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Combinatorial ablation and immunotherapy

April 11, 2024

Combinatorial ablation and immunotherapy is an oncological treatment that combines various tumor-ablation techniques with immunotherapy treatment.[1][2][3][4] Combining ablation therapy of tumors with immunotherapy enhances the immunostimulating response and has synergistic effects for curative metastatic cancer treatment.[2][3] Various ablative techniques are utilized including cryoablation, radiofrequency ablation, laser ablation, photodynamic ablation, stereotactic radiation therapy, alpha-emitting radiation therapy, hyperthermia therapy, HIFU.[5][6][7][8][9] Thus, combinatorial ablation of tumors and immunotherapy is a way of achieving an autologous, in-vivo tumor lysate vaccine and treating metastatic disease.

Combinatorial ablation and immunotherapy
Specialtyoncology
[edit on Wikidata]

Mechanism of action edit

Take magnetic hyperthermia for example. By applying magnetic nanoparticle-mediated hyperthermia with a threshold of 43 °C in order not to damage surrounding normal tissues, a significant quantity of heat-shock proteins (HSP) is expressed within and around the tumor tissues, inducing tumor-specific immune responses. In vivo experiments have indicated that magnetic nanoparticle-mediated hyperthermia can induce the regression of not only a local tumor tissue exposed to heat, but also distant metastatic tumors unexposed to heat. Partially or entirely ablating primary or secondary metastatic tumors induces necrosis of tumor cells, resulting in the release of antigens and presentation of antigens to the immune system. The released tumor antigens help activate anti-tumor T cells, which can destroy remaining malignant cells in local and distant tumors. Combining immunotherapy (ie: checkpoint inhibitors, CAR-T cell therapy) and vaccine adjuvants (ie: interferon, saponin) with ablation synergizes the immune reaction, and can treat metastatic disease with curative intent.[3][10][11][12][13][14]

Ablation therapies edit

Various local ablation therapies exist to induce necrosis of tumor cells and release tumor antigens to stimulate an immunological response. These ablation therapies can be combined with a systemic immunotherapy:

  • Thermal ablation – local thermal ablation of tumor:
  • Ablation with alpha radiation therapy
    • A new type of ablation therapy that utilizes alpha radiation is now undergoing clinical trials for treatment of several types of solid tumors. Alpha particles are emitted from intratumorally-inserted seeds that have Ra-224 atoms fixed to their surface. When the radium decays, its short-lived daughter isotopes are released from the seeds by recoil energy, disperse in the tumor, and emit high energy alpha particles, which destroy the tumor. This therapy is called "Diffusing Alpha-emitting Radiation Therapy" or DaRT.[15][16]
  • Nanotechnology in thermal ablation and immunotherapy
    • Currently nanotechnologies has been continuously developed for cancer immunotherapy for their versatility in integration of therapeutic and diagnostic (or termed 'theranostic') multimodalities. For example, iron oxide nanoparticles can generate heat under alternating magnetic field (100 kHz to 1 MHz); and they can also be utilized as imaging contrast agents for magnetic resonance imaging (MRI) for visualizing and monitoring the generation, distribution and biological activities of iron oxide nanoparticles. Magnetic nanoparticles can be concentrated to the tumor site via externally applied magnetic field, which is also advantageous in minimizing dose-related side effects. Localized heat can also trigger release of certain anti-cancer immuno-therapeutics loading from the nano-scale cargos if the nanomaterials are heat-responsive. From biological aspect, local heating can in addition significantly increase the extravasation of nanoscale drug carriers from tumor vessels, which enhances the performance of anti-cancer drug delivery to target cancers.

