^Gomes FV, Grace AA (April 2021). "Beyond Dopamine Receptor Antagonism: New Targets for Schizophrenia Treatment and Prevention". International Journal of Molecular Sciences. 22 (9): 4467. doi:10.3390/ijms22094467. PMC8123139. PMID 33922888.
^Clinical trial number NCT04512066 for "Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Effects of RO6889450 (Ralmitaront) in Patients With Schizophrenia or Schizoaffective Disorder and Negative Symptoms" at ClinicalTrials.gov
^Clinical trial number NCT03669640 for "A Trial of the Efficacy and the Safety of RO6889450 (Ralmitaront) vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder" at ClinicalTrials.gov
^"Ralmitaront: Relationships: Trace Amine-Associated Receptor 1". Global Substance Registration System (GSRS). U.S. Food and Drug Administration.
^Clinical trial number NCT02699372 for "The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of RO6889450 in Healthy Volunteers" at ClinicalTrials.gov
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.
ralmitaront, inntooltip, international, nonproprietary, name, usantooltip, united, states, adopted, name, developmental, code, names, 7906, 6889450, investigational, antipsychotic, drug, which, undergoing, clinical, trial, treatment, negative, symptoms, schizo. Ralmitaront INNTooltip International Nonproprietary Name USANTooltip United States Adopted Name developmental code names RG 7906 and RO 6889450 is an investigational antipsychotic drug which is undergoing a clinical trial for the treatment negative symptoms in schizophrenia and schizoaffective disorder 1 2 3 Another clinical trial targeting acute psychotic symptoms of schizophrenia has been terminated due to lack of efficacy 4 It is a partial agonist of the TAAR1 5 The medication is being developed by the pharmaceutical company Hoffmann La Roche 1 Ralmitaront had completed phase 1 clinical trials 1 6 RalmitarontClinical dataOther namesRG 7906 RO 6889450IdentifiersIUPAC name 5 Ethyl 4 methyl N 4 2S morpholin 2 yl phenyl 1H pyrazole 3 carboxamideCAS Number2133417 13 5PubChem CID130429734ChemSpider88298290UNIIQA8MW1Q80PKEGGD11830ChEMBLChEMBL4594376CompTox Dashboard EPA DTXSID901336976Chemical and physical dataFormulaC 17H 22N 4O 2Molar mass314 389 g mol 13D model JSmol Interactive imageSMILES CCC1 C C NN1 C O NC2 CC C C C2 C H 3CNCCO3 CInChI InChI 1S C17H22N4O2 c1 3 14 11 2 16 21 20 14 17 22 19 13 6 4 12 5 7 13 15 10 18 8 9 23 15 h4 7 15 18H 3 8 10H2 1 2H3 H 19 22 H 20 21 t15 m1 s1Key XHHXGKRFUPEPFM OAHLLOKOSA NSee also editList of investigational antipsychotics Monoamine receptor modulatorsReferences edit a b c Ralmitaront Roche AdisInsight Springer Nature Switzerland AG Gomes FV Grace AA April 2021 Beyond Dopamine Receptor Antagonism New Targets for Schizophrenia Treatment and Prevention International Journal of Molecular Sciences 22 9 4467 doi 10 3390 ijms22094467 PMC 8123139 PMID 33922888 Clinical trial number NCT04512066 for Phase 2 Randomized Double Blind Placebo Controlled Study to Assess the Effects of RO6889450 Ralmitaront in Patients With Schizophrenia or Schizoaffective Disorder and Negative Symptoms at ClinicalTrials gov Clinical trial number NCT03669640 for A Trial of the Efficacy and the Safety of RO6889450 Ralmitaront vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder at ClinicalTrials gov Ralmitaront Relationships Trace Amine Associated Receptor 1 Global Substance Registration System GSRS U S Food and Drug Administration Clinical trial number NCT02699372 for The Safety Tolerability Pharmacokinetics and Pharmacodynamics Study of RO6889450 in Healthy Volunteers at ClinicalTrials gov nbsp This drug article relating to the nervous system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Ralmitaront amp oldid 1188193148, wikipedia, wiki, book, books, library,
