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Photoimmunotherapy

January 01, 1970

Photoimmunotherapy (PIT) is an oncological treatment that combines photodynamic therapy of tumor with immunotherapy treatment. Combining photodynamic therapy with immunotherapy enhances the immunostimulating response and has synergistic effects for metastatic cancer treatment.[1][2][3]

Photoimmunotherapy
Specialtyoncology
[edit on Wikidata]

PIT is type of molecular targeted cancer therapy, which allows the selective destruction of cancer cells without any damage to normal tissues. It is a light-based cancer therapy, which was developed and pioneered by Professor Julia Levy and colleagues at the University of British Columbia, Canada, in 1983. [4] Professor Julia Levy's research has also been pivotal in the clinical approval of Visudyne and Photofrin. Over the last 35 years, PIT has been studied extensively in vitro and in vivo by numerous research teams all over the world. More recently, significant strides in PIT have been made by Professor Kobayashi and his colleagues at National Cancer Institute, Bethesda, Maryland.

Conventional photodynamic therapy (PDT) uses a non-specific photosensitizer which can be activated by a non-ionizing light to kill cancer cells. Photosensitizers are molecules that rapidly destroy cells though the production of reactive oxygen species (ROS) when exposed to light at specific wavelength.[5] However, this PDT treatment results in serious side effects because non-targeted photosensitizers are also taken up by normal tissues.

PIT treatment avoids the side effects problem through the creation of a targeted-photosensitizer, which involves two components: a monoclonal antibody (mAb) which recognizes specific proteins on the surface of cancer cells, and a non-targeted photosensitizer. Even though the new mAb-based photosensitizers are distributed throughout the body, it can be activated by light for targeted PIT only when bound to specific proteins on cancer cellular membrane.[6]

PIT has been previously published using a vast number of photosensitizers, such as porphyrins, chlorins and phthalocyanine dyes. The research team at Professor Kobayashi’s lab coupled anti-tumor antibodies targeting human epidermal growth factor receptors to a water soluble phthalocyanine dye, IRDye 700DX,[7] which is activated by near-infrared light. IRDye 700DX was chosen for its hydrophilicity and strong cytotoxicity induced upon association with the cellular membrane and subsequent activation.[6] A variety of cancers, such as breast and pancreatic cancers over-express epidermal growth factor receptors.[8] This new photosensitizing compound utilizing IRDye 700DX NHS Ester was referred to as "mAb-IR700 conjugates".

In Vitro studies showed that mAb-IR700 killed tumor cells seconds after the near-infrared light irradiation. There was also a positive correlation between the intensity of excitation light and percentage of cell death. Infrared light alone or mAb-IR700 conjugate alone did not cause any damage to normal cells. When tumor-xenografted mice were treated with mAb-IR700 and near-infrared light, significant tumor shrinkage was observed. With fractionated administration of mAB–IR700 conjugate followed by systematic repeated NIR light irradiation to the tumor, 80 percent of tumor cells were eradicated and the mice’s survival were significantly prolonged.[9] Based on the current hypothesis, cell death induced by PIT was caused by rapid expansion of local water upon the formation of holes in the membrane.

Another desirable feature of PIT using mAb-IR700 conjugate is that it also emits fluorescence light upon activation. Therefore before PIT, mAb-IR700 can be administered at a lower dosage to guide the application of excitation light to tumor tissues, further minimizing unnecessary light exposure to surrounding tissues.

PIT is a promising highly selective and clinically feasible therapeutic method for treatment of mAb-binding tumors with minimal off-target effects. For future directions, researchers are trying to conjugate a variety of other monoclonal antibodies to phthalocyanine, creating a highly flexible therapeutic platform.