See also edit

References edit

  1. ^ Dupuy; et al. (2014). "Thermal ablation of tumours: biological mechanisms and advances in therapy". Nature Reviews Cancer. 14 (3): 199–208. doi:10.1038/nrc3672. PMID 24561446. S2CID 9224039.
  2. ^ a b Mehta, Amol; Oklu, Rahmi; Sheth, Rahul A. (2015). "Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response?". Gastroenterology Research and Practice. 2016: 1–11. doi:10.1155/2016/9251375. PMC 4802022. PMID 27051417.
  3. ^ a b c "Immunotherapy could transform systemic power of locoregional IO treatments". 2016. from the original on 2020-12-01. Retrieved 2017-05-03.
  4. ^ Dranoff, Glenn (2016). Cancer Immunology and Immunotherapy. Springer. p. 218. ISBN 9783642141362. from the original on 2021-03-17. Retrieved 2021-10-18.
  5. ^ Prof. Yona Keisari. "Development of Cancer Treatments Integrating Radiotherapy or Electrochemical Ablation and Immunotherapy". from the original on 2018-03-17. Retrieved 2017-05-03.
  6. ^ Ito, A; Tanaka, K; Kondo, K; Shinkai, M; Honda, H; Matsumoto, K; Saida, T; Kobayashi, T (2003). "Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma". Cancer Science. 94 (3): 308–13. doi:10.1111/j.1349-7006.2003.tb01438.x. PMID 12824927.
  7. ^ Xiaoming Yang (2016). "Radiofrequency hyperthermia promotes the therapeutic effects on chemotherapeutic-resistant breast cancer when combined with heat shock protein promoter-controlled HSV-TK gene therapy: Toward imaging-guided interventional gene therapy". Oncotarget. 7 (40): 65042–65051. doi:10.18632/oncotarget.11346. PMC 5323137. PMID 27542255.
  8. ^ Braiden, V; Ohtsuru, A; Kawashita, Y; Miki, F; Sawada, T; Ito, M; Cao, Y; Kaneda, Y; Koji, T; Yamashita, S (2000). "Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter". Human Gene Therapy. 11 (18): 2453–63. doi:10.1089/10430340050207948. PMID 11119417.
  9. ^ Takeda, Tsutomu; Takeda, Takashi (2016). "Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia". Hyperthermic Oncology from Bench to Bedside. pp. 319–327. doi:10.1007/978-981-10-0719-4_30. ISBN 978-981-10-0717-0.
  10. ^ Zhu, Jun; Zhang, Yan; Zhang, Aili; He, Kun; Liu, Ping; Xu, Lisa X. (2015). "Cryo-thermal therapy elicits potent anti-tumor immunity". Scientific Reports. 6 (1): 27136. doi:10.1038/srep27136. PMC 4891716. PMID 27256519.
  11. ^ Cryosurgery initiates inflammation and leaves tumor-specific antigens intact, which may induce an anti-tumor immune response.Sabel (2005). "Immunologic response to cryoablation of breast cancer". Gland Surg. 3 (2): 88–93. doi:10.3978/j.issn.2227-684X.2014.03.04. PMC 4115762. PMID 25083502.
  12. ^ Machlenkin, A.; Goldberger, O.; Tirosh, B.; Paz, A.; Volovitz, I.; Bar-Haim, E.; Lee, S. H.; Vadai, E.; Tzehoval, E.; Eisenbach, L. (2005). "Combined Dendritic Cell Cryotherapy of Tumor Induces Systemic Antimetastatic Immunity". Clinical Cancer Research. 11 (13): 4955–4961. doi:10.1158/1078-0432.CCR-04-2422. PMID 16000595. S2CID 15624452. from the original on 2019-08-06. Retrieved 2017-05-04.
  13. ^ Mehta, Amol; Oklu, Rahmi; Sheth, Rahul A. (2016). "Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response". Gastroenterol Res Pract. 2016: 1–11. doi:10.1155/2016/9251375. PMC 4802022. PMID 27051417.
  14. ^ Chatterjee, D. K.; Diagaradjane, P.; Krishnan, S. (2012). "Nanoparticle-mediated hyperthermia in cancer therapy". Therapeutic Delivery. 2 (8): 1001–1014. doi:10.4155/tde.11.72. PMC 3323111. PMID 22506095.
  15. ^ Arazi, Lior (2007). "Treatment of solid tumors by interstitial release of recoiling short-lived alpha-emitters". Phys. Med. Biol. 52 (16): 5025–5042. Bibcode:2007PMB....52.5025A. doi:10.1088/0031-9155/52/16/021. PMID 17671351. S2CID 1585204. Retrieved May 24, 2020.
  16. ^ Cooks, Tomer (2008). "Growth retardation and destruction of experimental squamous cell carcinoma by interstitial radioactive wires releasing diffusing alpha-emitting atoms". Int. J. Cancer. 122 (7): 1657–1664. doi:10.1002/ijc.23268. PMID 18059026.

