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Wikipedia

Pindobind

Pindobind is a compound developed by researchers associated with Stanford University,[1] identified as a central nervous system depressant,[2] which generated a response in animals reducing offensive actions such as chasing, while also notably reducing tendencies of the test animal to evade when stimulated to do so.[2] It acts as an irreversible beta blocker and irreversible 5-HT1A receptor antagonist.

Pindobind
Names
IUPAC name
2-Bromo-N-[4-(2-{[2-hydroxy-3-(1H-indol-4-yloxy)propyl]amino}-2-propanyl)-1-methylcyclohexyl]acetamide
Identifiers
  • 106469-52-7 Y
3D model (JSmol)
  • Interactive image
ChemSpider
  • 4661
  • 4827
  • DTXSID80910012
  • InChI=1S/C23H34BrN3O3/c1-22(2,16-7-10-23(3,11-8-16)27-21(29)13-24)26-14-17(28)15-30-20-6-4-5-19-18(20)9-12-25-19/h4-6,9,12,16-17,25-26,28H,7-8,10-11,13-15H2,1-3H3,(H,27,29)
    Key: XSAGAZCYTLNCEN-UHFFFAOYSA-N
  • InChI=1/C23H34BrN3O3/c1-22(2,16-7-10-23(3,11-8-16)27-21(29)13-24)26-14-17(28)15-30-20-6-4-5-19-18(20)9-12-25-19/h4-6,9,12,16-17,25-26,28H,7-8,10-11,13-15H2,1-3H3,(H,27,29)
    Key: XSAGAZCYTLNCEN-UHFFFAOYAL
  • BrCC(=O)NC1(C)CCC(CC1)C(NCC(O)COc2cccc3c2cc[nH]3)(C)C
Properties
C23H34BrN3O3
Molar mass 480.447 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

See also edit

References edit

  1. ^ Peroutka, Stephen J.; Pitha, Josef (Jul 20, 1993), Method for relieving anxiety using 5-hydroxytryptamine-1a-receptor-binding compounds, retrieved 2016-06-04
  2. ^ a b Bell, R; Hobson, H (1993). "Effects of pindobind 5-hydroxytryptamine1A (5-HT1A), a novel and potent 5-HT1A antagonist, on social and agonistic behaviour in male albino mice". Pharmacology Biochemistry and Behavior. 46 (1): 67–72. doi:10.1016/0091-3057(93)90318-N. PMID 8255924.

pindobind, compound, developed, researchers, associated, with, stanford, university, identified, central, nervous, system, depressant, which, generated, response, animals, reducing, offensive, actions, such, chasing, while, also, notably, reducing, tendencies,. Pindobind is a compound developed by researchers associated with Stanford University 1 identified as a central nervous system depressant 2 which generated a response in animals reducing offensive actions such as chasing while also notably reducing tendencies of the test animal to evade when stimulated to do so 2 It acts as an irreversible beta blocker and irreversible 5 HT1A receptor antagonist Pindobind Names IUPAC name 2 Bromo N 4 2 2 hydroxy 3 1H indol 4 yloxy propyl amino 2 propanyl 1 methylcyclohexyl acetamide Identifiers CAS Number 106469 52 7 Y 3D model JSmol Interactive image ChemSpider 4661 PubChem CID 4827 CompTox Dashboard EPA DTXSID80910012 InChI InChI 1S C23H34BrN3O3 c1 22 2 16 7 10 23 3 11 8 16 27 21 29 13 24 26 14 17 28 15 30 20 6 4 5 19 18 20 9 12 25 19 h4 6 9 12 16 17 25 26 28H 7 8 10 11 13 15H2 1 3H3 H 27 29 Key XSAGAZCYTLNCEN UHFFFAOYSA NInChI 1 C23H34BrN3O3 c1 22 2 16 7 10 23 3 11 8 16 27 21 29 13 24 26 14 17 28 15 30 20 6 4 5 19 18 20 9 12 25 19 h4 6 9 12 16 17 25 26 28H 7 8 10 11 13 15H2 1 3H3 H 27 29 Key XSAGAZCYTLNCEN UHFFFAOYAL SMILES BrCC O NC1 C CCC CC1 C NCC O COc2cccc3c2cc nH 3 C C Properties Chemical formula C 23H 34Br N 3O 3 Molar mass 480 447 g mol 1 Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Infobox referencesSee also editPindolol PhenoxybenzamineReferences edit Peroutka Stephen J Pitha Josef Jul 20 1993 Method for relieving anxiety using 5 hydroxytryptamine 1a receptor binding compounds retrieved 2016 06 04 a b Bell R Hobson H 1993 Effects of pindobind 5 hydroxytryptamine1A 5 HT1A a novel and potent 5 HT1A antagonist on social and agonistic behaviour in male albino mice Pharmacology Biochemistry and Behavior 46 1 67 72 doi 10 1016 0091 3057 93 90318 N PMID 8255924 Retrieved from https en wikipedia org w index php title Pindobind amp oldid 1057887140, wikipedia, wiki, book, books, library,

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