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Sabeeha Merchant

December 15, 2023

Sabeeha Sabanali Merchant (born 1959) is a professor of plant biology at the University of California, Berkeley. She studies the photosynthetic metabolism and metalloenzymes In 2010 Merchant led the team that sequenced the Chlamydomonas genome.[1][2] She was elected a member of the National Academy of Sciences in 2012.

Sabeeha Merchant
Born
Sabeeha Sabanali Merchant

(1959-08-31) August 31, 1959 (age 64)
Mumbai
Alma materUniversity of Wisconsin–Madison (PhD)
AwardsGilbert Morgan Smith Medal (2006)
Member of the National Academy of Sciences (2012)
Scientific career
InstitutionsUniversity of California, Berkeley
University of California, Los Angeles
ThesisThe Chlamydomonas reinhardi chloroplast coupling factor 1 : its purification, properties, and aspects of its synthesis in vivo (1983)
Websitewww.chem.ucla.edu/dept/Faculty/merchant

Early life and education edit

Merchant was born in Mumbai.[3] She was unsure what to specialise in, and took an aptitude test at the age of 12.[3] Merchant scored well in the science and the humanities, but was selected for the sciences as there were not enough girls in the class.[3] Merchant attended the J.B. Petit High School for Girls.[4] At the age of fifteen, Merchant started university at St. Xavier's College, where she was one of five women in a class of 300.[5] She relocated to the United States. She joined the University of Wisconsin–Madison in 1978 and became interested in the chemistry of living cells whilst working under the supervision of Glenn Chambliss.[3][5] Merchant majored in molecular biology and earned her bachelor's degree in 1979. She joined the Enzyme Institute to work as Henry A. Lardy's secretary, but he encouraged her to apply for graduate programs. She eventually earned her PhD at the University of Wisconsin–Madison in 1983.[6] She worked alongside Bruce Selman on the single-cell alga Chlamydomonas reinhardtii.[7] Chlamydomonas reinhardtii is a model organism as it can build the relevant systems for photosynthesis in the absence of light. During her doctorate Merchant purified chloroplast coupling factor 1, a component of the pathway that uses ATP synthase to synthesize adenosine triphosphate.

Research and career edit

After completing her PhD, Merchant joined Lawrence Bogorad at Harvard University.[8] She started working on light-regulated gene expression.[3] Unfortunately, four months into her postdoctoral research fellowship there was a fire in the laboratory.[3] During this time she began to read in the library, investigating role of metals in the regulation of photosynthetic electron transport in Chlamydomonas.[3] She studied how cells detect the levels of copper and developed antibodies.[3]

Merchant was the first to demonstrate that the RNA for Chlamydomonas reinhardtii plastocyanin is produced when copper is available.[3] She used pulse-chase analysis to show that whilst plastocyanin is continuously translated, it becomes degraded in systems without enough copper.[9] Merchant showed that the RNA of cytochrome c6, an iron-based protein, is only present in copper deficient cells.[10] She showed that chlamydomonas also contained cytochrome c6, which could step in during photosynthesis if needed.[3]

In 1987 Merchant moved to the University of California, Los Angeles (UCLA).[3] She works on metal nutrient deficiency, which requires water purification systems to generate water that is free of metal contaminants.[3] In her lab experiments are performed in rigorously cleaned glassware, using hydrochloric acid to remove surface metal ions.[3] Her early work considered signalling that responded to copper, but she has since expanded into iron sensing and the impact of iron deficiencies on photosynthesis. In an effort to understand copper sensing, she studied mutants that did not produce plastocyanin.[11] She discovered that the regulator for plastocyanin and cytochrome c regulation was CRR1 (Copper Response Regulator). She worked with Todd Yeates on the structure and genetics of plastocyanin and cytochrome c, uncovering the crystal structures of both proteins.[12][13] She was awarded the National Academy of Sciences Gilbert Morgan Smith Medal for her contributions to the assembly of metalloenzymes.[14] In 2007 she led a team that sequenced the Chlamydomonas genome.[15] Her inaugural article was published in PNAS in 2009.[16] She spent 2012 on a sabbatical at the Max Planck Institute of Molecular Plant Physiology.[17] She was appointed director of the Institute for Genomics and Proteomics at UCLA in 2014.[18] She also served on the Life Sciences jury for the Infosys Prize in 2017.