April 11, 2024
combinatorial, ablation, immunotherapy, oncological, treatment, that, combines, various, tumor, ablation, techniques, with, immunotherapy, treatment, combining, ablation, therapy, tumors, with, immunotherapy, enhances, immunostimulating, response, synergistic,. Combinatorial ablation and immunotherapy is an oncological treatment that combines various tumor ablation techniques with immunotherapy treatment 1 2 3 4 Combining ablation therapy of tumors with immunotherapy enhances the immunostimulating response and has synergistic effects for curative metastatic cancer treatment 2 3 Various ablative techniques are utilized including cryoablation radiofrequency ablation laser ablation photodynamic ablation stereotactic radiation therapy alpha emitting radiation therapy hyperthermia therapy HIFU 5 6 7 8 9 Thus combinatorial ablation of tumors and immunotherapy is a way of achieving an autologous in vivo tumor lysate vaccine and treating metastatic disease Combinatorial ablation and immunotherapySpecialtyoncology edit on Wikidata Contents 1 Mechanism of action 2 Ablation therapies 3 See also 4 ReferencesMechanism of action editTake magnetic hyperthermia for example By applying magnetic nanoparticle mediated hyperthermia with a threshold of 43 C in order not to damage surrounding normal tissues a significant quantity of heat shock proteins HSP is expressed within and around the tumor tissues inducing tumor specific immune responses In vivo experiments have indicated that magnetic nanoparticle mediated hyperthermia can induce the regression of not only a local tumor tissue exposed to heat but also distant metastatic tumors unexposed to heat Partially or entirely ablating primary or secondary metastatic tumors induces necrosis of tumor cells resulting in the release of antigens and presentation of antigens to the immune system The released tumor antigens help activate anti tumor T cells which can destroy remaining malignant cells in local and distant tumors Combining immunotherapy ie checkpoint inhibitors CAR T cell therapy and vaccine adjuvants ie interferon saponin with ablation synergizes the immune reaction and can treat metastatic disease with curative intent 3 10 11 12 13 14 Ablation therapies editVarious local ablation therapies exist to induce necrosis of tumor cells and release tumor antigens to stimulate an immunological response These ablation therapies can be combined with a systemic immunotherapy Thermal ablation local thermal ablation of tumor Cryoablation Radiofrequency ablation High intensity focused ultrasound ablation Laser ablation Photodynamic ablation Hyperthermia therapy Ablation with alpha radiation therapy A new type of ablation therapy that utilizes alpha radiation is now undergoing clinical trials for treatment of several types of solid tumors Alpha particles are emitted from intratumorally inserted seeds that have Ra 224 atoms fixed to their surface When the radium decays its short lived daughter isotopes are released from the seeds by recoil energy disperse in the tumor and emit high energy alpha particles which destroy the tumor This therapy is called Diffusing Alpha emitting Radiation Therapy or DaRT 15 16 Nanotechnology in thermal ablation and immunotherapy Currently nanotechnologies has been continuously developed for cancer immunotherapy for their versatility in integration of therapeutic and diagnostic or termed theranostic multimodalities For example iron oxide nanoparticles can generate heat under alternating magnetic field 100 kHz to 1 MHz and they can also be utilized as imaging contrast agents for magnetic resonance imaging MRI for visualizing and monitoring the generation distribution and biological activities of iron oxide nanoparticles Magnetic nanoparticles can be concentrated to the tumor site via externally applied magnetic field which is also advantageous in minimizing dose related side effects Localized heat can also trigger release of certain anti cancer immuno therapeutics loading from the nano scale cargos if the nanomaterials are heat responsive