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List of investigational antipsychotics

December 15, 2023

This is a list of investigational antipsychotics, or antipsychotics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Receptor modulators edit

Monoamine receptor modulators edit

  • Brilaroxazine (RP5063; oxaripiprazole) – atypical antipsychotic (D2/3/4 and 5-HT1A partial agonist and 5-HT2A/2B/7 antagonist)[1]
  • FKF-02SC (TGOF-02N) – atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions)[2]
  • Masupirdine (SUVN-502) – 5-HT6 receptor antagonist[3]
  • N-methyl amisulpride (LB-102) – D2,3, 5-HT7, receptor antagonists (methylated version of amisulpride)[4]
  • Ralmitaront (RG-7906, RO-6889450) – TAAR1 agonist[5]
  • Ulotaront (SEP-856, SEP-363856) – 5-HT1A receptor and TAAR1 agonist[6]
  • Usmarapride (SUVN-D4010) – 5-HT4 receptor partial agonist[7]

Glutamate receptor modulators edit

  • Pomaglumetad methionil (DB-103, LY-2140023, LY-2812223) – mGluR2 and mGluR3 agonist[8]

Acetylcholine receptor modulators edit

Cannabinoid receptor modulators edit

  • Cannabidiol (CBD; GW-42003, GWP-42003, GWP-42003-P, ECP-012A; Arvisol, Epidiolex) – cannabinoid receptor modulator, antioxidant, other actions[13][14]

Other/mixed receptor modulators edit

Enzyme inhibitors edit

Ion channel modulators edit

Others edit

  • TS-134 (TS-1341) – undefined mechanism of action[25]
  • Kratom – Has shown antipsychotic-like effects on par with haloperidol[26][27]

See also edit

References edit

  1. ^ "Brilaroxazine - Reviva Biopharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  2. ^ "FKF 02SC - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  3. ^ "Masupirdine - Suven Life Sciences - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  4. ^ "N-methyl amisulpride - LB pharmaceuticals - AdisInsight". adisinsight.springer.com. Retrieved 2023-02-21.
  5. ^ "Ralmitaront - AdisInsight". adisinsight.springer.com. Springer. Retrieved 10 July 2021.
  6. ^ "SEP 363856 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  7. ^ "SUVN D4010 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  8. ^ "Pomaglumetad methionil - Denovo Biopharma/Eli Lilly and Company - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  9. ^ "Emraclidine - Cerevel Therapeutics - AdisInsight". adisinsight.springer.com. Retrieved 2023-02-15.
  10. ^ "APN 1125 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  11. ^ "ML 007 - AdisInsight". adisinsight.springer.com. Retrieved 2023-02-15.
  12. ^ "HTL 0016878 - AdisInsight". adisinsight.springer.com. Retrieved 2023-02-21.
  13. ^ "Cannabidiol - GW Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  14. ^ "Cannabidiol - Echo Pharmaceuticals - AdisInsight". adisinsight.springer.com. Retrieved 14 February 2020.
  15. ^ "CVN 766 - AdisInsight". adisinsight.springer.com. Retrieved 2023-02-19.
  16. ^ "Deudextromethorphan - Avanir Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  17. ^ Nguyen, Linda; Thomas, Kelan L.; Lucke-Wold, Brandon P.; Cavendish, John Z.; Crowe, Molly S.; Matsumoto, Rae R. (March 2016). "Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders". Pharmacology & Therapeutics. 159: 1–22. doi:10.1016/j.pharmthera.2016.01.016. ISSN 1879-016X. PMID 26826604.
  18. ^ "Roluperidone - Minerva Neurosciences - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  19. ^ "TAK 041 - AdisInsight". adisinsight.springer.com. Retrieved 2023-02-21.
  20. ^ "Luvadaxistat - Takeda - AdisInsight". adisinsight.springer.com. Retrieved 2023-02-21.
  21. ^ "MK 8189 - AdisInsight". adisinsight.springer.com. Retrieved 2023-02-21.
  22. ^ "BI 409306 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  23. ^ "Sodium benzoate - SyneuRx - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  24. ^ "Evenamide - Newron Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  25. ^ "TS 134 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
  26. ^ Vijeepallam, K.; Pandy, V.; Kunasegaran, T.; Murugan, D. D.; Naidu, M. (2016). "Mitragyna speciosa Leaf Extract Exhibits Antipsychotic-Like Effect with the Potential to Alleviate Positive and Negative Symptoms of Psychosis in Mice". Frontiers in Pharmacology. 7: 464. doi:10.3389/fphar.2016.00464. PMC 5138496. PMID 27999544.
  27. ^ Johnson, L. E.; Balyan, L.; Magdalany, A.; Saeed, F.; Salinas, R.; Wallace, S.; Veltri, C. A.; Swogger, M. T.; Walsh, Z.; Grundmann, O. (2020). "The Potential for Kratom as an Antidepressant and Antipsychotic". The Yale Journal of Biology and Medicine. 93 (2): 283–289. PMC 7309668. PMID 32607089.