See also edit

References edit

  1. ^ Wang C, Xu L, Liang C, Xiang J, Peng R, Liu Z (2014). "Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to inhibit cancer metastasis". Adv Mater. 26 (48): 8154–62. Bibcode:2014AdM....26.8154W. doi:10.1002/adma.201402996. PMID 25331930. S2CID 5421261.
  2. ^ Lin, Z; et al. (2015). "Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes". Sci Rep. 5: 11709. Bibcode:2015NatSR...511709L. doi:10.1038/srep11709. PMC 4485034. PMID 26122018.
  3. ^ Chen, Q; et al. (2016). "Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy". Nat Commun. 7: 13193. Bibcode:2016NatCo...713193C. doi:10.1038/ncomms13193. PMC 5078754. PMID 27767031.
  4. ^ Mew, Daphne; Chi-Kit Wat; G. H. Neil Towers; Julia Levy (March 1983). "Photoimmunotherapy: treatment of animal tumors with tumor-specific monoclonal antibody-hematoporphyrin conjugates". The Journal of Immunology. 130 (3): 1473–1477. doi:10.4049/jimmunol.130.3.1473. PMID 6185591. S2CID 7320471.
  5. ^ Park, S (May 2007). "Delivery of photosensitizers for photodynamic therapy". Korean J Gastroenterol. 49 (5): 300–313. PMID 17525518.
  6. ^ a b Mitsunaga, M; Ogawa, M; Kosaka, N; Rosenblum, L. T; Choyke, P. L; Kobayashi, H (2011). "Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules". Nature Medicine. 17 (12): 1685–1691. doi:10.1038/nm.2554. PMC 3233641. PMID 22057348.
  7. ^ Peng, Xinzhan; Daniel R. Draney; William M. Volcheck; Gregory R. Bashford; Donald T. Lamb; Daniel L. Grone; Yonghong Zhang; Craig M. Johnson (14 February 2006). Achilefu, Samuel; Bornhop, Darryl J; Raghavachari, Ramesh (eds.). "Phthalocyanine dye as an extremely photostable and highly fluorescent near-infrared labeling reagent". Proc. SPIE 6097, Optical Molecular Probes for Biomedical Applications, 60970E. Optical Molecular Probes for Biomedical Applications. 6097: 60970E. Bibcode:2006SPIE.6097..113P. doi:10.1117/12.669173. S2CID 98409379.
  8. ^ McKeage K, Perry CM., Trastuzumab: a review of its use in the treatment of metastatic breast cancer overexpressing HER2., Drugs. 2002;62(1):209-43.
  9. ^ Makoto Mitsunaga, Takahito Nakajima, Kohei Sano, Peter L. Choyke, and Hisataka Kobayashi, (2012) Near-infrared Theranostic Photoimmunotherapy (PIT): Repeated Exposure of Light Enhances the Effect of Immunoconjugate, Bioconjugate Chem., 2012, 23 (3), 604–609

Bibliography edit

  • Kobayashi, Hisataka. "Illuminating the cancer-targeting potential of near-infrared photoimmunotherapy."
  • Sato, Kazuhide; et al. (May 2014). "Photoimmunotherapy: comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor". Molecular Oncology. 8 (3): 620–632. doi:10.1016/j.molonc.2014.01.006. PMC 4004687. PMID 24508062.

External links edit

  • Technical information on IRDye 700DX NIR Dye
  • Hisataka Kobayashi, M.D., Ph.D.