From biological aspect local heating can in addition significantly increase the extravasation of nanoscale drug carriers from tumor vessels which enhances the performance of anti cancer drug delivery to target cancers See also editCryoimmunology PhotoimmunotherapyReferences edit Dupuy et al 2014 Thermal ablation of tumours biological mechanisms and advances in therapy Nature Reviews Cancer 14 3 199 208 doi 10 1038 nrc3672 PMID 24561446 S2CID 9224039 a b Mehta Amol Oklu Rahmi Sheth Rahul A 2015 Thermal Ablative Therapies and Immune Checkpoint Modulation Can Locoregional Approaches Effect a Systemic Response Gastroenterology Research and Practice 2016 1 11 doi 10 1155 2016 9251375 PMC 4802022 PMID 27051417 a b c Immunotherapy could transform systemic power of locoregional IO treatments 2016 Archived from the original on 2020 12 01 Retrieved 2017 05 03 Dranoff Glenn 2016 Cancer Immunology and Immunotherapy Springer p 218 ISBN 9783642141362 Archived from the original on 2021 03 17 Retrieved 2021 10 18 Prof Yona Keisari Development of Cancer Treatments Integrating Radiotherapy or Electrochemical Ablation and Immunotherapy Archived from the original on 2018 03 17 Retrieved 2017 05 03 Ito A Tanaka K Kondo K Shinkai M Honda H Matsumoto K Saida T Kobayashi T 2003 Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma Cancer Science 94 3 308 13 doi 10 1111 j 1349 7006 2003 tb01438 x PMID 12824927 Xiaoming Yang 2016 Radiofrequency hyperthermia promotes the therapeutic effects on chemotherapeutic resistant breast cancer when combined with heat shock protein promoter controlled HSV TK gene therapy Toward imaging guided interventional gene therapy Oncotarget 7 40 65042 65051 doi 10 18632 oncotarget 11346 PMC 5323137 PMID 27542255 Braiden V Ohtsuru A Kawashita Y Miki F Sawada T Ito M Cao Y Kaneda Y Koji T Yamashita S 2000 Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter Human Gene Therapy 11 18 2453 63 doi 10 1089 10430340050207948 PMID 11119417 Takeda Tsutomu Takeda Takashi 2016 Combination by Hyperthermia and Immunotherapy DC Therapy and Hyperthermia Hyperthermic Oncology from Bench to Bedside pp 319 327 doi 10 1007 978 981 10 0719 4 30 ISBN 978 981 10 0717 0 Zhu Jun Zhang Yan Zhang Aili He Kun Liu Ping Xu Lisa X 2015 Cryo thermal therapy elicits potent anti tumor immunity Scientific Reports 6 1 27136 doi 10 1038 srep27136 PMC 4891716 PMID 27256519 Cryosurgery initiates inflammation and leaves tumor specific antigens intact which may induce an anti tumor immune response Sabel 2005 Immunologic response to cryoablation of breast cancer Gland Surg 3 2 88 93 doi 10 3978 j issn 2227 684X 2014 03 04 PMC 4115762 PMID 25083502 Machlenkin A Goldberger O Tirosh B Paz A Volovitz I Bar Haim E Lee S H Vadai E Tzehoval E Eisenbach L 2005 Combined Dendritic Cell Cryotherapy of Tumor Induces Systemic Antimetastatic Immunity Clinical Cancer Research 11 13 4955 4961 doi 10 1158 1078 0432 CCR 04 2422 PMID 16000595 S2CID 15624452 Archived from the original on 2019 08 06 Retrieved 2017 05 04 Mehta Amol Oklu Rahmi Sheth Rahul A 2016 Thermal Ablative Therapies and Immune Checkpoint Modulation Can Locoregional Approaches Effect a Systemic Response Gastroenterol Res Pract 2016 1 11 doi 10 1155 2016 9251375 PMC 4802022 PMID 27051417 Chatterjee D K Diagaradjane P Krishnan S 2012 Nanoparticle mediated hyperthermia in cancer therapy Therapeutic Delivery 2 8 1001 1014 doi 10 4155 tde 11 72 PMC 3323111 PMID 22506095 Arazi Lior 2007 Treatment of solid tumors by interstitial release of recoiling short lived alpha emitters Phys Med Biol 52 16 5025 5042 Bibcode 2007PMB 52 5025A doi 10 1088 0031 9155 52 16 021 PMID 17671351 S2CID 1585204 Retrieved May 24 2020 Cooks Tomer 2008 Growth retardation and destruction of experimental squamous cell carcinoma by interstitial radioactive wires releasing diffusing alpha emitting atoms Int J Cancer 122 7 1657 1664 doi 10 1002 ijc 23268 PMID 18059026 Retrieved from https en wikipedia org w index php title Combinatorial ablation and immunotherapy amp 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