Merchant moved to the University of California, Berkeley in 2018.[19] At Berkeley, she is a Professor of Plant and Microbial Biology.[20] Her lab continue to investigate the metabolism of iron and copper, as well as comparative genomics of algae and bioenergy.[20]

Merchant has served as the editor-in-chief of the Annual Review of Plant Biology since 2005,[21] and was editor-in-chief of The Plant Cell from 2015-2019.[22]

Awards and honors edit

Her awards and honors include;

References edit

  1. ^ Merchant, Sabeeha (1998). Molecular Biology of Chlamydomonas: Chloroplasts and Mitochondria. Advances in Photosynthesis. Springer. ISBN 978-0-7923-5174-0
  2. ^ Sabeeha Merchant publications from Europe PubMed Central
  3. ^ a b c d e f g h i j k l m Davis, Tinsley H. (2015-03-03). "Profile of Sabeeha Merchant". Proceedings of the National Academy of Sciences. 112 (9): 2633–2634. Bibcode:2015PNAS..112.2633D. doi:10.1073/pnas.1500798112. ISSN 0027-8424. PMC 4352817. PMID 25675533.
  4. ^ "Indian-American scientist honoured by US". indiatimes.com. The Times of India. February 9, 2006. Retrieved 2019-05-23.
  5. ^ a b "MGM 2007". www.chem.uzh.ch. Retrieved 2019-05-23.
  6. ^ "Meet our new faculty: Sabeeha Merchant, biology". Berkeley News. 2018-11-26. Retrieved 2019-05-23.
  7. ^ "Merchant publications from Ph.D. thesis research". www.chem.ucla.edu. Retrieved 2019-05-23.
  8. ^ Merchant, Sabeeha. "Lawrence Bogorad 1921 - 2003: A Biographical Memoir" (PDF). NAS. Retrieved 2019-05-23.
  9. ^ "Studies on chloroplast development in Chlamydomonas reinhardtii IV. Control of rapid chlorophyll formation in greening y-1 cells". Plant and Cell Physiology. 1976. doi:10.1093/oxfordjournals.pcp.a075363. ISSN 1471-9053.
  10. ^ Merchant, S; Bogorad, L (1986). "Regulation by copper of the expression of plastocyanin and cytochrome c552 in Chlamydomonas reinhardi". Molecular and Cellular Biology. 6 (2): 462–9. doi:10.1128/mcb.6.2.462. OCLC 679283371. PMC 367534. PMID 3023849.
  11. ^ Merchant, S.; Bogorad, L. (1987). "Metal ion regulated gene expression: use of a plastocyanin-less mutant of Chlamydomonas reinhardtii to study the Cu(II)-dependent expression of cytochrome c-552". The EMBO Journal. 6 (9): 2531–2535. doi:10.1002/j.1460-2075.1987.tb02540.x. ISSN 0261-4189. PMC 553670. PMID 2824187.
  12. ^ Kerfeld, Cheryl A.; Anwar, Haroon P.; Interrante, Robert; Merchant, Sabeeha; Yeates, Todd O. (1995). "The Structure of Chloroplast Cytochromec6at 1.9 Å Resolution: Evidence for Functional Oligomerization". Journal of Molecular Biology. 250 (5): 627–647. doi:10.1006/jmbi.1995.0404. ISSN 0022-2836. PMID 7623381.
