SEMA4F

Semaphorin-4F is a protein that in humans is encoded by the SEMA4F gene.^[5][6]

SEMA4F
Identifiers
Aliases	SEMA4F, M-SEMA, PRO2353, S4F, SEMAM, SEMAW, m-Sema-M, ssemaphorin 4F
External IDs	OMIM: 603706; MGI: 1340055; HomoloGene: 3147; GeneCards: SEMA4F; OMA:SEMA4F - orthologs
Gene location (Human) Chr. Chromosome 2 (human)^[1] Band 2p13.1 Start 74,654,228 bp^[1] End 74,683,853 bp^[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)^[2] Band 6 C3|6 35.94 cM Start 82,888,866 bp^[2] End 82,916,750 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell middle temporal gyrus prefrontal cortex superior frontal gyrus sural nerve postcentral gyrus Brodmann area 23 Brodmann area 46 Brodmann area 9 spinal ganglia Top expressed in trigeminal ganglion substantia nigra ventromedial nucleus entorhinal cortex condyle primary motor cortex arcuate nucleus external carotid artery supraoptic nucleus pons More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropilin binding semaphorin receptor binding chemorepellent activity Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane endoplasmic reticulum extracellular space postsynaptic density cell junction dendrite cell projection perikaryon Biological process cell differentiation cell-cell signaling nervous system development axon guidance multicellular organism development negative regulation of axon extension retinal ganglion cell axon guidance negative chemotaxis neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10505 20355 Ensembl ENSG00000135622 ENSMUSG00000000627 UniProt O95754 Q9Z123 RefSeq (mRNA) NM_001271661 NM_001271662 NM_004263 NM_001113481 NM_011350 NM_001308374 RefSeq (protein) NP_001258590 NP_001258591 NP_004254 NP_001295303 NP_035480 Location (UCSC) Chr 2: 74.65 – 74.68 Mb Chr 6: 82.89 – 82.92 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000135622 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000627 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Encinas JA, Kikuchi K, Chedotal A, de Castro F, Goodman CS, Kimura T (March 1999). "Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2491–6. Bibcode:1999PNAS...96.2491E. doi:10.1073/pnas.96.5.2491. PMC 26812. PMID 10051670.
6. "Entrez Gene: SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F".

Further reading

• Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL (November 1998). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. doi:10.1016/S0896-6273(00)80625-X. PMID 9856463.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Schultze W, Eulenburg V, Lessmann V, Herrmann L, Dittmar T, Gundelfinger ED, Heumann R, Erdmann KS (August 2001). "Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95". Journal of Neurochemistry. 78 (3): 482–9. doi:10.1046/j.1471-4159.2001.00447.x. PMID 11483650.
• Francks C, Fisher SE, Olson RK, Pennington BF, Smith SD, DeFries JC, Monaco AP (March 2002). "Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1". Psychiatric Genetics. 12 (1): 35–41. doi:10.1097/00041444-200203000-00005. hdl:11858/00-001M-0000-0012-C9C5-5. PMID 11901358. S2CID 15050388.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.