This gene encodes a protein that contains a ubiquitin associated protein domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000154127 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032020 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Kikuno R, Ohara O (Feb 2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
^Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN (Oct 2002). "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein". Mol Cell Biol. 22 (21): 7491–500. doi:10.1128/MCB.22.21.7491-7500.2002. PMC135669. PMID 12370296.
^ ab"Entrez Gene: STS-1 Cbl-interacting protein Sts-1".
Further readingedit
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
Guo F, Sigua C, Bali P, et al. (2005). "Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells". Blood. 105 (3): 1246–55. doi:10.1182/blood-2004-05-2041. PMID 15388581.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130. S2CID 1324257.
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
gene, 1981, american, spaceflight, ubiquitin, associated, domain, containing, protein, protein, that, humans, encoded, ubash3b, gene, ubash3bavailable, structurespdbortholog, search, pdbe, rcsblist, codes2cpw, 2e5kidentifiersaliasesubash3b, sts1, tula, tula2, . For 1981 American spaceflight see STS 1 Ubiquitin associated and SH3 domain containing protein B is a protein that in humans is encoded by the UBASH3B gene 5 6 7 UBASH3BAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes2CPW 2E5KIdentifiersAliasesUBASH3B STS 1 STS1 TULA 2 p70 TULA2 ubiquitin associated and SH3 domain containing BExternal IDsOMIM 609201 MGI 1920078 HomoloGene 13152 GeneCards UBASH3BGene location Human Chr Chromosome 11 human 1 Band11q24 1Start122 655 722 bp 1 End122 814 473 bp 1 Gene location Mouse Chr Chromosome 9 mouse 2 Band9 9 A5 1Start40 922 394 bp 2 End41 072 993 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inponscerebellumcerebellar cortexcerebellar hemispherecerebellar vermisstromal cell of endometriumbloodspleenmonocytebone marrow cellsTop expressed intrigeminal ganglionsupraoptic nucleusotolith organutriclesecondary oocytecerebellar vermisfacial motor nucleusbloodpontine nucleilateral geniculate nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein tyrosine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity identical protein binding phosphoprotein binding ubiquitin protein ligase binding phosphatase activityCellular componentcytoplasm nucleusBiological processregulation of release of sequestered calcium ion into cytosol negative regulation of signal transduction peptidyl tyrosine dephosphorylation negative regulation of platelet aggregation regulation of osteoclast differentiation negative regulation of protein kinase activity negative regulation of osteoclast differentiation negative regulation of bone resorption platelet activation collagen activated tyrosine kinase receptor signaling pathway collagen activated signaling pathway platelet aggregation regulation of protein bindingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8495972828EnsemblENSG00000154127ENSMUSG00000032020UniProtQ8TF42Q8BGG7RefSeq mRNA NM 032873NM 001363365NM 176860NM 001357412RefSeq protein NP 116262NP 001350294NP 789830NP 001344341Location UCSC Chr 11 122 66 122 81 MbChr 9 40 92 41 07 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene encodes a protein that contains a ubiquitin associated protein domain at the N terminus an SH3 domain and a C terminal domain with similarities to the catalytic motif of phosphoglycerate mutase The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor EGFR and platelet derived growth factor receptor 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000154127 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000032020 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Nagase T Kikuno R Ohara O Feb 2002 Prediction of the coding sequences of unidentified human genes XXII The complete sequences of 50 new cDNA clones which code for large proteins DNA Res 8 6 319 27 doi 10 1093 dnares 8 6 319 PMID 11853319 Carpino N Kobayashi R Zang H Takahashi Y Jou ST Feng J Nakajima H Ihle JN Oct 2002 Identification cDNA cloning and targeted deletion of p70 a novel ubiquitously expressed SH3 domain containing protein Mol Cell Biol 22 21 7491 500 doi 10 1128 MCB 22 21 7491 7500 2002 PMC 135669 PMID 12370296 a b Entrez Gene STS 1 Cbl interacting protein Sts 1 Further reading editMaruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Bonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Gevaert K Goethals M Martens L et al 2004 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N terminal peptides Nat Biotechnol 21 5 566 9 doi 10 1038 nbt810 PMID 12665801 S2CID 23783563 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Kowanetz K Crosetto N Haglund K et al 2004 Suppressors of T cell receptor signaling Sts 1 and Sts 2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases J Biol Chem 279 31 32786 95 doi 10 1074 jbc M403759200 PMID 15159412 Guo F Sigua C Bali P et al 2005 Mechanistic role of heat shock protein 70 in Bcr Abl mediated resistance to apoptosis in human acute leukemia cells Blood 105 3 1246 55 doi 10 1182 blood 2004 05 2041 PMID 15388581 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Otsuki T Ota T Nishikawa T et al 2007 Signal sequence and keyword trap in silico for selection of full length human cDNAs encoding secretion or membrane proteins from oligo capped cDNA libraries DNA Res 12 2 117 26 doi 10 1093 dnares 12 2 117 PMID 16303743 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Hoeller D Crosetto N Blagoev B et al 2006 Regulation of ubiquitin binding proteins by monoubiquitination Nat Cell Biol 8 2 163 9 doi 10 1038 ncb1354 PMID 16429130 S2CID 1324257 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title STS 1 gene amp oldid 1115957565, wikipedia, wiki, book, books, library,