External links edit

  • AdisInsight – Springer
  • 2016 Medicines in Development for Mental Health – PhRMA

December 15, 2023
list, investigational, antipsychotics, this, list, investigational, antipsychotics, antipsychotics, that, currently, under, development, clinical, approved, chemical, generic, names, listed, first, with, developmental, code, names, synonyms, brand, names, pare. This is a list of investigational antipsychotics or antipsychotics that are currently under development for clinical use but are not yet approved Chemical generic names are listed first with developmental code names synonyms and brand names in parentheses Contents 1 Receptor modulators 1 1 Monoamine receptor modulators 1 2 Glutamate receptor modulators 1 3 Acetylcholine receptor modulators 1 4 Cannabinoid receptor modulators 1 5 Other mixed receptor modulators 2 Enzyme inhibitors 3 Ion channel modulators 4 Others 5 See also 6 References 7 External linksReceptor modulators editMonoamine receptor modulators edit Brilaroxazine RP5063 oxaripiprazole atypical antipsychotic D2 3 4 and 5 HT1A partial agonist and 5 HT2A 2B 7 antagonist 1 FKF 02SC TGOF 02N atypical antipsychotic D2 and 5 HT2A receptor antagonist other actions 2 Masupirdine SUVN 502 5 HT6 receptor antagonist 3 N methyl amisulpride LB 102 D2 3 5 HT7 receptor antagonists methylated version of amisulpride 4 Ralmitaront RG 7906 RO 6889450 TAAR1 agonist 5 Ulotaront SEP 856 SEP 363856 5 HT1A receptor and TAAR1 agonist 6 Usmarapride SUVN D4010 5 HT4 receptor partial agonist 7 Glutamate receptor modulators edit Pomaglumetad methionil DB 103 LY 2140023 LY 2812223 mGluR2 and mGluR3 agonist 8 Acetylcholine receptor modulators edit Emraclidine CVL 231 M4 muscarinic acetylcholine receptor positive allosteric modulator 9 KarXT xanomeline trospium combined M1 and M4 muscarinic acetylcholine receptor agonist and peripherally selective muscarinic acetylcholine receptor antagonist 10 ML 007 M1 and M4 muscarinic acetylcholine receptor agonist 11 NBI 1117568 HTL 0016878 M4 muscarinic acetylcholine receptor agonist 12 Cannabinoid receptor modulators edit Cannabidiol CBD GW 42003 GWP 42003 GWP 42003 P ECP 012A Arvisol Epidiolex cannabinoid receptor modulator antioxidant other actions 13 14 Other mixed receptor modulators edit CVN766 Orexin receptor type 1 antagonist 15 Deudextromethorphan d DM AVP 786 CTP 786 s1 receptor agonist serotonin norepinephrine reuptake inhibitor uncompetitive NMDA receptor antagonist muscarinic acetylcholine receptor agonist other actions 16 17 Roluperidone CYR 101 MIN 101 MT 210 5 HT2A and s2 receptor antagonist 18 TAK 041 NBI 1065846 GPR139 receptor agonist 19 Enzyme inhibitors editLuvadaxistat NBI 1065844 TAK 831 D amino acid oxidase inhibitor 20 MK 8189 phosphodiesterase 10A inhibitor 21 Osoresnontrine BI 409306 SUB 166499 phosphodiesterase 9A inhibitor 22 Sodium benzoate SND 11 SND 12 SND 13 SND 14 Clozaben NaBen D amino acid oxidase inhibitor 23 Ion channel modulators editEvenamide NW 3509 NW 3509A Nav1 3 Nav1 7 and Nav1 8 voltage gated sodium channel blocker 24 Others editTS 134 TS 1341 undefined mechanism of action 25 Kratom Has shown antipsychotic like effects