January 01, 1970
photoimmunotherapy, oncological, treatment, that, combines, photodynamic, therapy, tumor, with, immunotherapy, treatment, combining, photodynamic, therapy, with, immunotherapy, enhances, immunostimulating, response, synergistic, effects, metastatic, cancer, tr. Photoimmunotherapy PIT is an oncological treatment that combines photodynamic therapy of tumor with immunotherapy treatment Combining photodynamic therapy with immunotherapy enhances the immunostimulating response and has synergistic effects for metastatic cancer treatment 1 2 3 PhotoimmunotherapySpecialtyoncology edit on Wikidata PIT is type of molecular targeted cancer therapy which allows the selective destruction of cancer cells without any damage to normal tissues It is a light based cancer therapy which was developed and pioneered by Professor Julia Levy and colleagues at the University of British Columbia Canada in 1983 4 Professor Julia Levy s research has also been pivotal in the clinical approval of Visudyne and Photofrin Over the last 35 years PIT has been studied extensively in vitro and in vivo by numerous research teams all over the world More recently significant strides in PIT have been made by Professor Kobayashi and his colleagues at National Cancer Institute Bethesda Maryland Conventional photodynamic therapy PDT uses a non specific photosensitizer which can be activated by a non ionizing light to kill cancer cells Photosensitizers are molecules that rapidly destroy cells though the production of reactive oxygen species ROS when exposed to light at specific wavelength 5 However this PDT treatment results in serious side effects because non targeted photosensitizers are also taken up by normal tissues PIT treatment avoids the side effects problem through the creation of a targeted photosensitizer which involves two components a monoclonal antibody mAb which recognizes specific proteins on the surface of cancer cells and a non targeted photosensitizer Even though the new mAb based photosensitizers are distributed throughout the body it can be activated by light for targeted PIT only when bound to specific proteins on cancer cellular membrane 6 PIT has been previously published using a vast number of photosensitizers such as porphyrins chlorins and phthalocyanine dyes The research team at Professor Kobayashi s lab coupled anti tumor antibodies targeting human epidermal growth factor receptors to a water soluble phthalocyanine dye IRDye 700DX 7 which is activated by near infrared light IRDye 700DX was chosen for its hydrophilicity and strong cytotoxicity induced upon association with the cellular membrane and subsequent activation 6 A variety of cancers such as breast and pancreatic cancers over express epidermal growth factor receptors 8 This new photosensitizing compound utilizing IRDye 700DX NHS Ester was referred to as mAb IR700 conjugates In Vitro studies showed that mAb IR700 killed tumor cells seconds after the near infrared light irradiation There was also a positive correlation between the intensity of excitation light and percentage of cell death Infrared light alone or mAb IR700 conjugate alone did not cause any damage to normal cells When tumor xenografted mice were treated with mAb IR700 and near infrared light significant tumor shrinkage was observed With fractionated administration of mAB IR700 conjugate followed by systematic repeated NIR light irradiation to the tumor 80 percent of tumor cells were eradicated and the mice s survival were significantly prolonged 9 Based on the current hypothesis cell death induced by PIT was caused by rapid expansion of local water upon the formation of holes in the membrane Another desirable feature of PIT using mAb IR700 conjugate is that it also emits fluorescence light upon activation Therefore before PIT mAb IR700 can be administered at a lower dosage to guide the application of excitation light to tumor tissues further minimizing unnecessary light exposure to surrounding tissues PIT is a promising highly selective and clinically feasible therapeutic method for treatment of mAb binding tumors with minimal off target effects For future directions researchers are trying to conjugate a variety of other monoclonal antibodies to phthalocyanine creating a highly flexible therapeutic platform Contents 1 See also 2 References 3 Bibliography 4 External linksSee also editCombinatorial ablation and immunotherapy CryoimmunotherapyReferences edit Wang C Xu L Liang C Xiang J Peng R Liu Z 2014 Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti CTLA 4 therapy to inhibit cancer metastasis Adv Mater 26 48 8154 62 Bibcode 2014AdM 26 8154W doi 10 1002 adma 201402996 PMID 25331930 S2CID 5421261 Lin Z et al 2015 Photothermal ablation of bone metastasis of breast cancer using PEGylated multi walled carbon nanotubes Sci Rep 5 11709 Bibcode 2015NatSR 511709L doi 10 1038 srep11709 PMC 4485034 PMID 26122018 Chen Q et al 2016 Photothermal therapy with immune adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy Nat Commun 7 13193 Bibcode 2016NatCo 713193C doi 10 1038 ncomms13193 PMC 5078754 PMID 27767031 Mew Daphne Chi Kit Wat G H Neil Towers Julia Levy March 1983 Photoimmunotherapy treatment of animal tumors with tumor specific monoclonal antibody hematoporphyrin conjugates The Journal of Immunology 130 3 1473 1477 doi 10 4049 jimmunol 130 3 1473 PMID 6185591 S2CID 7320471 Park S May 2007 Delivery of photosensitizers for photodynamic therapy Korean J Gastroenterol 49 5 300 313 PMID 17525518 a b Mitsunaga M Ogawa M Kosaka N Rosenblum L T Choyke P L Kobayashi H 2011 Cancer cell selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules Nature Medicine 17 12 1685 1691 doi 10 1038 nm 2554 PMC 3233641 PMID 22057348 Peng Xinzhan Daniel R Draney William M Volcheck Gregory R Bashford Donald T Lamb Daniel L Grone Yonghong Zhang Craig M Johnson 14 February 2006 Achilefu Samuel Bornhop Darryl J Raghavachari Ramesh eds Phthalocyanine dye as an extremely photostable and highly fluorescent near infrared labeling reagent Proc SPIE 6097 Optical Molecular Probes for Biomedical Applications 60970E Optical Molecular Probes for Biomedical Applications 6097 60970E Bibcode 2006SPIE 6097 113P doi 10 1117 12 669173 S2CID 98409379 McKeage K Perry CM Trastuzumab a review of its use in the treatment of metastatic breast cancer overexpressing HER2 Drugs 2002 62 1 209 43 Makoto Mitsunaga Takahito Nakajima Kohei Sano Peter L Choyke and Hisataka Kobayashi 2012 Near infrared Theranostic Photoimmunotherapy PIT Repeated Exposure of Light Enhances the Effect of Immunoconjugate Bioconjugate Chem 2012 23 3 604 609Bibliography editKobayashi Hisataka Illuminating the cancer targeting potential of near infrared photoimmunotherapy Sato Kazuhide et al May 2014 Photoimmunotherapy comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor Molecular Oncology 8 3 620 632 doi 10 1016 j molonc 2014 01 006 PMC 4004687 PMID 24508062 External links editTechnical information on IRDye 700DX NIR Dye Hisataka Kobayashi M D Ph D Retrieved from https en wikipedia org w index php title Photoimmunotherapy amp oldid 1174996312, wikipedia, wiki, book, books, library,

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