  13. ^ Redinbo, Matthew R.; Cascio, Duilio; Choukair, Marie K.; Rice, Danny; Merchant, Sabeeha; Yeates, Todd O. (1993-10-12). "The 1.5-.ANG. crystal structure of plastocyanin from the green alga Chlamydomonas reinhardtii". Biochemistry. 32 (40): 10560–10567. doi:10.1021/bi00091a005. ISSN 0006-2960. PMID 8399201.
  14. ^ a b "Gilbert Morgan Smith Medal". www.nasonline.org. Retrieved 2019-05-23.
  15. ^ Grossman, Arthur R.; Rokhsar, Daniel S.; Grigoriev, Igor V.; Zhou, Kemin; Werner, Gregory; Szajkowski, Lukasz; Porter, Aaron; Poliakov, Alexander; Otillar, Bobby (2007-10-12). "The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions". Science. 318 (5848): 245–250. Bibcode:2007Sci...318..245M. doi:10.1126/science.1143609. ISSN 0036-8075. PMC 2875087. PMID 17932292.
  16. ^ Merchant, S. S. (2009). "His protects heme as it crosses the membrane". Proceedings of the National Academy of Sciences. 106 (25): 10069–10070. Bibcode:2009PNAS..10610069M. doi:10.1073/pnas.0905189106. ISSN 0027-8424. PMC 2700887. PMID 19541628.
  17. ^ "Humboldt Research Award for Prof. Dr. Sabeeha Merchant". www.mpimp-golm.mpg.de. Retrieved 2019-05-23.
  18. ^ "Sabeeha Merchant appointed director, UCLA-Department of Energy Institute". UCLA. Retrieved 2019-05-23.
  19. ^ "Meet our new faculty: Sabeeha Merchant, biology". Berkeley News. 2018-11-26. Retrieved 2019-05-23.
  20. ^ a b "SMerchant | Department of Plant & Microbial Biology | UC Berkeley". plantandmicrobiology.berkeley.edu. Retrieved 2019-05-23.
  21. ^ Delmer, Deborah (2 June 2004). "Preface by the Editor". Annual Review of Plant Biology. 55 (1). doi:10.1146/annurev.pp.55.042204.100001. Retrieved 8 October 2021.
  22. ^ Salomé, Patrice A. (18 October 2019). "Sabeeha Merchant". The Plant Cell. 31 (12): 2814–2816. doi:10.1105/tpc.19.00817. ISSN 1040-4651. PMC 6925020. PMID 31628163. Retrieved 8 October 2021.
  23. ^ "Charles Albert Shull Award". ASPB. Retrieved 2019-05-23.
  24. ^ "California prof gets National Science Award". Rediff. Retrieved 2019-05-23.
  25. ^ "Newsroom". UCLA. Retrieved 2019-05-23.
  26. ^ "Fellow of ASPB". ASPB. Retrieved 2019-05-23.
  27. ^ "Charles F. Kettering Award". ASPB. Retrieved 2019-05-23.
  28. ^ "Humboldt Research Award for Prof. Dr. Sabeeha Merchant". www.mpimp-golm.mpg.de. Retrieved 2019-05-23.
  29. ^ "Sabeeha Merchant". www.nasonline.org. Retrieved 2019-05-23.
  30. ^ "Sabeeha Merchant receives 2012 Darbaker Prize in Phycology | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2019-05-23.
  31. ^ "Sabeeha Merchant elected to German National Academy of Sciences Leopoldina | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2019-05-23.
  32. ^ https://aspb.org/membership/aspb-pioneer-members/

