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Wikipedia

REL

January 01, 1970

For other uses, see REL (disambiguation).

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.[5] The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer.[6] c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.[7]

REL
Identifiers
AliasesREL, C-Rel, REL proto-oncogene, NF-kB subunit, HIVEN86A, IMD92
External IDsOMIM: 164910; MGI: 97897; HomoloGene: 2182; GeneCards: REL; OMA:REL - orthologs
Orthologs
SpeciesHumanMouse
Entrez

5966

19696

Ensembl

ENSG00000162924

ENSMUSG00000020275

UniProt

Q04864

P15307

RefSeq (mRNA)

NM_001291746
NM_002908

NM_009044

RefSeq (protein)

NP_001278675
NP_002899

NP_033070

Location (UCSC)Chr 2: 60.88 – 60.93 MbChr 11: 23.69 – 23.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162924 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020275 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.
  6. ^ Li T, Li X, Chen YH (May 2020). "c-Rel is a myeloid checkpoint for cancer immunotherapy". Nature Cancer. 1 (5): 507–517. doi:10.1038/s43018-020-0061-3. PMC 7808269. PMID 33458695.
  7. ^ Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (March 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene. 23 (13): 2275–86. doi:10.1038/sj.onc.1207410. PMID 14755244.

Further reading edit

  • Rayet B, Gélinas C (2000). "Aberrant rel/nfkb genes and activity in human cancer". Oncogene. 18 (49): 6938–47. doi:10.1038/sj.onc.1203221. PMID 10602468.
  • Kunsch C, Ruben SM, Rosen CA (1992). "Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation". Mol. Cell. Biol. 12 (10): 4412–21. doi:10.1128/mcb.12.10.4412. PMC 360365. PMID 1406630.
  • Neumann M, Tsapos K, Scheppler JA, et al. (1992). "Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B.". Oncogene. 7 (11): 2095–104. PMID 1437141.
  • Kochel T, Rice NR (1992). "v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro". Oncogene. 7 (3): 567–72. PMID 1549370.
  • Kumar S, Rabson AB, Gélinas C (1992). "The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein". Mol. Cell. Biol. 12 (7): 3094–106. doi:10.1128/mcb.12.7.3094. PMC 364524. PMID 1620118.
  • Lu D, Thompson JD, Gorski GK, et al. (1991). "Alterations at the rel locus in human lymphoma". Oncogene. 6 (7): 1235–41. PMID 1650444.
  • Muchardt C, Seeler JS, Nirula A, et al. (1992). "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products". J. Virol. 66 (1): 244–50. doi:10.1128/JVI.66.1.244-250.1992. PMC 238281. PMID 1727488.
  • Hansen SK, Nerlov C, Zabel U, et al. (1992). "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene". EMBO J. 11 (1): 205–13. doi:10.1002/j.1460-2075.1992.tb05043.x. PMC 556441. PMID 1740106.
  • Davis N, Ghosh S, Simmons DL, et al. (1991). "Rel-associated pp40: an inhibitor of the rel family of transcription factors". Science. 253 (5025): 1268–71. Bibcode:1991Sci...253.1268D. doi:10.1126/science.1891714. PMID 1891714.
  • Lim MY, Davis N, Zhang JY, Bose HR (1990). "The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70". Virology. 175 (1): 149–60. doi:10.1016/0042-6822(90)90195-W. PMID 2155506.
  • Brownell E, Mittereder N, Rice NR (1989). "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon". Oncogene. 4 (7): 935–42. PMID 2666912.
  • Brownell E, O'Brien SJ, Nash WG, Rice N (1986). "Genetic characterization of human c-rel sequences". Mol. Cell. Biol. 5 (10): 2826–31. doi:10.1128/mcb.5.10.2826. PMC 367021. PMID 3016517.
  • Brownell E, Kozak CA, Fowle JR, et al. (1986). "Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat". Am. J. Hum. Genet. 39 (2): 194–202. PMC 1683919. PMID 3529946.
  • John S, Reeves RB, Lin JX, et al. (1995). "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins". Mol. Cell. Biol. 15 (3): 1786–96. doi:10.1128/mcb.15.3.1786. PMC 230403. PMID 7862168.
  • Xu X, Gélinas C (1995). "The v-Rel oncoprotein complexes with new Rel- and RelA-related proteins in transformed cells". Virology. 207 (2): 362–8. doi:10.1006/viro.1995.1095. PMID 7886940.
  • Mackman N (1994). "Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers". J. Biol. Chem. 269 (42): 26363–7. doi:10.1016/S0021-9258(18)47202-X. PMID 7929355.
  • Sif S, Gilmore TD (1994). "Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1". J. Virol. 68 (11): 7131–8. doi:10.1128/JVI.68.11.7131-7138.1994. PMC 237152. PMID 7933095.
  • Hansen SK, Baeuerle PA, Blasi F (1994). "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription". Mol. Cell. Biol. 14 (4): 2593–603. doi:10.1128/mcb.14.4.2593. PMC 358627. PMID 8139561.
  • Beg AA, Baldwin AS (1994). "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor". Oncogene. 9 (5): 1487–92. PMID 8152812.

