Semenogelin is a protein that is involved in the formation of a gel matrix that encases ejaculated spermatozoa, preventing capacitation.[1] It blocks capacitation mainly via inhibition of reactive oxygen species (ROS) generation.[1]
Proteolysis by prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely.[2] The cleavage products of the semenogelins constitute the main antibacterial components in human seminal plasma.[3]
Semenogelin along with prostate-specific antigen, are commonly tested for during crime scene investigation.
Referencesedit
^ abde Lamirande E, Lamothe G (May 2010). "Levels of semenogelin in human spermatozoa decrease during capacitation: involvement of reactive oxygen species and zinc". Hum Reprod. 25 (7): 1619–1630. doi:10.1093/humrep/deq110. PMID 20501468.
^Edström, AM; Malm, J; Frohm, B; Martellini, JA; Giwercman, A; Mörgelin, M; Cole, AM; Sørensen, OE (Sep 1, 2008). "The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins". Journal of Immunology. 181 (5): 3413–21. doi:10.4049/jimmunol.181.5.3413. PMC2585754. PMID 18714013.
April 11, 2024
semenogelin, protein, that, involved, formation, matrix, that, encases, ejaculated, spermatozoa, preventing, capacitation, blocks, capacitation, mainly, inhibition, reactive, oxygen, species, generation, proteolysis, prostate, specific, antigen, breaks, down, . Semenogelin is a protein that is involved in the formation of a gel matrix that encases ejaculated spermatozoa preventing capacitation 1 It blocks capacitation mainly via inhibition of reactive oxygen species ROS generation 1 Proteolysis by prostate specific antigen PSA breaks down the gel matrix and allows the spermatozoa to move more freely 2 The cleavage products of the semenogelins constitute the main antibacterial components in human seminal plasma 3 There are two variants of the semenogelin protein semenogelin 1 and semenogelin 2 Semenogelin along with prostate specific antigen are commonly tested for during crime scene investigation References edit a b de Lamirande E Lamothe G May 2010 Levels of semenogelin in human spermatozoa decrease during capacitation involvement of reactive oxygen species and zinc Hum Reprod 25 7 1619 1630 doi 10 1093 humrep deq110 PMID 20501468 Entrez Gene SEMG2 semenogelin II Edstrom AM Malm J Frohm B Martellini JA Giwercman A Morgelin M Cole AM Sorensen OE Sep 1 2008 The major bactericidal activity of human seminal plasma is zinc dependent and derived from fragmentation of the semenogelins Journal of Immunology 181 5 3413 21 doi 10 4049 jimmunol 181 5 3413 PMC 2585754 PMID 18714013 Retrieved from https en wikipedia org w index php title Semenogelin amp oldid 1171071498, wikipedia, wiki, book, books, library,