December 15, 2023
sabeeha, merchant, sabeeha, sabanali, merchant, born, 1959, professor, plant, biology, university, california, berkeley, studies, photosynthetic, metabolism, metalloenzymes, 2010, merchant, team, that, sequenced, chlamydomonas, genome, elected, member, nationa. Sabeeha Sabanali Merchant born 1959 is a professor of plant biology at the University of California Berkeley She studies the photosynthetic metabolism and metalloenzymes In 2010 Merchant led the team that sequenced the Chlamydomonas genome 1 2 She was elected a member of the National Academy of Sciences in 2012 Sabeeha MerchantBornSabeeha Sabanali Merchant 1959 08 31 August 31 1959 age 64 MumbaiAlma materUniversity of Wisconsin Madison PhD AwardsGilbert Morgan Smith Medal 2006 Member of the National Academy of Sciences 2012 Scientific careerInstitutionsUniversity of California Berkeley University of California Los AngelesThesisThe Chlamydomonas reinhardi chloroplast coupling factor 1 its purification properties and aspects of its synthesis in vivo 1983 Websitewww wbr chem wbr ucla wbr edu wbr dept wbr Faculty wbr merchant Contents 1 Early life and education 2 Research and career 2 1 Awards and honors 3 ReferencesEarly life and education editMerchant was born in Mumbai 3 She was unsure what to specialise in and took an aptitude test at the age of 12 3 Merchant scored well in the science and the humanities but was selected for the sciences as there were not enough girls in the class 3 Merchant attended the J B Petit High School for Girls 4 At the age of fifteen Merchant started university at St Xavier s College where she was one of five women in a class of 300 5 She relocated to the United States She joined the University of Wisconsin Madison in 1978 and became interested in the chemistry of living cells whilst working under the supervision of Glenn Chambliss 3 5 Merchant majored in molecular biology and earned her bachelor s degree in 1979 She joined the Enzyme Institute to work as Henry A Lardy s secretary but he encouraged her to apply for graduate programs She eventually earned her PhD at the University of Wisconsin Madison in 1983 6 She worked alongside Bruce Selman on the single cell alga Chlamydomonas reinhardtii 7 Chlamydomonas reinhardtii is a model organism as it can build the relevant systems for photosynthesis in the absence of light During her doctorate Merchant purified chloroplast coupling factor 1 a component of the pathway that uses ATP synthase to synthesize adenosine triphosphate Research and career editAfter completing her PhD Merchant joined Lawrence Bogorad at Harvard University 8 She started working on light regulated gene expression 3 Unfortunately four months into her postdoctoral research fellowship there was a fire in the laboratory 3 During this time she began to read in the library investigating role of metals in the regulation of photosynthetic electron transport in Chlamydomonas 3 She studied how cells detect the levels of copper and developed antibodies 3 Merchant was the first to demonstrate that the RNA for Chlamydomonas reinhardtii plastocyanin is produced when copper is available 3 She used pulse chase analysis to show that whilst plastocyanin is continuously translated it becomes degraded in systems without enough copper 9 Merchant showed that the RNA of cytochrome c6 an iron based protein is only present in copper deficient cells 10 She showed that chlamydomonas also contained cytochrome c6 which could step in during photosynthesis if needed 3 In 1987 Merchant moved to the University of California Los Angeles UCLA 3 She works on metal nutrient deficiency which requires water purification systems to generate water that is free of metal contaminants 3 In her lab experiments are performed in rigorously cleaned glassware using hydrochloric acid to remove surface metal ions 3 Her early work considered signalling that responded to copper but she has since expanded into iron sensing and the impact of iron deficiencies on photosynthesis In an effort to understand copper sensing she studied mutants that did not produce plastocyanin 11 She discovered that the regulator for plastocyanin and cytochrome c regulation was CRR1 Copper Response Regulator She worked with Todd Yeates on the structure and genetics of plastocyanin and cytochrome c uncovering the crystal structures of both proteins 12 13 She was awarded the National Academy of Sciences Gilbert Morgan Smith Medal for her contributions to the assembly of metalloenzymes 14 In 2007 she led a team that sequenced the Chlamydomonas genome 15 Her inaugural article was published in PNAS in 2009 16 She spent 2012 on a sabbatical at the Max Planck Institute of Molecular Plant Physiology 17 She was appointed director of the Institute for Genomics and Proteomics at UCLA in 2014 18 She also served on the Life Sciences jury for the Infosys Prize in 2017 Merchant moved to the University of California Berkeley in 2018 19 At Berkeley she is a Professor of Plant and Microbial Biology 20 Her lab continue to investigate the metabolism of iron and copper as well as comparative genomics of algae and bioenergy 20 Merchant has served as the editor in chief of the Annual Review of Plant Biology since 2005 21 and was editor in chief of The Plant Cell from 