External links edit


 

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
other, uses, disambiguation, proto, oncogene, protein, that, humans, encoded, gene, protein, member, family, transcription, factors, contains, homology, domain, terminus, terminal, transactivation, domains, myeloid, checkpoint, protein, that, targeted, treatin. For other uses see REL disambiguation The proto oncogene c Rel is a protein that in humans is encoded by the REL gene 5 The c Rel protein is a member of the NF kB family of transcription factors and contains a Rel homology domain RHD at its N terminus and two C terminal transactivation domains c Rel is a myeloid checkpoint protein that can be targeted for treating cancer 6 c Rel has an important role in B cell survival and proliferation The REL gene is amplified or mutated in several human B cell lymphomas including diffuse large B cell lymphoma and Hodgkin s lymphoma 7 RELIdentifiersAliasesREL C Rel REL proto oncogene NF kB subunit HIVEN86A IMD92External IDsOMIM 164910 MGI 97897 HomoloGene 2182 GeneCards REL OMA REL orthologsGene location Human Chr Chromosome 2 human 1 Band2p16 1Start60 881 521 bp 1 End60 931 612 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 A3 2 11 14 36 cMStart23 686 847 bp 2 End23 720 970 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbone marrowsecondary oocytebone marrow cellsmonocytemucosa of urinary bladderhuman penissuperficial temporal arteryappendixnipplelower lobe of lungTop expressed inbloodspleenconjunctival fornixbone marrowsecondary oocytecumulus cellepidermissubcutaneous adipose tissuecorneahair follicleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionRNA polymerase II cis regulatory region sequence specific DNA binding DNA binding sequence specific DNA binding chromatin binding DNA binding transcription activator activity RNA polymerase II specific protein binding DNA binding transcription factor activity DNA binding transcription factor activity RNA polymerase II specific RNA polymerase II transcription regulatory region sequence specific DNA bindingCellular componentcytoplasm cytosol I kappaB NF kappaB complex transcription regulator complex nucleoplasm nucleusBiological processresponse to cytokine regulation of transcription DNA templated negative regulation of transcription by RNA polymerase II negative regulation of interferon beta production negative regulation of gene expression transcription DNA templated positive regulation of transcription DNA templated NIK NF kappaB signaling positive regulation of I kappaB kinase NF kappaB signaling innate immune response inflammatory response positive regulation of transcription by RNA polymerase II negative regulation of neuron death I kappaB kinase NF kappaB signaling transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez596619696EnsemblENSG00000162924ENSMUSG00000020275UniProtQ04864P15307RefSeq mRNA NM 001291746NM 002908NM 009044RefSeq protein NP 001278675NP 002899NP 033070Location UCSC Chr 2 60 88 60 93 MbChr 11 23 69 23 72 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000162924 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020275 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Ruben SM Klement JF Coleman TA Maher M Chen CH Rosen CA Jun 1992 I Rel a novel rel related protein that inhibits NF kappa B transcriptional activity Genes Dev 6 5 745 60 doi 10 1101 gad 6 5 745 PMID 1577270 Li T Li X Chen YH May 2020 c Rel is a myeloid checkpoint for cancer immunotherapy Nature Cancer 1 5 507 517 doi 10 1038 s43018 020 0061 3 PMC 7808269 PMID 33458695 Gilmore TD Kalaitzidis D Liang MC Starczynowski DT March 2004 The c Rel transcription factor and B cell proliferation a deal with the devil Oncogene 23 13 2275 86 doi 10 1038 sj onc 1207410 PMID 14755244 Further reading editRayet B Gelinas C 2000 Aberrant rel nfkb genes and activity