal ion binding zinc ion bindingCellular componentextracellular region extracellular exosome nucleus extracellular space protein containing complexBiological processnegative regulation of calcium ion import insemination antibacterial humoral response positive regulation of serine type endopeptidase activity protein heterooligomerization negative regulation of flagellated sperm motility antimicrobial humoral response coagulation sperm capacitationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6406n aEnsemblENSG00000124233n aUniProtP04279n aRefSeq mRNA NM 198139NM 003007n aRefSeq protein NP 002998n aLocation UCSC Chr 20 45 21 45 21 Mbn aPubMed search 2 n aWikidataView Edit HumanSee also editSemenogelinReferences edit a b c GRCh38 Ensembl release 89 ENSG00000124233 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lilja H Abrahamsson PA Lundwall A Mar 1989 Semenogelin the predominant protein in human semen Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa J Biol Chem 264 3 1894 900 doi 10 1016 S0021 9258 18 94272 9 PMID 2912989 Jonsson M Linse S Frohm B Lundwall A Malm J Apr 2005 Semenogelins I and II bind zinc and regulate the activity of prostate specific antigen Biochem J 387 Pt 2 447 53 doi 10 1042 BJ20041424 PMC 1134973 PMID 15563730 a b Entrez Gene SEMG1 semenogelin I Further reading editRobert M Gagnon C 1999 Semenogelin I a coagulum forming multifunctional seminal vesicle protein Cell Mol Life Sci 55 6 7 944 60 doi 10 1007 s000180050346 PMID 10412373 S2CID 31516685 Ulvsback M Lazure C Lilja H et al 1992 Gene structure of semenogelin I and II The predominant proteins in human semen are encoded by two homologous genes on chromosome 20 J Biol Chem 267 25 18080 4 doi 10 1016 S0021 9258 19 37155 8 PMID 1517240 Schneider K Kausler W Tripier D et al 1989 Isolation and structure determination of two peptides occurring in human seminal plasma Biol Chem Hoppe Seyler 370 4 353 6 doi 10 1515 bchm3 1989 370 1 353 PMID 2757795 Li CH Hammonds RG Ramasharma K Chung D 1985 Human seminal alpha inhibins isolation characterization and structure Proc Natl Acad Sci U S A 82 12 4041 4 Bibcode 1985PNAS 82 4041L doi 10 1073 pnas 82 12 4041 PMC 397930 PMID 3889920 Lilja H Jeppsson JO 1985 Amino acid sequence of the predominant basic protein in human seminal plasma FEBS Lett 182 1 181 4 doi 10 1016 0014 5793 85 81179 0 PMID 3972122 S2CID 31277428 Ramasharma K Sairam MR Seidah NG et al 1984 Isolation structure and synthesis of a human seminal plasma peptide with inhibin like activity Science 223 4641 1199 202 Bibcode 1984Sci 223 1199R doi 10 1126 science 6422553 PMID 6422553 Lilja H Laurell CB Jeppsson JO 1984 Characterization of the predominant basic protein in human seminal plasma one cleavage product of the major seminal vesicle protein Scand J Clin Lab Invest 44 5 439 46 doi 10 3109 00365518409083835 PMID 6484484 Seidah NG Ramasharma K Sairam MR Chretien M 1984 Partial amino acid sequence of a human seminal plasma peptide with inhibin like activity FEBS Lett 167 1 98 102 doi 10 1016 0014 5793 84 80840 6 PMID 6698208 S2CID 27647296 Khan Z Smyth DG 1993 Isolation and identification of N terminally extended forms of 5 oxoprolylglutamylprolinamide Glp Glu Pro NH2 a thyrotropin releasing hormone TRH like peptide present in human semen Eur J Biochem 212 1 35 40 doi 10 1111 j 1432 1033 1993 tb17629 x PMID 8444163 Lundwall A 1996 The structure of the semenogelin gene locus nucleotide sequence of the intergenic and the flanking DNA Eur J Biochem 235 3 466 70 doi 10 1111 j 1432 1033 1996 00466 x PMID 8654389 Malm J Hellman J Magnusson H et al 1996 Isolation and characterization of the major gel proteins in human semen semenogelin I and semenogelin II Eur J Biochem 238 1 48 53 doi 10 1111 j 1432 1033 1996 0048q x PMID 8665951 Bjartell A Malm J Moller C et al 1997 Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry J Androl 17 1 17 26 doi 10 1002 j 1939 4640 1996 tb00582 x PMID 8833737 S2CID 20337870 Robert M Gibbs BF Jacobson E Gagnon C 1997 Characterization of prostate specific antigen proteolytic activity on its major physiological substrate the sperm motility inhibitor precursor semenogelin I Biochemistry 36 13 3811 9 doi 10 1021 bi9626158 PMID 9092810 Peter A Lilja H Lundwall A Malm J 1998 Semenogelin I and semenogelin II the major gel forming proteins in human semen are substrates for transglutaminase Eur J Biochem 252 2 216 21 doi 10 1046 j 1432 1327 1998 2520216 x PMID 9523691 Lovgren J Airas K Lilja H 1999 Enzymatic action of human glandular kallikrein 2 hK2 Substrate specificity and regulation by Zn2 and extracellular protease inhibitors Eur J Biochem 262 3 781 9 doi 10 1046 j 1432 1327 1999 00433 x PMID 10411640 Malm J Hellman J Hogg P Lilja H 2000 Enzymatic action of prostate specific antigen PSA or hK3 substrate specificity and regulation by Zn 2 a tight binding inhibitor Prostate 45 2 132 9 doi 10 1002 1097 0045 20001001 45 2 lt 132 AID PROS7 gt 3 0 CO 2 3 PMID 11027412 S2CID 35309283 Deloukas P Matthews LH Ashurst J et al 2002 The DNA sequence and comparative analysis of human chromosome 20 Nature 414 6866 865 71 Bibcode 2001Natur 414 865D doi 10 1038 414865a PMID 11780052 Brillard Bourdet M Rehault S Juliano L et al 2002 Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin derived synthetic substrates Eur J Biochem 269 1 390 5 doi 10 1046 j 0014 2956 2001 02667 x PMID 11784334 nbsp This article on a gene on human chromosome 20 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Semenogelin I amp oldid 1191466478, wikipedia, wiki, book, books, library,