2015 2019 22 Awards and honors edit Her awards and honors include 1999 American Society of Plant Biologists Charles Albert Shull Award 23 2004 University of California Los Angeles Herbert Newby McCoy Award 24 2005 Fellow of the American Association for the Advancement of Science 25 2008 Fellow of the American Society of Plant Biologists 26 2006 Gilbert Morgan Smith Medal 14 2010 American Society of Plant Biologists Charles F Kettering Award 27 2012 Alexander von Humboldt Foundation Humboldt Award 28 2012 Elected to the National Academy of Sciences 29 2012 Darbaker Prize Botanical Society of America 30 2014 Elected to the American Academy of Arts and Sciences 2016 Elected to the Academy of Sciences Leopoldina 31 Recognized as a Pioneer Member of the American Society of Plant Biologists 32 References edit Merchant Sabeeha 1998 Molecular Biology of Chlamydomonas Chloroplasts and Mitochondria Advances in Photosynthesis Springer ISBN 978 0 7923 5174 0 Sabeeha Merchant publications from Europe PubMed Central a b c d e f g h i j k l m Davis Tinsley H 2015 03 03 Profile of Sabeeha Merchant Proceedings of the National Academy of Sciences 112 9 2633 2634 Bibcode 2015PNAS 112 2633D doi 10 1073 pnas 1500798112 ISSN 0027 8424 PMC 4352817 PMID 25675533 Indian American scientist honoured by US indiatimes com The Times of India February 9 2006 Retrieved 2019 05 23 a b MGM 2007 www chem uzh ch Retrieved 2019 05 23 Meet our new faculty Sabeeha Merchant biology Berkeley News 2018 11 26 Retrieved 2019 05 23 Merchant publications from Ph D thesis research www chem ucla edu Retrieved 2019 05 23 Merchant Sabeeha Lawrence Bogorad 1921 2003 A Biographical Memoir PDF NAS Retrieved 2019 05 23 Studies on chloroplast development in Chlamydomonas reinhardtii IV Control of rapid chlorophyll formation in greening y 1 cells Plant and Cell Physiology 1976 doi 10 1093 oxfordjournals pcp a075363 ISSN 1471 9053 Merchant S Bogorad L 1986 Regulation by copper of the expression of plastocyanin and cytochrome c552 in Chlamydomonas reinhardi Molecular and Cellular Biology 6 2 462 9 doi 10 1128 mcb 6 2 462 OCLC 679283371 PMC 367534 PMID 3023849 Merchant S Bogorad L 1987 Metal ion regulated gene expression use of a plastocyanin less mutant of Chlamydomonas reinhardtii to study the Cu II dependent expression of cytochrome c 552 The EMBO Journal 6 9 2531 2535 doi 10 1002 j 1460 2075 1987 tb02540 x ISSN 0261 4189 PMC 553670 PMID 2824187 Kerfeld Cheryl A Anwar Haroon P Interrante Robert Merchant Sabeeha Yeates Todd O 1995 The Structure of Chloroplast Cytochromec6at 1 9 A Resolution Evidence for Functional Oligomerization Journal of Molecular Biology 250 5 627 647 doi 10 1006 jmbi 1995 0404 ISSN 0022 2836 PMID 7623381 Redinbo Matthew R Cascio Duilio Choukair Marie K Rice Danny Merchant Sabeeha Yeates Todd O 1993 10 12 The 1 5 ANG crystal structure of plastocyanin from the green alga Chlamydomonas reinhardtii Biochemistry 32 40 10560 10567 doi 10 1021 bi00091a005 ISSN 0006 2960 PMID 8399201 a b Gilbert Morgan Smith Medal www nasonline org Retrieved 2019 05 23 Grossman Arthur R Rokhsar Daniel S Grigoriev Igor V Zhou Kemin Werner Gregory Szajkowski Lukasz Porter Aaron Poliakov Alexander Otillar Bobby 2007 10 12 The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions Science 318 5848 245 250 Bibcode 2007Sci 318 245M doi 10 1126 science 1143609 ISSN 0036 8075 PMC 2875087 PMID 17932292 Merchant S S 2009 His protects heme as it crosses the membrane Proceedings of the National Academy of Sciences 106 25 10069 10070 Bibcode 2009PNAS 10610069M doi 10 1073 pnas 0905189106 ISSN 0027 8424 PMC 2700887 PMID 19541628 Humboldt Research Award for Prof Dr Sabeeha Merchant www mpimp golm mpg de Retrieved 2019 05 23 Sabeeha Merchant appointed director UCLA Department of Energy Institute UCLA Retrieved 2019 05 23 Meet our new faculty Sabeeha Merchant biology Berkeley News 2018 11 26 Retrieved 2019 05 23 a b SMerchant Department of Plant amp Microbial Biology UC Berkeley plantandmicrobiology berkeley edu Retrieved 2019 05 23 Delmer Deborah 2 June 2004 Preface by the Editor Annual Review of Plant Biology 55 1 doi 10 1146 annurev pp 55 042204 100001 Retrieved 8 October 2021 Salome Patrice A 18 October 2019 Sabeeha Merchant The Plant Cell 31 12 2814 2816 doi 10 1105 tpc 19 00817 ISSN 1040 4651 PMC 6925020 PMID 31628163 Retrieved 8 October 2021 Charles Albert Shull Award ASPB Retrieved 2019 05 23 California prof gets National Science Award Rediff Retrieved 2019 05 23 Newsroom UCLA Retrieved 2019 05 23 Fellow of ASPB ASPB Retrieved 2019 05 23 Charles F Kettering Award ASPB Retrieved 2019 05 23 Humboldt Research Award for Prof Dr Sabeeha Merchant www mpimp golm mpg de Retrieved 2019 05 23 Sabeeha Merchant www nasonline org Retrieved 2019 05 23 Sabeeha Merchant receives 2012 Darbaker Prize in Phycology UCLA Chemistry and Biochemistry www chemistry ucla edu Retrieved 2019 05 23 Sabeeha Merchant elected to German National Academy of Sciences Leopoldina UCLA Chemistry and Biochemistry www chemistry ucla edu Retrieved 2019 05 23 https aspb org membership aspb pioneer members Retrieved from https en wikipedia org w index php title Sabeeha Merchant amp oldid 1136141593, wikipedia, wiki, book, books, library,

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