on par with haloperidol 26 27 See also editList of investigational drugsReferences edit Brilaroxazine Reviva Biopharmaceuticals AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 FKF 02SC AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 Masupirdine Suven Life Sciences AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 N methyl amisulpride LB pharmaceuticals AdisInsight adisinsight springer com Retrieved 2023 02 21 Ralmitaront AdisInsight adisinsight springer com Springer Retrieved 10 July 2021 SEP 363856 AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 SUVN D4010 AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 Pomaglumetad methionil Denovo Biopharma Eli Lilly and Company AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 Emraclidine Cerevel Therapeutics AdisInsight adisinsight springer com Retrieved 2023 02 15 APN 1125 AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 ML 007 AdisInsight adisinsight springer com Retrieved 2023 02 15 HTL 0016878 AdisInsight adisinsight springer com Retrieved 2023 02 21 Cannabidiol GW Pharmaceuticals AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 Cannabidiol Echo Pharmaceuticals AdisInsight adisinsight springer com Retrieved 14 February 2020 CVN 766 AdisInsight adisinsight springer com Retrieved 2023 02 19 Deudextromethorphan Avanir Pharmaceuticals AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 Nguyen Linda Thomas Kelan L Lucke Wold Brandon P Cavendish John Z Crowe Molly S Matsumoto Rae R March 2016 Dextromethorphan An update on its utility for neurological and neuropsychiatric disorders Pharmacology amp Therapeutics 159 1 22 doi 10 1016 j pharmthera 2016 01 016 ISSN 1879 016X PMID 26826604 Roluperidone Minerva Neurosciences AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 TAK 041 AdisInsight adisinsight springer com Retrieved 2023 02 21 Luvadaxistat Takeda AdisInsight adisinsight springer com Retrieved 2023 02 21 MK 8189 AdisInsight adisinsight springer com Retrieved 2023 02 21 BI 409306 AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 Sodium benzoate SyneuRx AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 Evenamide Newron Pharmaceuticals AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 TS 134 AdisInsight adisinsight springer com Springer Retrieved 14 February 2020 Vijeepallam K Pandy V Kunasegaran T Murugan D D Naidu M 2016 Mitragyna speciosa Leaf Extract Exhibits Antipsychotic Like Effect with the Potential to Alleviate Positive and Negative Symptoms of Psychosis in Mice Frontiers in Pharmacology 7 464 doi 10 3389 fphar 2016 00464 PMC 5138496 PMID 27999544 Johnson L E Balyan L Magdalany A Saeed F Salinas R Wallace S Veltri C A Swogger M T Walsh Z Grundmann O 2020 The Potential for Kratom as an Antidepressant and Antipsychotic The Yale Journal of Biology and Medicine 93 2 283 289 PMC 7309668 PMID 32607089 External links editAdisInsight Springer 2016 Medicines in Development for Mental Health PhRMA Retrieved from https en wikipedia org w index php title List of investigational antipsychotics amp oldid 1189296002, wikipedia, wiki, book, books, library,

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