in human cancer Oncogene 18 49 6938 47 doi 10 1038 sj onc 1203221 PMID 10602468 Kunsch C Ruben SM Rosen CA 1992 Selection of optimal kappa B Rel DNA binding motifs interaction of both subunits of NF kappa B with DNA is required for transcriptional activation Mol Cell Biol 12 10 4412 21 doi 10 1128 mcb 12 10 4412 PMC 360365 PMID 1406630 Neumann M Tsapos K Scheppler JA et al 1992 Identification of complex formation between two intracellular tyrosine kinase substrates human c Rel and the p105 precursor of p50 NF kappa B Oncogene 7 11 2095 104 PMID 1437141 Kochel T Rice NR 1992 v rel and c rel protein complexes bind to the NF kappa B site in vitro Oncogene 7 3 567 72 PMID 1549370 Kumar S Rabson AB Gelinas C 1992 The RxxRxRxxC motif conserved in all Rel kappa B proteins is essential for the DNA binding activity and redox regulation of the v Rel oncoprotein Mol Cell Biol 12 7 3094 106 doi 10 1128 mcb 12 7 3094 PMC 364524 PMID 1620118 Lu D Thompson JD Gorski GK et al 1991 Alterations at the rel locus in human lymphoma Oncogene 6 7 1235 41 PMID 1650444 Muchardt C Seeler JS Nirula A et al 1992 Regulation of human immunodeficiency virus enhancer function by PRDII BF1 and c rel gene products J Virol 66 1 244 50 doi 10 1128 JVI 66 1 244 250 1992 PMC 238281 PMID 1727488 Hansen SK Nerlov C Zabel U et al 1992 A novel complex between the p65 subunit of NF kappa B and c Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene EMBO J 11 1 205 13 doi 10 1002 j 1460 2075 1992 tb05043 x PMC 556441 PMID 1740106 Davis N Ghosh S Simmons DL et al 1991 Rel associated pp40 an inhibitor of the rel family of transcription factors Science 253 5025 1268 71 Bibcode 1991Sci 253 1268D doi 10 1126 science 1891714 PMID 1891714 Lim MY Davis N Zhang JY Bose HR 1990 The v rel oncogene product is complexed with cellular proteins including its proto oncogene product and heat shock protein 70 Virology 175 1 149 60 doi 10 1016 0042 6822 90 90195 W PMID 2155506 Brownell E Mittereder N Rice NR 1989 A human rel proto oncogene cDNA containing an Alu fragment as a potential coding exon Oncogene 4 7 935 42 PMID 2666912 Brownell E O Brien SJ Nash WG Rice N 1986 Genetic characterization of human c rel sequences Mol Cell Biol 5 10 2826 31 doi 10 1128 mcb 5 10 2826 PMC 367021 PMID 3016517 Brownell E Kozak CA Fowle JR et al 1986 Comparative genetic mapping of cellular rel sequences in man mouse and the domestic cat Am J Hum Genet 39 2 194 202 PMC 1683919 PMID 3529946 John S Reeves RB Lin JX et al 1995 Regulation of cell type specific interleukin 2 receptor alpha chain gene expression potential role of physical interactions between Elf 1 HMG I Y and NF kappa B family proteins Mol Cell Biol 15 3 1786 96 doi 10 1128 mcb 15 3 1786 PMC 230403 PMID 7862168 Xu X Gelinas C 1995 The v Rel oncoprotein complexes with new Rel and RelA related proteins in transformed cells Virology 207 2 362 8 doi 10 1006 viro 1995 1095 PMID 7886940 Mackman N 1994 Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c Rel p65 heterodimers J Biol Chem 269 42 26363 7 doi 10 1016 S0021 9258 18 47202 X PMID 7929355 Sif S Gilmore TD 1994 Interaction of the v Rel oncoprotein with cellular transcription factor Sp1 J Virol 68 11 7131 8 doi 10 1128 JVI 68 11 7131 7138 1994 PMC 237152 PMID 7933095 Hansen SK Baeuerle PA Blasi F 1994 Purification reconstitution and I kappa B association of the c Rel p65 RelA complex a strong activator of transcription Mol Cell Biol 14 4 2593 603 doi 10 1128 mcb 14 4 2593 PMC 358627 PMID 8139561 Beg AA Baldwin AS 1994 Activation of multiple NF kappa B Rel DNA binding complexes by tumor necrosis factor Oncogene 9 5 1487 92 PMID 8152812 External links editGenes rel at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title REL amp oldid 1115546495, wikipedia, wiki, book, books, library,

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